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Found 847 with Last Name = 'brandl' and Initial = 't'
TargetPlasma kallikrein(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM212110(US9290485, 142)
Affinity DataIC50:  0.0224nMpH: 7.8 T: 2°CAssay Description:Enzymatic reactions were conducted in ⿿assay buffer⿿, comprising 50 mM Hepes/NaOH at pH 7.8, 150 mM NaCl, 1 mM EDTA and 0.05% (w/v) CHAPS. For th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM212116(US9290485, 148)
Affinity DataIC50:  0.0300nMpH: 7.8 T: 2°CAssay Description:Enzymatic reactions were conducted in ⿿assay buffer⿿, comprising 50 mM Hepes/NaOH at pH 7.8, 150 mM NaCl, 1 mM EDTA and 0.05% (w/v) CHAPS. For th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM212114(US9290485, 146)
Affinity DataIC50:  0.0400nMpH: 7.8 T: 2°CAssay Description:Enzymatic reactions were conducted in ⿿assay buffer⿿, comprising 50 mM Hepes/NaOH at pH 7.8, 150 mM NaCl, 1 mM EDTA and 0.05% (w/v) CHAPS. For th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM211977(US9290485, 9)
Affinity DataIC50:  0.0912nMpH: 7.8 T: 2°CAssay Description:Enzymatic reactions were conducted in ⿿assay buffer⿿, comprising 50 mM Hepes/NaOH at pH 7.8, 150 mM NaCl, 1 mM EDTA and 0.05% (w/v) CHAPS. For th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM212115(US9290485, 147)
Affinity DataIC50:  0.100nMpH: 7.8 T: 2°CAssay Description:Enzymatic reactions were conducted in ⿿assay buffer⿿, comprising 50 mM Hepes/NaOH at pH 7.8, 150 mM NaCl, 1 mM EDTA and 0.05% (w/v) CHAPS. For th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM212136(US9290485, 168)
Affinity DataIC50:  0.100nMpH: 7.8 T: 2°CAssay Description:Enzymatic reactions were conducted in ⿿assay buffer⿿, comprising 50 mM Hepes/NaOH at pH 7.8, 150 mM NaCl, 1 mM EDTA and 0.05% (w/v) CHAPS. For th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM212004(US9290485, 36)
Affinity DataIC50:  0.134nMpH: 7.8 T: 2°CAssay Description:Enzymatic reactions were conducted in ⿿assay buffer⿿, comprising 50 mM Hepes/NaOH at pH 7.8, 150 mM NaCl, 1 mM EDTA and 0.05% (w/v) CHAPS. For th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM212135(US9290485, 167)
Affinity DataIC50:  0.200nMpH: 7.8 T: 2°CAssay Description:Enzymatic reactions were conducted in ⿿assay buffer⿿, comprising 50 mM Hepes/NaOH at pH 7.8, 150 mM NaCl, 1 mM EDTA and 0.05% (w/v) CHAPS. For th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM212134(US9290485, 166)
Affinity DataIC50:  0.200nMpH: 7.8 T: 2°CAssay Description:Enzymatic reactions were conducted in ⿿assay buffer⿿, comprising 50 mM Hepes/NaOH at pH 7.8, 150 mM NaCl, 1 mM EDTA and 0.05% (w/v) CHAPS. For th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM211974(US9290485, 6)
Affinity DataIC50:  0.200nMpH: 7.8 T: 2°CAssay Description:Enzymatic reactions were conducted in ⿿assay buffer⿿, comprising 50 mM Hepes/NaOH at pH 7.8, 150 mM NaCl, 1 mM EDTA and 0.05% (w/v) CHAPS. For th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM212113(US9290485, 145)
Affinity DataIC50:  0.200nMpH: 7.8 T: 2°CAssay Description:Enzymatic reactions were conducted in ⿿assay buffer⿿, comprising 50 mM Hepes/NaOH at pH 7.8, 150 mM NaCl, 1 mM EDTA and 0.05% (w/v) CHAPS. For th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Novartis

US Patent
LigandPNGBDBM196124(US9206232, 125)
Affinity DataIC50: <0.300nMAssay Description:The inhibitory activity of certain compounds of Table A against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus)
Novartis

US Patent
LigandPNGBDBM110357(US8613914, 125 | US9206232, 129)
Affinity DataIC50: <0.300nMAssay Description:The inhibitory activity of certain compounds against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length NS3-4A prot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM212141(US9290485, 173)
Affinity DataIC50:  0.400nMpH: 7.8 T: 2°CAssay Description:Enzymatic reactions were conducted in ⿿assay buffer⿿, comprising 50 mM Hepes/NaOH at pH 7.8, 150 mM NaCl, 1 mM EDTA and 0.05% (w/v) CHAPS. For th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Novartis

US Patent
LigandPNGBDBM110396(US8613914, 170 | US9206232, 170)
Affinity DataIC50:  0.5nMAssay Description:The inhibitory activity of certain compounds of Table A against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus)
Novartis

US Patent
LigandPNGBDBM110396(US8613914, 170 | US9206232, 170)
Affinity DataIC50:  0.5nMAssay Description:The inhibitory activity of certain compounds against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length NS3-4A prot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Novartis

US Patent
LigandPNGBDBM110400(US8613914, 174 | US9206232, 174)
Affinity DataIC50:  0.600nMAssay Description:The inhibitory activity of certain compounds of Table A against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus)
Novartis

US Patent
LigandPNGBDBM110400(US8613914, 174 | US9206232, 174)
Affinity DataIC50:  0.600nMAssay Description:The inhibitory activity of certain compounds against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length NS3-4A prot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus)
Novartis

US Patent
LigandPNGBDBM110393(US8613914, 167 | US9206232, 167)
Affinity DataIC50:  0.600nMAssay Description:The inhibitory activity of certain compounds against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length NS3-4A prot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Novartis

US Patent
LigandPNGBDBM110393(US8613914, 167 | US9206232, 167)
Affinity DataIC50:  0.600nMAssay Description:The inhibitory activity of certain compounds of Table A against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Novartis

US Patent
LigandPNGBDBM110388(US8613914, 162 | US9206232, 162)
Affinity DataIC50:  0.800nMAssay Description:The inhibitory activity of certain compounds of Table A against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Novartis

US Patent
LigandPNGBDBM110280(US8613914, 48 | US9206232, 48)
Affinity DataIC50:  0.900nMAssay Description:The inhibitory activity of certain compounds of Table A against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Novartis

US Patent
LigandPNGBDBM110273(US8613914, 41 | US9206232, 41)
Affinity DataIC50:  0.900nMAssay Description:The inhibitory activity of certain compounds of Table A against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Novartis

US Patent
LigandPNGBDBM110388(US8613914, 162 | US9206232, 162)
Affinity DataIC50:  0.900nMAssay Description:The inhibitory activity of certain compounds of Table A against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Novartis

US Patent
LigandPNGBDBM196120(US9206232, 77)
Affinity DataIC50:  0.900nMAssay Description:The inhibitory activity of certain compounds of Table A against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus)
Novartis

US Patent
LigandPNGBDBM110388(US8613914, 162 | US9206232, 162)
Affinity DataIC50:  0.900nMAssay Description:The inhibitory activity of certain compounds against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length NS3-4A prot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus)
Novartis

US Patent
LigandPNGBDBM110309(US8613914, 77)
Affinity DataIC50:  0.900nMAssay Description:The inhibitory activity of certain compounds against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length NS3-4A prot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus)
Novartis

US Patent
LigandPNGBDBM110280(US8613914, 48 | US9206232, 48)
Affinity DataIC50:  0.900nMAssay Description:The inhibitory activity of certain compounds against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length NS3-4A prot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus)
Novartis

US Patent
LigandPNGBDBM110273(US8613914, 41 | US9206232, 41)
Affinity DataIC50:  0.900nMAssay Description:The inhibitory activity of certain compounds against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length NS3-4A prot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM212124(US9290485, 156)
Affinity DataIC50:  0.920nMpH: 7.8 T: 2°CAssay Description:Enzymatic reactions were conducted in ⿿assay buffer⿿, comprising 50 mM Hepes/NaOH at pH 7.8, 150 mM NaCl, 1 mM EDTA and 0.05% (w/v) CHAPS. For th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50329791((Z)-3-((4-(N-(2-(dimethylamino)ethyl)methylsulfona...)
Affinity DataIC50:  1nMAssay Description:Inhibition of TGFbeta receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Novartis

US Patent
LigandPNGBDBM110294(US8613914, 62 | US9206232, 62)
Affinity DataIC50:  1nMAssay Description:The inhibitory activity of certain compounds against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length NS3-4A prot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus)
Novartis

US Patent
LigandPNGBDBM110277(US8613914, 45 | US9206232, 45)
Affinity DataIC50:  1nMAssay Description:The inhibitory activity of certain compounds against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length NS3-4A prot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus)
Novartis

US Patent
LigandPNGBDBM110264(US8613914, 32 | US9206232, 32)
Affinity DataIC50:  1nMAssay Description:The inhibitory activity of certain compounds against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length NS3-4A prot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus)
Novartis

US Patent
LigandPNGBDBM110397(US8613914, 171 | US9206232, 171)
Affinity DataIC50:  1nMAssay Description:The inhibitory activity of certain compounds against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length NS3-4A prot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus)
Novartis

US Patent
LigandPNGBDBM110383(US8613914, 157 | US9206232, 157)
Affinity DataIC50:  1nMAssay Description:The inhibitory activity of certain compounds against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length NS3-4A prot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Novartis

US Patent
LigandPNGBDBM110294(US8613914, 62 | US9206232, 62)
Affinity DataIC50:  1nMAssay Description:The inhibitory activity of certain compounds of Table A against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Novartis

US Patent
LigandPNGBDBM110277(US8613914, 45 | US9206232, 45)
Affinity DataIC50:  1nMAssay Description:The inhibitory activity of certain compounds of Table A against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Novartis

US Patent
LigandPNGBDBM110264(US8613914, 32 | US9206232, 32)
Affinity DataIC50:  1nMAssay Description:The inhibitory activity of certain compounds of Table A against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Novartis

US Patent
LigandPNGBDBM110383(US8613914, 157 | US9206232, 157)
Affinity DataIC50:  1nMAssay Description:The inhibitory activity of certain compounds of Table A against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Novartis

US Patent
LigandPNGBDBM110397(US8613914, 171 | US9206232, 171)
Affinity DataIC50:  1nMAssay Description:The inhibitory activity of certain compounds of Table A against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Novartis

US Patent
LigandPNGBDBM110378(US8613914, 152 | US9206232, 152)
Affinity DataIC50:  1.10nMAssay Description:The inhibitory activity of certain compounds of Table A against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus)
Novartis

US Patent
LigandPNGBDBM110378(US8613914, 152 | US9206232, 152)
Affinity DataIC50:  1.10nMAssay Description:The inhibitory activity of certain compounds against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length NS3-4A prot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus)
Novartis

US Patent
LigandPNGBDBM110295(US8613914, 63 | US9206232, 63)
Affinity DataIC50:  1.20nMAssay Description:The inhibitory activity of certain compounds against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length NS3-4A prot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM212109(US9290485, 141)
Affinity DataIC50:  1.20nMpH: 7.8 T: 2°CAssay Description:Enzymatic reactions were conducted in ⿿assay buffer⿿, comprising 50 mM Hepes/NaOH at pH 7.8, 150 mM NaCl, 1 mM EDTA and 0.05% (w/v) CHAPS. For th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Novartis

US Patent
LigandPNGBDBM110295(US8613914, 63 | US9206232, 63)
Affinity DataIC50:  1.20nMAssay Description:The inhibitory activity of certain compounds of Table A against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Novartis

US Patent
LigandPNGBDBM110382(US8613914, 156 | US9206232, 156)
Affinity DataIC50:  1.30nMAssay Description:The inhibitory activity of certain compounds of Table A against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus)
Novartis

US Patent
LigandPNGBDBM110382(US8613914, 156 | US9206232, 156)
Affinity DataIC50:  1.30nMAssay Description:The inhibitory activity of certain compounds against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length NS3-4A prot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus)
Novartis

US Patent
LigandPNGBDBM110360(US8613914, 128 | US9206232, 128)
Affinity DataIC50:  1.40nMAssay Description:The inhibitory activity of certain compounds against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length NS3-4A prot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Novartis

US Patent
LigandPNGBDBM110287(US8613914, 55 | US9206232, 55)
Affinity DataIC50:  1.40nMAssay Description:The inhibitory activity of certain compounds of Table A against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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