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Found 48 with Last Name = 'brashear' and Initial = 'km'
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50107412(3-(2-{2-Oxo-3-[2-(5,6,7,8-tetrahydro-[1,8]naphthyr...)
Affinity DataIC50:  0.0400nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50153027((S)-3-Pyrimidin-5-yl-9-(5,6,7,8-tetrahydro-[1,8]na...)
Affinity DataIC50:  0.0700nMAssay Description:Inhibitory activity against alpha v beta-3 receptor using scintillation proximity assay (SPAV3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50153031((S)-3-(2-Methyl-pyrimidin-5-yl)-9-(5,6,7,8-tetrahy...)
Affinity DataIC50:  0.0800nMAssay Description:Inhibitory activity against alpha v beta-3 receptor using scintillation proximity assay (SPAV3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50134778((S)-3-(6-Methoxy-pyridin-3-yl)-3-{2-oxo-3-[3-(5,6,...)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of alphaV-beta3 integrin bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50134777((S)-3-(2,3-Dihydro-benzofuran-6-yl)-3-{2-oxo-3-[3-...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of alphaV-beta3 integrin bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50153026((S)-3-(2-Methoxy-pyrimidin-5-yl)-9-(5,6,7,8-tetrah...)
Affinity DataIC50:  0.110nMAssay Description:Inhibitory activity against alpha v beta-3 receptor using scintillation proximity assay (SPAV3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50107410(3-(2,3-Dihydro-benzofuran-6-yl)-3-(2-{2-oxo-3-[2-(...)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50153029((S)-3-Quinolin-3-yl-9-(5,6,7,8-tetrahydro-[1,8]nap...)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity against alpha v beta-3 receptor using scintillation proximity assay (SPAV3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50153023((S)-3-(2,3-Dihydro-benzofuran-6-yl)-9-(5,6,7,8-tet...)
Affinity DataIC50:  0.210nMAssay Description:Inhibitory activity against alpha v beta-3 receptor using scintillation proximity assay (SPAV3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50134780((S)-3-{2-Oxo-3-[3-(5,6,7,8-tetrahydro-[1,8]naphthy...)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of alphaV-beta3 integrin bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50107411((S)-3-(2-Oxo-2,3-dihydro-benzooxazol-6-yl)-3-(2-{(...)
Affinity DataIC50:  0.290nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50121151(3-[5-(3-Cyclopropyl-5,6,7,8-tetrahydro-[1,8]naphth...)
Affinity DataIC50:  0.290nMAssay Description:Inhibition of binding to human integrin receptor alpha V beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50107407(3-(4-Ethoxy-3-fluoro-phenyl)-3-(2-{2-oxo-3-[2-(5,6...)
Affinity DataIC50:  0.310nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50107415(3-Benzo[1,3]dioxol-5-yl-3-(2-{2-oxo-3-[2-(5,6,7,8-...)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50107397((S)-3-(2-{(S)-2-Oxo-3-[2-(5,6,7,8-tetrahydro-[1,8]...)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50134776((S)-3-(3-Fluoro-4-methoxy-phenyl)-3-{2-oxo-3-[3-(5...)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of alphaV-beta3 integrin bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50121147(2-(2,3-Dihydro-benzofuran-6-yl)-3-[methyl-(3-1,2,3...)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of binding to human integrin receptor alpha V beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50134779((S)-3-{3-[3-(7-Hydroxy-5,6,7,8-tetrahydro-[1,8]nap...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of alphaV-beta3 integrin bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50107417(3-(3-Fluoro-4-methoxy-phenyl)-3-(2-{2-oxo-3-[2-(5,...)
Affinity DataIC50:  0.490nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50121153(3-{[5-(3-Cyclopropyl-5,6,7,8-tetrahydro-[1,8]napht...)
Affinity DataIC50:  0.490nMAssay Description:Inhibition of binding to human integrin receptor alpha V beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50153024((S)-3-(2-Isopropyl-pyrimidin-5-yl)-9-(5,6,7,8-tetr...)
Affinity DataIC50:  0.520nMAssay Description:Inhibitory activity against alpha v beta-3 receptor using scintillation proximity assay (SPAV3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50107413(3-(2-Fluoro-biphenyl-4-yl)-3-(2-{2-oxo-3-[2-(5,6,7...)
Affinity DataIC50:  0.570nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50153030((S)-3-(6-Methoxy-pyridin-3-yl)-9-(5,6,7,8-tetrahyd...)
Affinity DataIC50:  0.650nMAssay Description:Inhibitory activity against alpha v beta-3 receptor using scintillation proximity assay (SPAV3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50121148(2-(2,3-Dihydro-benzofuran-6-yl)-3-(3-1,2,3,4,6,7,8...)
Affinity DataIC50:  0.720nMAssay Description:Inhibition of binding to human integrin receptor alpha V beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50121154(2-(2,3-Dihydro-benzofuran-6-yl)-3-[methyl-(5-5,6,7...)
Affinity DataIC50:  0.740nMAssay Description:Inhibition of binding to human integrin receptor alpha V beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50121146(2-Quinolin-3-yl-3-(5-5,6,7,8-tetrahydro-[1,8]napht...)
Affinity DataIC50:  0.820nMAssay Description:Inhibition of binding to human integrin receptor alpha V beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50153025(3-(3-Fluoro-phenyl)-9-(5,6,7,8-tetrahydro-[1,8]nap...)
Affinity DataIC50:  0.930nMAssay Description:Inhibitory activity against alpha v beta-3 receptor using scintillation proximity assay (SPAV3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50121150(2-(2,3-Dihydro-benzofuran-6-yl)-3-(5-5,6,7,8-tetra...)
Affinity DataIC50:  1nMAssay Description:Inhibition of binding to human integrin receptor alpha V beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50107419(3-(2,3-Dihydro-benzofuran-5-yl)-3-(2-{2-oxo-3-[2-(...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116975((S)-3-Quinolin-3-yl-3-(5-5,6,7,8-tetrahydro-[1,8]n...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of binding to human integrin receptor alpha V beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50107420(3-(3-Fluoro-phenyl)-3-(2-{2-oxo-3-[2-(5,6,7,8-tetr...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50107416(3-Benzo[b]thiophen-6-yl-3-(2-{2-oxo-3-[2-(5,6,7,8-...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116981((S)-3-(2,3-Dihydro-benzofuran-6-yl)-3-(5-5,6,7,8-t...)
Affinity DataIC50:  3nMAssay Description:Inhibition of binding to human integrin receptor alpha V beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50134775((S)-3-(6-Methoxy-pyridin-3-yl)-3-{2-oxo-3-[3-oxo-3...)
Affinity DataIC50:  3nMAssay Description:Inhibition of alphaV-beta3 integrin bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135968(3-Pyrimidin-5-yl-3-(5-5,6,7,8-tetrahydro-[1,8]naph...)
Affinity DataIC50:  3.30nMAssay Description:Inhibitory activity against alpha v beta-3 receptor using scintillation proximity assay (SPAV3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50107406(3-Benzothiazol-6-yl-3-(2-{2-oxo-3-[2-(5,6,7,8-tetr...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50107418(3-(2-{2-Oxo-3-[2-(5,6,7,8-tetrahydro-[1,8]naphthyr...)
Affinity DataIC50:  4nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50107408(3-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-3-(2-{2-oxo...)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50153028((E)-3-(3-Fluoro-phenyl)-9-(5,6,7,8-tetrahydro-[1,8...)
Affinity DataIC50:  7.20nMAssay Description:Inhibitory activity against alpha v beta-3 receptor using scintillation proximity assay (SPAV3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50121145(2-(3-Fluoro-phenyl)-3-(5-5,6,7,8-tetrahydro-[1,8]n...)
Affinity DataIC50:  11nMAssay Description:Inhibition of binding to human integrin receptor alpha V beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116974((S)-3-(3-Fluoro-phenyl)-3-(5-5,6,7,8-tetrahydro-[1...)
Affinity DataIC50:  22.7nMAssay Description:Inhibitory activity against alpha v beta-3 receptor using scintillation proximity assay (SPAV3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116974((S)-3-(3-Fluoro-phenyl)-3-(5-5,6,7,8-tetrahydro-[1...)
Affinity DataIC50:  23nMAssay Description:Inhibition of binding to human integrin receptor alpha V beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50107409(3-Indan-5-yl-3-(2-{2-oxo-3-[2-(5,6,7,8-tetrahydro-...)
Affinity DataIC50:  29nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50121149(2-Phenyl-3-(5-5,6,7,8-tetrahydro-[1,8]naphthyridin...)
Affinity DataIC50:  57nMAssay Description:Inhibition of binding to human integrin receptor alpha V beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50121152((S)-3-Phenyl-3-(5-5,6,7,8-tetrahydro-[1,8]naphthyr...)
Affinity DataIC50:  84nMAssay Description:Inhibition of binding to human integrin receptor alpha V beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50134781((S)-3-(6-Methoxy-pyridin-3-yl)-3-{2-oxo-3-[3-(7-ox...)
Affinity DataIC50:  141nMAssay Description:Inhibition of alphaV-beta3 integrin bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50107414(3-(2-{2-Oxo-3-[2-(5,6,7,8-tetrahydro-[1,8]naphthyr...)
Affinity DataIC50:  230nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50134778((S)-3-(6-Methoxy-pyridin-3-yl)-3-{2-oxo-3-[3-(5,6,...)
Affinity DataIC50:  3.47E+4nMAssay Description:Inhibition of alphaIIb-beta3 integrin mediated platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed