TargetAndrogen receptor(Rattus norvegicus (Rat))
Universidad Nacional Aut£Noma De M£Xico
Curated by ChEMBL
Universidad Nacional Aut£Noma De M£Xico
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]-MIB from rat prostate cytosolic androgen receptor by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetcDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Metropolitan University-Xochimilco
Metropolitan University-Xochimilco
Affinity DataIC50: 1.30nMpH: 6.5 T: 2°CAssay Description:The reaction mixtures contained a final volume of 1 mL, 1 mM DTT, sodium phosphate buffer 40 mM, at pH 6.5, 2 mM, NADPH, 2 nM [1,2,6,7-3H]T or [1,2,3...More data for this Ligand-Target Pair
TargetcDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Metropolitan University-Xochimilco
Metropolitan University-Xochimilco
Affinity DataIC50: 1.60nMpH: 6.5 T: 2°CAssay Description:The reaction mixtures contained a final volume of 1 mL, 1 mM DTT, sodium phosphate buffer 40 mM, at pH 6.5, 2 mM, NADPH, 2 nM [1,2,6,7-3H]T or [1,2,3...More data for this Ligand-Target Pair
TargetcDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Metropolitan University-Xochimilco
Metropolitan University-Xochimilco
Affinity DataIC50: 2nMpH: 6.5 T: 2°CAssay Description:The reaction mixtures contained a final volume of 1 mL, 1 mM DTT, sodium phosphate buffer 40 mM, at pH 6.5, 2 mM, NADPH, 2 nM [1,2,6,7-3H]T or [1,2,3...More data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico
Curated by ChEMBL
National University Of Mexico
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human prostate 5alpha-reductase type 2 assessed as conversion of [3H]testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico
Curated by ChEMBL
National University Of Mexico
Curated by ChEMBL
Affinity DataIC50: 3.58nMAssay Description:The activity of the isozyme 5α-R type 2 was assayed as previously described [Hirosumi et al., J. Steroid Biochem. Mol. Biol., 52:357-363; Bratoe...More data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico
Curated by ChEMBL
National University Of Mexico
Curated by ChEMBL
Affinity DataIC50: 4.90nMpH: 6.5 T: 2°CAssay Description:The IC50 values for the synthesized steroids with human prostate 5alpha-reductase enzyme.More data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico
Curated by ChEMBL
National University Of Mexico
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of human prostate 5alpha-reductase type 2 assessed as conversion of [3H]testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico
Curated by ChEMBL
National University Of Mexico
Curated by ChEMBL
Affinity DataIC50: 8.5nMAssay Description:Inhibition of human prostate 5alpha-reductase type 2 assessed as conversion of [3H]testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
TargetcDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Metropolitan University-Xochimilco
Metropolitan University-Xochimilco
Affinity DataIC50: 8.5nMpH: 6.5 T: 2°CAssay Description:The reaction mixture contained a final volume of 1 mL: 1 mM dithiothreitol, sodium phosphate buffer 40 mM, at pH 6.5 for human prostate, 2 mM NADPH, ...More data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico
Curated by ChEMBL
National University Of Mexico
Curated by ChEMBL
Affinity DataIC50: 8.5nMpH: 6.5 T: 2°CAssay Description:The IC50 values for the synthesized steroids with human prostate 5alpha-reductase enzyme.More data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico
Curated by ChEMBL
National University Of Mexico
Curated by ChEMBL
Affinity DataIC50: 8.5nMAssay Description:The activity of the isozyme 5α-R type 2 was assayed as previously described [Hirosumi et al., J. Steroid Biochem. Mol. Biol., 52:357-363; Bratoe...More data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico
Curated by ChEMBL
National University Of Mexico
Curated by ChEMBL
Affinity DataIC50: 8.5nMAssay Description:Inhibition of human prostate type 2 5alpha-reductase assessed as transformation of testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
TargetcDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Metropolitan University-Xochimilco
Metropolitan University-Xochimilco
Affinity DataIC50: 10nMpH: 6.5 T: 2°CAssay Description:The reaction mixture contained a final volume of 1 mL: 1 mM dithiothreitol, sodium phosphate buffer 40 mM, at pH 6.5 for human prostate, 2 mM NADPH, ...More data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico
Curated by ChEMBL
National University Of Mexico
Curated by ChEMBL
Affinity DataIC50: 13nMpH: 6.5 T: 2°CAssay Description:The IC50 values for the synthesized steroids with human prostate 5alpha-reductase enzyme.More data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico
Curated by ChEMBL
National University Of Mexico
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of human prostate 5alpha-reductase type 2 assessed as conversion of [3H]testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico
Curated by ChEMBL
National University Of Mexico
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of human prostate 5alpha-reductase type 2 assessed as conversion of [3H]testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
TargetcDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Metropolitan University-Xochimilco
Metropolitan University-Xochimilco
Affinity DataIC50: 19nMpH: 6.5 T: 2°CAssay Description:The reaction mixture contained a final volume of 1 mL: 1 mM dithiothreitol, sodium phosphate buffer 40 mM, at pH 6.5 for human prostate, 2 mM NADPH, ...More data for this Ligand-Target Pair
TargetcDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Metropolitan University-Xochimilco
Metropolitan University-Xochimilco
Affinity DataIC50: 22nMpH: 6.5 T: 2°CAssay Description:The reaction mixture contained a final volume of 1 mL: 1 mM dithiothreitol, sodium phosphate buffer 40 mM, at pH 6.5 for human prostate, 2 mM NADPH, ...More data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico
Curated by ChEMBL
National University Of Mexico
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of human prostate 5-alpha reductase 2 assessed as decrease in conversion of testosterone to dihydrotestosterone by chromatographic methodMore data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico
Curated by ChEMBL
National University Of Mexico
Curated by ChEMBL
Affinity DataIC50: 35nMAssay Description:Inhibition of human prostate 5-alpha reductase 2 assessed as decrease in conversion of testosterone to dihydrotestosterone by chromatographic methodMore data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico
Curated by ChEMBL
National University Of Mexico
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of human prostate 5alpha-reductase type 2 assessed as conversion of [3H]testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
TargetcDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Metropolitan University-Xochimilco
Metropolitan University-Xochimilco
Affinity DataIC50: 50nMpH: 6.5 T: 2°CAssay Description:The reaction mixtures contained a final volume of 1 mL, 1 mM DTT, sodium phosphate buffer 40 mM, at pH 6.5, 2 mM, NADPH, 2 nM [1,2,6,7-3H]T or [1,2,3...More data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico
Curated by ChEMBL
National University Of Mexico
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of human prostate 5alpha-reductase type 2 assessed as conversion of [3H]testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
TargetcDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Metropolitan University-Xochimilco
Metropolitan University-Xochimilco
Affinity DataIC50: 63nMpH: 6.5 T: 2°CAssay Description:The reaction mixtures contained a final volume of 1 mL, 1 mM DTT, sodium phosphate buffer 40 mM, at pH 6.5, 2 mM, NADPH, 2 nM [1,2,6,7-3H]T or [1,2,3...More data for this Ligand-Target Pair
TargetcDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Metropolitan University-Xochimilco
Metropolitan University-Xochimilco
Affinity DataIC50: 70nMpH: 6.5 T: 2°CAssay Description:The reaction mixture contained a final volume of 1 mL: 1 mM dithiothreitol, sodium phosphate buffer 40 mM, at pH 6.5 for human prostate, 2 mM NADPH, ...More data for this Ligand-Target Pair
TargetcDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Metropolitan University-Xochimilco
Metropolitan University-Xochimilco
Affinity DataIC50: 73nMpH: 6.5 T: 2°CAssay Description:The reaction mixtures contained a final volume of 1 mL, 1 mM DTT, sodium phosphate buffer 40 mM, at pH 6.5, 2 mM, NADPH, 2 nM [1,2,6,7-3H]T or [1,2,3...More data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico
Curated by ChEMBL
National University Of Mexico
Curated by ChEMBL
Affinity DataIC50: 76nMAssay Description:Inhibition of human prostate 5-alpha reductase 2 assessed as decrease in conversion of testosterone to dihydrotestosterone by chromatographic methodMore data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Universidad Nacional Aut£Noma De M£Xico
Curated by ChEMBL
Universidad Nacional Aut£Noma De M£Xico
Curated by ChEMBL
Affinity DataIC50: 291nMAssay Description:Inhibition of rat liver microsomes 5alpha-reductase1 using [1,2,6,7-3H]T as substrate measured after 60 mins by chromatographic methodMore data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico
Curated by ChEMBL
National University Of Mexico
Curated by ChEMBL
Affinity DataIC50: 360nMpH: 6.5 T: 2°CAssay Description:The IC50 values for the synthesized steroids with human prostate 5alpha-reductase enzyme.More data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico
Curated by ChEMBL
National University Of Mexico
Curated by ChEMBL
Affinity DataIC50: 370nMpH: 6.5 T: 2°CAssay Description:The IC50 values for the synthesized steroids with human prostate 5alpha-reductase enzyme.More data for this Ligand-Target Pair
TargetcDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Metropolitan University-Xochimilco
Metropolitan University-Xochimilco
Affinity DataIC50: 500nMpH: 6.5 T: 2°CAssay Description:The reaction mixtures contained a final volume of 1 mL, 1 mM DTT, sodium phosphate buffer 40 mM, at pH 6.5, 2 mM, NADPH, 2 nM [1,2,6,7-3H]T or [1,2,3...More data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
National University of Mexico City
National University of Mexico City
Affinity DataIC50: 550nMpH: 7.5Assay Description:The activity of the 5α-R type 1 isozyme was determined by following the conversion of T to DHT at pH 7.5. 2 nM of [1,2,6,7 3H] T, and different ...More data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
National University of Mexico City
National University of Mexico City
Affinity DataIC50: 630nMpH: 7.5Assay Description:The activity of the 5α-R type 1 isozyme was determined by following the conversion of T to DHT at pH 7.5. 2 nM of [1,2,6,7 3H] T, and different ...More data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
National University of Mexico City
National University of Mexico City
Affinity DataIC50: 650nMpH: 7.5Assay Description:The activity of the 5α-R type 1 isozyme was determined by following the conversion of T to DHT at pH 7.5. 2 nM of [1,2,6,7 3H] T, and different ...More data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
National University of Mexico City
National University of Mexico City
Affinity DataIC50: 700nMpH: 7.5Assay Description:The activity of the 5α-R type 1 isozyme was determined by following the conversion of T to DHT at pH 7.5. 2 nM of [1,2,6,7 3H] T, and different ...More data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico
Curated by ChEMBL
National University Of Mexico
Curated by ChEMBL
Affinity DataIC50: 711nMAssay Description:Inhibition of human prostate 5-alpha reductase 2 assessed as decrease in conversion of testosterone to dihydrotestosterone by chromatographic methodMore data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
National University of Mexico City
National University of Mexico City
Affinity DataIC50: 800nMpH: 7.5Assay Description:The activity of the 5α-R type 1 isozyme was determined by following the conversion of T to DHT at pH 7.5. 2 nM of [1,2,6,7 3H] T, and different ...More data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
National University of Mexico City
National University of Mexico City
Affinity DataIC50: 800nMpH: 7.5Assay Description:The activity of the 5α-R type 1 isozyme was determined by following the conversion of T to DHT at pH 7.5. 2 nM of [1,2,6,7 3H] T, and different ...More data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
National University of Mexico City
National University of Mexico City
Affinity DataIC50: 800nMpH: 7.5Assay Description:The activity of the 5α-R type 1 isozyme was determined by following the conversion of T to DHT at pH 7.5. 2 nM of [1,2,6,7 3H] T, and different ...More data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
National University of Mexico City
National University of Mexico City
Affinity DataIC50: 900nMpH: 7.5Assay Description:The activity of the 5α-R type 1 isozyme was determined by following the conversion of T to DHT at pH 7.5. 2 nM of [1,2,6,7 3H] T, and different ...More data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
National University of Mexico City
National University of Mexico City
Affinity DataIC50: 900nMpH: 7.5Assay Description:The activity of the 5α-R type 1 isozyme was determined by following the conversion of T to DHT at pH 7.5. 2 nM of [1,2,6,7 3H] T, and different ...More data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
National University of Mexico City
National University of Mexico City
Affinity DataIC50: 900nMpH: 7.5Assay Description:The activity of the 5α-R type 1 isozyme was determined by following the conversion of T to DHT at pH 7.5. 2 nM of [1,2,6,7 3H] T, and different ...More data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
National University of Mexico City
National University of Mexico City
Affinity DataIC50: 1.00E+3nMpH: 7.5Assay Description:The activity of the 5α-R type 1 isozyme was determined by following the conversion of T to DHT at pH 7.5. 2 nM of [1,2,6,7 3H] T, and different ...More data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
National University of Mexico City
National University of Mexico City
Affinity DataIC50: 5.00E+3nMpH: 7.5Assay Description:The activity of the 5α-R type 1 isozyme was determined by following the conversion of T to DHT at pH 7.5. 2 nM of [1,2,6,7 3H] T, and different ...More data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
National University of Mexico City
National University of Mexico City
Affinity DataIC50: 5.00E+3nMpH: 7.5Assay Description:The activity of the 5α-R type 1 isozyme was determined by following the conversion of T to DHT at pH 7.5. 2 nM of [1,2,6,7 3H] T, and different ...More data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Universidad Nacional Aut£Noma De M£Xico
Curated by ChEMBL
Universidad Nacional Aut£Noma De M£Xico
Curated by ChEMBL
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of rat liver microsomes 5alpha-reductase1 using [1,2,6,7-3H]T as substrate measured after 60 mins by chromatographic methodMore data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Universidad Nacional Aut£Noma De M£Xico
Curated by ChEMBL
Universidad Nacional Aut£Noma De M£Xico
Curated by ChEMBL
Affinity DataIC50: 8.30E+4nMAssay Description:Inhibition of rat liver microsomes 5alpha-reductase1 using [1,2,6,7-3H]T as substrate measured after 60 mins by chromatographic methodMore data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Universidad Nacional Aut£Noma De M£Xico
Curated by ChEMBL
Universidad Nacional Aut£Noma De M£Xico
Curated by ChEMBL
Affinity DataIC50: 8.80E+4nMAssay Description:Inhibition of rat liver type 1 5alpha-reductase assessed as transformation of testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Universidad Nacional Aut£Noma De M£Xico
Curated by ChEMBL
Universidad Nacional Aut£Noma De M£Xico
Curated by ChEMBL
Affinity DataIC50: 9.45E+4nMAssay Description:Inhibition of rat liver 5alpha-reductase type 1 assessed as conversion of [3H]testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair