Compile Data Set for Download or QSAR
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Found 66 with Last Name = 'bratoeff' and Initial = 'e'
TargetAndrogen receptor(Rattus norvegicus (Rat))
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM26258((1S,2R,9R,10R,11S,14S,15S)-14-hydroxy-9,14,15-trim...)
Affinity DataIC50:  1nMAssay Description:Displacement of [3H]-MIB from rat prostate cytosolic androgen receptor by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Metropolitan University-Xochimilco

LigandPNGBDBM50025356(4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10...)
Affinity DataIC50:  1.30nMpH: 6.5 T: 2°CAssay Description:The reaction mixtures contained a final volume of 1 mL, 1 mM DTT, sodium phosphate buffer 40 mM, at pH 6.5, 2 mM, NADPH, 2 nM [1,2,6,7-3H]T or [1,2,3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Metropolitan University-Xochimilco

LigandPNGBDBM235657(4-Bromo-17α-hydroxypregn-4-ene-3,20-dione (7b...)
Affinity DataIC50:  1.60nMpH: 6.5 T: 2°CAssay Description:The reaction mixtures contained a final volume of 1 mL, 1 mM DTT, sodium phosphate buffer 40 mM, at pH 6.5, 2 mM, NADPH, 2 nM [1,2,6,7-3H]T or [1,2,3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Metropolitan University-Xochimilco

LigandPNGBDBM235655(17α-Hydroxypregn-4-ene-3,20-dione (5))
Affinity DataIC50:  2nMpH: 6.5 T: 2°CAssay Description:The reaction mixtures contained a final volume of 1 mL, 1 mM DTT, sodium phosphate buffer 40 mM, at pH 6.5, 2 mM, NADPH, 2 nM [1,2,6,7-3H]T or [1,2,3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico

Curated by ChEMBL
LigandPNGBDBM50102599(CHEMBL3342891)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human prostate 5alpha-reductase type 2 assessed as conversion of [3H]testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico

Curated by ChEMBL
LigandPNGBDBM243079(17-Oxaandrost-5-ene-3β-yl-p-fluorobenzoate (2...)
Affinity DataIC50:  3.58nMAssay Description:The activity of the isozyme 5α-R type 2 was assayed as previously described [Hirosumi et al., J. Steroid Biochem. Mol. Biol., 52:357-363; Bratoe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico

Curated by ChEMBL
LigandPNGBDBM92330(Steroid, 10b)
Affinity DataIC50:  4.90nMpH: 6.5 T: 2°CAssay Description:The IC50 values for the synthesized steroids with human prostate 5alpha-reductase enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico

Curated by ChEMBL
LigandPNGBDBM50102603(CHEMBL3342894)
Affinity DataIC50:  8nMAssay Description:Inhibition of human prostate 5alpha-reductase type 2 assessed as conversion of [3H]testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico

Curated by ChEMBL
LigandPNGBDBM50334788((17beta-(N-tert-butylcarbamoyl)-4-aza-5alpha-andro...)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of human prostate 5alpha-reductase type 2 assessed as conversion of [3H]testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetcDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Metropolitan University-Xochimilco

LigandPNGBDBM233039(Finasteride (3))
Affinity DataIC50:  8.5nMpH: 6.5 T: 2°CAssay Description:The reaction mixture contained a final volume of 1 mL: 1 mM dithiothreitol, sodium phosphate buffer 40 mM, at pH 6.5 for human prostate, 2 mM NADPH, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico

Curated by ChEMBL
LigandPNGBDBM92326(Finasteride, 3)
Affinity DataIC50:  8.5nMpH: 6.5 T: 2°CAssay Description:The IC50 values for the synthesized steroids with human prostate 5alpha-reductase enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico

Curated by ChEMBL
LigandPNGBDBM50334788((17beta-(N-tert-butylcarbamoyl)-4-aza-5alpha-andro...)
Affinity DataIC50:  8.5nMAssay Description:The activity of the isozyme 5α-R type 2 was assayed as previously described [Hirosumi et al., J. Steroid Biochem. Mol. Biol., 52:357-363; Bratoe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico

Curated by ChEMBL
LigandPNGBDBM50334788((17beta-(N-tert-butylcarbamoyl)-4-aza-5alpha-andro...)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of human prostate type 2 5alpha-reductase assessed as transformation of testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetcDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Metropolitan University-Xochimilco

LigandPNGBDBM233040(17α-Acetoxyprogesterone (6))
Affinity DataIC50:  10nMpH: 6.5 T: 2°CAssay Description:The reaction mixture contained a final volume of 1 mL: 1 mM dithiothreitol, sodium phosphate buffer 40 mM, at pH 6.5 for human prostate, 2 mM NADPH, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico

Curated by ChEMBL
LigandPNGBDBM92329(Steroid, 10a)
Affinity DataIC50:  13nMpH: 6.5 T: 2°CAssay Description:The IC50 values for the synthesized steroids with human prostate 5alpha-reductase enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico

Curated by ChEMBL
LigandPNGBDBM50102601(CHEMBL3342892)
Affinity DataIC50:  13nMAssay Description:Inhibition of human prostate 5alpha-reductase type 2 assessed as conversion of [3H]testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico

Curated by ChEMBL
LigandPNGBDBM50102605(CHEMBL3342895)
Affinity DataIC50:  15nMAssay Description:Inhibition of human prostate 5alpha-reductase type 2 assessed as conversion of [3H]testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Metropolitan University-Xochimilco

LigandPNGBDBM233043(6-Chloro-3,20-dioxopregna-4,6-diene-17α-yl ac...)
Affinity DataIC50:  19nMpH: 6.5 T: 2°CAssay Description:The reaction mixture contained a final volume of 1 mL: 1 mM dithiothreitol, sodium phosphate buffer 40 mM, at pH 6.5 for human prostate, 2 mM NADPH, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Metropolitan University-Xochimilco

LigandPNGBDBM233042(3,20-Dioxo-6,7-epoxypregn-4-ene-7α-yl acetate...)
Affinity DataIC50:  22nMpH: 6.5 T: 2°CAssay Description:The reaction mixture contained a final volume of 1 mL: 1 mM dithiothreitol, sodium phosphate buffer 40 mM, at pH 6.5 for human prostate, 2 mM NADPH, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico

Curated by ChEMBL
LigandPNGBDBM50234463(CHEMBL4085478)
Affinity DataIC50:  29nMAssay Description:Inhibition of human prostate 5-alpha reductase 2 assessed as decrease in conversion of testosterone to dihydrotestosterone by chromatographic methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico

Curated by ChEMBL
LigandPNGBDBM50234464(CHEMBL4063904)
Affinity DataIC50:  35nMAssay Description:Inhibition of human prostate 5-alpha reductase 2 assessed as decrease in conversion of testosterone to dihydrotestosterone by chromatographic methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico

Curated by ChEMBL
LigandPNGBDBM50102606(CHEMBL3342896)
Affinity DataIC50:  50nMAssay Description:Inhibition of human prostate 5alpha-reductase type 2 assessed as conversion of [3H]testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Metropolitan University-Xochimilco

LigandPNGBDBM235659(4-Bromo-3,20-dioxopregn-4-ene-17-yl-4-ethylbenzoat...)
Affinity DataIC50:  50nMpH: 6.5 T: 2°CAssay Description:The reaction mixtures contained a final volume of 1 mL, 1 mM DTT, sodium phosphate buffer 40 mM, at pH 6.5, 2 mM, NADPH, 2 nM [1,2,6,7-3H]T or [1,2,3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico

Curated by ChEMBL
LigandPNGBDBM50102602(CHEMBL3342893)
Affinity DataIC50:  50nMAssay Description:Inhibition of human prostate 5alpha-reductase type 2 assessed as conversion of [3H]testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Metropolitan University-Xochimilco

LigandPNGBDBM235656(4-Chloro-17α-hydroxypregn-4-ene-3,20-dione (7...)
Affinity DataIC50:  63nMpH: 6.5 T: 2°CAssay Description:The reaction mixtures contained a final volume of 1 mL, 1 mM DTT, sodium phosphate buffer 40 mM, at pH 6.5, 2 mM, NADPH, 2 nM [1,2,6,7-3H]T or [1,2,3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Metropolitan University-Xochimilco

LigandPNGBDBM233041(3,20-Dioxopregna-4,6-dien-17α-yl acetate (7))
Affinity DataIC50:  70nMpH: 6.5 T: 2°CAssay Description:The reaction mixture contained a final volume of 1 mL: 1 mM dithiothreitol, sodium phosphate buffer 40 mM, at pH 6.5 for human prostate, 2 mM NADPH, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Metropolitan University-Xochimilco

LigandPNGBDBM235658(4-Chloro-3,20-dioxopregn-4-ene-17-yl-4-ethylbenzoa...)
Affinity DataIC50:  73nMpH: 6.5 T: 2°CAssay Description:The reaction mixtures contained a final volume of 1 mL, 1 mM DTT, sodium phosphate buffer 40 mM, at pH 6.5, 2 mM, NADPH, 2 nM [1,2,6,7-3H]T or [1,2,3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico

Curated by ChEMBL
LigandPNGBDBM50234466(CHEMBL4093235)
Affinity DataIC50:  76nMAssay Description:Inhibition of human prostate 5-alpha reductase 2 assessed as decrease in conversion of testosterone to dihydrotestosterone by chromatographic methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50462940(CHEMBL4244937)
Affinity DataIC50:  291nMAssay Description:Inhibition of rat liver microsomes 5alpha-reductase1 using [1,2,6,7-3H]T as substrate measured after 60 mins by chromatographic methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico

Curated by ChEMBL
LigandPNGBDBM92327(Steroid, 9a)
Affinity DataIC50:  360nMpH: 6.5 T: 2°CAssay Description:The IC50 values for the synthesized steroids with human prostate 5alpha-reductase enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico

Curated by ChEMBL
LigandPNGBDBM92328(Steroid, 9b)
Affinity DataIC50:  370nMpH: 6.5 T: 2°CAssay Description:The IC50 values for the synthesized steroids with human prostate 5alpha-reductase enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Metropolitan University-Xochimilco

LigandPNGBDBM235654(3,20-Dioxopregn-4-ene-17-yl acetate (4))
Affinity DataIC50:  500nMpH: 6.5 T: 2°CAssay Description:The reaction mixtures contained a final volume of 1 mL, 1 mM DTT, sodium phosphate buffer 40 mM, at pH 6.5, 2 mM, NADPH, 2 nM [1,2,6,7-3H]T or [1,2,3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
National University of Mexico City

LigandPNGBDBM243088(17-Chloro-16-formylandrost-5,16-diene-3β-yl-p...)
Affinity DataIC50:  550nMpH: 7.5Assay Description:The activity of the 5α-R type 1 isozyme was determined by following the conversion of T to DHT at pH 7.5. 2 nM of [1,2,6,7 3H] T, and different ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
National University of Mexico City

LigandPNGBDBM50334788((17beta-(N-tert-butylcarbamoyl)-4-aza-5alpha-andro...)
Affinity DataIC50:  630nMpH: 7.5Assay Description:The activity of the 5α-R type 1 isozyme was determined by following the conversion of T to DHT at pH 7.5. 2 nM of [1,2,6,7 3H] T, and different ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
National University of Mexico City

LigandPNGBDBM243084(17-Chloro-16-formylandrost-5,16-diene-3β-yl-b...)
Affinity DataIC50:  650nMpH: 7.5Assay Description:The activity of the 5α-R type 1 isozyme was determined by following the conversion of T to DHT at pH 7.5. 2 nM of [1,2,6,7 3H] T, and different ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
National University of Mexico City

LigandPNGBDBM243085(17-Chloro-16-formylandrost-5,16-diene-3β-yl-p...)
Affinity DataIC50:  700nMpH: 7.5Assay Description:The activity of the 5α-R type 1 isozyme was determined by following the conversion of T to DHT at pH 7.5. 2 nM of [1,2,6,7 3H] T, and different ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
National University Of Mexico

Curated by ChEMBL
LigandPNGBDBM50234469(CHEMBL4072502)
Affinity DataIC50:  711nMAssay Description:Inhibition of human prostate 5-alpha reductase 2 assessed as decrease in conversion of testosterone to dihydrotestosterone by chromatographic methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
National University of Mexico City

LigandPNGBDBM243082(17-Oxaandrost-5-ene-3β-yl-p-iodobenzoate (5))
Affinity DataIC50:  800nMpH: 7.5Assay Description:The activity of the 5α-R type 1 isozyme was determined by following the conversion of T to DHT at pH 7.5. 2 nM of [1,2,6,7 3H] T, and different ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
National University of Mexico City

LigandPNGBDBM243087(17-Chloro-16-formylandros-5,16-diene-3β-yl-p-...)
Affinity DataIC50:  800nMpH: 7.5Assay Description:The activity of the 5α-R type 1 isozyme was determined by following the conversion of T to DHT at pH 7.5. 2 nM of [1,2,6,7 3H] T, and different ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
National University of Mexico City

LigandPNGBDBM243081(17-Oxaandrost-5-ene-3β-yl-p-bromobenzoate (4))
Affinity DataIC50:  800nMpH: 7.5Assay Description:The activity of the 5α-R type 1 isozyme was determined by following the conversion of T to DHT at pH 7.5. 2 nM of [1,2,6,7 3H] T, and different ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
National University of Mexico City

LigandPNGBDBM243079(17-Oxaandrost-5-ene-3β-yl-p-fluorobenzoate (2...)
Affinity DataIC50:  900nMpH: 7.5Assay Description:The activity of the 5α-R type 1 isozyme was determined by following the conversion of T to DHT at pH 7.5. 2 nM of [1,2,6,7 3H] T, and different ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
National University of Mexico City

LigandPNGBDBM243086(17-Chloro-16-formylandrost-5,16-diene-3β-yl-p...)
Affinity DataIC50:  900nMpH: 7.5Assay Description:The activity of the 5α-R type 1 isozyme was determined by following the conversion of T to DHT at pH 7.5. 2 nM of [1,2,6,7 3H] T, and different ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
National University of Mexico City

LigandPNGBDBM243089(17-Chloro-16-formylandrost-5,16-diene-3β-yl-p...)
Affinity DataIC50:  900nMpH: 7.5Assay Description:The activity of the 5α-R type 1 isozyme was determined by following the conversion of T to DHT at pH 7.5. 2 nM of [1,2,6,7 3H] T, and different ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
National University of Mexico City

LigandPNGBDBM243078(17-Oxaandrost-5-ene-3β-yl-benzoate (1))
Affinity DataIC50:  1.00E+3nMpH: 7.5Assay Description:The activity of the 5α-R type 1 isozyme was determined by following the conversion of T to DHT at pH 7.5. 2 nM of [1,2,6,7 3H] T, and different ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
National University of Mexico City

LigandPNGBDBM243080(17-Oxaandrost-5-ene-3β-yl-p-chlorobenzoate (3...)
Affinity DataIC50:  5.00E+3nMpH: 7.5Assay Description:The activity of the 5α-R type 1 isozyme was determined by following the conversion of T to DHT at pH 7.5. 2 nM of [1,2,6,7 3H] T, and different ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
National University of Mexico City

LigandPNGBDBM243083(17-Oxaandrost-5-ene-3β−yl-p-methylbenzo...)
Affinity DataIC50:  5.00E+3nMpH: 7.5Assay Description:The activity of the 5α-R type 1 isozyme was determined by following the conversion of T to DHT at pH 7.5. 2 nM of [1,2,6,7 3H] T, and different ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50462939(CHEMBL4247033)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of rat liver microsomes 5alpha-reductase1 using [1,2,6,7-3H]T as substrate measured after 60 mins by chromatographic methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50462938(CHEMBL4238710)
Affinity DataIC50:  8.30E+4nMAssay Description:Inhibition of rat liver microsomes 5alpha-reductase1 using [1,2,6,7-3H]T as substrate measured after 60 mins by chromatographic methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50135045(CHEMBL3735672)
Affinity DataIC50:  8.80E+4nMAssay Description:Inhibition of rat liver type 1 5alpha-reductase assessed as transformation of testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50102597(CHEMBL3342904)
Affinity DataIC50:  9.45E+4nMAssay Description:Inhibition of rat liver 5alpha-reductase type 1 assessed as conversion of [3H]testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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