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Found 87 with Last Name = 'brenneman' and Initial = 'd'
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318133((14S)-16-amino-10,14-dicyclohexyl-2-oxa-10,15,17,2...)
Affinity DataKi:  5nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318123((14S)-16-amino-10,14-dicyclohexyl-2-oxa-10,15,17-t...)
Affinity DataKi:  5nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318131((14S)-16-amino-10,14-dicyclohexyl-20-fluoro-2-oxa-...)
Affinity DataKi:  8nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318125((14S)-16-amino-10-cyclohexyl-14-(propan-2-yl)-2-ox...)
Affinity DataKi:  8nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Kannalife Sciences

Curated by ChEMBL
LigandPNGBDBM50174316(CHEMBL3809355)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]CP 55940 from human CB1 receptor after 1 hr by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM17786((4S)-4-(2-amino-6-phenoxy-3,4-dihydroquinazolin-3-...)
Affinity DataKi:  11nM ΔG°:  -45.0kJ/molepH: 5.0 T: 2°CAssay Description:BACE-1 activity was measured at pH 5 using the FS1 FRET substrate. Compounds were preincubated with recombinant BACE-1 for 20 min before adding subst...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318132((14S)-16-amino-10,14-dicyclohexyl-20-methoxy-2-oxa...)
Affinity DataKi:  12nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318124((14S)-16-amino-14-cyclohexyl-10-(oxan-4-yl)-2-oxa-...)
Affinity DataKi:  17nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318129(4-[(14S)-16-amino-14-cyclohexyl-11-oxo-2-oxa-10,15...)
Affinity DataKi:  20nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318128((14S)-16-amino-10-(oxan-4-yl)-14-(propan-2-yl)-2-o...)
Affinity DataKi:  22nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM17785(2-aminoquinazoline, 3 | 4-(2-amino-6-phenoxy-3,4-d...)
Affinity DataKi:  30nM ΔG°:  -42.5kJ/molepH: 5.0 T: 2°CAssay Description:BACE-1 activity was measured at pH 5 using the FS1 FRET substrate. Compounds were preincubated with recombinant BACE-1 for 20 min before adding subst...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318127((15S)-17-amino-11,15-dicyclohexyl-2-oxa-11,16,18-t...)
Affinity DataKi:  31nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Kannalife Sciences

Curated by ChEMBL
LigandPNGBDBM50092588(4-(1,1-Dimethyl-heptyl)-2'-isopropyl-5'-methyl-bip...)
Affinity DataKi:  33nMAssay Description:Displacement of [3H]CP 55940 from human CB1 receptor after 1 hr by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM17784(2-aminoquinazoline, 2 | 3-[(2-amino-6-phenoxy-3,4-...)
Affinity DataKi:  158nM ΔG°:  -38.4kJ/molepH: 5.0 T: 2°CAssay Description:BACE-1 activity was measured at pH 5 using the FS1 FRET substrate. Compounds were preincubated with recombinant BACE-1 for 20 min before adding subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318126((15R)-17-amino-11,15-dicyclohexyl-2-oxa-11,16,18-t...)
Affinity DataKi:  186nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM10887(Sulfamate 7 | Topiramate (TPM) | US11535599, Examp...)
Affinity DataKi:  300nMAssay Description:Inhibition of human carbonic anhydrase 2 by ThermoFluor methodMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Kannalife Sciences

Curated by ChEMBL
LigandPNGBDBM50174315(CHEMBL3810140)
Affinity DataKi:  842nMAssay Description:Displacement of [3H]-HU-243 from CB1 receptor in Sabra rat brain synaptosomes after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM17783(2-aminoquinazoline, 1 | 3-(2-amino-6-benzoyl-3,4-d...)
Affinity DataKi:  900nM ΔG°:  -34.2kJ/molepH: 5.0 T: 2°CAssay Description:BACE-1 activity was measured at pH 5 using the FS1 FRET substrate. Compounds were preincubated with recombinant BACE-1 for 20 min before adding subst...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318130(4-[(14S)-16-amino-14-cyclohexyl-11-oxo-2-oxa-10,15...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Kannalife Sciences

Curated by ChEMBL
LigandPNGBDBM50318484(2-((1R,6R)-6-Isopropenyl-3-methyl-cyclohex-2-enyl)...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-HU-243 from CB1 receptor in Sabra rat brain synaptosomes after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060848(CHEMBL3394751)
Affinity DataIC50:  3.90nMAssay Description:Displacement of [125I]-Tyr14-nociceptin from human ORL1 expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060837(CHEMBL3394744)
Affinity DataIC50:  4.20nMAssay Description:Displacement of [125I]-Tyr14-nociceptin from human ORL1 expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318133((14S)-16-amino-10,14-dicyclohexyl-2-oxa-10,15,17,2...)
Affinity DataIC50:  7nMAssay Description:Inhibition of BACE1 assessed as amyloid beta (1-40) productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060843(CHEMBL3394748)
Affinity DataIC50:  8nMAssay Description:Displacement of [125I]-Tyr14-nociceptin from human ORL1 expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060893(CHEMBL3394753)
Affinity DataIC50:  8.80nMAssay Description:Displacement of [125I]-Tyr14-nociceptin from human ORL1 expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060844(CHEMBL3394749)
Affinity DataIC50:  14nMAssay Description:Displacement of [125I]-Tyr14-nociceptin from human ORL1 expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318123((14S)-16-amino-10,14-dicyclohexyl-2-oxa-10,15,17-t...)
Affinity DataIC50:  17nMAssay Description:Inhibition of BACE1 assessed as amyloid beta (1-40) productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060903(CHEMBL3394756)
Affinity DataIC50:  18nMAssay Description:Displacement of [125I]-Tyr14-nociceptin from human ORL1 expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060846(CHEMBL3394750)
Affinity DataIC50:  26nMAssay Description:Displacement of [125I]-Tyr14-nociceptin from human ORL1 expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060836(CHEMBL3394743)
Affinity DataIC50:  29nMAssay Description:Displacement of [3H]DAMGO from human Mu opioid receptor expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060842(CHEMBL3394747)
Affinity DataIC50:  29nMAssay Description:Displacement of [3H]DAMGO from human Mu opioid receptor expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318131((14S)-16-amino-10,14-dicyclohexyl-20-fluoro-2-oxa-...)
Affinity DataIC50:  30nMAssay Description:Inhibition of BACE1 assessed as amyloid beta (1-40) productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060904(CHEMBL3394742)
Affinity DataIC50:  34nMAssay Description:Displacement of [125I]-Tyr14-nociceptin from human ORL1 expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318127((15S)-17-amino-11,15-dicyclohexyl-2-oxa-11,16,18-t...)
Affinity DataIC50:  34nMAssay Description:Inhibition of BACE1 assessed as amyloid beta (1-40) productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060838(CHEMBL3394745)
Affinity DataIC50:  36nMAssay Description:Displacement of [3H]DAMGO from human Mu opioid receptor expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318132((14S)-16-amino-10,14-dicyclohexyl-20-methoxy-2-oxa...)
Affinity DataIC50:  36nMAssay Description:Inhibition of BACE1 assessed as amyloid beta (1-40) productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060897(CHEMBL3394754)
Affinity DataIC50:  37nMAssay Description:Displacement of [125I]-Tyr14-nociceptin from human ORL1 expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060863(CHEMBL3394752)
Affinity DataIC50:  41nMAssay Description:Displacement of [125I]-Tyr14-nociceptin from human ORL1 expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060841(CHEMBL3394746)
Affinity DataIC50:  47nMAssay Description:Displacement of [3H]DAMGO from human Mu opioid receptor expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060863(CHEMBL3394752)
Affinity DataIC50:  57nMAssay Description:Displacement of [3H]DAMGO from human Mu opioid receptor expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060836(CHEMBL3394743)
Affinity DataIC50:  61nMAssay Description:Displacement of [125I]-Tyr14-nociceptin from human ORL1 expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060844(CHEMBL3394749)
Affinity DataIC50:  69nMAssay Description:Displacement of [3H]DAMGO from human Mu opioid receptor expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318124((14S)-16-amino-14-cyclohexyl-10-(oxan-4-yl)-2-oxa-...)
Affinity DataIC50:  73nMAssay Description:Inhibition of BACE1 assessed as amyloid beta (1-40) productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060848(CHEMBL3394751)
Affinity DataIC50:  79nMAssay Description:Displacement of [3H]DAMGO from human Mu opioid receptor expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060843(CHEMBL3394748)
Affinity DataIC50:  80nMAssay Description:Displacement of [3H]DAMGO from human Mu opioid receptor expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060902(CHEMBL3394755)
Affinity DataIC50:  82nMAssay Description:Displacement of [125I]-Tyr14-nociceptin from human ORL1 expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318125((14S)-16-amino-10-cyclohexyl-14-(propan-2-yl)-2-ox...)
Affinity DataIC50:  90nMAssay Description:Inhibition of BACE1 assessed as amyloid beta (1-40) productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060838(CHEMBL3394745)
Affinity DataIC50:  100nMAssay Description:Displacement of [125I]-Tyr14-nociceptin from human ORL1 expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060846(CHEMBL3394750)
Affinity DataIC50:  103nMAssay Description:Displacement of [3H]DAMGO from human Mu opioid receptor expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM17786((4S)-4-(2-amino-6-phenoxy-3,4-dihydroquinazolin-3-...)
Affinity DataIC50:  110nMpH: 4.0 T: 2°CAssay Description:Cathepsin D activity was measured at pH 4 using a FRET peptide substrate. Compounds were preincubated with recombinant human liver cathepsin D for 20...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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