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Found 615 with Last Name = 'bresciani' and Initial = 'a'
TargetRelaxin receptor 1(Homo sapiens (Human))
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50563230(CHEMBL4754949)
Affinity DataKi:  1.10nMAssay Description:Displacement of Eu3+-labelled H2 relaxin from human RXFP1 expressed in human HEK-293T cells in presence of 10 % FCS by competition binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRelaxin receptor 1(Homo sapiens (Human))
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50563231(CHEMBL4780098)
Affinity DataKi:  2.88E+3nMAssay Description:Displacement of Eu3+-labelled H2 relaxin from human RXFP1 expressed in human HEK-293T cells in presence of 10 % FCS by competition binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50461260(CHEMBL4228926)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50461249(CHEMBL1215628)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFalcipain 2(Plasmodium falciparum)
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50461249(CHEMBL1215628)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of Plasmodium falciparum falcipain-2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50461249(CHEMBL1215628)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50461256(CHEMBL4228143)
Affinity DataIC50:  1nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50461256(CHEMBL4228143)
Affinity DataIC50:  1nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50461260(CHEMBL4228926)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))TBA
LigandPNGBDBM50612449(CHEMBL5271471)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human HDAC3 expressed in baculovirus infected insect cells using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincubated for 10 mins f...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetFalcipain 2(Plasmodium falciparum)
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50461265(CHEMBL4226307)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of Plasmodium falciparum falcipain-2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50461248(CHEMBL4227295)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50175036(CHEMBL3809599)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of recombinant human His-tagged HDAC1 expressed in insect cells preincubated for 10 mins followed by addition of FLUOR DE LYS as fluoresce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50612447(CHEMBL5285293)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human recombinant his tagged HDAC1 expressed in baculovirus expression system using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Promidis

Curated by ChEMBL
LigandPNGBDBM50592391(CHEMBL5187766)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of G9a (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50612445(CHEMBL5282110)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human recombinant his tagged HDAC1 expressed in baculovirus expression system using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50612449(CHEMBL5271471)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human recombinant his tagged HDAC1 expressed in baculovirus expression system using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50612450(CHEMBL5279520)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human recombinant his tagged HDAC1 expressed in baculovirus expression system using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetFalcipain 2(Plasmodium falciparum)
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50461271(CHEMBL4224764)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of Plasmodium falciparum falcipain-2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFalcipain 2(Plasmodium falciparum)
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50461272(CHEMBL4227031)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of Plasmodium falciparum falcipain-2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Promidis

Curated by ChEMBL
LigandPNGBDBM50592384(CHEMBL5195846)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of G9a (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFalcipain 2(Plasmodium falciparum)
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50461269(CHEMBL4227166)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of Plasmodium falciparum falcipain-2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50612449(CHEMBL5271471)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of human HDAC2More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Promidis

Curated by ChEMBL
LigandPNGBDBM50446376(CHEMBL3109630)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of G9a (unknown origin)More data for this Ligand-Target Pair
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50352418(CHEMBL1823863)
Affinity DataIC50:  3nMAssay Description:Displacement of Bodipy-labelled cyclopamine from Smo expressed in COS-1 cells in presence of 2% FBS after 4 to 6 hrs by FACS flow cytometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFalcipain 2(Plasmodium falciparum)
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50461270(CHEMBL4227486)
Affinity DataIC50:  3nMAssay Description:Inhibition of Plasmodium falciparum falcipain-2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50612452(CHEMBL5285418)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant his tagged HDAC1 expressed in baculovirus expression system using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
Irbm

Curated by ChEMBL
LigandPNGBDBM50547574(CHEMBL4747964)
Affinity DataIC50:  3nMAssay Description:Binding affinity to human KEAP1 Kelch domain (322 to 609 residues) incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
Irbm

Curated by ChEMBL
LigandPNGBDBM50547568(CHEMBL4791554)
Affinity DataIC50:  3.10nMAssay Description:Binding affinity to human KEAP1 Kelch domain (322 to 609 residues) incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50612453(CHEMBL5285433)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human recombinant his tagged HDAC1 expressed in baculovirus expression system using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50258549((S)-2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-(1-(5-(...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human recombinant his tagged HDAC1 expressed in baculovirus expression system using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincu...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
Irbm

Curated by ChEMBL
LigandPNGBDBM50547569(CHEMBL4764193)
Affinity DataIC50:  3.40nMAssay Description:Binding affinity to human KEAP1 Kelch domain (322 to 609 residues) incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))TBA
LigandPNGBDBM50612445(CHEMBL5282110)
Affinity DataIC50: <3.5nMAssay Description:Inhibition of human HDAC3 expressed in baculovirus infected insect cells using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincubated for 10 mins f...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone deacetylase 3(Homo sapiens (Human))TBA
LigandPNGBDBM50608555(CHEMBL5269165)
Affinity DataIC50: <3.5nMAssay Description:Inhibition of human HDAC3 expressed in baculovirus infected insect cells using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincubated for 10 mins f...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50612445(CHEMBL5282110)
Affinity DataIC50: <3.5nMAssay Description:Inhibition of human HDAC2More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50608555(CHEMBL5269165)
Affinity DataIC50: <3.5nMAssay Description:Inhibition of human HDAC2More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50608555(CHEMBL5269165)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of human recombinant his tagged HDAC1 expressed in baculovirus expression system using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
Irbm

Curated by ChEMBL
LigandPNGBDBM50547572(CHEMBL4788971)
Affinity DataIC50:  3.60nMAssay Description:Binding affinity to human KEAP1 Kelch domain (322 to 609 residues) incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50461256(CHEMBL4228143)
Affinity DataIC50:  4nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
Irbm

Curated by ChEMBL
LigandPNGBDBM50547573(CHEMBL4747827)
Affinity DataIC50:  4.20nMAssay Description:Binding affinity to human KEAP1 Kelch domain (322 to 609 residues) incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
Irbm

Curated by ChEMBL
LigandPNGBDBM50547571(CHEMBL4755277)
Affinity DataIC50:  4.70nMAssay Description:Binding affinity to human KEAP1 Kelch domain (322 to 609 residues) incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
Irbm

Curated by ChEMBL
LigandPNGBDBM50547566(CHEMBL4790062)
Affinity DataIC50:  4.80nMAssay Description:Binding affinity to human KEAP1 Kelch domain (322 to 609 residues) incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
Irbm

Curated by ChEMBL
LigandPNGBDBM50547567(CHEMBL4781886)
Affinity DataIC50:  4.80nMAssay Description:Binding affinity to human KEAP1 Kelch domain (322 to 609 residues) incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50352268(CHEMBL1822467)
Affinity DataIC50:  5nMAssay Description:Displacement of BODIPY-cyclopamine from Smo expressed in COS-1 cells after 4 to 6 hrs by Flow Cytometry analysis in presence of 2% fetal calf serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Promidis

Curated by ChEMBL
LigandPNGBDBM50592392(CHEMBL5193402)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of G9a (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Promidis

Curated by ChEMBL
LigandPNGBDBM50592390(CHEMBL5172085)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of G9a (unknown origin) assessed as effect on H3K9 methylation by cell based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Promidis

Curated by ChEMBL
LigandPNGBDBM50446376(CHEMBL3109630)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of G9a (unknown origin) assessed as effect on H3K9 methylation by cell based assayMore data for this Ligand-Target Pair
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50352268(CHEMBL1822467)
Affinity DataIC50:  6nMAssay Description:Displacement of BODIPY-cyclopamine from Smo expressed in COS-1 cells after 4 to 6 hrs by Flow Cytometry analysis in presence of 20% normal human seru...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFalcipain 2(Plasmodium falciparum)
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50461267(CHEMBL4227427)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of Plasmodium falciparum falcipain-2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50352419(CHEMBL1823864)
Affinity DataIC50:  7nMAssay Description:Displacement of Bodipy-labelled cyclopamine from Smo expressed in COS-1 cells in presence of 2% FBS after 4 to 6 hrs by FACS flow cytometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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