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Found 892 with Last Name = 'brewer' and Initial = 'jt'
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50368698(CHEMBL4161906)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]N-Methyl-SSR504734 from human GlyT1c expressed in cell membranes incubated for 1 hr by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50368757(CHEMBL4169829)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]N-Methyl-SSR504734 from human GlyT1c expressed in cell membranes incubated for 1 hr by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50368693(CHEMBL4171521)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]N-Methyl-SSR504734 from human GlyT1c expressed in cell membranes incubated for 1 hr by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50365388(CHEMBL4165362)
Affinity DataKi:  1nMAssay Description:Inhibition of [3H]N-Methyl-SSR504734 binding to human recombinant GlyT1c expressed in CHO cell membranes incubated for 1 hr by liquid scintillation s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM308636(BDBM308807 | US9656955, Example 150 | trans-N-[2-c...)
Affinity DataKi: <1nMAssay Description:Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50368701(CHEMBL4173657)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]N-Methyl-SSR504734 from human GlyT1c expressed in cell membranes incubated for 1 hr by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50368759(CHEMBL4159998)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]N-Methyl-SSR504734 from human GlyT1c expressed in cell membranes incubated for 1 hr by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50368692(CHEMBL4165340)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]N-Methyl-SSR504734 from human GlyT1c expressed in cell membranes incubated for 1 hr by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50368752(CHEMBL4166406)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]N-Methyl-SSR504734 from human GlyT1c expressed in cell membranes incubated for 1 hr by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50368702(CHEMBL4161781)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]N-Methyl-SSR504734 from human GlyT1c expressed in cell membranes incubated for 1 hr by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50368767(CHEMBL4163697)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]N-Methyl-SSR504734 from human GlyT1c expressed in cell membranes incubated for 1 hr by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50366117(CHEMBL4176089)
Affinity DataKi:  2nMAssay Description:Inhibition of [3H]N-Methyl-SSR504734 binding to human recombinant GlyT1c expressed in CHO cell membranes incubated for 1 hr by liquid scintillation s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM309129((3R,4S)-4-(4-fluorophenyl)-N-[4-fluoro-3-(trifluor...)
Affinity DataKi:  2nMAssay Description:Inhibition of [3H]N-Methyl-SSR504734 binding to human recombinant GlyT1c expressed in CHO cell membranes incubated for 1 hr by liquid scintillation s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM308813((3R,4S)-4-(4-fluorophenyl)-1-[(1-methyl-1H-imidazo...)
Affinity DataKi:  2nMAssay Description:Inhibition of [3H]N-Methyl-SSR504734 binding to human recombinant GlyT1c expressed in CHO cell membranes incubated for 1 hr by liquid scintillation s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50365371(CHEMBL4168242)
Affinity DataKi:  2nMAssay Description:Inhibition of [3H]N-Methyl-SSR504734 binding to human recombinant GlyT1c expressed in CHO cell membranes incubated for 1 hr by liquid scintillation s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM294231(US9586942, 5*)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]N-Methyl-SSR504734 from human GlyT1c expressed in cell membranes incubated for 1 hr by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50368771(CHEMBL4166296)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]N-Methyl-SSR504734 from human GlyT1c expressed in cell membranes incubated for 1 hr by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50368758(CHEMBL4173253)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]N-Methyl-SSR504734 from human GlyT1c expressed in cell membranes incubated for 1 hr by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50365378(CHEMBL4160468)
Affinity DataKi:  3nMAssay Description:Inhibition of [3H]N-Methyl-SSR504734 binding to human recombinant GlyT1c expressed in CHO cell membranes incubated for 1 hr by liquid scintillation s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50366116(CHEMBL4174148)
Affinity DataKi:  3nMAssay Description:Inhibition of [3H]N-Methyl-SSR504734 binding to human recombinant GlyT1c expressed in CHO cell membranes incubated for 1 hr by liquid scintillation s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM141044(US8653100, 4)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]N-Methyl-SSR504734 from human GlyT1c expressed in cell membranes incubated for 1 hr by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50365372(CHEMBL4176431)
Affinity DataKi:  3nMAssay Description:Inhibition of [3H]N-Methyl-SSR504734 binding to human recombinant GlyT1c expressed in CHO cell membranes incubated for 1 hr by liquid scintillation s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM309315((3R,4S)-4-(4-fluorophenyl)-N-[4-fluoro-3-(trifluor...)
Affinity DataKi:  3nMAssay Description:Inhibition of [3H]N-Methyl-SSR504734 binding to human recombinant GlyT1c expressed in CHO cell membranes incubated for 1 hr by liquid scintillation s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50368699(CHEMBL4167917)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]N-Methyl-SSR504734 from human GlyT1c expressed in cell membranes incubated for 1 hr by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50368760(CHEMBL4164744)
Affinity DataKi:  3.30nMAssay Description:Displacement of [3H]N-Methyl-SSR504734 from human GlyT1c expressed in cell membranes incubated for 1 hr by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50368697(CHEMBL4162953)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]N-Methyl-SSR504734 from human GlyT1c expressed in cell membranes incubated for 1 hr by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM308815((3R,4S)-4-(4-fluorophenyl)-1-[(1-methyl-1H-imidazo...)
Affinity DataKi:  4nMAssay Description:Inhibition of [3H]N-Methyl-SSR504734 binding to human recombinant GlyT1c expressed in CHO cell membranes incubated for 1 hr by liquid scintillation s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM308876(N-{(3R,4S)-4-(4-fluorophenyl)-1-[(1-methyl-1H-imid...)
Affinity DataKi:  5nMAssay Description:Inhibition of [3H]N-Methyl-SSR504734 binding to human recombinant GlyT1c expressed in CHO cell membranes incubated for 1 hr by liquid scintillation s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50365385(CHEMBL4166232)
Affinity DataKi:  5nMAssay Description:Inhibition of [3H]N-Methyl-SSR504734 binding to human recombinant GlyT1c expressed in CHO cell membranes incubated for 1 hr by liquid scintillation s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50368783(CHEMBL4165214)
Affinity DataKi:  5.70nMAssay Description:Displacement of [3H]N-Methyl-SSR504734 from human GlyT1c expressed in cell membranes incubated for 1 hr by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50365377(CHEMBL4161927)
Affinity DataKi:  7nMAssay Description:Inhibition of [3H]N-Methyl-SSR504734 binding to human recombinant GlyT1c expressed in CHO cell membranes incubated for 1 hr by liquid scintillation s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50365375(CHEMBL4162798)
Affinity DataKi:  8nMAssay Description:Inhibition of [3H]N-Methyl-SSR504734 binding to human recombinant GlyT1c expressed in CHO cell membranes incubated for 1 hr by liquid scintillation s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM308854(N-{(3R,4S)-4-(4-fluorophenyl)-1-[(1-methyl-1H-imid...)
Affinity DataKi:  8nMAssay Description:Inhibition of [3H]N-Methyl-SSR504734 binding to human recombinant GlyT1c expressed in CHO cell membranes incubated for 1 hr by liquid scintillation s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50368695(CHEMBL4172640)
Affinity DataKi:  9.5nMAssay Description:Displacement of [3H]N-Methyl-SSR504734 from human GlyT1c expressed in cell membranes incubated for 1 hr by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM309283(N-{(3R,4S)-4-(4-fluorophenyl)-1-[(1-methyl-1H-imid...)
Affinity DataKi: <10nMAssay Description:Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM309284(5-chloro-N-{(3R,4S)-1-[(1-methyl-1H-imidazol-4-yl)...)
Affinity DataKi: <10nMAssay Description:Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM309285(N-{((3R,4S)-1-[(1-methyl-1H-imidazol-4-yl)sulfonyl...)
Affinity DataKi: <10nMAssay Description:Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM309286(5-fluoro-N-{(3R,4S)-4-(4-fluorophenyl)-1-[(1-methy...)
Affinity DataKi: <10nMAssay Description:Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM309291(Trans-1-[(1-methyl-1H-imidazol-4-yl)sulfonyl]-4-(t...)
Affinity DataKi: <10nMAssay Description:Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM309293(Trans-N-[2-chloro-4-(trifluoromethyl)benzyl]-4-(3-...)
Affinity DataKi: <10nMAssay Description:Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM308599(US9656955, Example 85 | trans-4-(4-fluorophenyl)-1...)
Affinity DataKi: <10nMAssay Description:Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM308602(BDBM308812 | US9656955, Example 88 | trans-4-(4-fl...)
Affinity DataKi: <10nMAssay Description:Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM308608(BDBM308811 | US9656955, Example 94 | trans-N-(3-ch...)
Affinity DataKi: <10nMAssay Description:Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM309311(US9656955, Example 836 | trans-4-(4-fluorophenyl)-...)
Affinity DataKi: <10nMAssay Description:Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM309312((3R,4S)-4-(4-fluorophenyl)-1-[(1-methyl-1H-1,2,3-t...)
Affinity DataKi: <10nMAssay Description:Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM309313((3R,4S)-4-(4-fluorophenyl)-N-[4-fluoro-3-(trifluor...)
Affinity DataKi: <10nMAssay Description:Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM309314((3R,4S)-4-(4-fluorophenyl)-1-[(1-methyl-1H-1,2,3-t...)
Affinity DataKi: <10nMAssay Description:Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM309315((3R,4S)-4-(4-fluorophenyl)-N-[4-fluoro-3-(trifluor...)
Affinity DataKi: <10nMAssay Description:Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM309316((3R,4S)-N-(3-chlorophenyl)-4-(4-fluorophenyl)-1-[(...)
Affinity DataKi: <10nMAssay Description:Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM309317((3R,4S)-N-(3-chloro-4-fluorophenyl)-4-(4-fluorophe...)
Affinity DataKi: <10nMAssay Description:Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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