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Found 86 with Last Name = 'brewer' and Initial = 'm'
TargetCannabinoid receptor 1(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234380(CHEMBL245876 | quinolin-8-yl 4-methyl-3-(piperidin...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234380(CHEMBL245876 | quinolin-8-yl 4-methyl-3-(piperidin...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]CP55940 from human CB2 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50118216((4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl di...)
Affinity DataKi:  7.30E+6nMAssay Description:Inhibition of Trypanosoma cruzi trans-SialidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM4706((2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-...)
Affinity DataKi:  1.23E+7nMAssay Description:Inhibition of Trypanosoma cruzi trans-SialidaseMore data for this Ligand-Target Pair
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50374929(CHEMBL402364)
Affinity DataIC50:  60nMAssay Description:Inhibition of human integrin alpha-4-beta-7-MAdCAM interaction in human RPMI 8866 cells by whole-cell adhesion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50374925(CHEMBL272367)
Affinity DataIC50:  180nMAssay Description:Inhibition of human integrin alpha-4-beta-7-MAdCAM interaction in human RPMI 8866 cells by whole-cell adhesion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50374930(CHEMBL257458)
Affinity DataIC50:  260nMAssay Description:Inhibition of human integrin alpha-4-beta-7-MAdCAM interaction in human RPMI 8866 cells by whole-cell adhesion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50374933(CHEMBL402647)
Affinity DataIC50:  900nMAssay Description:Inhibition of human integrin alpha-4-beta-7-MAdCAM interaction in human RPMI 8866 cells by whole-cell adhesion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50374928(CHEMBL404714)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human integrin alpha-4-beta-7-MAdCAM interaction in human RPMI 8866 cells by whole-cell adhesion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50374927(CHEMBL255836)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human integrin alpha-4-beta-7-MAdCAM interaction in human RPMI 8866 cells by whole-cell adhesion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50374935(CHEMBL271052)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human integrin alpha-4-beta-7-MAdCAM interaction in human RPMI 8866 cells by whole-cell adhesion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50374926(CHEMBL272366)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of human integrin alpha-4-beta-7-MAdCAM interaction in human RPMI 8866 cells by whole-cell adhesion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50374923(CHEMBL255561)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of human integrin alpha-4-beta-7-MAdCAM interaction in human RPMI 8866 cells by whole-cell adhesion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50374934(CHEMBL271051)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of human integrin alpha-4-beta-7-MAdCAM interaction in human RPMI 8866 cells by whole-cell adhesion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50374924(CHEMBL406677)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of human integrin alpha-4-beta-7-MAdCAM interaction in human RPMI 8866 cells by whole-cell adhesion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50374936(CHEMBL402795)
Affinity DataIC50:  8.60E+3nMAssay Description:Inhibition of human integrin alpha-4-beta-7-MAdCAM interaction in human RPMI 8866 cells by whole-cell adhesion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50374932(CHEMBL271050)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human integrin alpha-4-beta-7-MAdCAM interaction in human RPMI 8866 cells by whole-cell adhesion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50374930(CHEMBL257458)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of integrin alpha-5-beta-1-fibronectin interactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50374929(CHEMBL402364)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of integrin alpha-5-beta-1-fibronectin interactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50374935(CHEMBL271052)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of integrin alpha-5-beta-1-fibronectin interactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50374931(CHEMBL402126)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human integrin alpha-4-beta-7-MAdCAM interaction in human RPMI 8866 cells by whole-cell adhesion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50374930(CHEMBL257458)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of integrin alpha-4-beta-1-VCAM interactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50374935(CHEMBL271052)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of integrin alpha-4-beta-1-VCAM interactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50374929(CHEMBL402364)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of integrin alpha-4-beta-1-VCAM interactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266507(3-(benzo[d]thiazol-2-yl)-4-(2,5-dimethylphenyl)but...)
Affinity DataIC50:  1.20E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266479(3-(benzo[d]thiazol-2-yl)-4-(3-fluorophenyl)but-3-e...)
Affinity DataIC50:  1.20E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266509(3-(benzo[d]thiazol-2-yl)-4-(3-(trifluoromethyl)phe...)
Affinity DataIC50:  1.50E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266386(3-(benzo[d]thiazol-2-yl)-4-(2-isopropoxyphenyl)but...)
Affinity DataIC50:  1.50E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266506(3-(benzo[d]thiazol-2-yl)-4-(2-ethoxyphenyl)but-3-e...)
Affinity DataIC50:  1.60E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266478(3-(benzo[d]thiazol-2-yl)-4-(3,4-dimethoxyphenyl)bu...)
Affinity DataIC50:  1.80E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266444(2-(4,5-dimethyl-3-(propoxycarbonyl)thiophen-2-ylca...)
Affinity DataIC50:  2.10E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266334(2-(2-acetyl-5-tert-butylthiophen-3-ylcarbamoyl)ben...)
Affinity DataIC50:  2.70E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266335((5-(2-(benzo[d][1,3]dioxol-5-ylamino)-2-oxoethylth...)
Affinity DataIC50:  2.80E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266510(2-(2-acetylthiophen-3-ylcarbamoyl)benzoate | cid_2...)
Affinity DataIC50:  2.90E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266386(3-(benzo[d]thiazol-2-yl)-4-(2-isopropoxyphenyl)but...)
Affinity DataIC50:  2.90E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by TIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266477(3-(benzo[d]thiazol-2-yl)-4-(3-methoxyphenyl)but-3-...)
Affinity DataIC50:  3.10E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266506(3-(benzo[d]thiazol-2-yl)-4-(2-ethoxyphenyl)but-3-e...)
Affinity DataIC50:  4.20E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by TIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM4733(5-Acetylamino-6-aminopyridine-2-carboxylic acid | ...)
Affinity DataIC50:  4.40E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-SialidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266508(3-(benzo[d]thiazol-2-yl)-4-(3-hydroxyphenyl)but-3-...)
Affinity DataIC50:  5.20E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by TIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266705(4-acetamido-3-(hydroxymethyl)benzoate)
Affinity DataIC50:  5.40E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-SialidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50377984(Cephulac Syrup | Cholac | Chronulac | Constilac | ...)
Affinity DataIC50:  5.70E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-SialidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266707((3S,4S,5R)-4-acetamido-3,5-dihydroxycyclohex-1-eny...)
Affinity DataIC50:  1.50E+6nMAssay Description:Inhibition of Trypanosoma cruzi trans-SialidaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266703(ethyl (3S,4R,5R)-4-acetamido-3-hydroxy-5-(2-hydrox...)
Affinity DataIC50:  5.00E+6nMAssay Description:Inhibition of Trypanosoma cruzi trans-SialidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234385(CHEMBL253671 | N-(4-chlorophenyl)-4-methyl-3-(pipe...)
Affinity DataEC50:  1.41E+4nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234387((4-cyclohexyl-3-(pyrrolidin-1-ylsulfonyl)phenyl)(o...)
Affinity DataEC50: >2.00E+4nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234388((3-(azepan-1-ylsulfonyl)-4-methylphenyl)(octahydro...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234386((4-methyl-3-(thiomorpholinosulfonyl)phenyl)(octahy...)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234390(4-methyl-N-(1-methylcyclohexyl)-3-(piperidin-1-yls...)
Affinity DataEC50:  18nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234389((4-methyl-3-(piperidin-1-ylsulfonyl)phenyl)(octahy...)
Affinity DataEC50:  6nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234392(CHEMBL254531 | N-cyclohexyl-3-(pyrrolidin-1-ylsulf...)
Affinity DataEC50: >2.00E+4nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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