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Found 66 with Last Name = 'brewer' and Initial = 'ml'
TargetCannabinoid receptor 1(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234380(CHEMBL245876 | quinolin-8-yl 4-methyl-3-(piperidin...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234380(CHEMBL245876 | quinolin-8-yl 4-methyl-3-(piperidin...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]CP55940 from human CB2 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50118216((4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl di...)
Affinity DataKi:  7.30E+6nMAssay Description:Inhibition of Trypanosoma cruzi trans-SialidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM4706((2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-...)
Affinity DataKi:  1.23E+7nMAssay Description:Inhibition of Trypanosoma cruzi trans-SialidaseMore data for this Ligand-Target Pair
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266507(3-(benzo[d]thiazol-2-yl)-4-(2,5-dimethylphenyl)but...)
Affinity DataIC50:  1.20E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266479(3-(benzo[d]thiazol-2-yl)-4-(3-fluorophenyl)but-3-e...)
Affinity DataIC50:  1.20E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266509(3-(benzo[d]thiazol-2-yl)-4-(3-(trifluoromethyl)phe...)
Affinity DataIC50:  1.50E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266386(3-(benzo[d]thiazol-2-yl)-4-(2-isopropoxyphenyl)but...)
Affinity DataIC50:  1.50E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266506(3-(benzo[d]thiazol-2-yl)-4-(2-ethoxyphenyl)but-3-e...)
Affinity DataIC50:  1.60E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266478(3-(benzo[d]thiazol-2-yl)-4-(3,4-dimethoxyphenyl)bu...)
Affinity DataIC50:  1.80E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266444(2-(4,5-dimethyl-3-(propoxycarbonyl)thiophen-2-ylca...)
Affinity DataIC50:  2.10E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266334(2-(2-acetyl-5-tert-butylthiophen-3-ylcarbamoyl)ben...)
Affinity DataIC50:  2.70E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266335((5-(2-(benzo[d][1,3]dioxol-5-ylamino)-2-oxoethylth...)
Affinity DataIC50:  2.80E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266510(2-(2-acetylthiophen-3-ylcarbamoyl)benzoate | cid_2...)
Affinity DataIC50:  2.90E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266386(3-(benzo[d]thiazol-2-yl)-4-(2-isopropoxyphenyl)but...)
Affinity DataIC50:  2.90E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by TIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266477(3-(benzo[d]thiazol-2-yl)-4-(3-methoxyphenyl)but-3-...)
Affinity DataIC50:  3.10E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266506(3-(benzo[d]thiazol-2-yl)-4-(2-ethoxyphenyl)but-3-e...)
Affinity DataIC50:  4.20E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by TIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM4733(5-Acetylamino-6-aminopyridine-2-carboxylic acid | ...)
Affinity DataIC50:  4.40E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-SialidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266508(3-(benzo[d]thiazol-2-yl)-4-(3-hydroxyphenyl)but-3-...)
Affinity DataIC50:  5.20E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by TIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266705(4-acetamido-3-(hydroxymethyl)benzoate)
Affinity DataIC50:  5.40E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-SialidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50377984(Cephulac Syrup | Cholac | Chronulac | Constilac | ...)
Affinity DataIC50:  5.70E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-SialidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266707((3S,4S,5R)-4-acetamido-3,5-dihydroxycyclohex-1-eny...)
Affinity DataIC50:  1.50E+6nMAssay Description:Inhibition of Trypanosoma cruzi trans-SialidaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50266703(ethyl (3S,4R,5R)-4-acetamido-3-hydroxy-5-(2-hydrox...)
Affinity DataIC50:  5.00E+6nMAssay Description:Inhibition of Trypanosoma cruzi trans-SialidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234399(4-methyl-3-(piperidin-1-ylsulfonyl)-N-(quinolin-8-...)
Affinity DataEC50:  4nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234405((3-(4-hydroxypiperidin-1-ylsulfonyl)-4-methylpheny...)
Affinity DataEC50:  215nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234403((S)-N-(1-cyclohexylethyl)-4-methyl-3-(piperidin-1-...)
Affinity DataEC50:  5nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234400(4-methyl-N-(2-(methylsulfonyl)phenyl)-3-(piperidin...)
Affinity DataEC50:  6nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234401((3-(azetidin-1-ylsulfonyl)-4-methylphenyl)(octahyd...)
Affinity DataEC50:  13nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234407((4-chloro-3-(pyrrolidin-1-ylsulfonyl)phenyl)(octah...)
Affinity DataEC50:  4nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234406(4-chloro-N-cyclohexyl-3-(pyrrolidin-1-ylsulfonyl)b...)
Affinity DataEC50:  3nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234404(CHEMBL254325 | [3-(1,1-dioxo-1lambda-6-thiomorphol...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234408(CHEMBL253462 | N-(3-chlorophenyl)-4-methyl-3-(pipe...)
Affinity DataEC50:  27nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234410((4-chloro-3-(pyrrolidin-1-ylsulfonyl)phenyl)((tran...)
Affinity DataEC50:  3nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234409((4-methyl-3-(piperidin-1-ylsulfonyl)phenyl)(piperi...)
Affinity DataEC50:  82nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234413(5-(decahydroisoquinoline-2-carbonyl)-N-isopropyl-2...)
Affinity DataEC50:  2.28E+3nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234412((4-isopropyl-3-(pyrrolidin-1-ylsulfonyl)phenyl)(oc...)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234415(CHEMBL253461 | N-(2-chlorophenyl)-N,4-dimethyl-3-(...)
Affinity DataEC50: >2.00E+4nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234414(CHEMBL402768 | N-(2-chlorophenyl)-4-methyl-3-(pipe...)
Affinity DataEC50:  5nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234419(((trans)-octahydroisoquinolin-2(1H)-yl)(3-(pyrroli...)
Affinity DataEC50: >2.00E+4nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234417(CHEMBL254730 | N-cyclohexyl-4-isopropyl-3-(pyrroli...)
Affinity DataEC50:  4nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234418((2,3-Dichloro-phenyl)-[5-methoxy-2-methyl-3-(2-mor...)
Affinity DataEC50:  0.650nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234411((R)-N-(1-cyclohexylethyl)-4-methyl-3-(piperidin-1-...)
Affinity DataEC50:  18nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234416(CHEMBL439248 | N-(isoquinolin-1-yl)-4-methyl-3-(pi...)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234421(CHEMBL253056 | N-cyclohexyl-N,4-dimethyl-3-(piperi...)
Affinity DataEC50:  119nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234422((4-methyl-3-(pyrrolidin-1-ylsulfonyl)phenyl)(octah...)
Affinity DataEC50:  4nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234420(5-(decahydroisoquinoline-2-carbonyl)-2-methyl-N-ph...)
Affinity DataEC50: >2.00E+4nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234402(4-methyl-N-phenyl-3-(piperidin-1-ylsulfonyl)benzam...)
Affinity DataEC50:  139nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234398(CHEMBL269477 | N-(2-methoxyphenyl)-4-methyl-3-(pip...)
Affinity DataEC50:  21nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234394((4-methyl-3-(piperidin-1-ylsulfonyl)phenyl)((trans...)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234396((4-methyl-3-(morpholinosulfonyl)phenyl)(octahydroi...)
Affinity DataEC50:  5nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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