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Found 193 with Last Name = 'brielmann' and Initial = 'h'
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50315610((4-Trifluoromethylphenyl)-[7-(3-trifluoromethylpyr...)
Affinity DataIC50:  0.210nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsazepine-induced calcium mobilization by FLIPR ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50315616(3-[3-(Trifluoromethyl)pyridin-2-yl]-N-[5-(trifluor...)
Affinity DataIC50:  0.230nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsazepine-induced calcium mobilization by FLIPR ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50272889(2-(isopropoxymethyl)-N-(4-(trifluoromethyl)phenyl)...)
Affinity DataIC50:  0.300nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50272976(2-((2,6-dimethylmorpholino)methyl)-N-(4-(trifluoro...)
Affinity DataIC50:  0.400nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50191713(CHEMBL214989 | N-(4-tert-butylphenyl)-4-[3-(N-meth...)
Affinity DataIC50:  0.400nMAssay Description:Antagonist activity against low pH(5.0-5.5)-activated rat VR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50272848(2-methyl-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifl...)
Affinity DataIC50:  0.5nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50272850(2-(methoxymethyl)-N-(4-(trifluoromethyl)phenyl)-7-...)
Affinity DataIC50:  0.5nMAssay Description:Antagonist activity at rat TRPV1 receptor assessed as inhibition of low pH-induced activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50272890(2-(benzyloxymethyl)-N-(4-(trifluoromethyl)phenyl)-...)
Affinity DataIC50:  0.5nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50315608((4-Trifluoromethylphenyl)-[7-(3-trifluoromethylpyr...)
Affinity DataIC50:  0.630nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsazepine-induced calcium mobilization by FLIPR ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50191726((4-Trifluoromethylphenyl)-[7-(3-trifluoromethylpyr...)
Affinity DataIC50:  0.800nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50191713(CHEMBL214989 | N-(4-tert-butylphenyl)-4-[3-(N-meth...)
Affinity DataIC50:  0.800nMAssay Description:Antagonist activity against capsaicin-activated human VR1 by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50315609((4-Trifluoromethylphenyl)-[7-(3-trifluoromethylpyr...)
Affinity DataIC50:  0.830nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsazepine-induced calcium mobilization by FLIPR ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50273167((5-Trifluoromethylpyridin-2-yl)-[7-(3-trifluoromet...)
Affinity DataIC50:  0.850nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsazepine-induced calcium mobilization by FLIPR ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50272851(2-(ethoxymethyl)-N-(4-(trifluoromethyl)phenyl)-7-(...)
Affinity DataIC50:  0.900nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM20557(AMG 517 | CHEMBL229430 | JMC503515 Compound 23 | N...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50191748(CHEMBL214331 | N-(4-tert-butylphenyl)-4-(3-fluorop...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity against low pH(5.0-5.5)-activated rat VR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50273251(2-(isopropoxymethyl)-7-(3-(trifluoromethyl)pyridin...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50273213(2-(((2S,6R)-2,6-dimethylmorpholino)methyl)-7-(3-(t...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50191726((4-Trifluoromethylphenyl)-[7-(3-trifluoromethylpyr...)
Affinity DataIC50:  1.10nMAssay Description:Antagonist activity against capsaicin-activated human VR1 by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50191726((4-Trifluoromethylphenyl)-[7-(3-trifluoromethylpyr...)
Affinity DataIC50:  1.10nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsazepine-induced calcium mobilization by FLIPR ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50191726((4-Trifluoromethylphenyl)-[7-(3-trifluoromethylpyr...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50273085(2-((diethylamino)methyl)-N-(4-(trifluoromethyl)phe...)
Affinity DataIC50:  1.20nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50191726((4-Trifluoromethylphenyl)-[7-(3-trifluoromethylpyr...)
Affinity DataIC50:  1.40nMAssay Description:Antagonist activity against low pH(5.0-5.5)-activated rat VR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50272850(2-(methoxymethyl)-N-(4-(trifluoromethyl)phenyl)-7-...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50272850(2-(methoxymethyl)-N-(4-(trifluoromethyl)phenyl)-7-...)
Affinity DataIC50:  1.5nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50315612(7-[3-(Trifluoromethyl)pyridin-2-yl]-N-[5-(trifluor...)
Affinity DataIC50:  1.65nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsazepine-induced calcium mobilization by FLIPR ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50273285(2-(((2S,6R)-2,6-dimethylmorpholino)methyl)-7-(3-(t...)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50160039(CHEMBL183752 | N-(4-tert-Butyl-phenyl)-4-(3-chloro...)
Affinity DataIC50:  2nMAssay Description:Antagonist activity against low pH(5.0-5.5)-activated rat VR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50273166(2-(3-((2S,6R)-2,6-dimethylmorpholino)propyl)-N-(4-...)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50272974(2-(2-methoxyethyl)-N-(4-(trifluoromethyl)phenyl)-7...)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50273087(2-(morpholinomethyl)-N-(4-(trifluoromethyl)phenyl)...)
Affinity DataIC50:  2.10nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50315615(7-(3-(trifluoromethyl)pyridin-2-yl)-N-(5-(trifluor...)
Affinity DataIC50:  2.20nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsazepine-induced calcium mobilization by FLIPR ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50273167((5-Trifluoromethylpyridin-2-yl)-[7-(3-trifluoromet...)
Affinity DataIC50:  2.5nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50273165(2-(3-morpholinopropyl)-N-(4-(trifluoromethyl)pheny...)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50191748(CHEMBL214331 | N-(4-tert-butylphenyl)-4-(3-fluorop...)
Affinity DataIC50:  3nMAssay Description:Antagonist activity against capsaicin-activated human VR1 by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50315615(7-(3-(trifluoromethyl)pyridin-2-yl)-N-(5-(trifluor...)
Affinity DataIC50:  3.25nMpH: 5.0Assay Description:Inhibition of rat TRPV1 at pH 5 to 5.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50232114((R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50272849((4-(4-(trifluoromethyl)phenylamino)-7-(3-(trifluor...)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50160031(CHEMBL180902 | N-(4-tert-Butyl-phenyl)-4-(3-triflu...)
Affinity DataIC50:  4nMAssay Description:Antagonist activity against low pH(5.0-5.5)-activated rat VR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50191708(CHEMBL386251 | N-(4-tert-butylphenyl)-4-(3-(ethyls...)
Affinity DataIC50:  4nMAssay Description:Antagonist activity against low pH(5.0-5.5)-activated rat VR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50273250(2-(ethoxymethyl)-7-(3-(trifluoromethyl)pyridin-2-y...)
Affinity DataIC50:  4.5nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50191705(CHEMBL214628 | N-(4-tert-butylphenyl)-4-(3-(hydrox...)
Affinity DataIC50:  5nMAssay Description:Antagonist activity against low pH(5.0-5.5)-activated rat VR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50160027(CHEMBL183045 | N-(4-tert-Butyl-phenyl)-4-(3-nitro-...)
Affinity DataIC50:  5nMAssay Description:Antagonist activity against capsaicin-activated human VR1 by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50160027(CHEMBL183045 | N-(4-tert-Butyl-phenyl)-4-(3-nitro-...)
Affinity DataIC50:  5nMAssay Description:Antagonist activity against low pH(5.0-5.5)-activated rat VR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50273053(2-((cyclohexylamino)methyl)-N-(4-(trifluoromethyl)...)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50160031(CHEMBL180902 | N-(4-tert-Butyl-phenyl)-4-(3-triflu...)
Affinity DataIC50:  6nMAssay Description:Antagonist activity against capsaicin-activated human VR1 by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50315614((4-Trifluoromethylphenyl)-[7-(3-trifluoromethylpyr...)
Affinity DataIC50:  6.10nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsazepine-induced calcium mobilization by FLIPR ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50273214(7-(3-(trifluoromethyl)pyridin-2-yl)-N-(6-(trifluor...)
Affinity DataIC50:  7nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50273214(7-(3-(trifluoromethyl)pyridin-2-yl)-N-(6-(trifluor...)
Affinity DataIC50:  7.10nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsazepine-induced calcium mobilization by FLIPR ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50273088(2-((4-cyclopentylpiperazin-1-yl)methyl)-N-(4-(trif...)
Affinity DataIC50:  8nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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