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Found 74 with Last Name = 'brizuela' and Initial = 'l'
TargetCathepsin K(Homo sapiens (Human))
Jilin University

Curated by ChEMBL
LigandPNGBDBM50517806(CHEMBL4541720)
Affinity DataKi:  1.10nMAssay Description:Inhibition of recombinant His-tagged human cathepsin K expressed in Escherichia coliMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Jilin University

Curated by ChEMBL
LigandPNGBDBM50517805(CHEMBL4454648)
Affinity DataKi:  7.20nMAssay Description:Inhibition of recombinant His-tagged human cathepsin K expressed in Escherichia coliMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Jilin University

Curated by ChEMBL
LigandPNGBDBM50517806(CHEMBL4541720)
Affinity DataKi:  195nMAssay Description:Inhibition of human liver cathepsin LMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Jilin University

Curated by ChEMBL
LigandPNGBDBM50517806(CHEMBL4541720)
Affinity DataKi:  239nMAssay Description:Inhibition of recombinant human cathepsin S expressed in Escherichia coliMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Jilin University

Curated by ChEMBL
LigandPNGBDBM50517805(CHEMBL4454648)
Affinity DataKi:  406nMAssay Description:Inhibition of human liver cathepsin LMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Jilin University

Curated by ChEMBL
LigandPNGBDBM50517805(CHEMBL4454648)
Affinity DataKi:  735nMAssay Description:Inhibition of recombinant human cathepsin S expressed in Escherichia coliMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Jilin University

Curated by ChEMBL
LigandPNGBDBM50517806(CHEMBL4541720)
Affinity DataKi:  909nMAssay Description:Inhibition of human liver cathepsin BMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Jilin University

Curated by ChEMBL
LigandPNGBDBM50517805(CHEMBL4454648)
Affinity DataKi:  3.35E+3nMAssay Description:Inhibition of human liver cathepsin BMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Jilin University

Curated by ChEMBL
LigandPNGBDBM50517806(CHEMBL4541720)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of recombinant His-tagged human cathepsin K expressed in Escherichia coliMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Jilin University

Curated by ChEMBL
LigandPNGBDBM50517805(CHEMBL4454648)
Affinity DataIC50:  15nMAssay Description:Inhibition of recombinant His-tagged human cathepsin K expressed in Escherichia coliMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Mitotix

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Cyclin-dependent kinase 1-cyclin B1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Mitotix

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against cyclin-dependent kinase 4-cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCathepsin S(Homo sapiens (Human))
Jilin University

Curated by ChEMBL
LigandPNGBDBM50517806(CHEMBL4541720)
Affinity DataIC50:  332nMAssay Description:Inhibition of recombinant human cathepsin S expressed in Escherichia coliMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Mitotix

Curated by ChEMBL
LigandPNGBDBM50088615(2-(4-Chloro-phenyl)-5,7-dihydroxy-8-(1-methyl-1,2,...)
Affinity DataIC50:  550nMAssay Description:Inhibitory activity against cyclin-dependent kinase 4-cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Mitotix

Curated by ChEMBL
LigandPNGBDBM50088606(2-(2-Bromo-phenyl)-5,7-dihydroxy-8-(1-methyl-1,2,3...)
Affinity DataIC50:  650nMAssay Description:Inhibitory activity against cyclin-dependent kinase 4-cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Mitotix

Curated by ChEMBL
LigandPNGBDBM50088612(2-(2-Chloro-phenyl)-5,7-dihydroxy-8-(1-methyl-1,2,...)
Affinity DataIC50:  800nMAssay Description:Inhibitory activity against cyclin-dependent kinase 4-cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Mitotix

Curated by ChEMBL
LigandPNGBDBM50451015(CHEMBL9052)
Affinity DataIC50:  800nMAssay Description:Inhibitory activity against cyclin-dependent kinase 4-cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Jilin University

Curated by ChEMBL
LigandPNGBDBM50517806(CHEMBL4541720)
Affinity DataIC50:  915nMAssay Description:Inhibition of human liver cathepsin BMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50088606(2-(2-Bromo-phenyl)-5,7-dihydroxy-8-(1-methyl-1,2,3...)
Affinity DataIC50:  980nMAssay Description:Inhibitory activity against cyclin-dependent kinase 4-cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Mitotix

Curated by ChEMBL
LigandPNGBDBM50451018(CHEMBL8675)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity against cyclin-dependent kinase 4-cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Jilin University

Curated by ChEMBL
LigandPNGBDBM50517805(CHEMBL4454648)
Affinity DataIC50:  1.02E+3nMAssay Description:Inhibition of recombinant human cathepsin S expressed in Escherichia coliMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50088612(2-(2-Chloro-phenyl)-5,7-dihydroxy-8-(1-methyl-1,2,...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibitory activity against cyclin-dependent kinase 4-cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Mitotix

Curated by ChEMBL
LigandPNGBDBM50088608(2-(2,4-Dichloro-phenyl)-5,7-dihydroxy-8-(1-methyl-...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibitory activity against cyclin-dependent kinase 4-cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50088610(2-(3-Chloro-phenyl)-5,7-dihydroxy-8-(1-methyl-1,2,...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibitory activity against cyclin-dependent kinase 4-cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Jilin University

Curated by ChEMBL
LigandPNGBDBM50517806(CHEMBL4541720)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human liver cathepsin LMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50088615(2-(4-Chloro-phenyl)-5,7-dihydroxy-8-(1-methyl-1,2,...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibitory activity against Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50088608(2-(2,4-Dichloro-phenyl)-5,7-dihydroxy-8-(1-methyl-...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibitory activity against cyclin-dependent kinase 4-cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Mitotix

Curated by ChEMBL
LigandPNGBDBM50088619(2-(2-Fluoro-phenyl)-5,7-dihydroxy-8-(1-methyl-1,2,...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibitory activity against cyclin-dependent kinase 4-cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Mitotix

Curated by ChEMBL
LigandPNGBDBM6961(13-(4-hydroxyphenyl)-11-azatetracyclo[8.7.0.0^{2,7...)
Affinity DataIC50:  1.90E+3nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50088619(2-(2-Fluoro-phenyl)-5,7-dihydroxy-8-(1-methyl-1,2,...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibitory activity against cyclin-dependent kinase 4-cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Mitotix

Curated by ChEMBL
LigandPNGBDBM6960(13-(3-aminophenyl)-11-azatetracyclo[8.7.0.0^{2,7}....)
Affinity DataIC50:  2.30E+3nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Mitotix

Curated by ChEMBL
LigandPNGBDBM50088610(2-(3-Chloro-phenyl)-5,7-dihydroxy-8-(1-methyl-1,2,...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibitory activity against cyclin-dependent kinase 4-cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Mitotix

Curated by ChEMBL
LigandPNGBDBM50451019(CHEMBL269124)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibitory activity against cyclin-dependent kinase 4-cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Jilin University

Curated by ChEMBL
LigandPNGBDBM50517805(CHEMBL4454648)
Affinity DataIC50:  2.71E+3nMAssay Description:Inhibition of human liver cathepsin LMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Jilin University

Curated by ChEMBL
LigandPNGBDBM50517805(CHEMBL4454648)
Affinity DataIC50:  3.37E+3nMAssay Description:Inhibition of human liver cathepsin BMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Mitotix

Curated by ChEMBL
LigandPNGBDBM6943(13-phenyl-11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}...)
Affinity DataIC50:  3.60E+3nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Mitotix

Curated by ChEMBL
LigandPNGBDBM6947(13-phenyl-11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}...)
Affinity DataIC50:  5.80E+3nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Mitotix

Curated by ChEMBL
LigandPNGBDBM50451014(CHEMBL8815)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibitory activity against Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Mitotix

Curated by ChEMBL
LigandPNGBDBM50088607(4-[2-(2-Chloro-phenyl)-5,7-dihydroxy-4-oxo-4H-chro...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibitory activity against cyclin-dependent kinase 4-cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Mitotix

Curated by ChEMBL
LigandPNGBDBM6962(13-(4-chlorophenyl)-11-azatetracyclo[8.7.0.0^{2,7}...)
Affinity DataIC50:  9.90E+3nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50088607(4-[2-(2-Chloro-phenyl)-5,7-dihydroxy-4-oxo-4H-chro...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibitory activity against cyclin-dependent kinase 4-cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibitory activity against cyclin-dependent kinase 4-cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50088614(2-(2-Chloro-phenyl)-5,7-dihydroxy-8-((S)-2-hydroxy...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibitory activity against Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Mitotix

Curated by ChEMBL
LigandPNGBDBM6953(11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}]heptadeca...)
Affinity DataIC50:  1.74E+4nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Mitotix

Curated by ChEMBL
LigandPNGBDBM6945(13-phenyl-11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}...)
Affinity DataIC50:  1.95E+4nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Mitotix

Curated by ChEMBL
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibitory activity against cyclin-dependent kinase 4-cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Mitotix

Curated by ChEMBL
LigandPNGBDBM50088609(2-(2-Chloro-phenyl)-5,7-dihydroxy-8-pyridin-4-yl-c...)
Affinity DataIC50:  2.10E+4nMAssay Description:Inhibitory activity against cyclin-dependent kinase 4-cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Mitotix

Curated by ChEMBL
LigandPNGBDBM6950(14-phenyl-11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}...)
Affinity DataIC50:  2.20E+4nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50088609(2-(2-Chloro-phenyl)-5,7-dihydroxy-8-pyridin-4-yl-c...)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibitory activity against cyclin-dependent kinase 4-cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Mitotix

Curated by ChEMBL
LigandPNGBDBM50451020(CHEMBL8620)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibitory activity against cyclin-dependent kinase 4-cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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