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Found 107 with Last Name = 'brown' and Initial = 'ed'
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataKi:  3nMAssay Description:Inhibition assay using Esherichia coli dihydrofolate reductase (DHFR). More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataKi:  3.80nMAssay Description:Inhibition of Escherichia coli Dihydrofolate reductase in presence of 100 uM Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

LigandPNGBDBM18049(3-({[(4-{[(carbamimidamidomethanimidoyl)sulfanyl]m...)
Affinity DataKi:  11.5nM ΔG°:  -45.3kJ/molepH: 7.5 T: 2°CAssay Description:The oxidation of NADPH was monitored at 340 nm using a Molecular Devices SpectraMax Plus 96-well microtiter plate reading spectrophotometer. Plots we...More data for this Ligand-Target Pair
TargetBifunctional protein GlmU(Escherichia coli)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM50294336(5-amino-2-(4-aminophenylamino)benzenesulfonic acid...)
Affinity DataKi:  17nMAssay Description:Competitive inhibition of Acetyltransferase activity of Escherichia coli BL21(DE3) GlmU in presence of AcCoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional protein GlmU(Escherichia coli)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM50483325(CHEMBL1652297 | Mac0029665)
Affinity DataKi:  23nMAssay Description:Competitive inhibition of Acetyltransferase activity of Escherichia coli BL21(DE3) GlmU in presence of AcCoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM50130955(3-amino-1-{[4-({[[(aminocarbonothioyl)amino](imini...)
Affinity DataKi:  26nMAssay Description:Inhibition constant against Dihydrofolate reductaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

LigandPNGBDBM50130950(5-(4-Chloro-phenylsulfanyl)-quinazoline-2,4-diamin...)
Affinity DataKi:  38nMAssay Description:Inhibition assay using Esherichia coli dihydrofolate reductase (DHFR). More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM50130956(5-(4-methylphenoxy)quinazoline-2,4-diamine, 2a | 5...)
Affinity DataKi:  41nMAssay Description:Inhibition of Escherichia coli Dihydrofolate reductase in presence of 100 uM Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM50130950(5-(4-Chloro-phenylsulfanyl)-quinazoline-2,4-diamin...)
Affinity DataKi:  61nMAssay Description:Inhibition of Escherichia coli Dihydrofolate reductase in presence of 100 uM Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM50130950(5-(4-Chloro-phenylsulfanyl)-quinazoline-2,4-diamin...)
Affinity DataKi:  61nMAssay Description:Inhibition of Escherichia coli Dihydrofolate reductase in presence of 100 uM Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM50130951(CHEMBL85364 | N-(4-chloro-2-cyanophenyl)imidodicar...)
Affinity DataKi:  65nMAssay Description:Inhibition constant against Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM18046(5-((4-methylphenyl)thio)-quinazoline 2,4-diamine, ...)
Affinity DataKi:  73nMAssay Description:Inhibition of Escherichia coli Dihydrofolate reductase in presence of 30 uM Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM50130952(5-(4-(trifluoromethyl)benzyloxy)quinazoline-2,4-di...)
Affinity DataKi:  130nMAssay Description:Inhibition of Escherichia coli Dihydrofolate reductase in presence of 30 uM Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

LigandPNGBDBM18046(5-((4-methylphenyl)thio)-quinazoline 2,4-diamine, ...)
Affinity DataKi:  150nMAssay Description:Inhibition assay using Esherichia coli dihydrofolate reductase (DHFR). More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

LigandPNGBDBM59168(5-(4-fluorophenoxy)quinazoline-2,4-diamine, 2b)
Affinity DataKi:  180nMAssay Description:Inhibition assay using Esherichia coli dihydrofolate reductase (DHFR). More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM50130954(6,7-Dimethyl-4a,5,6,7,8,8a-hexahydro-quinazoline-2...)
Affinity DataKi:  190nMAssay Description:Inhibition constant against Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

LigandPNGBDBM50130956(5-(4-methylphenoxy)quinazoline-2,4-diamine, 2a | 5...)
Affinity DataKi:  230nMAssay Description:Inhibition assay using Esherichia coli dihydrofolate reductase (DHFR). More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional protein GlmU(Escherichia coli)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM50483326(CHEMBL1652296 | Mac0008028)
Affinity DataKi:  404nMAssay Description:Competitive inhibition of Acetyltransferase activity of Escherichia coli BL21(DE3) GlmU in presence of AcCoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

LigandPNGBDBM59166(6,7-dimethyl-5,6,7,8-tetrahydroquinazoline-2,4-dia...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition assay using Esherichia coli dihydrofolate reductase (DHFR). More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

LigandPNGBDBM59167(6-methyl-5,6,7,8-tetrahydroquinazoline-2,4-diamine...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition assay using Esherichia coli dihydrofolate reductase (DHFR). More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM50130953(2,4-Diamino-1,6-bis-(4-fluoro-phenyl)-[1,3,5]triaz...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition constant against Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM50130957(3-Heptyl-4-hydroxy-1H-quinolin-2-one | CHEMBL80014)
Affinity DataKi:  1.10E+4nMAssay Description:Inhibition constant against Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM50130958(7-Methyl-4a,5,6,7,8,8a-hexahydro-quinazoline-2,4-d...)
Affinity DataKi:  2.30E+4nMAssay Description:Inhibition constant against Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  3nMpH: 7.0 T: 2°CAssay Description:The DHFR inhibition observed with each derivative was characterized by determination and comparison of the IC50 values. IC50 determinations were perf...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  18nMAssay Description:Inhibition of Escherichia coli Dihydrofolate reductase in presence of 30 uM Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  37nMAssay Description:Inhibition of Escherichia coli Dihydrofolate reductase in presence of 100 uM Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

LigandPNGBDBM18067(3-({[(3-{[(carbamimidamidomethanimidoyl)sulfanyl]m...)
Affinity DataIC50:  75nMpH: 7.0 T: 2°CAssay Description:The DHFR inhibition observed with each derivative was characterized by determination and comparison of the IC50 values. IC50 determinations were perf...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

LigandPNGBDBM18049(3-({[(4-{[(carbamimidamidomethanimidoyl)sulfanyl]m...)
Affinity DataIC50:  75nMpH: 7.0 T: 2°CAssay Description:The DHFR inhibition observed with each derivative was characterized by determination and comparison of the IC50 values. IC50 determinations were perf...More data for this Ligand-Target Pair
TargetCystathionine beta-lyase MetC(Escherichia coli K-12)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM50370860(CHEMBL219268)
Affinity DataIC50:  79nMAssay Description:Inhibition of Escherichia coli CBLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM50130955(3-amino-1-{[4-({[[(aminocarbonothioyl)amino](imini...)
Affinity DataIC50:  109nMAssay Description:Inhibition of Escherichia coli Dihydrofolate reductase in presence of 30 uM Dihydrofolate reductaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCystathionine beta-lyase MetC(Escherichia coli K-12)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM50370870(CHEMBL218090)
Affinity DataIC50:  280nMAssay Description:Inhibition of Escherichia coli CBLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM50130955(3-amino-1-{[4-({[[(aminocarbonothioyl)amino](imini...)
Affinity DataIC50:  302nMAssay Description:Inhibition of Escherichia coli Dihydrofolate reductase in presence of 100 uM Dihydrofolate reductaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM18046(5-((4-methylphenyl)thio)-quinazoline 2,4-diamine, ...)
Affinity DataIC50:  310nMAssay Description:Inhibition of Escherichia coli Dihydrofolate reductase in presence of 30 uM Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM50130951(CHEMBL85364 | N-(4-chloro-2-cyanophenyl)imidodicar...)
Affinity DataIC50:  320nMAssay Description:Inhibition of Escherichia coli Dihydrofolate reductase in presence of 30 uM Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM50130950(5-(4-Chloro-phenylsulfanyl)-quinazoline-2,4-diamin...)
Affinity DataIC50:  320nMAssay Description:Inhibition of Escherichia coli Dihydrofolate reductase in presence of 30 uM Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM50130950(5-(4-Chloro-phenylsulfanyl)-quinazoline-2,4-diamin...)
Affinity DataIC50:  320nMAssay Description:Inhibition constant against Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM50130956(5-(4-methylphenoxy)quinazoline-2,4-diamine, 2a | 5...)
Affinity DataIC50:  420nMAssay Description:Inhibition of Escherichia coli Dihydrofolate reductase in presence of 100 uM Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM50130956(5-(4-methylphenoxy)quinazoline-2,4-diamine, 2a | 5...)
Affinity DataIC50:  420nMAssay Description:Inhibition of Escherichia coli Dihydrofolate reductase in presence of 100 uM Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM50130950(5-(4-Chloro-phenylsulfanyl)-quinazoline-2,4-diamin...)
Affinity DataIC50:  510nMAssay Description:Inhibition constant against Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM50130950(5-(4-Chloro-phenylsulfanyl)-quinazoline-2,4-diamin...)
Affinity DataIC50:  510nMAssay Description:Inhibition of Escherichia coli Dihydrofolate reductase in presence of 100 uM Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystathionine beta-lyase MetC(Escherichia coli K-12)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM50370869(CHEMBL220764)
Affinity DataIC50:  530nMAssay Description:Inhibition of Escherichia coli CBLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-hexosaminidase subunit alpha(Homo sapiens (Human))
Research Institute, Hospital For Sick Children

LigandPNGBDBM68271(M-31850)
Affinity DataIC50:  600nMT: 2°CAssay Description:Enzyme assay based on 4-MU substrates with HTS to identify inhibitory compounds for Hex.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM50130951(CHEMBL85364 | N-(4-chloro-2-cyanophenyl)imidodicar...)
Affinity DataIC50:  620nMAssay Description:Inhibition of Escherichia coli Dihydrofolate reductase in presence of 100 uM Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystathionine beta-lyase MetC(Escherichia coli K-12)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM50370861(CHEMBL221848)
Affinity DataIC50:  650nMAssay Description:Inhibition of Escherichia coli CBLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM50130952(5-(4-(trifluoromethyl)benzyloxy)quinazoline-2,4-di...)
Affinity DataIC50:  660nMAssay Description:Inhibition of Escherichia coli Dihydrofolate reductase in presence of 30 uM Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM50130954(6,7-Dimethyl-4a,5,6,7,8,8a-hexahydro-quinazoline-2...)
Affinity DataIC50:  790nMAssay Description:Inhibition of Escherichia coli Dihydrofolate reductase in presence of 30 uM Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM18046(5-((4-methylphenyl)thio)-quinazoline 2,4-diamine, ...)
Affinity DataIC50:  820nMAssay Description:Inhibition of Escherichia coli Dihydrofolate reductase in presence of 100 uM Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM50130952(5-(4-(trifluoromethyl)benzyloxy)quinazoline-2,4-di...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of Escherichia coli Dihydrofolate reductase in presence of 30 uM Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystathionine beta-lyase MetC(Escherichia coli K-12)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM50370865(CHEMBL221706)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of Escherichia coli CBLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Mcmaster University

Curated by ChEMBL
LigandPNGBDBM50130954(6,7-Dimethyl-4a,5,6,7,8,8a-hexahydro-quinazoline-2...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of Escherichia coli Dihydrofolate reductase in presence of 100 uM Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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