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Found 236 with Last Name = 'bruno' and Initial = 'i'
LigandPNGBDBM50478489(CRAMBESCIDIN 816 HYDROCHLORIDE | Crambescidin 816 ...)
Affinity DataIC50:  0.150nMAssay Description:Antagonist activity at voltage-dependent L-type calcium channel in mouse neurobalstoma-rat glioma NG 108-15 hybrid cells assessed as inhibition of KC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50317647((3S,6S,9S,14aR)-6-((1H-indol-3-yl)methyl)-9-benzyl...)
Affinity DataIC50:  25nMAssay Description:Inhibition of full length HDAC3 expressed in HEK293 cells after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50317647((3S,6S,9S,14aR)-6-((1H-indol-3-yl)methyl)-9-benzyl...)
Affinity DataIC50:  68nMAssay Description:Inhibition of full length HDAC1 expressed in HEK293 cells after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))TBA
LigandPNGBDBM50405790(CHEMBL5284121)
Affinity DataIC50:  150nMAssay Description:Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
"G. D'Annunzio" University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50540553(CHEMBL4644726)
Affinity DataIC50:  170nMAssay Description:Antagonist activity at GAL4-tagged human PPARalpha LBD expressed in human HepG2 cells assessed as inhibition of Wy14,643-induced receptor transactiva...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50317647((3S,6S,9S,14aR)-6-((1H-indol-3-yl)methyl)-9-benzyl...)
Affinity DataIC50:  179nMAssay Description:Inhibition of full length HDAC2 expressed in HEK293 cells after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))TBA
LigandPNGBDBM50464480(CHEMBL4282628)
Affinity DataIC50:  180nMAssay Description:Inhibition of mPGES1 in IL-1beta-stimulated human A549 cell microsomes using PGH2 as substrate assessed as reduction in PGE2 production preincubated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))TBA
LigandPNGBDBM50405760(CHEMBL5284133)
Affinity DataIC50:  200nMAssay Description:Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
"G. D'Annunzio" University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50540555(CHEMBL4642691)
Affinity DataIC50:  210nMAssay Description:Antagonist activity at GAL4-tagged human PPARalpha LBD expressed in human HepG2 cells assessed as inhibition of Wy14,643-induced receptor transactiva...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
"G. D'Annunzio" University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50540566(CHEMBL4636567)
Affinity DataIC50:  240nMAssay Description:Antagonist activity at GAL4-tagged human PPARalpha LBD expressed in human HepG2 cells assessed as inhibition of Wy14,643-induced receptor transactiva...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))TBA
LigandPNGBDBM50464484(CHEMBL4290910)
Affinity DataIC50:  260nMAssay Description:Inhibition of mPGES1 in IL-1beta-stimulated human A549 cell microsomes using PGH2 as substrate assessed as reduction in PGE2 production preincubated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
"G. D'Annunzio" University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50540554(CHEMBL4636810)
Affinity DataIC50:  330nMAssay Description:Antagonist activity at GAL4-tagged human PPARalpha LBD expressed in human HepG2 cells assessed as inhibition of Wy14,643-induced receptor transactiva...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50339570(4'-(1-Phenylsulfanylmethyl-1H-[1,2,3]triazol-4-yl)...)
Affinity DataIC50:  400nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))TBA
LigandPNGBDBM50061980(CHEMBL3394323)
Affinity DataIC50:  410nMAssay Description:Inhibition of mPGES-1 in interleukin-1beta-stimulated human A549 cells microsomal membranes assessed as reduction in PGE2 formation incubated for 15 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))TBA
LigandPNGBDBM50464486(CHEMBL4293214)
Affinity DataIC50:  540nMAssay Description:Inhibition of mPGES1 in IL-1beta-stimulated human A549 cell microsomes using PGH2 as substrate assessed as reduction in PGE2 production preincubated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50339571(4-{4-[2'-(Naphthalen-1-yloxymethyl)-biphenyl-4-yl]...)
Affinity DataIC50:  600nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))TBA
LigandPNGBDBM50464479(CHEMBL4283041)
Affinity DataIC50:  600nMAssay Description:Inhibition of mPGES1 in IL-1beta-stimulated human A549 cell microsomes using PGH2 as substrate assessed as reduction in PGE2 production preincubated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
"G. D'Annunzio" University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50155330(CHEMBL3781890)
Affinity DataIC50:  650nMAssay Description:Antagonist activity at PPARalpha (unknown origin) expressed in HEK293A cells assessed as inhibition of GW7647-induced transactivation after 16 to 18 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))TBA
LigandPNGBDBM50386165(CHEMBL2042365)
Affinity DataIC50:  680nMAssay Description:Inhibition of mPGES1 in IL-1beta-stimulated human A549 cell assessed as inhibition of PGE2 production preincubated for 15 mins before substrate addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
"G. D'Annunzio" University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50155326(CHEMBL3780463)
Affinity DataIC50:  680nMAssay Description:Antagonist activity at PPARalpha (unknown origin) expressed in HEK293A cells assessed as inhibition of GW7647-induced transactivation after 16 to 18 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))TBA
LigandPNGBDBM50539779(CHEMBL4647475)
Affinity DataIC50:  700nMAssay Description:Inhibition of mPGES1 in human A549 cells assessed as reduction in IL-1beta induced PGE2 release using PGH2 as substrate preincubated for 15 mins foll...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
"G. D'Annunzio" University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50155332(CHEMBL3781465)
Affinity DataIC50:  800nMAssay Description:Antagonist activity at PPARalpha (unknown origin) expressed in HEK293A cells assessed as inhibition of GW7647-induced transactivation after 16 to 18 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50339571(4-{4-[2'-(Naphthalen-1-yloxymethyl)-biphenyl-4-yl]...)
Affinity DataIC50:  800nMAssay Description:Inhibition of human recombinant 5-lipooxygenase expressed in Escherichia coli MV1190 by cell free assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
"G. D'Annunzio" University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50155329(CHEMBL3779912)
Affinity DataIC50:  820nMAssay Description:Antagonist activity at PPARalpha (unknown origin) expressed in HEK293A cells assessed as inhibition of GW7647-induced transactivation after 16 to 18 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
"G. D'Annunzio" University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50155324(CHEMBL3780894)
Affinity DataIC50:  850nMAssay Description:Antagonist activity at PPARalpha (unknown origin) expressed in HEK293A cells assessed as inhibition of GW7647-induced transactivation after 16 to 18 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50339572(4'-(1-Phenylsulfanylmethyl-1H-[1,2,3]triazol-4-yl)...)
Affinity DataIC50:  900nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50386165(CHEMBL2042365)
Affinity DataIC50:  900nMAssay Description:Inhibition of human recombinant 5-lipoxygenase in cell-free system preincubated for 10 mins before substrate arachidonic acid addition measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))TBA
LigandPNGBDBM50390010(CHEMBL2071516)
Affinity DataIC50:  900nMAssay Description:Inhibition of mPGES-1-mediated PGE2 formation in IL-1beta-stimulated human A549 cells preincubated for 10 mins measured after 1 min by RP-HPLC analys...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))TBA
LigandPNGBDBM50386164(CHEMBL2042366)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of mPGES1 in IL-1beta-stimulated human A549 cell assessed as inhibition of PGE2 production preincubated for 15 mins before substrate addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
"G. D'Annunzio" University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50540556(CHEMBL4636520)
Affinity DataIC50:  1.10E+3nMAssay Description:Antagonist activity at GAL4-tagged human PPARalpha LBD expressed in human HepG2 cells assessed as inhibition of Wy14,643-induced receptor transactiva...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))TBA
LigandPNGBDBM50386154(CHEMBL2042361)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of mPGES1 in IL-1beta-stimulated human A549 cell assessed as inhibition of PGE2 production preincubated for 15 mins before substrate addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50386163(CHEMBL2042367)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophil preincubated for 15 mins before substrate arachidonic acid addition measured after 10 mins by HPLC m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
"G. D'Annunzio" University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50540552(CHEMBL4636990)
Affinity DataIC50:  1.20E+3nMAssay Description:Antagonist activity at GAL4-tagged human PPARalpha LBD expressed in human HepG2 cells assessed as inhibition of Wy14,643-induced receptor transactiva...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 6B(Homo sapiens (Human))
Institute Of Biomolecular Chemistry (Icb)

Curated by ChEMBL
LigandPNGBDBM50535443(CHEMBL4591907)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of recombinant human JMJD3 expressed in baculovirus infected Sf9 cells using biotinylated histone H3 peptide as substrate incubated for 15...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1F(Mus musculus)
University Of Brussels

Curated by ChEMBL
LigandPNGBDBM50101817(Adalat | Adalat Cc | Afeditab Cr | BAY-A-1040 | CH...)
Affinity DataIC50:  1.20E+3nMAssay Description:Antagonist activity at voltage-dependent L-type calcium channel in mouse neurobalstoma-rat glioma NG 108-15 hybrid cells assessed as inhibition of KC...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))TBA
LigandPNGBDBM50539778(CHEMBL4636106)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of mPGES1 in human A549 cells assessed as reduction in IL-1beta induced PGE2 release using PGH2 as substrate preincubated for 15 mins foll...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))TBA
LigandPNGBDBM50061981(CHEMBL3394322)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of mPGES-1 in interleukin-1beta-stimulated human A549 cells microsomal membranes assessed as reduction in PGE2 formation incubated for 15 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50386164(CHEMBL2042366)
Affinity DataIC50:  1.47E+3nMAssay Description:Inhibition of human recombinant 5-lipoxygenase in cell-free system preincubated for 10 mins before substrate arachidonic acid addition measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
"G. D'Annunzio" University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50540557(CHEMBL4642679)
Affinity DataIC50:  1.50E+3nMAssay Description:Antagonist activity at GAL4-tagged human PPARalpha LBD expressed in human HepG2 cells assessed as inhibition of Wy14,643-induced receptor transactiva...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
"G. D'Annunzio" University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50540571(CHEMBL4632967)
Affinity DataIC50:  1.52E+3nMAssay Description:Antagonist activity at GAL4-tagged human PPARalpha LBD expressed in human HepG2 cells assessed as inhibition of Wy14,643-induced receptor transactiva...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))TBA
LigandPNGBDBM50464485(CHEMBL4279158)
Affinity DataIC50:  1.64E+3nMAssay Description:Inhibition of mPGES1 in IL-1beta-stimulated human A549 cell microsomes using PGH2 as substrate assessed as reduction in PGE2 production preincubated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
"G. D'Annunzio" University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50540568(CHEMBL4634884)
Affinity DataIC50:  1.70E+3nMAssay Description:Antagonist activity at GAL4-tagged human PPARalpha LBD expressed in human HepG2 cells assessed as inhibition of Wy14,643-induced receptor transactiva...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50339573(4'-[1-(2-o-Tolyl-ethyl)-1H-[1,2,3]triazol-4-yl]-bi...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))TBA
LigandPNGBDBM50405791(CHEMBL5285589)
Affinity DataIC50:  1.70E+3nMAssay Description:Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin E synthase(Homo sapiens (Human))TBA
LigandPNGBDBM50539781(CHEMBL4647634)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of mPGES1 in human A549 cells assessed as reduction in IL-1beta induced PGE2 release using PGH2 as substrate preincubated for 15 mins foll...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50386163(CHEMBL2042367)
Affinity DataIC50:  1.96E+3nMAssay Description:Inhibition of human recombinant 5-lipoxygenase in cell-free system preincubated for 10 mins before substrate arachidonic acid addition measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50317649(6-((3S,6S,9S,14aR)-6-((1H-indol-3-yl)methyl)-9-ben...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of full length HDAC6 expressed in HEK293 cells after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50386164(CHEMBL2042366)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophil preincubated for 15 mins before substrate arachidonic acid addition measured after 10 mins by HPLC m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50386154(CHEMBL2042361)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human recombinant 5-lipoxygenase in cell-free system preincubated for 10 mins before substrate arachidonic acid addition measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50386165(CHEMBL2042365)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophil preincubated for 15 mins before substrate arachidonic acid addition measured after 10 mins by HPLC m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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