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Found 73 with Last Name = 'bryant' and Initial = 'ml'
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036257(((S)-1-{(1S,2R)-3-[Benzenesulfonyl-(3-methyl-butyl...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity of the compound for HIV-1 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036261((S)-N*1*-{(1S,2R)-3-[Benzenesulfonyl-(3-methyl-but...)
Affinity DataKi:  1nMAssay Description:Binding affinity of the compound for HIV-1 protease was determined in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036251(CHEMBL141265 | [(1S,2R)-3-(Benzenesulfonyl-isobuty...)
Affinity DataKi:  3.20nMAssay Description:Binding affinity of the compound for HIV-1 protease was determined in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036252(CHEMBL347671 | {(1S,2R)-1-Benzyl-3-[(4-chloro-benz...)
Affinity DataKi:  4.10nMAssay Description:Binding affinity of the compound for HIV-1 protease was determined.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036262(CHEMBL348282 | [(1S,2R)-3-(Benzenesulfonyl-cyclohe...)
Affinity DataKi:  6.70nMAssay Description:Binding affinity of the compound for HIV-1 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036253(CHEMBL347431 | {(1S,2R)-3-[Benzenesulfonyl-(3-meth...)
Affinity DataKi:  10nMAssay Description:Binding affinity of the compound for HIV-1 protease was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036259((S)-N*1*-{(1S,2R)-1-Benzyl-2-hydroxy-3-[methanesul...)
Affinity DataKi:  13nMAssay Description:Binding affinity of the compound for HIV-1 protease was determined in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036258(((S)-1-{(1S,2R)-1-Benzyl-2-hydroxy-3-[methanesulfo...)
Affinity DataKi:  57nMAssay Description:Binding affinity of the compound for HIV-1 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036260(CHEMBL156424 | {(1S,2R)-1-Benzyl-3-[(3-chloro-benz...)
Affinity DataKi:  61nMAssay Description:Binding affinity of the compound for HIV-1 protease was determined.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036255(CHEMBL154197 | [(1S,2R)-3-(Benzenesulfonyl-benzyl-...)
Affinity DataKi:  125nMAssay Description:Binding affinity of the compound for HIV-1 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036254(CHEMBL155051 | {(1S,2R)-1-Benzyl-2-hydroxy-3-[(3-m...)
Affinity DataKi:  128nMAssay Description:Binding affinity of the compound for HIV-1 protease was determined.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036264(CHEMBL154600 | {(1S,2R)-1-Benzyl-3-[(2-chloro-benz...)
Affinity DataKi:  227nMAssay Description:Binding affinity of the compound for HIV-1 protease was determined.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036263(CHEMBL154638 | {(1S,2S)-3-[Benzenesulfonyl-(3-meth...)
Affinity DataKi:  295nMAssay Description:Binding affinity of the compound for HIV-1 protease was determined.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036256(CHEMBL154798 | {(1S,2R)-1-Benzyl-2-hydroxy-3-[meth...)
Affinity DataKi:  1.87E+3nMAssay Description:Binding affinity of the compound for HIV-1 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036261((S)-N*1*-{(1S,2R)-3-[Benzenesulfonyl-(3-methyl-but...)
Affinity DataIC50:  1.5nMAssay Description:Ability of the compound to inhibit HIV-1 protease was determined using spectrofluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036257(((S)-1-{(1S,2R)-3-[Benzenesulfonyl-(3-methyl-butyl...)
Affinity DataIC50:  2.20nMAssay Description:Ability of the compound to inhibit HIV-1 protease was determined using spectrofluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Monsanto Corporate Research

LigandPNGBDBM490((2S)-N-[(2S,3R)-4-[benzyl(tert-butylcarbamoyl)amin...)
Affinity DataIC50:  3nMpH: 6.4 T: 2°CAssay Description:IC50 values for inhibition of recombinant HIV protease were determined using the spectrofluorometric assay, which utilized an intramolecularly quench...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50288806(CHEMBL336684 | {(1S,2R)-1-Benzyl-2-hydroxy-3-[isob...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against HIV-1 protease in spectrofluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50288807(CHEMBL263540 | N-{(1S,2R)-1-Benzyl-2-hydroxy-3-[is...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity of the compound was evaluated against recombinant HIV-1 protease using spectrofluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Monsanto Corporate Research

LigandPNGBDBM486((2S)-N-[(2S,3R)-4-[(tert-butylcarbamoyl)(3-methylb...)
Affinity DataIC50:  3nMpH: 6.4 T: 2°CAssay Description:IC50 values for inhibition of recombinant HIV protease were determined using the spectrofluorometric assay, which utilized an intramolecularly quench...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50288817(CHEMBL139444 | N-{(1S,2R)-1-Benzyl-2-hydroxy-3-[is...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity of the compound was evaluated against recombinant HIV-1 protease using spectrofluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Monsanto Corporate Research

LigandPNGBDBM488((2S)-N-[(2S,3R)-4-[(tert-butylcarbamoyl)(cyclohexy...)
Affinity DataIC50:  5nMpH: 6.4 T: 2°CAssay Description:IC50 values for inhibition of recombinant HIV protease were determined using the spectrofluorometric assay, which utilized an intramolecularly quench...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50288804(CHEMBL139538 | N-{(1S,2R)-1-Benzyl-2-hydroxy-3-[is...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity of the compound was evaluated against recombinant HIV-1 protease using spectrofluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036251(CHEMBL141265 | [(1S,2R)-3-(Benzenesulfonyl-isobuty...)
Affinity DataIC50:  6nMAssay Description:Inhibitory activity against HIV-1 protease in spectrofluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036251(CHEMBL141265 | [(1S,2R)-3-(Benzenesulfonyl-isobuty...)
Affinity DataIC50:  6nMAssay Description:Ability of the compound to inhibit HIV-1 protease was determined using spectrofluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50288808(3-Amino-N-{(1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl-...)
Affinity DataIC50:  6nMAssay Description:Inhibitory activity of the compound was evaluated against recombinant HIV-1 protease using spectrofluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Monsanto Corporate Research

LigandPNGBDBM483((2S)-N-[(2S,3R)-4-[(tert-butylcarbamoyl)(2-methylp...)
Affinity DataIC50:  6nMpH: 6.4 T: 2°CAssay Description:IC50 values for inhibition of recombinant HIV protease were determined using the spectrofluorometric assay, which utilized an intramolecularly quench...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50288815(CHEMBL344233 | N-{(1S,2R)-1-Benzyl-2-hydroxy-3-[is...)
Affinity DataIC50:  6nMAssay Description:Inhibitory activity against HIV-1 protease in spectrofluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50288811(4-Amino-N-{(1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl-...)
Affinity DataIC50:  9nMAssay Description:Inhibitory activity of the compound was evaluated against recombinant HIV-1 protease using spectrofluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50288805(CHEMBL343108 | N-{(1S,2R)-1-Benzyl-2-hydroxy-3-[is...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against HIV-1 protease in spectrofluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036252(CHEMBL347671 | {(1S,2R)-1-Benzyl-3-[(4-chloro-benz...)
Affinity DataIC50:  10nMAssay Description:Ability of the compound to inhibit HIV-1 protease was determined using spectrofluorometric assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50288812(5-Amino-N-{(1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl-...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity of the compound was evaluated against recombinant HIV-1 protease using spectrofluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Monsanto Corporate Research

LigandPNGBDBM485((Hydroxyethyl)urea Isostere deriv. 13 | benzyl N-[...)
Affinity DataIC50:  13nMpH: 6.4 T: 2°CAssay Description:IC50 values for inhibition of recombinant HIV protease were determined using the spectrofluorometric assay, which utilized an intramolecularly quench...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036262(CHEMBL348282 | [(1S,2R)-3-(Benzenesulfonyl-cyclohe...)
Affinity DataIC50:  14nMAssay Description:Ability of the compound to inhibit HIV-1 protease was determined using spectrofluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50288803(CHEMBL141046 | N-{(1S,2R)-1-Benzyl-2-hydroxy-3-[is...)
Affinity DataIC50:  14nMAssay Description:Inhibitory activity against HIV-1 protease in spectrofluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50288802(CHEMBL423189 | N-{(1S,2R)-1-Benzyl-2-hydroxy-3-[is...)
Affinity DataIC50:  15nMAssay Description:Inhibitory activity against HIV-1 protease in spectrofluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036253(CHEMBL347431 | {(1S,2R)-3-[Benzenesulfonyl-(3-meth...)
Affinity DataIC50:  16nMAssay Description:Ability of the compound to inhibit HIV-1 protease was determined using spectrofluorometric assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Monsanto Corporate Research

LigandPNGBDBM489((Hydroxyethyl)urea Isostere deriv. 17 | benzyl N-[...)
Affinity DataIC50:  19nMpH: 6.4 T: 2°CAssay Description:IC50 values for inhibition of recombinant HIV protease were determined using the spectrofluorometric assay, which utilized an intramolecularly quench...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Monsanto Corporate Research

LigandPNGBDBM494((2S)-N-[(2S,3R)-4-[(tert-butylcarbamoyl)(pyridin-4...)
Affinity DataIC50:  19nMpH: 6.4 T: 2°CAssay Description:IC50 values for inhibition of recombinant HIV protease were determined using the spectrofluorometric assay, which utilized an intramolecularly quench...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036259((S)-N*1*-{(1S,2R)-1-Benzyl-2-hydroxy-3-[methanesul...)
Affinity DataIC50:  27nMAssay Description:Ability of the compound to inhibit HIV-1 protease was determined using spectrofluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50288814(CHEMBL341697 | N-{(1S,2R)-1-Benzyl-2-hydroxy-3-[is...)
Affinity DataIC50:  27nMAssay Description:Inhibitory activity against HIV-1 protease in spectrofluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Monsanto Corporate Research

LigandPNGBDBM487((Hydroxyethyl)urea Isostere deriv. 15 | benzyl N-[...)
Affinity DataIC50:  29nMpH: 6.4 T: 2°CAssay Description:IC50 values for inhibition of recombinant HIV protease were determined using the spectrofluorometric assay, which utilized an intramolecularly quench...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Monsanto Corporate Research

LigandPNGBDBM481((Hydroxyethyl)urea Isostere deriv. 9 | benzyl N-[(...)
Affinity DataIC50:  35nMpH: 6.4 T: 2°CAssay Description:IC50 values for inhibition of recombinant HIV protease were determined using the spectrofluorometric assay, which utilized an intramolecularly quench...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50288816(CHEMBL140653 | N-{(1S,2R)-1-Benzyl-2-hydroxy-3-[is...)
Affinity DataIC50:  37nMAssay Description:Inhibitory activity against HIV-1 protease in spectrofluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50288813(CHEMBL141002 | N-{(1S,2R)-1-Benzyl-2-hydroxy-3-[is...)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity of the compound was evaluated against recombinant HIV-1 protease using spectrofluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50288810(CHEMBL139309 | N-{(1S,2R)-1-Benzyl-2-hydroxy-3-[is...)
Affinity DataIC50:  49nMAssay Description:Inhibitory activity against HIV-1 protease in spectrofluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036260(CHEMBL156424 | {(1S,2R)-1-Benzyl-3-[(3-chloro-benz...)
Affinity DataIC50:  92nMAssay Description:Ability of the compound to inhibit HIV-1 protease was determined using spectrofluorometric assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50036258(((S)-1-{(1S,2R)-1-Benzyl-2-hydroxy-3-[methanesulfo...)
Affinity DataIC50:  100nMAssay Description:Ability of the compound to inhibit HIV-1 protease was determined using spectrofluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Monsanto Corporate Research

LigandPNGBDBM493((Hydroxyethyl)urea Isostere deriv. 21 | benzyl N-[...)
Affinity DataIC50:  105nMpH: 6.4 T: 2°CAssay Description:IC50 values for inhibition of recombinant HIV protease were determined using the spectrofluorometric assay, which utilized an intramolecularly quench...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Monsanto Corporate Research

LigandPNGBDBM477((2S)-N-[(2S,3R)-4-[(butylcarbamoyl)(2-methylpropyl...)
Affinity DataIC50:  126nMpH: 6.4 T: 2°CAssay Description:IC50 values for inhibition of recombinant HIV protease were determined using the spectrofluorometric assay, which utilized an intramolecularly quench...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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