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Found 420 with Last Name = 'bryce' and Initial = 'ra'
TargetThymidine phosphorylase(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50121753(1-(5-Chloro-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin...)
Affinity DataKi:  17nMAssay Description:Inhibitory activity against human thymidine phosphorylaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)
Affinity DataKi:  20nMAssay Description:Inhibitory activity against thymidine phosphorylaseMore data for this Ligand-Target Pair
TargetThymidine phosphorylase(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)
Affinity DataKi:  20nMAssay Description:Inhibition of human recombinant thymidine phosphorylase by [3H]thymidine incorporation assayMore data for this Ligand-Target Pair
TargetThymidine phosphorylase(Escherichia coli)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50122770(6-Amino-5-bromo-1H-pyrimidine-2,4-dione | 6-Amino-...)
Affinity DataKi:  800nMAssay Description:Inhibitory activity against Escherichia coli thymidine phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50122770(6-Amino-5-bromo-1H-pyrimidine-2,4-dione | 6-Amino-...)
Affinity DataKi:  2.60E+3nMAssay Description:Inhibitory activity against Escherichia coli thymidine phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50134399(1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione | 7...)
Affinity DataKi:  2.50E+4nMAssay Description:Inhibition of bovine xanthine oxidase using hypoxanthine as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50134399(1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione | 7...)
Affinity DataKi:  7.00E+4nMAssay Description:Inhibition of bovine xanthine oxidase using xanthine as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50118216((4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl di...)
Affinity DataKi:  7.30E+6nMAssay Description:Inhibition of Trypanosoma cruzi trans-SialidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM4706((2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-...)
Affinity DataKi:  1.23E+7nMAssay Description:Inhibition of Trypanosoma cruzi trans-SialidaseMore data for this Ligand-Target Pair
TargetThymidine phosphorylase(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50134398(1-methyl-2,5-dioxo-4-pentylimidazolidine-4-carbald...)
Affinity DataKi:  1.25E+7nMAssay Description:Inhibitory activity against Escherichia coli phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50134398(1-methyl-2,5-dioxo-4-pentylimidazolidine-4-carbald...)
Affinity DataKi:  2.50E+7nMAssay Description:Inhibitory activity against Escherichia coli thymidine phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Mus musculus)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50134397(5-Methyl-1H-pyrimidine-2,4-dione | CHEMBL993 | THY...)
Affinity DataKi:  3.47E+8nMAssay Description:Inhibitory activity against mouse liver thymidine phosphorylase at 0.15 mM thymidine substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Homo sapiens (Human))
University Of Manchester

LigandPNGBDBM35536(symmetric dicoumarol analogue, 12)
Affinity DataIC50:  0.180nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Homo sapiens (Human))
University Of Manchester

LigandPNGBDBM35534(symmetric dicoumarol analogue, 10)
Affinity DataIC50:  0.410nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Homo sapiens (Human))
University Of Manchester

LigandPNGBDBM35537(symmetric dicoumarol analogue, 13)
Affinity DataIC50:  0.420nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Homo sapiens (Human))
University Of Manchester

LigandPNGBDBM35544(4-hydroxy-2H-chromen-2-one core, 20)
Affinity DataIC50:  2.20nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Homo sapiens (Human))
University Of Manchester

LigandPNGBDBM35541(4-hydroxy-2H-chromen-2-one core, 17)
Affinity DataIC50:  2.5nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Homo sapiens (Human))
University Of Manchester

LigandPNGBDBM35525(3,3''''-methylenebis(4-hydroxy-coumarin | 3,3''''-...)
Affinity DataIC50:  2.60nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB

TargetNAD(P)H dehydrogenase [quinone] 1(Homo sapiens (Human))
University Of Manchester

LigandPNGBDBM35527(symmetric dicoumarol analogue, 3)
Affinity DataIC50:  2.80nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Homo sapiens (Human))
University Of Manchester

LigandPNGBDBM35531(symmetric dicoumarol analogue, 7)
Affinity DataIC50:  3.80nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Homo sapiens (Human))
University Of Manchester

LigandPNGBDBM35530(symmetric dicoumarol analogue, 6)
Affinity DataIC50:  4.5nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Homo sapiens (Human))
University Of Manchester

LigandPNGBDBM35533(symmetric dicoumarol analogue, 9)
Affinity DataIC50:  4.90nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Homo sapiens (Human))
University Of Manchester

LigandPNGBDBM50055714(3-(4,7-dihydroxy-2-oxo-2H-3-chromenylmethyl)-4,7-d...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant NQO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Homo sapiens (Human))
University Of Manchester

LigandPNGBDBM35525(3,3''''-methylenebis(4-hydroxy-coumarin | 3,3''''-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant NQO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB

TargetNAD(P)H dehydrogenase [quinone] 1(Homo sapiens (Human))
University Of Manchester

LigandPNGBDBM35529(symmetric dicoumarol analogue, 5)
Affinity DataIC50:  6nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Homo sapiens (Human))
The University Of Manchester And Manchester Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50317140(5-(2-(diethylamino)ethylamino)-7-hydroxy-8,9-dimet...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant NQO2 assessed as reduction of DCPIP by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Homo sapiens (Human))
University Of Manchester

LigandPNGBDBM35547(4-hydroxy-2H-chromen-2-one core, 23)
Affinity DataIC50:  6nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Homo sapiens (Human))
University Of Manchester

LigandPNGBDBM35543(4-hydroxy-2H-chromen-2-one core, 19)
Affinity DataIC50:  6.30nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Homo sapiens (Human))
University Of Manchester

LigandPNGBDBM35546(4-hydroxy-2H-chromen-2-one core, 22)
Affinity DataIC50:  6.30nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Homo sapiens (Human))
University Of Manchester

LigandPNGBDBM35540(4-hydroxy-2H-chromen-2-one core, 16)
Affinity DataIC50:  7.70nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Homo sapiens (Human))
The University Of Manchester And Manchester Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50008356(5-(2-(diethylamino)ethylamino)-8-methoxy-1-methyl-...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant NQO2 assessed as reduction of DCPIP by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Homo sapiens (Human))
University Of Manchester

LigandPNGBDBM35532(symmetric dicoumarol analogue, 8)
Affinity DataIC50:  9nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Homo sapiens (Human))
University Of Manchester

LigandPNGBDBM35552(4-hydroxy-2H-chromen-2-one core, 29)
Affinity DataIC50:  9.90nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Homo sapiens (Human))
The University Of Manchester And Manchester Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50515994(CHEMBL4514167)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant human NQO2 expressed in Escherichia coli using DCPIP as substrate by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Homo sapiens (Human))
University Of Manchester

LigandPNGBDBM35528(symmetric dicoumarol analogue, 4)
Affinity DataIC50:  11nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Homo sapiens (Human))
The University Of Manchester And Manchester Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50515978(CHEMBL1967497)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant human NQO2 expressed in Escherichia coli using DCPIP as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Homo sapiens (Human))
The University Of Manchester And Manchester Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50354527(CHEMBL1836819)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant NQO2 assessed as reduction of DCPIP by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Homo sapiens (Human))
University Of Manchester

LigandPNGBDBM35526(symmetric dicoumarol analogue, 2)
Affinity DataIC50:  14nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Homo sapiens (Human))
University Of Manchester

LigandPNGBDBM35550(4-hydroxy-2H-chromen-2-one core, 26)
Affinity DataIC50:  14nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Homo sapiens (Human))
The University Of Manchester And Manchester Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50150962(CHEMBL3770366)
Affinity DataIC50:  15nMAssay Description:Inhibition of human recombinant NQO2 using DCPIPas substrate and NRH as cofactor measured for 1 min by spectrophotometry in the absence of BSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Homo sapiens (Human))
The University Of Manchester And Manchester Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50150963(CHEMBL3770674)
Affinity DataIC50:  15nMAssay Description:Inhibition of human recombinant NQO2 using DCPIPas substrate and NRH as cofactor measured for 1 min by spectrophotometry in the absence of BSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Homo sapiens (Human))
University Of Manchester

LigandPNGBDBM35548(4-hydroxy-2H-chromen-2-one core, 24)
Affinity DataIC50:  15nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Homo sapiens (Human))
The University Of Manchester And Manchester Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50515995(CHEMBL4435240)
Affinity DataIC50:  15nMAssay Description:Inhibition of recombinant human NQO2 expressed in Escherichia coli using DCPIP as substrate by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Homo sapiens (Human))
The University Of Manchester And Manchester Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50008344(5-(2-(diethylamino)ethylamino)-8-hydroxy-1-methyl-...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human recombinant NQO2 assessed as reduction of DCPIP by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Homo sapiens (Human))
The University Of Manchester And Manchester Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50317138(5-(2-(diethylamino)ethylamino)-7,10-dimethoxy-6H-i...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human recombinant NQO2 assessed as reduction of DCPIP by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Homo sapiens (Human))
The University Of Manchester And Manchester Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50515985(CHEMBL1237241 | TCMDC-142036)
Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant human NQO2 expressed in Escherichia coli using DCPIP as substrate by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50122764(2-Amino-1-(5-bromo-2,6-dioxo-1,2,3,6-tetrahydro-py...)
Affinity DataIC50:  19nMAssay Description:Inhibitory activity against Escherichia coli thymidine phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50122764(2-Amino-1-(5-bromo-2,6-dioxo-1,2,3,6-tetrahydro-py...)
Affinity DataIC50:  19nMAssay Description:Inhibitory concentration against human thymidine phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50121753(1-(5-Chloro-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against Escherichia coli thymidine phosphorylaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50122764(2-Amino-1-(5-bromo-2,6-dioxo-1,2,3,6-tetrahydro-py...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant thymidine phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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