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Found 268 with Last Name = 'buehlmayer' and Initial = 'p'
TargetTyrosine-protein kinase SYK [2-635](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM222932(US9315500, 2.2)
Affinity DataIC50:  0.600nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145270(CHEMBL81994 | {4-[(9-Fluoro-5,6-dihydro-4H-3-thia-...)
Affinity DataIC50:  1nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK [2-635](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM222933(US9315500, 2.3)
Affinity DataIC50:  1.10nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK [2-635](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM222934(US9315500, 2.4)
Affinity DataIC50:  1.30nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK [2-635](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM222931(US9315500, 2.1)
Affinity DataIC50:  1.60nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK [2-635](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM222935(US9315500, 2.5)
Affinity DataIC50:  1.60nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK [2-635](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM222952(US9315500, 3.2)
Affinity DataIC50:  1.80nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145282(1-{4-[(9-Fluoro-5,6-dihydro-4H-3-thia-1-aza-benzo[...)
Affinity DataIC50:  2nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145277(1-{4-[(9-Fluoro-5,6-dihydro-4H-3-thia-1-aza-benzo[...)
Affinity DataIC50:  2nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145279(1-{4-[(9-Fluoro-5,6-dihydro-4H-3-thia-1-aza-benzo[...)
Affinity DataIC50:  2nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145280(CHEMBL84453 | Cyclopropyl-{4-[(9-fluoro-5,6-dihydr...)
Affinity DataIC50:  2nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145289(CHEMBL312362 | {4-[(9-Fluoro-5,6-dihydro-4H-3-thia...)
Affinity DataIC50:  2nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Novartis Institute Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320214(3-(7-amino-3-(4-(4-methylpiperazin-1-yl)phenyl)pyr...)
Affinity DataIC50:  2nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK [2-635](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM222936(US9315500, 2.6)
Affinity DataIC50:  2nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK [2-635](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM222953(US9315500, 3.3)
Affinity DataIC50:  2nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145266(1-{4-[(9-Fluoro-5,6-dihydro-4H-3-thia-1-aza-benzo[...)
Affinity DataIC50:  2nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145235(CHEMBL432169 | {4-[(9-Fluoro-5,6-dihydro-4H-3-thia...)
Affinity DataIC50:  2nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK [2-635](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM222955(US9315500, 1.1)
Affinity DataIC50:  2nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145252(1-{4-[(9-Fluoro-5,6-dihydro-4H-3-thia-1-aza-benzo[...)
Affinity DataIC50:  2nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145244(CHEMBL82158 | {4-[(9-Fluoro-5,6-dihydro-4H-3-thia-...)
Affinity DataIC50:  2nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50399042(CHEMBL2178812)
Affinity DataIC50:  2.10nMAssay Description:Antagonist activity at human S1P1R receptor expressed in CHO cell membranes by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK [2-635](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM222937(US9315500, 2.7)
Affinity DataIC50:  2.10nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK [2-635](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM222938(US9315500, 2.8)
Affinity DataIC50:  2.30nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50399045(CHEMBL2178809)
Affinity DataIC50:  2.60nMAssay Description:Antagonist activity at human S1P1R receptor expressed in CHO cell membranes by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK [2-635](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM222939(US9315500, 2.9)
Affinity DataIC50:  2.70nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuropeptide Y receptor type 5(Rat 6B)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145232(CHEMBL311229 | {4-[(9-Methyl-4,5-dihydro-6-oxa-3-t...)
Affinity DataIC50:  2.90nMAssay Description:In vitro binding affinity of the compound against rat neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50089060(CHEMBL273597 | Naphthalene-1-sulfonic acid [4-(4-a...)
Affinity DataIC50:  3nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145243(CHEMBL83830 | N,N-dimethyl-N'-({4-[(19-Fluoro-2-me...)
Affinity DataIC50:  3nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145272(2-(Cyclopropylmethyl-methyl-amino)-1-{4-[(9-fluoro...)
Affinity DataIC50:  3nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145256(1-{4-[(9-Fluoro-5,6-dihydro-4H-3-thia-1-aza-benzo[...)
Affinity DataIC50:  3nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50399039(CHEMBL2178814)
Affinity DataIC50:  3.40nMAssay Description:Antagonist activity at human S1P1R receptor expressed in CHO cell membranes by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145267(4-[(9-Fluoro-5,6-dihydro-4H-3-thia-1-aza-benzo[e]a...)
Affinity DataIC50:  4nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145241((R)-5-{4-[(9-Fluoro-5,6-dihydro-4H-3-thia-1-aza-be...)
Affinity DataIC50:  4nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Novartis Institute Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320225(CHEMBL1085316 | N-(4-(7-amino-3-(3-(4-methylpipera...)
Affinity DataIC50:  4nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145259(2-Dimethylamino-1-{4-[(9-fluoro-5,6-dihydro-4H-3-t...)
Affinity DataIC50:  4nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Novartis Institute Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320205(CHEMBL1083001 | N-(4-(7-amino-3-(4-(4-methylpipera...)
Affinity DataIC50:  4nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145295(1-{4-[(9-Fluoro-5,6-dihydro-4H-3-thia-1-aza-benzo[...)
Affinity DataIC50:  4nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145232(CHEMBL311229 | {4-[(9-Methyl-4,5-dihydro-6-oxa-3-t...)
Affinity DataIC50:  5nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Novartis Institute Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320209(1-(4-(7-amino-3-(4-(4-methylpiperazin-1-yl)phenyl)...)
Affinity DataIC50:  5nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145242(2-Methyl-1-{4-[(9-methyl-4,5-dihydro-6-oxa-3-thia-...)
Affinity DataIC50:  5nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptor measured as Ca+ responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145293(1-{4-[(9-Fluoro-5,6-dihydro-4H-3-thia-1-aza-benzo[...)
Affinity DataIC50:  5nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145287(CHEMBL309685 | {4-[(9-Fluoro-4,5-dihydro-6-oxa-3-t...)
Affinity DataIC50:  5nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK [2-635](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM222940(US9315500, 2.10)
Affinity DataIC50:  5.20nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK [2-635](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM222941(US9315500, 2.11)
Affinity DataIC50:  5.40nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuropeptide Y receptor type 5(Rat 6B)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145236(1-{4-[(9-Fluoro-4,5-dihydro-6-oxa-3-thia-1-aza-ben...)
Affinity DataIC50:  6nMAssay Description:In vitro binding affinity of the compound against rat neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145275(1-{4-[(9-Fluoro-5,6-dihydro-4H-3-thia-1-aza-benzo[...)
Affinity DataIC50:  6nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145283(1-{4-[(5,6-Dihydro-4H-3-thia-1-aza-benzo[e]azulen-...)
Affinity DataIC50:  6nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145297(CHEMBL79308 | N-{4-[(9-Fluoro-5,6-dihydro-4H-3-thi...)
Affinity DataIC50:  6nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Novartis Institute Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320224(1-(4-(7-amino-3-(3-(4-methylpiperazin-1-yl)phenyl)...)
Affinity DataIC50:  6nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145238(2-(Cyclopropylmethyl-amino)-1-{4-[(9-fluoro-5,6-di...)
Affinity DataIC50:  6nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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