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Found 276 with Last Name = 'burgess' and Initial = 'jp'
TargetCannabinoid receptor 1(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50176988(8-Chloro-1-(2,4-dichloro-phenyl)-1,3a,4,5,6,10b-he...)
Affinity DataKi:  0.000350nMAssay Description:Binding affinity to CB1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by PDSP Ki Database
LigandPNGBDBM86812(CAS_45263784 | NSC_45263784 | rac-2-(6-fluoro-5-(4...)
Affinity DataKi:  0.00900nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by PDSP Ki Database
LigandPNGBDBM50100717(2-(pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane | 2-P...)
Affinity DataKi:  0.0200nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by PDSP Ki Database
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.0260nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by PDSP Ki Database
LigandPNGBDBM86815(CAS_45266019 | NSC_45266019 | rac-2-(6-fluoro-5-(4...)
Affinity DataKi:  0.0290nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by PDSP Ki Database
LigandPNGBDBM86816(CAS_45263769 | NSC_45263769 | rac-2-(5-(4-chloroph...)
Affinity DataKi:  0.0440nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by PDSP Ki Database
LigandPNGBDBM86810(CAS_45266065 | NSC_45266065 | rac-2-(6-fluoro-5-(3...)
Affinity DataKi:  0.0530nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by PDSP Ki Database
LigandPNGBDBM86805(CAS_45263788 | NSC_45263788 | US9150581, RTI-7527-...)
Affinity DataKi:  0.0730nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by PDSP Ki Database
LigandPNGBDBM86819(CAS_45263772 | NSC_45263772 | rac-2-(6-fluoro-5-(3...)
Affinity DataKi:  0.0870nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by PDSP Ki Database
LigandPNGBDBM86817(CAS_45263779 | NSC_45263779 | rac-4-(5-(7-aza-bicy...)
Affinity DataKi:  0.0950nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by PDSP Ki Database
LigandPNGBDBM86807(CAS_45263775 | NSC_45263775 | rac-3-(5-(7-aza-bicy...)
Affinity DataKi:  0.100nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by PDSP Ki Database
LigandPNGBDBM86818(CAS_45266054 | NSC_45266054 | rac-2-(6-fluoro-5-(3...)
Affinity DataKi:  0.120nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by PDSP Ki Database
LigandPNGBDBM50166908(5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca...)
Affinity DataKi:  0.120nMMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by PDSP Ki Database
LigandPNGBDBM86809(3'-(4-fluorophenyl)deschloroepibatidine | CAS_...)
Affinity DataKi:  0.150nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by PDSP Ki Database
LigandPNGBDBM86820(CAS_45263774 | NSC_45263774 | rac-3'-(3-chloro...)
Affinity DataKi:  0.170nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by PDSP Ki Database
LigandPNGBDBM86822(CAS_45263767 | NSC_45263767 | rac-3'-(3-nitrop...)
Affinity DataKi:  0.170nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by PDSP Ki Database
LigandPNGBDBM86821(CAS_45263766 | NSC_45263766 | rac-3'-(3-fluoro...)
Affinity DataKi:  0.200nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by PDSP Ki Database
LigandPNGBDBM86811(3-(4-chlorophenyl)deschloroepibatidine | CAS_44452...)
Affinity DataKi:  0.210nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by PDSP Ki Database
LigandPNGBDBM86806(CAS_45263762 | NSC_45263762 | US9150581, RTI-7527-...)
Affinity DataKi:  0.240nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by PDSP Ki Database
LigandPNGBDBM86814(CAS_45266060 | NSC_45266060 | rac-3'-(4-nitrop...)
Affinity DataKi:  0.340nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by PDSP Ki Database
LigandPNGBDBM86813(CAS_45266021 | NSC_45266021 | rac-3-(4-aminophenyl...)
Affinity DataKi:  0.340nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by PDSP Ki Database
LigandPNGBDBM86823(CAS_45263792 | NSC_45263792 | rac-3-(3-methoxyphen...)
Affinity DataKi:  0.430nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by PDSP Ki Database
LigandPNGBDBM86824(CAS_45266048 | NSC_45266048 | rac-3-phenyldeschlor...)
Affinity DataKi:  0.5nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  0.560nMAssay Description:Binding affinity was determined as ability to displace [3H]-U-69, radioligand from Opioid receptor kappa 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50039026(4-((R)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl...)
Affinity DataKi:  0.910nMAssay Description:Affinity of [H]DADLE to the delta opioid receptor from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50039026(4-((R)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl...)
Affinity DataKi:  0.910nMAssay Description:Binding affinity towards opioid Delta receptor using [3H]DADLE as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  0.930nMAssay Description:Compound was tested for the inhibition of [35S]-GTP-gammaS, binding in Guinea pig Caudate stimulated by the opioid receptor agonist Mu-DAMGOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM82551(C18130 | CAS_105618-26-6 | NOR-BNI (HCI)2 | NORBNI)
Affinity DataKi:  1.09nMAssay Description:Ability to displace [3H]U-69593 from Opioid receptor kappa 1 of guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by PDSP Ki Database
LigandPNGBDBM86808(CAS_45263778 | NSC_45263778 | rac-3'-(3-aminop...)
Affinity DataKi:  1.16nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM21278(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl...)
Affinity DataKi:  1.18nMAssay Description:Displacement of [3H]SR141716 from human CB1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMu-type opioid receptor(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity was determined as ability to displace [3H]-DAMGO radioligand from Mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)
Affinity DataKi:  1.5nMMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(GUINEA PIG)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50045767((+)-N-phenethyl trans-3(R),4(R)-dimethyl-4-(3-hydr...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity was determined against Mu opioid receptor using [3H]-Naltrexone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50039029((+)-4-((alpha R)-((2S,5R)-4-allyl-2,5-dimethylpipe...)
Affinity DataKi:  1.57nMAssay Description:Affinity of [H]DADLE to the delta opioid receptor from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50039029((+)-4-((alpha R)-((2S,5R)-4-allyl-2,5-dimethylpipe...)
Affinity DataKi:  1.60nMAssay Description:Compound was evaluated for binding affinity towards Opioid receptor delta 1 by displacement of [3H]-DADLE radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50039029((+)-4-((alpha R)-((2S,5R)-4-allyl-2,5-dimethylpipe...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity towards opioid Delta receptor using [3H]DADLE as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50098462(4-[(1-Allyl-3-methyl-piperidin-4-yl)-(3-hydroxy-ph...)
Affinity DataKi:  1.85nMAssay Description:Affinity of [H]DADLE to the delta opioid receptor from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  2.10nMAssay Description:Binding affinity was determined against Mu opioid receptor using [3H]naltrexone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50089153(4-[(8-Allyl-8-aza-bicyclo[3.2.1]oct-3-yl)-(3-metho...)
Affinity DataKi:  3.28nMAssay Description:Compound was evaluated for binding affinity towards Opioid receptor mu 1 by displacement of [3H]-DAMGO radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50116621(3-[7-Amino-4-methyl-2-(3-phenyl-propyl)-2-aza-bicy...)
Affinity DataKi:  3.30nMAssay Description:Ability to displace [3H]DAMGO from Opioid receptor mu 1 of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50089153(4-[(8-Allyl-8-aza-bicyclo[3.2.1]oct-3-yl)-(3-metho...)
Affinity DataKi:  3.30nMAssay Description:Compound was evaluated for binding affinity towards Opioid receptor delta 1 by displacement of [3H]-DADLE radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50089156(CHEMBL3085003 | N,N-Diethyl-4-{(3-methoxy-phenyl)-...)
Affinity DataKi:  3.5nMAssay Description:Compound was evaluated for binding affinity towards Opioid receptor delta 1 by displacement of [3H]-DADLE radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50089156(CHEMBL3085003 | N,N-Diethyl-4-{(3-methoxy-phenyl)-...)
Affinity DataKi:  3.51nMAssay Description:Compound was evaluated for binding affinity towards Opioid receptor mu 1 by displacement of [3H]-DAMGO radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50089154(4-[[((Z)-8-But-2-enyl)-8-aza-bicyclo[3.2.1]oct-3-y...)
Affinity DataKi:  3.70nMAssay Description:Compound was evaluated for binding affinity towards Opioid receptor delta 1 by displacement of [3H]-DADLE radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  3.90nMAssay Description:Binding affinity was determined against Opioid receptor kappa 1
using [3H]-Ethylketocyclazocine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50116622(CHEMBL117457 | N-[5-(3-Hydroxy-phenyl)-4-methyl-2-...)
Affinity DataKi:  4.30nMAssay Description:Ability to displace [3H]U-69593 from Opioid receptor kappa 1 of guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  4.70nMAssay Description:Compound was tested for the inhibition of [35S]-GTP-gammaS, binding to Opioid receptor kappa 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50116624(3-Guanidino-N-[5-(3-hydroxy-phenyl)-4-methyl-2-phe...)
Affinity DataKi:  5.20nMAssay Description:Ability to displace [3H]DAMGO from Opioid receptor mu 1 of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50176988(8-Chloro-1-(2,4-dichloro-phenyl)-1,3a,4,5,6,10b-he...)
Affinity DataKi:  5.55nMAssay Description:Displacement of [3H]SR141716 from human CB1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50083637(4-(((3S,4R)-1-allyl-3-methylpiperidin-4-yl)(phenyl...)
Affinity DataKi:  5.58nMAssay Description:Affinity of [H]DADLE to the delta opioid receptor from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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