TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.0500nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.0600nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.0700nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.0700nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.0800nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.0800nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.0900nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.0900nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.100nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.100nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.100nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 0.100nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.100nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.100nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 0.100nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Method 1:Vanin-1 Enzymatic Assay:The test compounds are dissolved in 100% DMSO at a concentration of 10 mM and in a first step diluted in DMSO to a c...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.110nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.110nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.110nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.110nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.110nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.110nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.120nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.120nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.120nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.120nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.130nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.130nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.130nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.140nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.140nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.140nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.140nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.140nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.150nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.150nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.150nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.160nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.160nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.160nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.160nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.160nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.170nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.170nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.180nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.180nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.180nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.180nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.180nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Blueprint Medicines
US Patent
Blueprint Medicines
US Patent
Affinity DataIC50: 0.190nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand Info