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Found 316 with Last Name = 'burt' and Initial = 's'
TargetHIV-1 protease(Human immunodeficiency virus)
State University of New York

LigandPNGBDBM517((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-h...)
Affinity DataKi:  0.370nMAssay Description:Enzyme inhibition assay for silanediols, carbinols, and indinavir using assay system C.More data for this Ligand-Target Pair
TargetHIV-1 protease(Human immunodeficiency virus)
State University of New York

LigandPNGBDBM40773(Silanediol, 17b)
Affinity DataKi:  2.70nMAssay Description:Enzyme inhibition assay for silanediols, carbinols, and indinavir using assay system C.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHIV-1 protease(Human immunodeficiency virus)
State University of New York

LigandPNGBDBM40774(Carbinol, 18b)
Affinity DataKi:  3.80nMAssay Description:Enzyme inhibition assay for silanediols, carbinols, and indinavir using assay system C.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50121452((S)-2-{(S)-2-[(Benzyloxycarbonylamino-methyl)-hydr...)
Affinity DataKi:  11nMAssay Description:Competitive inhibition of thermolysin evaluated using the substrate FAGLA (Sigma); Competitive binding observedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50121453(CHEMBL334233 | Sodium; (S)-2-[(S)-2-({dihydroxy-[(...)
Affinity DataKi:  41nMAssay Description:Competitive inhibition of thermolysin evaluated using the substrate FAGLA (Sigma); Competitive binding observedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50121454((S)-2-[(Aminomethyl-diphenyl-silanyl)-methyl]-4-me...)
Affinity DataKi:  41nMAssay Description:Competitive inhibition of thermolysin evaluated using the substrate FAGLA (Sigma); Competitive binding observedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Molsoft

Curated by ChEMBL
LigandPNGBDBM50232469(CHEMBL252145 | N,N-bis(tosylmethyl)hexan-1-amine)
Affinity DataKi:  1.70E+3nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHIV-1 protease(Human immunodeficiency virus)
State University of New York

LigandPNGBDBM40775(Carbinol, 18a)
Affinity DataKi:  3.20E+3nMAssay Description:Enzyme inhibition assay for silanediols, carbinols, and indinavir using assay system C.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHIV-1 protease(Human immunodeficiency virus)
State University of New York

LigandPNGBDBM40772(Silanediol, 17a)
Affinity DataKi:  3.20E+3nMAssay Description:Enzyme inhibition assay for silanediols, carbinols, and indinavir using assay system C.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Molsoft

Curated by ChEMBL
LigandPNGBDBM50232467(CHEMBL399303 | phenyl-N,N-bis(tosylmethyl)methanam...)
Affinity DataKi:  7.50E+3nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Molsoft

Curated by ChEMBL
LigandPNGBDBM50232470(2-phenyl-N,N-bis(o-tolylthiomethyl)ethanamine | CH...)
Affinity DataKi:  7.50E+3nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Molsoft

Curated by ChEMBL
LigandPNGBDBM50232468(6-(((3-chlorobenzyl)(methyl)amino)methyl)-N2-o-tol...)
Affinity DataKi:  7.80E+3nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Molsoft

Curated by ChEMBL
LigandPNGBDBM50232466(2-(dimethylamino)ethyl 4-(5-(4-methoxybenzylidene)...)
Affinity DataKi:  8.10E+3nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Molsoft

Curated by ChEMBL
LigandPNGBDBM50232465(4-methoxy-benzoic acid 2-diethylaminomethyl-4-(1,1...)
Affinity DataKi:  1.13E+4nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Molsoft

Curated by ChEMBL
LigandPNGBDBM50232464(CHEMBL251947 | {3-[2-(4-bromo-phenyl)-benzo[d]imid...)
Affinity DataKi:  1.19E+4nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Molsoft

Curated by ChEMBL
LigandPNGBDBM50232471(CHEMBL251948 | N-(3-(benzyl(isopropyl)amino)propyl...)
Affinity DataKi:  2.09E+4nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Queen'S University Belfast

Curated by ChEMBL
LigandPNGBDBM50510337(CHEMBL4545652)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-AMC as substrate measured for every 2 mins for 60 mins by fluorescence-based microplate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Queen'S University Belfast

Curated by ChEMBL
LigandPNGBDBM50510318(CHEMBL4438891)
Affinity DataIC50:  0.260nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-AMC as substrate measured for every 2 mins for 60 mins by fluorescence-based microplate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Queen'S University Belfast

Curated by ChEMBL
LigandPNGBDBM50510331(CHEMBL4556228)
Affinity DataIC50:  0.470nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-AMC as substrate measured for every 2 mins for 60 mins by fluorescence-based microplate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50146428((S)-1-((1R,5S)-5-Benzoylamino-2-methyl-4-oxo-6-phe...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity of compound against angiotensin I converting enzyme was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Queen'S University Belfast

Curated by ChEMBL
LigandPNGBDBM50510316(CHEMBL4549828)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-AMC as substrate measured for every 2 mins for 60 mins by fluorescence-based microplate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Queen'S University Belfast

Curated by ChEMBL
LigandPNGBDBM50510339(CHEMBL4547118)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-AMC as substrate measured for every 2 mins for 60 mins by fluorescence-based microplate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Queen'S University Belfast

Curated by ChEMBL
LigandPNGBDBM50510329(CHEMBL4474978)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-AMC as substrate measured for every 2 mins for 60 mins by fluorescence-based microplate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50146425(CHEMBL95846 | Sodium; (S)-1-{(S)-3-[((R)-1-benzoyl...)
Affinity DataIC50:  3.80nMAssay Description:Inhibitory activity of compound against angiotensin I converting enzyme was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholecystokinin receptor type A(Cavia porcellus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50008629(4-Dipentylcarbamoyl-4-[(quinoline-3-carbonyl)-amin...)
Affinity DataIC50:  5.10nMAssay Description:Compound was evaluated for the binding affinity against Cholecystokinin type A receptor in pancreatic acinar cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Queen'S University Belfast

Curated by ChEMBL
LigandPNGBDBM50510333(CHEMBL4472825)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-AMC as substrate measured for every 2 mins for 60 mins by fluorescence-based microplate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Almac Discovery

Curated by ChEMBL
LigandPNGBDBM50465231(CHEMBL4288150 | US10766903, Example 30)
Affinity DataIC50:  6nMAssay Description:Inhibition of USP7 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Queen'S University Belfast

Curated by ChEMBL
LigandPNGBDBM50510320(CHEMBL4452627)
Affinity DataIC50:  7.10nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-AMC as substrate measured for every 2 mins for 60 mins by fluorescence-based microplate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50146430((S)-1-((1R,5R)-5-Benzoylamino-2-methyl-4-oxo-6-phe...)
Affinity DataIC50:  8.20nMAssay Description:Inhibitory activity of compound against angiotensin I converting enzyme was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Queen'S University Belfast

Curated by ChEMBL
LigandPNGBDBM50510330(CHEMBL4469392)
Affinity DataIC50:  9.80nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-AMC as substrate measured for every 2 mins for 60 mins by fluorescence-based microplate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Queen'S University Belfast

Curated by ChEMBL
LigandPNGBDBM50510327(CHEMBL4516598)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-AMC as substrate measured for every 2 mins for 60 mins by fluorescence-based microplate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Queen'S University Belfast

Curated by ChEMBL
LigandPNGBDBM50510326(CHEMBL4517035)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-AMC as substrate measured for every 2 mins for 60 mins by fluorescence-based microplate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50146431((S)-1-{3-[(1-Benzoylamino-3-methyl-butyl)-dihydrox...)
Affinity DataIC50:  14nMAssay Description:Inhibitory activity of compound against angiotensin I converting enzyme was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Queen'S University Belfast

Curated by ChEMBL
LigandPNGBDBM50510336(CHEMBL4473369)
Affinity DataIC50:  15nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-AMC as substrate measured for every 2 mins for 60 mins by fluorescence-based microplate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Queen'S University Belfast

Curated by ChEMBL
LigandPNGBDBM50510340(CHEMBL4462167)
Affinity DataIC50:  15nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-AMC as substrate measured for every 2 mins for 60 mins by fluorescence-based microplate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Queen'S University Belfast

Curated by ChEMBL
LigandPNGBDBM50510342(CHEMBL4446264)
Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-AMC as substrate measured for every 2 mins for 60 mins by fluorescence-based microplate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholecystokinin receptor type A(Cavia porcellus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50008661(4-Dipentylcarbamoyl-4-[(1H-indole-2-carbonyl)-amin...)
Affinity DataIC50:  19nMAssay Description:Compound was evaluated for the binding affinity against CCK A receptor in pancreatic acinar cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50146429((S)-1-{(S)-3-[((S)-1-Benzoylamino-2-phenyl-ethyl)-...)
Affinity DataIC50:  19nMAssay Description:Inhibitory activity of compound against angiotensin I converting enzyme was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Almac Discovery

Curated by ChEMBL
LigandPNGBDBM50465234(CHEMBL4283787 | US10766903, Example 46)
Affinity DataIC50:  22nMAssay Description:Inhibition of USP7 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Almac Discovery

Curated by ChEMBL
LigandPNGBDBM50465202(CHEMBL4290015 | US10766903, Example 29)
Affinity DataIC50:  24nMAssay Description:Inhibition of USP7 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Queen'S University Belfast

Curated by ChEMBL
LigandPNGBDBM50510328(CHEMBL4549915)
Affinity DataIC50:  26nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-AMC as substrate measured for every 2 mins for 60 mins by fluorescence-based microplate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Almac Discovery

Curated by ChEMBL
LigandPNGBDBM50465203(CHEMBL4281720 | US10766903, Example 28)
Affinity DataIC50:  30nMAssay Description:Inhibition of USP7 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Almac Discovery

Curated by ChEMBL
LigandPNGBDBM50465229(CHEMBL4283226 | US10766903, Example 27)
Affinity DataIC50:  30nMAssay Description:Inhibition of USP7 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholecystokinin receptor type A(Cavia porcellus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50017836(4-Dipentylcarbamoyl-4-[(quinoline-6-carbonyl)-amin...)
Affinity DataIC50:  31nMAssay Description:Compound was evaluated for the binding affinity against CCK A receptor in pancreatic acinar cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Queen'S University Belfast

Curated by ChEMBL
LigandPNGBDBM50510321(CHEMBL4520269)
Affinity DataIC50:  33nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-AMC as substrate measured for every 2 mins for 60 mins by fluorescence-based microplate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLegumain(Homo sapiens (Human))
Queen'S University Belfast

Curated by ChEMBL
LigandPNGBDBM50510319(CHEMBL4437001)
Affinity DataIC50:  34nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-AMC as substrate measured for every 2 mins for 60 mins by fluorescence-based microplate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Almac Discovery

Curated by ChEMBL
LigandPNGBDBM50465236(CHEMBL4291074 | US10766903, Example 25)
Affinity DataIC50:  35nMAssay Description:Inhibition of USP7 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Almac Discovery

Curated by ChEMBL
LigandPNGBDBM50465230(CHEMBL4289604 | US10766903, Example 104)
Affinity DataIC50:  39nMAssay Description:Inhibition of USP7 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Almac Discovery

Curated by ChEMBL
LigandPNGBDBM50465205(CHEMBL4287721 | US10766903, Example 107)
Affinity DataIC50:  40nMAssay Description:Inhibition of USP7 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50146426((S)-1-((1S,5S)-5-Benzoylamino-2-methyl-4-oxo-6-phe...)
Affinity DataIC50:  46nMAssay Description:Inhibitory activity of compound against angiotensin I converting enzyme was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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