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Found 42 with Last Name = 'busacca' and Initial = 'ca'
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116391(2-(2,6-Dichloro-phenylamino)-6,7-dimethyl-1,8-dihy...)
Affinity DataIC50:  12nMAssay Description:Inhibition of c-SRC with 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116401(6,7-Dimethyl-2-(2,4,6-trichloro-phenylamino)-1,8-d...)
Affinity DataIC50:  18nMAssay Description:Inhibitory activity against recombinant human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116405(6,7-Dimethyl-2-(2,4,6-tribromo-phenylamino)-1,8-di...)
Affinity DataIC50:  25nMAssay Description:Inhibitory activity against recombinant human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116391(2-(2,6-Dichloro-phenylamino)-6,7-dimethyl-1,8-dihy...)
Affinity DataIC50:  26nMAssay Description:Inhibitory activity against recombinant human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116399(2-(2-Chloro-6-methyl-phenylamino)-6,7-dimethyl-1,8...)
Affinity DataIC50:  27nMAssay Description:Inhibitory activity against recombinant human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116408(2-(2-Chloro-phenylamino)-6,7-dimethyl-1,8-dihydro-...)
Affinity DataIC50:  150nMAssay Description:Inhibitory activity against recombinant human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116398(2-(2,6-Dichloro-phenylamino)-1,6,7,8-tetrahydro-im...)
Affinity DataIC50:  380nMAssay Description:Inhibitory activity against recombinant human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116410(2-(2,6-Dimethyl-phenylamino)-6,6-dimethyl-1,6-dihy...)
Affinity DataIC50:  460nMAssay Description:Inhibitory activity against recombinant human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116402(2-(2,6-Dichloro-phenylamino)-6,6-dimethyl-1,6-dihy...)
Affinity DataIC50:  460nMAssay Description:Inhibitory activity against recombinant human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116397(6,6-Dimethyl-2-(2,4,6-tribromo-phenylamino)-1,6-di...)
Affinity DataIC50:  600nMAssay Description:Inhibitory activity against recombinant human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116406(6,6-Dimethyl-2-(2,4,6-trichloro-phenylamino)-1,6-d...)
Affinity DataIC50:  730nMAssay Description:Inhibitory activity against recombinant human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116409(2-(2-Chloro-6-methyl-phenylamino)-6,6-dimethyl-1,6...)
Affinity DataIC50:  770nMAssay Description:Inhibitory activity against recombinant human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116393(2-(2,6-Dichloro-phenylamino)-6,6-dimethyl-1,6,7,8-...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibitory activity against recombinant human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116394(2-(2,6-Dichloro-phenylamino)-3,6,6-trimethyl-3,6-d...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibitory activity against recombinant human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116403(2-[(2,6-Dichloro-phenyl)-methyl-amino]-6,6-dimethy...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibitory activity against recombinant human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116414(2-(2,6-Dichloro-phenylamino)-6-isobutyl-6-methyl-1...)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibitory activity against recombinant human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116411(2-(2,6-Dichloro-phenylamino)-6,6-diethyl-1,6-dihyd...)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibitory activity against recombinant human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116396(2-(2,6-Dichloro-benzyl)-6,6-dimethyl-1,6-dihydro-i...)
Affinity DataIC50:  9.60E+3nMAssay Description:Inhibitory activity against recombinant human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116395(2-(2,6-Dichloro-phenylamino)-6,6,8-trimethyl-1,6-d...)
Affinity DataIC50:  9.60E+3nMAssay Description:Inhibitory activity against recombinant human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116407(2-(2,6-Difluoro-phenylamino)-6,6-dimethyl-1,6-dihy...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibitory activity against recombinant human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sterling Winthrop Research

Curated by ChEMBL
LigandPNGBDBM50407402(CHEMBL2093896)
Affinity DataIC50:  2.10E+4nMAssay Description:Blockade of the delayed rectifier K+ current (IKr) of guinea pig myocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sterling Winthrop Research

Curated by ChEMBL
LigandPNGBDBM50407403(CHEMBL2092889)
Affinity DataIC50:  2.90E+4nMAssay Description:Blockade of the delayed rectifier K+ current (IKr) of guinea pig myocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Sterling Winthrop Research

Curated by ChEMBL
LigandPNGBDBM50407402(CHEMBL2093896)
Affinity DataIC50: >3.00E+4nMAssay Description:Blockade of Na+ current in frog oocytes expressing human cardiac sodium channel (HH1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Sterling Winthrop Research

Curated by ChEMBL
LigandPNGBDBM50407402(CHEMBL2093896)
Affinity DataIC50: >3.00E+4nMAssay Description:Blockade of Na+ current in frog oocytes expressing human cardiac sodium channel (HH1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Sterling Winthrop Research

Curated by ChEMBL
LigandPNGBDBM50407403(CHEMBL2092889)
Affinity DataIC50: >3.00E+4nMAssay Description:Blockade of Na+ current in frog oocytes expressing human cardiac sodium channel (HH1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sterling Winthrop Research

Curated by ChEMBL
LigandPNGBDBM50369030(CHEMBL1788206)
Affinity DataIC50:  3.80E+4nMAssay Description:Blockade of the delayed rectifier K+ current (IKr) of guinea pig myocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sterling Winthrop Research

Curated by ChEMBL
LigandPNGBDBM50407404(CHEMBL2092890)
Affinity DataIC50:  3.80E+4nMAssay Description:Blockade of the delayed rectifier K+ current (IKr) of guinea pig myocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116412(2-(4-Chloro-phenylamino)-6,6-dimethyl-1,6-dihydro-...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibitory activity against recombinant human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116392((2,6-Dichloro-phenyl)-(6,6-dimethyl-6,7,8,9-tetrah...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibitory activity against recombinant human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116415(2-(2,6-Diethyl-phenylamino)-6,6-dimethyl-1,6-dihyd...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibitory activity against recombinant human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116413(2-(2,4-Dichloro-phenylamino)-6,6-dimethyl-1,6-dihy...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibitory activity against recombinant human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116400(2-(2-Chloro-phenylamino)-6,6-dimethyl-1,6-dihydro-...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibitory activity against recombinant human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116404(6,6-Dimethyl-2-(2,3,5,6-tetrachloro-phenylamino)-1...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibitory activity against recombinant human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sterling Winthrop Research

Curated by ChEMBL
LigandPNGBDBM50031720((Dofetilide) N-[4-(2-{[2-(4-Methanesulfonylamino-p...)
Affinity DataIC50:  4.40E+4nMAssay Description:Blockade of the delayed rectifier K+ current (IKr) of guinea pig myocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116391(2-(2,6-Dichloro-phenylamino)-6,7-dimethyl-1,8-dihy...)
Affinity DataIC50:  8.00E+4nMAssay Description:Inhibition of Zeta-chain (TCR) associated protein kinase 70 kDa (ZAP70) with 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sterling Winthrop Research

Curated by ChEMBL
LigandPNGBDBM50369029(CHEMBL1788304)
Affinity DataIC50:  8.50E+4nMAssay Description:Blockade of the delayed rectifier K+ current (IKr) of guinea pig myocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Sterling Winthrop Research

Curated by ChEMBL
LigandPNGBDBM50369029(CHEMBL1788304)
Affinity DataIC50: >1.00E+5nMAssay Description:Blockade of Na+ current in frog oocytes expressing human cardiac sodium channel (HH1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116391(2-(2,6-Dichloro-phenylamino)-6,7-dimethyl-1,8-dihy...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Sterling Winthrop Research

Curated by ChEMBL
LigandPNGBDBM50407404(CHEMBL2092890)
Affinity DataIC50: >1.00E+5nMAssay Description:Blockade of Na+ current in frog oocytes expressing human cardiac sodium channel (HH1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116391(2-(2,6-Dichloro-phenylamino)-6,7-dimethyl-1,8-dihy...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Syk tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Sterling Winthrop Research

Curated by ChEMBL
LigandPNGBDBM50369030(CHEMBL1788206)
Affinity DataIC50:  1.26E+5nMAssay Description:Blockade of Na+ current in frog oocytes expressing human cardiac sodium channel (HH1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Sterling Winthrop Research

Curated by ChEMBL
LigandPNGBDBM50031720((Dofetilide) N-[4-(2-{[2-(4-Methanesulfonylamino-p...)
Affinity DataIC50: >3.00E+5nMAssay Description:Blockade of Na+ current in frog oocytes expressing human cardiac sodium channel (HH1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed