Affinity DataKi: 1.5nMAssay Description:Binding affinity to NK1 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 2.20nMAssay Description:Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 2.20nMAssay Description:Binding affinity to NK1 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 5.20nMAssay Description:Binding affinity to NK1 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 5.20nMAssay Description:Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Modulation of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: 3.70nMAssay Description:Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Modulation of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair
Affinity DataIC50: 4.20nMAssay Description:Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 4.5nMAssay Description:Modulation of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Modulation of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair
Affinity DataIC50: 6.20nMAssay Description:Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 6.5nMAssay Description:Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Modulation of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 9.33nMAssay Description:Inhibition of Nav1.7 by cell based whole-cell voltage clamp electrophysiology assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: 9.80nMAssay Description:Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10.5nMAssay Description:Inhibition of Nav1.7 by cell based whole-cell voltage clamp electrophysiology assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Modulation of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Modulation of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Modulation of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Modulation of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Modulation of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Modulation of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMpH: 6.8Assay Description:A solution of test compound was added to a diluted microsome preparation containing human mPGES-1 and pre-incubated for 15 minutes in potassium phosp...More data for this Ligand-Target Pair
Affinity DataIC50: 22.9nMAssay Description:Inhibition of Nav1.7 by cell based whole-cell voltage clamp electrophysiology assayMore data for this Ligand-Target Pair
Affinity DataIC50: 24.0nMAssay Description:Inhibition of Nav1.7 by cell based whole-cell voltage clamp electrophysiology assayMore data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Modulation of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Modulation of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 28.2nMAssay Description:Inhibition of Nav1.7 by cell based whole-cell voltage clamp electrophysiology assayMore data for this Ligand-Target Pair
Affinity DataIC50: 28.8nMAssay Description:Inhibition of Nav1.7 by cell based whole-cell voltage clamp electrophysiology assayMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Modulation of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair
Affinity DataIC50: 31nMpH: 6.8Assay Description:A solution of test compound was added to a diluted microsome preparation containing human mPGES-1 and pre-incubated for 15 minutes in potassium phosp...More data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Modulation of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 36nMpH: 6.8Assay Description:A solution of test compound was added to a diluted microsome preparation containing human mPGES-1 and pre-incubated for 15 minutes in potassium phosp...More data for this Ligand-Target Pair
Affinity DataIC50: 38.0nMAssay Description:Inhibition of Nav1.7 by cell based whole-cell voltage clamp electrophysiology assayMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMpH: 6.8Assay Description:A solution of test compound was added to a diluted microsome preparation containing human mPGES-1 and pre-incubated for 15 minutes in potassium phosp...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 41nMpH: 6.8Assay Description:A solution of test compound was added to a diluted microsome preparation containing human mPGES-1 and pre-incubated for 15 minutes in potassium phosp...More data for this Ligand-Target Pair
Affinity DataIC50: 44nMpH: 6.8Assay Description:A solution of test compound was added to a diluted microsome preparation containing human mPGES-1 and pre-incubated for 15 minutes in potassium phosp...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: 47nMAssay Description:Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 49nMAssay Description:Modulation of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: 52nMAssay Description:Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: 52nMAssay Description:Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assayMore data for this Ligand-Target Pair