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Found 552 with Last Name = 'caffrey' and Initial = 'cr'
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183768((2S,3S)-1-((S)-2-((R)-2-(tert-butoxycarbonyl)-3-ph...)
Affinity DataKi:  100nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183749((2S,3S)-diethyl 1-((S)-1-((S)-2-(tert-butoxycarbon...)
Affinity DataKi:  300nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183749((2S,3S)-diethyl 1-((S)-1-((S)-2-(tert-butoxycarbon...)
Affinity DataKi:  360nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain in presence of 31.6 uM substrate Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183779((2S,3S)-1-((S)-2-((S)-2-(tert-butoxycarbonyl)-3-ph...)
Affinity DataKi:  500nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183767((2R,3R)-dibenzyl 1-((S)-1-((S)-2-(tert-butoxycarbo...)
Affinity DataKi:  500nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183742((2R,3R)-diethyl 1-(6-(5-((3aS,4S,6aR)-2-oxo-hexahy...)
Affinity DataKi:  600nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183754((2S,3S)-dibenzyl 1-((R)-1-((S)-2-(tert-butoxycarbo...)
Affinity DataKi:  600nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183743((2S,3S)-dibenzyl 1-((S)-1-((S)-2-(tert-butoxycarbo...)
Affinity DataKi:  600nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183765((2S,3S)-dibenzyl 1-((S)-1-((R)-2-(tert-butoxycarbo...)
Affinity DataKi:  700nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183771((2S,3S)-dibenzyl 1-((R)-1-((R)-2-(tert-butoxycarbo...)
Affinity DataKi:  700nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183766((2S,3S)-dibenzyl 1-((S)-1-(2-(tert-butoxycarbonyl)...)
Affinity DataKi:  700nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183774((2S,3S)-dibenzyl 1-((S)-1-((S)-2-(tert-butoxycarbo...)
Affinity DataKi:  800nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183761((2S,3S)-dibenzyl 1-((R)-1-((S)-2-(tert-butoxycarbo...)
Affinity DataKi:  800nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183773((2S,3S)-1-((R)-2-((S)-2-(tert-butoxycarbonyl)-3-ph...)
Affinity DataKi:  800nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183753((2S,3S)-1-((S)-1-(2-(tert-butoxycarbonyl)acetyl)py...)
Affinity DataKi:  900nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183777((2S,3S)-diethyl 1-((R)-1-((S)-2-(tert-butoxycarbon...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183772((2S,3S)-diethyl 1-((S)-1-((S)-2-(tert-butoxycarbon...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183757((2S,3S)-dibenzyl 1-((S)-1-((R)-2-(tert-butoxycarbo...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183746((2S,3S)-dibenzyl 1-((R)-1-(2-(tert-butoxycarbonyl)...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183745((2S,3S)-dibenzyl 1-((S)-1-(2-(tert-butoxycarbonyl)...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183770((2S,3S)-dibenzyl 1-((R)-2-((S)-2-(tert-butoxycarbo...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183776((2S,3S)-dibenzyl 1-((R)-1-((S)-2-(tert-butoxycarbo...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Federal University Of Minas Gerais (Ufmg)

Curated by ChEMBL
LigandPNGBDBM50518231(CHEMBL597248 | GNF-Pf-4180 | MMV006169)
Affinity DataKi:  1.40E+3nMAssay Description:Competitive inhibition of Trypanosoma cruzi cruzainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Federal University Of Minas Gerais (Ufmg)

Curated by ChEMBL
LigandPNGBDBM50518231(CHEMBL597248 | GNF-Pf-4180 | MMV006169)
Affinity DataKi:  1.40E+3nMAssay Description:Competitive inhibition of recombinant Trypanosoma cruzi cruzain by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183763((2S,3S)-diethyl 1-(1-((S)-2-(tert-butoxycarbonyl)-...)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183751((2S,3S)-diethyl 1-((S)-1-((R)-2-(tert-butoxycarbon...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183758((2S,3S)-dibenzyl 1-((R)-1-(2-(tert-butoxycarbonyl)...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Federal University Of Minas Gerais (Ufmg)

Curated by ChEMBL
LigandPNGBDBM50518231(CHEMBL597248 | GNF-Pf-4180 | MMV006169)
Affinity DataKi:  1.70E+3nMAssay Description:Competitive inhibition of Trypanosoma cruzi cruzain assessed as inhibition constant using varying levels of Z-FR-AMC as substrate by Michaelis-Menten...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183748((2R,3R)-diethyl 1-((R)-1-((S)-2-(tert-butoxycarbon...)
Affinity DataKi:  1.90E+3nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183750((2R,3R)-diethyl 1-((S)-1-((S)-2-(tert-butoxycarbon...)
Affinity DataKi:  1.90E+3nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183778((2S,3S)-dibenzyl 1-((S)-2-((S)-2-(tert-butoxycarbo...)
Affinity DataKi:  1.90E+3nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183762((2S,3S)-dibenzyl 1-((S)-1-((S)-2-(tert-butoxycarbo...)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183747((2S,3S)-dibenzyl 1-((R)-1-((R)-2-(tert-butoxycarbo...)
Affinity DataKi:  2.80E+3nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Federal University Of Minas Gerais (Ufmg)

Curated by ChEMBL
LigandPNGBDBM50546138(CHEMBL4793916)
Affinity DataKi:  3.00E+3nMAssay Description:Competitive inhibition of recombinant Trypanosoma cruzi cruzain by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183769((2R,3R)-diethyl 1-((S)-1-((S)-2-(tert-butoxycarbon...)
Affinity DataKi:  3.10E+3nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183780((2R,3R)-diethyl 1-((R)-1-((S)-2-(tert-butoxycarbon...)
Affinity DataKi:  3.10E+3nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183764((2S,3S)-dibenzyl 1-((S)-1-(2-(tert-butoxycarbonyl)...)
Affinity DataKi:  3.10E+3nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183775((2S,3S)-diethyl 1-((S)-1-((S)-2-(tert-butoxycarbon...)
Affinity DataKi:  3.10E+3nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Federal University Of Minas Gerais (Ufmg)

Curated by ChEMBL
LigandPNGBDBM50575008(CHEMBL4851626)
Affinity DataKi:  3.20E+3nMAssay Description:Competitive inhibition of Trypanosoma cruzi cruzain assessed as inhibition constant using varying levels of Z-FR-AMC as substrate by Michaelis-Menten...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183759((2R,3R)-diethyl 1-(1-((S)-2-(tert-butoxycarbonyl)-...)
Affinity DataKi:  3.30E+3nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183744((2S,3S)-dibenzyl 1-((R)-2-((R)-2-(tert-butoxycarbo...)
Affinity DataKi:  3.90E+3nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50183760((2S,3S)-1-((R)-2-((R)-2-(tert-butoxycarbonyl)-3-ph...)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of Wuerzburg

Curated by ChEMBL
LigandPNGBDBM50546136(CHEMBL531738)
Affinity DataKi:  1.00E+4nMAssay Description:Mixed inhibition of recombinant Trypanosoma brucei rhodesain expressed in Pichia pastoris by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50378274(CHEMBL573437)
Affinity DataIC50:  0.140nMAssay Description:Inhibition of Ixodes ricinus asparaginyl endopeptidasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50378260(CHEMBL577594)
Affinity DataIC50:  0.230nMAssay Description:Inhibition of Ixodes ricinus asparaginyl endopeptidasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50378275(CHEMBL582897)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of Ixodes ricinus asparaginyl endopeptidasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50378276(CHEMBL582898)
Affinity DataIC50:  0.370nMAssay Description:Inhibition of Ixodes ricinus asparaginyl endopeptidasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50378280(CHEMBL576557)
Affinity DataIC50:  0.520nMAssay Description:Inhibition of Ixodes ricinus asparaginyl endopeptidasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetClan CD, family C13, asparaginyl endopeptidase-like cysteine peptidase(Trichomonas vaginalis G3)
Georgia Institute of Technology

LigandPNGBDBM22125(aza-peptide Michael acceptor, 5i | benzyl N-[(1S)-...)
Affinity DataIC50:  0.550nMT: 2°CAssay Description:AE activity in the induction medium was measured with the substrate Cbz-Ala-Ala-Asn-AMC. In a black 96-well microtiter plate, aza-peptidyl inhibitors...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLegumain(Ixodes ricinus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM22125(aza-peptide Michael acceptor, 5i | benzyl N-[(1S)-...)
Affinity DataIC50: <1nMT: 2°CAssay Description:AE activity in the induction medium was measured with the substrate Cbz-Ala-Ala-Asn-AMC. In a black 96-well microtiter plate, aza-peptidyl inhibitors...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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