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Found 354 with Last Name = 'catalano' and Initial = 'jg'
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM19783((2S)-3,3-dimethyl-1-{3-[4-(trifluoromethyl)phenyl]...)
Affinity DataIC50:  0.0720nMpH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM50084655(CHEMBL92708 | Calpeptin | Z-Leu-Nle-CHO | [(S)-1-(...)
Affinity DataIC50:  0.110nMAssay Description:Inhibiory activity against recombinant human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM50084655(CHEMBL92708 | Calpeptin | Z-Leu-Nle-CHO | [(S)-1-(...)
Affinity DataIC50:  0.110nMAssay Description:Inhibitory activity against human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Gsk

LigandPNGBDBM19783((2S)-3,3-dimethyl-1-{3-[4-(trifluoromethyl)phenyl]...)
Affinity DataIC50:  0.210nMAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM50179446((S)-4,4-dimethyl-2-oxo-1-((4-(trifluoromethyl)phen...)
Affinity DataIC50:  0.420nMAssay Description:Inhibition of recombinant human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM50139490(2,2,4,4-tetramethylpentan-3-yl(S)-1,2-dioxo-1-((R)...)
Affinity DataIC50:  0.710nMAssay Description:Inhibitory activity against human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM50139481((R)-2,2-dimethyl-6-phenylhexan-3-yl(S)-1,2-dioxo-1...)
Affinity DataIC50:  0.790nMAssay Description:Inhibitory activity against human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM50179439((S)-1-(benzo[d]thiazole-2-carbonyl)-4,4-dimethyl-2...)
Affinity DataIC50:  0.810nMAssay Description:Inhibition of recombinant human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM50152524((S)-(1-(4-fluorobenzyl)cyclobutyl)methyl 1-(1H-pyr...)
Affinity DataIC50:  0.830nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM50179454((S)-4,4-dimethyl-2-oxo-1-(2-(trifluoromethyl)-1,3,...)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM50139496((R)-4,4-dimethyl-1-phenylpentan-3-yl(S)-1,2-dioxo-...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM50139496((R)-4,4-dimethyl-1-phenylpentan-3-yl(S)-1,2-dioxo-...)
Affinity DataIC50:  1.10nMAssay Description:Inhibitory activity against human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM19793((2S)-1-(5,6-dichloro-1H-1,3-benzodiazol-1-yl)-3,3-...)
Affinity DataIC50:  1.40nMpH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM50179458((S)-1-(2-naphthoyl)-4,4-dimethyl-2-oxopyrrolidin-3...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of recombinant human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM50179438((S)-1-(1H-indole-5-carbonyl)-4,4-dimethyl-2-oxopyr...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of recombinant human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM50179437((S)-4,4-dimethyl-2-oxo-3-[(S)-1-((R)-1-phenyl-ethy...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of recombinant human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM19796((2S)-3,3-dimethyl-1-{3-[4-(trifluoromethyl)phenyl]...)
Affinity DataIC50:  2.10nMpH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM50179445((S)-4,4-dimethyl-2-oxo-1-((4-(trifluoromethyl)phen...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of recombinant human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM50138842(2,4-dimethylpentan-3-yl(S)-1,2-dioxo-1-((R)-1-phen...)
Affinity DataIC50:  2.5nMAssay Description:Inhibitory activity against human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM50165427(CHEMBL194068 | [(S)-1-((R)-1-Phenyl-ethylaminooxal...)
Affinity DataIC50:  2.5nMAssay Description:Inhibitory concentration against human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM50179440((S)-1-(benzo[b]thiophene-2-carbonyl)-4,4-dimethyl-...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of recombinant human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM50165424((S)-4,4-dimethyl-2-oxo-tetrahydrofuran-3-yl (S)-1,...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM50179442((S)-4,4-dimethyl-2-oxo-1-(2-phenylacetyl)pyrrolidi...)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM50165424((S)-4,4-dimethyl-2-oxo-tetrahydrofuran-3-yl (S)-1,...)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM19794((2S)-1-(5,6-dichloro-1H-1,3-benzodiazol-1-yl)-3,3-...)
Affinity DataIC50:  3.20nMpH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM19791((2S)-3,3-dimethyl-1-[3-(pyridin-4-yl)-1H-pyrazol-1...)
Affinity DataIC50:  3.80nMpH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM50179453((S)-1-(benzylcarbamoyl)-4,4-dimethyl-2-oxopyrrolid...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of recombinant human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM19786((2S)-3,3-dimethyl-1-{3-[4-(trifluoromethyl)phenyl]...)
Affinity DataIC50:  4nMpH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM50179441((S)-4,4-dimethyl-2-oxo-1-(phenylcarbamoyl)pyrrolid...)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of recombinant human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM50179435((S)-4,4-dimethyl-2-oxo-3-[(S)-1-((R)-1-phenyl-ethy...)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Gsk

LigandPNGBDBM50152524((S)-(1-(4-fluorobenzyl)cyclobutyl)methyl 1-(1H-pyr...)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of 10 uM Cbz-Val-Val-Arg-AMC binding to human cathepsin S in fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM19792((2S)-3,3-dimethyl-1-[3-(pyridin-3-yl)-1H-pyrazol-1...)
Affinity DataIC50:  5.5nMpH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM50165423(CHEMBL193582 | [(S)-1-((R)-1-Phenyl-ethylaminooxal...)
Affinity DataIC50:  5.70nMAssay Description:Inhibitory concentration against human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM50139492(CHEMBL355138 | [(S)-1-((R)-1-Phenyl-ethylaminooxal...)
Affinity DataIC50:  6.30nMAssay Description:Inhibitory activity against human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM19789((2S)-3,3-dimethyl-1-{4-[4-(trifluoromethyl)phenyl]...)
Affinity DataIC50:  6.40nMpH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM50179433((S)-4,4-dimethyl-2-oxo-1-(phenethylcarbamoyl)pyrro...)
Affinity DataIC50:  6.60nMAssay Description:Inhibition of recombinant human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM50179456(CHEMBL380300 | [(S)-1-((R)-1-phenyl-ethylaminooxal...)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of recombinant human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM50165420(CHEMBL197509 | [(S)-1-((R)-1-Phenyl-ethylaminooxal...)
Affinity DataIC50:  7.20nMAssay Description:Inhibitory concentration against human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM19782((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(2...)
Affinity DataIC50:  7.5nMpH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM50152535(CHEMBL362878 | [(S)-5-[(Morpholine-4-carbonyl)-ami...)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM19790((2S)-3,3-dimethyl-1-{4-[4-(trifluoromethyl)phenyl]...)
Affinity DataIC50:  7.60nMpH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Gsk

LigandPNGBDBM19793((2S)-1-(5,6-dichloro-1H-1,3-benzodiazol-1-yl)-3,3-...)
Affinity DataIC50:  7.90nMAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM50179434((S)-4,4-dimethyl-2-oxo-1-(phenylsulfonyl)pyrrolidi...)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of recombinant human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM50152527((1-benzylcyclobutyl)methyl(S)-1,2-dioxo-1-((R)-1-p...)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Gsk

LigandPNGBDBM19783((2S)-3,3-dimethyl-1-{3-[4-(trifluoromethyl)phenyl]...)
Affinity DataIC50:  8.70nMAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gsk

LigandPNGBDBM50179444((S)-1-(isoxazole-5-carbonyl)-4,4-dimethyl-2-oxopyr...)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of recombinant human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Gsk

LigandPNGBDBM19794((2S)-1-(5,6-dichloro-1H-1,3-benzodiazol-1-yl)-3,3-...)
Affinity DataIC50:  10nMAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Gsk

LigandPNGBDBM19789((2S)-3,3-dimethyl-1-{4-[4-(trifluoromethyl)phenyl]...)
Affinity DataIC50:  10nMAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Gsk

LigandPNGBDBM50152525(CHEMBL184403 | [(S)-1-((R)-1-Phenyl-ethylaminooxal...)
Affinity DataIC50:  11nMAssay Description:Inhibition of 10 uM Cbz-Val-Val-Arg-AMC binding to human cathepsin S in fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Gsk

LigandPNGBDBM19791((2S)-3,3-dimethyl-1-[3-(pyridin-4-yl)-1H-pyrazol-1...)
Affinity DataIC50:  11nMAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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