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Found 204 with Last Name = 'cato' and Initial = 'mj'
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342649(6-methyl-N-(4-(6-(piperazin-1-yl)pyridin-3-yl)phen...)
Affinity DataKi:  700nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235240(CHEMBL4065169)
Affinity DataIC50:  9nMAssay Description:In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235250(CHEMBL4104525)
Affinity DataIC50:  11nMAssay Description:Inhibition of Kv1.5 mediated ultra-rapid delayed rectifier current Ikur in human atrial myocytes by voltage-patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235240(CHEMBL4065169)
Affinity DataIC50:  11nMAssay Description:Inhibition of Kv1.5 mediated ultra-rapid delayed rectifier current Ikur in human atrial myocytes by voltage-patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50240267(CHEMBL2325014)
Affinity DataIC50:  11nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells measured after 5 to 10 mins post compound washout by PatchXpress automated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Mus musculus)
Merck

Curated by ChEMBL
LigandPNGBDBM50242510(CHEMBL4095146)
Affinity DataIC50:  11nMAssay Description:Inhibition of 50% inactivated mouse Nav1.7alpha incubated for 5 mins measured at 10 secs interval by PatchXpress automated electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50242509(CHEMBL4068937)
Affinity DataIC50:  21nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells incubated for 5 mins measured at 10 secs interval by PatchXpress automated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235255(CHEMBL4085436)
Affinity DataIC50:  23nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235259(CHEMBL4105245)
Affinity DataIC50:  26nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235250(CHEMBL4104525)
Affinity DataIC50:  29nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50242509(CHEMBL4068937)
Affinity DataIC50:  29nMAssay Description:Inhibition of Nav1.2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235275(CHEMBL4062996)
Affinity DataIC50:  30nMAssay Description:Tested for irreversible inhibitory activity against AdoMet-DC (S-adenosyl-methionine decarboxylase-) isolated from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Mus musculus)
Merck

Curated by ChEMBL
LigandPNGBDBM50242509(CHEMBL4068937)
Affinity DataIC50:  30nMAssay Description:Inhibition of [3H]PIA binding to rat cortical adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50242509(CHEMBL4068937)
Affinity DataIC50:  31nMAssay Description:Inhibition of NaV1.7 channel in human DRG neurons assessed as reduction of TTX-sensitive current by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235253(CHEMBL4075394)
Affinity DataIC50:  33nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194539(4-(3-(2-fluorophenyl)propanamido)-N,N-diisopropyl-...)
Affinity DataIC50:  36nMAssay Description:Inhibition of Kv1.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50242510(CHEMBL4095146)
Affinity DataIC50:  39nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells incubated for 5 mins measured at 10 secs interval by PatchXpress automated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235254(CHEMBL4095750)
Affinity DataIC50:  41nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235260(CHEMBL4088894)
Affinity DataIC50:  56nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235272(CHEMBL4067665)
Affinity DataIC50:  62nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235243(CHEMBL4100226)
Affinity DataIC50:  64nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235246(CHEMBL4097667)
Affinity DataIC50:  64nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50242508(CHEMBL4084948)
Affinity DataIC50:  74nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells incubated for 5 mins measured at 10 secs interval by PatchXpress automated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Mus musculus)
Merck

Curated by ChEMBL
LigandPNGBDBM50242509(CHEMBL4068937)
Affinity DataIC50:  82nMAssay Description:Inhibition of NaV1.7 channel in mouse DRG neurons assessed as reduction of TTX-sensitive current by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235264(CHEMBL4100098)
Affinity DataIC50:  84nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235271(CHEMBL4094177)
Affinity DataIC50:  84nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235241(CHEMBL4080304)
Affinity DataIC50:  90nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194512(CHEMBL216955 | N,N-diisopropyl-3-phenyl-4-(3-pheny...)
Affinity DataIC50:  94nMAssay Description:Inhibition of Kv1.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194549(CHEMBL217222 | N,N-diisopropyl-3-phenyl-4-(3-pheny...)
Affinity DataIC50:  100nMAssay Description:Inhibition of Kv1.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235265(CHEMBL4097545)
Affinity DataIC50:  110nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194510(CHEMBL386441 | methyl 5-(diisopropylamino)-3-(3-(3...)
Affinity DataIC50:  113nMAssay Description:Inhibition of Kv1.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235249(CHEMBL4094185)
Affinity DataIC50:  116nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235247(CHEMBL4079636)
Affinity DataIC50:  133nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50242504(CHEMBL4090017)
Affinity DataIC50:  134nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells incubated for 5 mins measured at 10 secs interval by PatchXpress automated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235266(CHEMBL4068841)
Affinity DataIC50:  136nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235269(CHEMBL4072707)
Affinity DataIC50:  137nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194540(CHEMBL217011 | methyl 3-(3-bromophenyl)-5-(diisopr...)
Affinity DataIC50:  137nMAssay Description:Inhibition of Kv1.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194514(CHEMBL217921 | methyl 4-(3-bromophenyl)-5-(diisopr...)
Affinity DataIC50:  147nMAssay Description:Inhibition of Kv1.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235258(CHEMBL4081003)
Affinity DataIC50:  148nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50242506(CHEMBL4077789)
Affinity DataIC50:  150nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells incubated for 5 mins measured at 10 secs interval by PatchXpress automated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194527(4-(3-(2-fluorobenzyl)ureido)-N,N-diisopropyl-3-phe...)
Affinity DataIC50:  150nMAssay Description:Inhibition of Kv1.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235268(CHEMBL4102309)
Affinity DataIC50:  153nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235256(CHEMBL4080956)
Affinity DataIC50:  161nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235261(CHEMBL4061731)
Affinity DataIC50:  171nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194517(CHEMBL385737 | methyl 3-(3-cyanophenyl)-5-(diisopr...)
Affinity DataIC50:  184nMAssay Description:Inhibition of Kv1.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50242507(CHEMBL4102898)
Affinity DataIC50:  190nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells incubated for 5 mins measured at 10 secs interval by PatchXpress automated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50348097(CHEMBL1800440)
Affinity DataIC50:  190nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235273(CHEMBL4084347)
Affinity DataIC50:  195nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194528(CHEMBL411970 | methyl 3-(4-cyanophenyl)-5-(diisopr...)
Affinity DataIC50:  215nMAssay Description:Inhibition of Kv1.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50348098(CHEMBL1800430)
Affinity DataIC50:  220nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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