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Found 245 with Last Name = 'cavallaro' and Initial = 'cl'
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071554(3-Hydroxy-4-[(2S,3S)-3-methyl-2-(2-naphthalen-2-yl...)
Affinity DataKi:  50nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071558(3-Hydroxy-6-methyl-4-[(2S,3S)-3-methyl-2-(2-naphth...)
Affinity DataKi:  50nMAssay Description:Inhibitory activity against plasmepsin-2 from Plasmodium falciparumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071554(3-Hydroxy-4-[(2S,3S)-3-methyl-2-(2-naphthalen-2-yl...)
Affinity DataKi:  90nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071546(3-Hydroxy-6-methyl-4-{(S)-2-[2-(naphthalen-2-yloxy...)
Affinity DataKi:  110nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071561(3-Hydroxy-4-{(2S,3S)-3-methyl-2-[2-(naphthalen-2-y...)
Affinity DataKi:  110nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071555(3-Hydroxy-4-{(2S,3S)-1-hydroxy-3-methyl-2-[2-(naph...)
Affinity DataKi:  180nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071559((S)-2-[2-(Naphthalen-2-yloxy)-acetylamino]-pentane...)
Affinity DataKi:  200nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071562(3-Hydroxy-4-{(S)-2-[2-(naphthalen-2-yloxy)-acetyla...)
Affinity DataKi:  200nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071550(CHEMBL74562 | N-[(1S,2S)-1-(1-Benzyl-3-butylcarbam...)
Affinity DataKi:  220nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071556(CHEMBL74943 | N-[(1S,2S)-1-(1-Benzyl-3-butylcarbam...)
Affinity DataKi:  220nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071558(3-Hydroxy-6-methyl-4-[(2S,3S)-3-methyl-2-(2-naphth...)
Affinity DataKi:  320nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071552(1-{[(1S,2S)-1-(1-Benzyl-3-butylcarbamoyl-2-hydroxy...)
Affinity DataKi:  410nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50146770(CHEMBL94646 | N-(1-{1-[1-Hydroxy-2-(3-phenyl-propy...)
Affinity DataKi:  440nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071551(CHEMBL427946 | N-[(S)-1-(1-Benzyl-3-butylcarbamoyl...)
Affinity DataKi:  500nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071562(3-Hydroxy-4-{(S)-2-[2-(naphthalen-2-yloxy)-acetyla...)
Affinity DataKi:  560nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071555(3-Hydroxy-4-{(2S,3S)-1-hydroxy-3-methyl-2-[2-(naph...)
Affinity DataKi:  560nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071549(CHEMBL309056 | N-[(S)-(1-Benzyl-3-butylcarbamoyl-2...)
Affinity DataKi:  590nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071553(1-({(1S,2S)-1-[1-Benzyl-2-hydroxy-3-(3-phenyl-prop...)
Affinity DataKi:  600nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071547(3-Hydroxy-4-{(R)-2-[2-(naphthalen-2-yloxy)-acetyla...)
Affinity DataKi:  700nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071557(3-Hydroxy-6-methyl-4-{(S)-4-methyl-2-[2-(naphthale...)
Affinity DataKi:  920nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071560(3-Hydroxy-6-methyl-4-{(S)-2-[2-(naphthalen-2-yloxy...)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50146770(CHEMBL94646 | N-(1-{1-[1-Hydroxy-2-(3-phenyl-propy...)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071551(CHEMBL427946 | N-[(S)-1-(1-Benzyl-3-butylcarbamoyl...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071550(CHEMBL74562 | N-[(1S,2S)-1-(1-Benzyl-3-butylcarbam...)
Affinity DataKi:  2.40E+3nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071553(1-({(1S,2S)-1-[1-Benzyl-2-hydroxy-3-(3-phenyl-prop...)
Affinity DataKi:  3.90E+3nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071557(3-Hydroxy-6-methyl-4-{(S)-4-methyl-2-[2-(naphthale...)
Affinity DataKi:  5.60E+3nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071546(3-Hydroxy-6-methyl-4-{(S)-2-[2-(naphthalen-2-yloxy...)
Affinity DataKi:  5.80E+3nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071549(CHEMBL309056 | N-[(S)-(1-Benzyl-3-butylcarbamoyl-2...)
Affinity DataKi:  6.20E+3nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071549(CHEMBL309056 | N-[(S)-(1-Benzyl-3-butylcarbamoyl-2...)
Affinity DataKi:  6.20E+3nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071560(3-Hydroxy-6-methyl-4-{(S)-2-[2-(naphthalen-2-yloxy...)
Affinity DataKi:  1.20E+4nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071547(3-Hydroxy-4-{(R)-2-[2-(naphthalen-2-yloxy)-acetyla...)
Affinity DataKi:  1.50E+4nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071549(CHEMBL309056 | N-[(S)-(1-Benzyl-3-butylcarbamoyl-2...)
Affinity DataKi: >3.00E+4nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071559((S)-2-[2-(Naphthalen-2-yloxy)-acetylamino]-pentane...)
Affinity DataKi: >3.00E+4nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM205048(US9249096, 65)
Affinity DataIC50:  1.60nMpH: 8.0 T: 2°CAssay Description:The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM205032(US9249096, 45)
Affinity DataIC50:  2.71nMpH: 8.0 T: 2°CAssay Description:The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM205029(US9249096, 42)
Affinity DataIC50:  2.93nMpH: 8.0 T: 2°CAssay Description:The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM205031(US9249096, 44)
Affinity DataIC50:  3.22nMpH: 8.0 T: 2°CAssay Description:The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM205033(US9249096, 46)
Affinity DataIC50:  3.25nMpH: 8.0 T: 2°CAssay Description:The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM205034(US9249096, 47)
Affinity DataIC50:  3.30nMpH: 8.0 T: 2°CAssay Description:The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM205027(US9249096, 40)
Affinity DataIC50:  3.65nMpH: 8.0 T: 2°CAssay Description:The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM205026(US9249096, 39)
Affinity DataIC50:  5.09nMpH: 8.0 T: 2°CAssay Description:The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM205039(US9249096, 53)
Affinity DataIC50:  5.24nMpH: 8.0 T: 2°CAssay Description:The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM205037(US9249096, 51)
Affinity DataIC50:  5.52nMpH: 8.0 T: 2°CAssay Description:The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM205047(US9249096, 64)
Affinity DataIC50:  5.61nMpH: 8.0 T: 2°CAssay Description:The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM205046(US9249096, 60)
Affinity DataIC50:  5.64nMpH: 8.0 T: 2°CAssay Description:The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM205041(US9249096, 55)
Affinity DataIC50:  5.80nMpH: 8.0 T: 2°CAssay Description:The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM205036(US9249096, 50)
Affinity DataIC50:  5.99nMpH: 8.0 T: 2°CAssay Description:The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM205043(US9249096, 57)
Affinity DataIC50:  6.30nMpH: 8.0 T: 2°CAssay Description:The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50399228(CHEMBL2180505)
Affinity DataIC50:  8nMAssay Description:Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50399220(CHEMBL2180186)
Affinity DataIC50:  13nMAssay Description:Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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