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Found 420 with Last Name = 'chen' and Initial = 'lj'
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM9291((3S,4aS,8aS)-N-tert-butyl-2-[(2R,3S)-2-hydroxy-3-[...)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of HIV-1 protease was determined in vitroChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM383((3S)-oxolan-3-yl N-[(2S,3S,5R)-5-benzyl-3-hydroxy-...)
Affinity DataIC50:  0.0600nMAssay Description:Compound was tested for inhibitory activity against Human immunodeficiency virus (HIV-1) proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM383((3S)-oxolan-3-yl N-[(2S,3S,5R)-5-benzyl-3-hydroxy-...)
Affinity DataIC50:  0.0600nMAssay Description:Inhibition of HIV-1 protease was determined in vitroChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM842(Benzocycloalkyl Amines deriv. 12 | CHEMBL419923 | ...)
Affinity DataIC50:  0.100nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM1046(CHEMBL298316 | L-685,927 | tert-butyl N-[(2S,3S,5R...)
Affinity DataIC50:  0.160nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM1039(CHEMBL297620 | Hydroxyethylene dipeptide isostere ...)
Affinity DataIC50:  0.170nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50035633(CHEMBL111143 | [(1S,2S,4R)-1-Benzyl-2-hydroxy-4-((...)
Affinity DataIC50:  0.180nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50035635(CHEMBL322984 | [(1S,2S,4R)-1-Benzyl-4-((1S,2S,3R)-...)
Affinity DataIC50:  0.190nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM1031(CHEMBL265514 | Hydroxyethylene dipeptide isostere ...)
Affinity DataIC50:  0.230nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM519((2S)-N-[(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarba...)
Affinity DataIC50:  0.230nMAssay Description:Inhibition of HIV-1 protease was determined in vitroChecked by AuthorMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM1030(CHEMBL296115 | L-685,434 | Urethane deriv. 1 | ter...)
Affinity DataIC50:  0.25nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50035630(CHEMBL108918 | [(1S,2S,4R)-1-Benzyl-2-hydroxy-4-((...)
Affinity DataIC50:  0.25nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM1040(CHEMBL296484 | Hydroxyethylene dipeptide isostere ...)
Affinity DataIC50:  0.260nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM1036(CHEMBL295904 | Hydroxyethylene dipeptide isostere ...)
Affinity DataIC50:  0.270nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM1038(CHEMBL265516 | Hydroxyethylene dipeptide isostere ...)
Affinity DataIC50:  0.290nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325294(5-((6-(4-hydroxy-3-methoxyphenyl)-2-oxoindolin-3-y...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM1037(CHEMBL296493 | Hydroxyethylene dipeptide isostere ...)
Affinity DataIC50:  0.310nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325308(5-((6-(4-hydroxyphenyl)-2-oxoindolin-3-ylidene)met...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325307(CHEMBL1223408 | N-(2-(diethylamino)ethyl)-5-((6-(4...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325296(CHEMBL1223263 | N-(3-(1H-imidazol-1-yl)propyl)-5-(...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325292(CHEMBL1223182 | N-(2-(dimethylamino)ethyl)-5-((6-(...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325310(CHEMBL1223478 | N-(3-(1H-imidazol-1-yl)propyl)-5-(...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50035628(CHEMBL430692 | [(1S,2S,4R)-1-Benzyl-2-hydroxy-4-((...)
Affinity DataIC50:  0.530nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325306(CHEMBL1223407 | N-(2-(dimethylamino)ethyl)-5-((6-(...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM1041(CHEMBL47514 | Hydroxyethylene dipeptide isostere 3...)
Affinity DataIC50:  0.600nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325293(CHEMBL1223183 | N-(2-(diethylamino)ethyl)-5-((6-(4...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50422052(CHEMBL109952 | L-700417)
Affinity DataIC50:  0.690nMAssay Description:Inhibition of HIV-1 protease was determined in vitroChecked by AuthorMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50035631(CHEMBL325551 | [(1S,2S,4R)-1-Benzyl-2-hydroxy-4-((...)
Affinity DataIC50:  0.700nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM1035(CHEMBL296855 | Hydroxyethylene dipeptide isostere ...)
Affinity DataIC50:  0.720nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325309(5-((6-(4-hydroxyphenyl)-2-oxoindolin-3-ylidene)met...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human YesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50086454(CHEMBL3425518)
Affinity DataIC50:  1nMAssay Description:Inhibition of human SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325295(5-((6-(4-hydroxy-3-methoxyphenyl)-2-oxoindolin-3-y...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50422053(CHEMBL322037)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of HIV-1 protease was determined in vitroChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50283953(CHEMBL357039 | {(1S,2S)-1-Benzyl-3-[(S)-3-benzyl-1...)
Affinity DataIC50:  1.80nMAssay Description:Compound was tested for inhibitory activity against Human immunodeficiency virus (HIV-1) proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50086457(CHEMBL3426217)
Affinity DataIC50:  2nMAssay Description:Inhibition of human SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50086451(CHEMBL3426222)
Affinity DataIC50:  2nMAssay Description:Inhibition of human SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50086455(CHEMBL3426219)
Affinity DataIC50:  2nMAssay Description:Inhibition of human SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325287(CHEMBL1223044 | N-(2-(dimethylamino)ethyl)-5-((6-(...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50086453(CHEMBL3426220 | US10266537, Compound 14)
Affinity DataIC50:  3nMAssay Description:Inhibition of human SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325291(CHEMBL1223118 | N-(3-(1H-imidazol-1-yl)propyl)-5-(...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50086450(CHEMBL3426223)
Affinity DataIC50:  4nMAssay Description:Inhibition of human SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50086456(CHEMBL3426218 | US10266537, Compound 17)
Affinity DataIC50:  4nMAssay Description:Inhibition of human SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325304(5-((6-(4-hydroxyphenyl)-2-oxoindolin-3-ylidene)met...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325289(5-((6-(4-hydroxy-3-methoxyphenyl)-2-oxoindolin-3-y...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50325302(CHEMBL1223338 | N-(2-(diethylamino)ethyl)-5-((6-(4...)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of human recombinant GST-Chk1after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50086586(CHEMBL3426234 | US10266537, Compound 29)
Affinity DataIC50:  5nMAssay Description:Inhibition of human SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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