Found 753 with Last Name = 'chen' and Initial = 'yl' 
Affinity DataKi: 2.70nMAssay Description:Binding affinity of the compound against [125I]-Try0-o-Corticotropin-releasing Factor to Corticotropin releasing hormone receptor 1 from ovineMore data for this Ligand-Target Pair
Affinity DataKi: 95nM ΔG°: -40.1kJ/molepH: 8.0 T: 2°CAssay Description:The testing for the inhibition activities of imidazole derivatives and cacodylate on gQC and sQC was evaluated at 25 C using the fluorescent substrat...More data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataKi: 262nM ΔG°: -37.6kJ/molepH: 8.0 T: 2°CAssay Description:The testing for the inhibition activities of imidazole derivatives and cacodylate on gQC and sQC was evaluated at 25 C using the fluorescent substrat...More data for this Ligand-Target Pair
Affinity DataKi: 607nM ΔG°: -35.5kJ/molepH: 8.0 T: 2°CAssay Description:The testing for the inhibition activities of imidazole derivatives and cacodylate on gQC and sQC was evaluated at 25 C using the fluorescent substrat...More data for this Ligand-Target Pair
Affinity DataKi: 1.70E+3nM ΔG°: -32.9kJ/molepH: 8.0 T: 2°CAssay Description:The testing for the inhibition activities of imidazole derivatives and cacodylate on gQC and sQC was evaluated at 25 C using the fluorescent substrat...More data for this Ligand-Target Pair
Affinity DataKi: 1.82E+3nM ΔG°: -32.8kJ/molepH: 8.0 T: 2°CAssay Description:The testing for the inhibition activities of imidazole derivatives and cacodylate on gQC and sQC was evaluated at 25 C using the fluorescent substrat...More data for this Ligand-Target Pair
Affinity DataKi: 5.75E+3nM ΔG°: -29.9kJ/molepH: 8.0 T: 2°CAssay Description:The testing for the inhibition activities of imidazole derivatives and cacodylate on gQC and sQC was evaluated at 25 C using the fluorescent substrat...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of binding of [125I]-Tyr0-sauvagine to Corticotropin releasing hormone receptor 2 (CRF2)More data for this Ligand-Target Pair
Affinity DataKi: 1.82E+6nM ΔG°: -15.6kJ/molepH: 8.0 T: 2°CAssay Description:The testing for the inhibition activities of imidazole derivatives and cacodylate on gQC and sQC was evaluated at 25 C using the fluorescent substrat...More data for this Ligand-Target Pair
Affinity DataKi: 6.70E+6nM ΔG°: -12.4kJ/molepH: 8.0 T: 2°CAssay Description:The testing for the inhibition activities of imidazole derivatives and cacodylate on gQC and sQC was evaluated at 25 C using the fluorescent substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.110nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.140nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.220nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.220nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.330nMAssay Description:In vitro inhibition of Acetylcholinesterase from human erythrocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 0.430nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.480nMAssay Description:In vitro inhibition of Acetylcholinesterase from human erythrocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 0.570nMAssay Description:In vitro inhibition of Acetylcholinesterase from human erythrocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Evaluated for the in vitro inhibition of the Acetylcholinesterase (AChE) from human erythrocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 0.950nMAssay Description:In vitro inhibition of Acetylcholinesterase from human erythrocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of gamma secretase C100Flag cleavaging activity in HeLa cell membranes assessed as M-amyloid beta-40 production by cell free assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMpH: 7.0 T: 2°CAssay Description:The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro. More data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMAssay Description:Inhibition of gamma secretase C100Flag cleavaging activity in HeLa cell membranes assessed as M-amyloid beta-40 production by cell free assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMpH: 7.0 T: 2°CAssay Description:The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro. More data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:Inhibition of gamma secretase C100Flag cleavaging activity in HeLa cell membranes assessed as M-amyloid beta-40 production by cell free assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.80nMAssay Description:In vitro inhibition of Acetylcholinesterase from human erythrocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 2.80nMAssay Description:Inhibition of gamma secretase C100Flag cleavaging activity in HeLa cell membranes assessed as M-amyloid beta-40 production by cell free assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.80nMAssay Description:Evaluated for the in vitro inhibition of the Acetylcholinesterase (AChE) from human erythrocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of gamma secretase C100Flag cleavaging activity in HeLa cell membranes assessed as M-amyloid beta-40 production by cell free assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human Haspin kinase domain using histone H3 biotin peptide as substrate preincubated with enzyme for 30 mins followed by substrate and ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.10nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
