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Found 120 with Last Name = 'ciurleo' and Initial = 'r'
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50270640((Z)-2-(5-(4-hydroxybenzylidene)-2,4-dioxothiazolid...)
Affinity DataIC50:  150nMAssay Description:Inhibition of ALR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Universit£

Curated by ChEMBL
LigandPNGBDBM50213307(CHEMBL396176 | [(5Z)-5-{[3-(carboxymethoxy)-4-meth...)
Affinity DataIC50:  200nMAssay Description:Inhibition of bovine aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Universit£

Curated by ChEMBL
LigandPNGBDBM50213303(CHEMBL233577 | [5-(3-carboxymethoxybenzylidene)-2,...)
Affinity DataIC50:  230nMAssay Description:Inhibition of bovine aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Universit£

Curated by ChEMBL
LigandPNGBDBM50213308(CHEMBL233782 | [5-(4-carboxymethoxy-3-methoxybenzy...)
Affinity DataIC50:  260nMAssay Description:Inhibition of bovine aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50214527(4-((5-(4-(benzyloxy)benzylidene)-2,4-dioxothiazoli...)
Affinity DataIC50:  400nMAssay Description:Inhibition of human protein-tyrosine phosphatase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Universit£

Curated by ChEMBL
LigandPNGBDBM50213305(CHEMBL233575 | [5-(4-carboxymethoxybenzylidene)-2,...)
Affinity DataIC50:  600nMAssay Description:Inhibition of bovine aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Universit£

Curated by ChEMBL
LigandPNGBDBM50213306(CHEMBL396175 | [5-(3-hydroxy-4-methoxybenzylidene)...)
Affinity DataIC50:  700nMAssay Description:Inhibition of bovine aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Universit£

Curated by ChEMBL
LigandPNGBDBM50213306(CHEMBL396175 | [5-(3-hydroxy-4-methoxybenzylidene)...)
Affinity DataIC50:  700nMAssay Description:Inhibition of bovine aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow molecular weight phosphotyrosine protein phosphatase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50214530(4-[2,4-dioxo-5-(4-phenoxybenzylidene)thiazolidin-3...)
Affinity DataIC50:  900nMAssay Description:Inhibition of human low molecular weight Protein-tyrosine phosphatase IF1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50214536(4-[5-(3-benzyloxybenzylidene)-2,4-dioxothiazolidin...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human protein-tyrosine phosphatase 1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50267098(4-{[5-(4-Benzyloxybenzylidene)-4-oxo-2-phenylimino...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of GST-tagged human PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50267069(4-{[4-Oxo-5-(4-phenoxybenzylidene)-2-phenyliminoth...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of GST-tagged human PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50214530(4-[2,4-dioxo-5-(4-phenoxybenzylidene)thiazolidin-3...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human protein-tyrosine phosphatase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50214527(4-((5-(4-(benzyloxy)benzylidene)-2,4-dioxothiazoli...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human T cell protein-tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Universit£

Curated by ChEMBL
LigandPNGBDBM16312((4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-i...)
Affinity DataIC50:  1.41E+3nMAssay Description:Inhibition of bovine aldose reductaseMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Universit£

Curated by ChEMBL
LigandPNGBDBM16312((4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-i...)
Affinity DataIC50:  1.41E+3nMAssay Description:Inhibition of bovine lens ALR2 assessed as reduction of D,L-glyceraldehyde by spectrophotometryMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50214527(4-((5-(4-(benzyloxy)benzylidene)-2,4-dioxothiazoli...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of human protein-tyrosine phosphatase 1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Universit£

Curated by ChEMBL
LigandPNGBDBM50270639((Z)-N-Hydroxy-2-[5-(4-Hydroxybenzylidene)-2,4-diox...)
Affinity DataIC50:  1.79E+3nMAssay Description:Inhibition of bovine lens ALR2 assessed as reduction of D,L-glyceraldehyde by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50267068(4-{[4-Oxo-5-(3-phenoxybenzylidene)-2-phenyliminoth...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of GST-tagged human PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50267100(4-[(5-Naphthalen-2-ylmethylene-4-oxo-2-phenylimino...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of GST-tagged human PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Universit£

Curated by ChEMBL
LigandPNGBDBM16312((4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-i...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of bovine lens aldose reductaseMore data for this Ligand-Target Pair
TargetLow molecular weight phosphotyrosine protein phosphatase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50214527(4-((5-(4-(benzyloxy)benzylidene)-2,4-dioxothiazoli...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human low molecular weight Protein-tyrosine phosphatase IF1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50214529(4-[5-(4-hydroxy-3-methoxybenzylidene)-2,4-dioxothi...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of human protein-tyrosine phosphatase 1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow molecular weight phosphotyrosine protein phosphatase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50267098(4-{[5-(4-Benzyloxybenzylidene)-4-oxo-2-phenylimino...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of GST-tagged human LMW PTP1B IF1 isoformMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50214530(4-[2,4-dioxo-5-(4-phenoxybenzylidene)thiazolidin-3...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of human T cell protein-tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50214530(4-[2,4-dioxo-5-(4-phenoxybenzylidene)thiazolidin-3...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of human protein-tyrosine phosphatase 1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Universit£

Curated by ChEMBL
LigandPNGBDBM50320788((Z)-5-(4-hydroxybenzylidene)-3-(3,3,3-trifluoro-2,...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of bovine lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Universit£

Curated by ChEMBL
LigandPNGBDBM50320782((Z)-5-[(4-Hydroxyphenyl)methylidene]-3-(3,3,3-trif...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of bovine lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow molecular weight phosphotyrosine protein phosphatase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50267070(4-{[5-(3-Benzyloxybenzylidene)-4-oxo-2-phenylimino...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of GST-tagged human LMW PTP1B IF1 isoformMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow molecular weight phosphotyrosine protein phosphatase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50267069(4-{[4-Oxo-5-(4-phenoxybenzylidene)-2-phenyliminoth...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of GST-tagged human LMW PTP1B IF1 isoformMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Universit£

Curated by ChEMBL
LigandPNGBDBM50271391((Z)-N-hydroxy-2-[2,4-Dioxo-5-(4-phenoxybenzylidene...)
Affinity DataIC50:  3.67E+3nMAssay Description:Inhibition of bovine lens ALR2 assessed as reduction of D,L-glyceraldehyde by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow molecular weight phosphotyrosine protein phosphatase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50267100(4-[(5-Naphthalen-2-ylmethylene-4-oxo-2-phenylimino...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of GST-tagged human LMW PTP1B IF1 isoformMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50267070(4-{[5-(3-Benzyloxybenzylidene)-4-oxo-2-phenylimino...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of GST-tagged human PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Universit£

Curated by ChEMBL
LigandPNGBDBM50270638((Z)-N-Hydroxy-2-(5-Naphthalen-1-ylmethylene-2,4-di...)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of bovine lens ALR2 assessed as reduction of D,L-glyceraldehyde by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow molecular weight phosphotyrosine protein phosphatase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50267068(4-{[4-Oxo-5-(3-phenoxybenzylidene)-2-phenyliminoth...)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of GST-tagged human LMW PTP1B IF1 isoformMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50214535((Z)-4-((5-(naphthalen-1-ylmethylene)-2,4-dioxothia...)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of human protein-tyrosine phosphatase 1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow molecular weight phosphotyrosine protein phosphatase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50214527(4-((5-(4-(benzyloxy)benzylidene)-2,4-dioxothiazoli...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of human low molecular weight Protein-tyrosine phosphatase IF2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow molecular weight phosphotyrosine protein phosphatase(Saccharomyces cerevisiae)
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50267069(4-{[4-Oxo-5-(4-phenoxybenzylidene)-2-phenyliminoth...)
Affinity DataIC50:  6.30E+3nMAssay Description:Inhibition of Saccharomyces cerevisiae Ltp1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50214532(4-(5-naphthalen-2ylmethylene-2,4-dioxothiazolidin-...)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of human protein-tyrosine phosphatase 1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Universit£

Curated by ChEMBL
LigandPNGBDBM50271345((Z)-2-[5-(4-Hydroxybenzylidene)-2,4-dioxothiazolid...)
Affinity DataIC50:  6.52E+3nMAssay Description:Inhibition of bovine lens ALR2 assessed as reduction of D,L-glyceraldehyde by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow molecular weight phosphotyrosine protein phosphatase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50214536(4-[5-(3-benzyloxybenzylidene)-2,4-dioxothiazolidin...)
Affinity DataIC50:  7.10E+3nMAssay Description:Inhibition of human low molecular weight Protein-tyrosine phosphatase IF1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Universit£

Curated by ChEMBL
LigandPNGBDBM50271392((Z)-2-[5-(4-Benzyloxybenzylidene)-2,4-dioxothiazol...)
Affinity DataIC50:  7.34E+3nMAssay Description:Inhibition of bovine lens ALR2 assessed as reduction of D,L-glyceraldehyde by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow molecular weight phosphotyrosine protein phosphatase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50267069(4-{[4-Oxo-5-(4-phenoxybenzylidene)-2-phenyliminoth...)
Affinity DataIC50:  8.20E+3nMAssay Description:Inhibition of GST-tagged human LMW PTP1B IF1 isoformMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Universit£

Curated by ChEMBL
LigandPNGBDBM50320777((Z)-5-[(4-Phenoxyphenyl)methylidene]-3-(3,3,3-trif...)
Affinity DataIC50:  8.30E+3nMAssay Description:Inhibition of bovine lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Universit£

Curated by ChEMBL
LigandPNGBDBM50320783((Z)-5-(4-phenoxybenzylidene)-3-(3,3,3-trifluoro-2,...)
Affinity DataIC50:  8.30E+3nMAssay Description:Inhibition of bovine lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Universit£

Curated by ChEMBL
LigandPNGBDBM50320784((Z)-5-(4-(benzyloxy)benzylidene)-3-(3,3,3-trifluor...)
Affinity DataIC50: >9.00E+3nMAssay Description:Inhibition of bovine lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Universit£

Curated by ChEMBL
LigandPNGBDBM50320778((Z)-5-[(4-Benzyloxyphenyl)methylidene]-3-(3,3,3-tr...)
Affinity DataIC50: >9.00E+3nMAssay Description:Inhibition of bovine lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow molecular weight phosphotyrosine protein phosphatase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50214529(4-[5-(4-hydroxy-3-methoxybenzylidene)-2,4-dioxothi...)
Affinity DataIC50:  9.10E+3nMAssay Description:Inhibition of human low molecular weight Protein-tyrosine phosphatase IF1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50214528(4-[5-(4-hydroxybenzylidene)-2,4-dioxothiazolidin-3...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human protein-tyrosine phosphatase 1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50214533(4-[5-(3-hydroxybenzylidene)-2,4-dioxothiazolidin-3...)
Affinity DataIC50:  1.02E+4nMAssay Description:Inhibition of human protein-tyrosine phosphatase 1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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