BindingDB PrimarySearch_ki

Found 174 with Last Name = 'colombo' and Initial = 'f'

Neuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL

PNG

BDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)

Ki: 4nMAssay Description:Displacement of [3H]-Epibatidine from alpha4beta2 nAChR in rat cerebral cortex membrane preincubated for 5 mins followed by [3H]-Epibatidine addition...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

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MCE
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3D Structure (crystal)

Neuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Universit£

Curated by ChEMBL

PNG

BDBM50357064(CHEMBL1917231)

Ki: 6.70nMAssay Description:Displacement of [3H]-epibatidine from wild type human alpha4beta2 nAChR transfected in human Hela cell membranes preincubated for 5 mins followed by ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL

PNG

BDBM50357064(CHEMBL1917231)

Ki: 12nMAssay Description:Displacement of [3H]-Epibatidine from alpha4beta2 nAChR in rat cerebral cortex membrane preincubated for 5 mins followed by [3H]-Epibatidine addition...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL

PNG

BDBM50549596(CHEMBL4785648)

Ki: 19nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 transfected in HEK293 cell membranes preincubated for 5 mins followed by [3H]-epibatidine add...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL

PNG

BDBM50549596(CHEMBL4785648)

Ki: 22nMAssay Description:Displacement of [3H]-Epibatidine from alpha4beta2 nAChR in rat cerebral cortex membrane preincubated for 5 mins followed by [3H]-Epibatidine addition...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Universit£

Curated by ChEMBL

PNG

BDBM50549596(CHEMBL4785648)

Ki: 46nMAssay Description:Displacement of [3H]-epibatidine from wild type human alpha4beta2 nAChR transfected in human Hela cell membranes preincubated for 5 mins followed by ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Universit£

Curated by ChEMBL

PNG

BDBM50259713(CHEMBL4095303)

Ki: 114nMAssay Description:Displacement of [3H]-epibatidine from wild type human alpha4beta2 nAChR transfected in human Hela cell membranes preincubated for 5 mins followed by ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL

PNG

BDBM50549595(CHEMBL4741357)

Ki: 131nMAssay Description:Displacement of [3H]-Epibatidine from alpha4beta2 nAChR in rat cerebral cortex membrane preincubated for 5 mins followed by [3H]-Epibatidine addition...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL

PNG

BDBM50549611(CHEMBL4758050)

Ki: 140nMAssay Description:Displacement of [3H]-Epibatidine from alpha4beta2 nAChR in rat cerebral cortex membrane preincubated for 5 mins followed by [3H]-Epibatidine addition...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL

PNG

BDBM50549611(CHEMBL4758050)

Ki: 180nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 transfected in HEK293 cell membranes preincubated for 5 mins followed by [3H]-epibatidine add...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL

PNG

BDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)

Ki: 234nMAssay Description:Displacement of [125I]alpha-bungarotoxin from alpha7nAChR in rat hippocampus membranes preincubated for 5 mins followed by [125I]alpha-bungarotoxin a...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

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MCE
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Details Article PubMed PDB

3D Structure (crystal)

Neuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL

PNG

BDBM50194315((2R,2'S)-2-(1-methyl-2-pyrrolidinyl)-1,4-benzodiox...)

Ki: 260nMAssay Description:Displacement of [3H]-Epibatidine from alpha4beta2 nAChR in rat cerebral cortex membrane preincubated for 5 mins followed by [3H]-Epibatidine addition...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL

PNG

BDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)

Ki: 261nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 transfected in HEK293 cell membranes preincubated for 5 mins followed by [3H]-epibatidine add...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

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MCE
KEGG PC cid PC sid PDB Similars

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL

PNG

BDBM50357064(CHEMBL1917231)

Ki: 310nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 transfected in HEK293 cell membranes preincubated for 5 mins followed by [3H]-epibatidine add...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL

PNG

BDBM50549614(CHEMBL4782049)

Ki: 335nMAssay Description:Displacement of [3H]-Epibatidine from alpha4beta2 nAChR in rat cerebral cortex membrane preincubated for 5 mins followed by [3H]-Epibatidine addition...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Universit£

Curated by ChEMBL

PNG

BDBM50549595(CHEMBL4741357)

Ki: 373nMAssay Description:Displacement of [3H]-epibatidine from wild type human alpha4beta2 nAChR transfected in human Hela cell membranes preincubated for 5 mins followed by ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL

PNG

BDBM50259713(CHEMBL4095303)

Ki: 410nMAssay Description:Displacement of [3H]-Epibatidine from alpha4beta2 nAChR in rat cerebral cortex membrane preincubated for 5 mins followed by [3H]-Epibatidine addition...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL

PNG

BDBM50357065(CHEMBL1917232)

Ki: 420nMAssay Description:Displacement of [3H]-Epibatidine from alpha4beta2 nAChR in rat cerebral cortex membrane preincubated for 5 mins followed by [3H]-Epibatidine addition...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL

PNG

BDBM50357064(CHEMBL1917231)

Ki: 430nMAssay Description:Displacement of [125I]alpha-bungarotoxin from alpha7nAChR in rat hippocampus membranes preincubated for 5 mins followed by [125I]alpha-bungarotoxin a...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL

PNG

BDBM50549613(CHEMBL4743341)

Ki: 550nMAssay Description:Displacement of [3H]-Epibatidine from alpha4beta2 nAChR in rat cerebral cortex membrane preincubated for 5 mins followed by [3H]-Epibatidine addition...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL

PNG

BDBM50549598(CHEMBL4747289)

Ki: 640nMAssay Description:Displacement of [3H]-Epibatidine from alpha4beta2 nAChR in rat cerebral cortex membrane preincubated for 5 mins followed by [3H]-Epibatidine addition...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL

PNG

BDBM50357065(CHEMBL1917232)

Ki: 700nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 transfected in HEK293 cell membranes preincubated for 5 mins followed by [3H]-epibatidine add...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL

PNG

BDBM50549615(CHEMBL4790023)

Ki: 1.10E+3nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 transfected in HEK293 cell membranes preincubated for 5 mins followed by [3H]-epibatidine add...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Universit£

Curated by ChEMBL

PNG

BDBM50194315((2R,2'S)-2-(1-methyl-2-pyrrolidinyl)-1,4-benzodiox...)

Ki: 1.18E+3nMAssay Description:Displacement of [3H]-epibatidine from wild type human alpha4beta2 nAChR transfected in human Hela cell membranes preincubated for 5 mins followed by ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL

PNG

BDBM50194315((2R,2'S)-2-(1-methyl-2-pyrrolidinyl)-1,4-benzodiox...)

Ki: 1.20E+3nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 transfected in HEK293 cell membranes preincubated for 5 mins followed by [3H]-epibatidine add...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL

PNG

BDBM50549612(CHEMBL4759608)

Ki: 1.70E+3nMAssay Description:Displacement of [3H]-Epibatidine from alpha4beta2 nAChR in rat cerebral cortex membrane preincubated for 5 mins followed by [3H]-Epibatidine addition...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL

PNG

BDBM50549608(CHEMBL4799765)

Ki: 1.90E+3nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 transfected in HEK293 cell membranes preincubated for 5 mins followed by [3H]-epibatidine add...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL

PNG

BDBM50549603(CHEMBL4778976)

Ki: 1.90E+3nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 transfected in HEK293 cell membranes preincubated for 5 mins followed by [3H]-epibatidine add...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL

PNG

BDBM50549609(CHEMBL4792229)

Ki: 2.10E+3nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 transfected in HEK293 cell membranes preincubated for 5 mins followed by [3H]-epibatidine add...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL

PNG

BDBM50549600(CHEMBL4755768)

Ki: 2.10E+3nMAssay Description:Displacement of [125I]alpha-bungarotoxin from alpha7nAChR in rat hippocampus membranes preincubated for 5 mins followed by [125I]alpha-bungarotoxin a...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL

PNG

BDBM50549617(CHEMBL4740421)

Ki: 2.20E+3nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 transfected in HEK293 cell membranes preincubated for 5 mins followed by [3H]-epibatidine add...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL

PNG

BDBM50549596(CHEMBL4785648)

Ki: 2.60E+3nMAssay Description:Displacement of [125I]alpha-bungarotoxin from alpha7nAChR in rat hippocampus membranes preincubated for 5 mins followed by [125I]alpha-bungarotoxin a...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL

PNG

BDBM50549598(CHEMBL4747289)

Ki: 2.70E+3nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 transfected in HEK293 cell membranes preincubated for 5 mins followed by [3H]-epibatidine add...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL

PNG

BDBM50357063(CHEMBL1917230)

Ki: 3.10E+3nMAssay Description:Displacement of [3H]-Epibatidine from alpha4beta2 nAChR in rat cerebral cortex membrane preincubated for 5 mins followed by [3H]-Epibatidine addition...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL

PNG

BDBM50549616(CHEMBL4776494)

Ki: 3.50E+3nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 transfected in HEK293 cell membranes preincubated for 5 mins followed by [3H]-epibatidine add...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL

PNG

BDBM50549599(CHEMBL4783337)

Ki: 3.90E+3nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 transfected in HEK293 cell membranes preincubated for 5 mins followed by [3H]-epibatidine add...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL

PNG

BDBM50549613(CHEMBL4743341)

Ki: 3.90E+3nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 transfected in HEK293 cell membranes preincubated for 5 mins followed by [3H]-epibatidine add...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL

PNG

BDBM50549610(CHEMBL4792797)

Ki: 4.50E+3nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 transfected in HEK293 cell membranes preincubated for 5 mins followed by [3H]-epibatidine add...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL

PNG

BDBM50549604(CHEMBL4744398)

Ki: 4.80E+3nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 transfected in HEK293 cell membranes preincubated for 5 mins followed by [3H]-epibatidine add...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL

PNG

BDBM50549597(CHEMBL4784011)

Ki: 5.30E+3nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 transfected in HEK293 cell membranes preincubated for 5 mins followed by [3H]-epibatidine add...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL

PNG

BDBM50549601(CHEMBL4762584)

Ki: 5.40E+3nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 transfected in HEK293 cell membranes preincubated for 5 mins followed by [3H]-epibatidine add...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL

PNG

BDBM50549600(CHEMBL4755768)

Ki: 5.80E+3nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 transfected in HEK293 cell membranes preincubated for 5 mins followed by [3H]-epibatidine add...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL

PNG

BDBM50549602(CHEMBL4798883)

Ki: 6.00E+3nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 transfected in HEK293 cell membranes preincubated for 5 mins followed by [3H]-epibatidine add...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL

PNG

BDBM50549608(CHEMBL4799765)

Ki: 6.50E+3nMAssay Description:Displacement of [3H]-Epibatidine from alpha4beta2 nAChR in rat cerebral cortex membrane preincubated for 5 mins followed by [3H]-Epibatidine addition...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL

PNG

BDBM50549614(CHEMBL4782049)

Ki: 6.70E+3nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 transfected in HEK293 cell membranes preincubated for 5 mins followed by [3H]-epibatidine add...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL

PNG

BDBM50549599(CHEMBL4783337)

Ki: 7.10E+3nMAssay Description:Displacement of [3H]-Epibatidine from alpha4beta2 nAChR in rat cerebral cortex membrane preincubated for 5 mins followed by [3H]-Epibatidine addition...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL

PNG

BDBM50549597(CHEMBL4784011)

Ki: 7.30E+3nMAssay Description:Displacement of [3H]-Epibatidine from alpha4beta2 nAChR in rat cerebral cortex membrane preincubated for 5 mins followed by [3H]-Epibatidine addition...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL

PNG

BDBM50549601(CHEMBL4762584)

Ki: 8.10E+3nMAssay Description:Displacement of [125I]alpha-bungarotoxin from alpha7nAChR in rat hippocampus membranes preincubated for 5 mins followed by [125I]alpha-bungarotoxin a...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Details Article PubMed

Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL

PNG

BDBM50549606(CHEMBL4762415)

Ki: 8.60E+3nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 transfected in HEK293 cell membranes preincubated for 5 mins followed by [3H]-epibatidine add...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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Neuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL

PNG

BDBM50549618(CHEMBL4788079)

Ki: 8.70E+3nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 transfected in HEK293 cell membranes preincubated for 5 mins followed by [3H]-epibatidine add...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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Targets 8▿
- Neuronal acetylcholine receptor subunit alpha-4/beta-2 43
- Neuronal acetylcholine receptor subunit alpha-3/beta-4 33
- Carbamoyl-phosphate synthase [ammonia], mitochondrial 33
- Neuronal acetylcholine receptor subunit alpha-7 24
- Hepatocyte growth factor receptor 22
- Aromatase 9
- Steroid 17-alpha-hydroxylase/17,20 lyase 8
- Fibroblast growth factor receptor 3 2
- ...
Publications 6▿
- J Med Chem 63: 15668-15692 (2020) 100
- ACS Med Chem Lett 11: 1305-1309 (2020) 33
- Eur J Med Chem 47: 239-54 (2012) 18
- Bioorg Med Chem Lett 28: 979-984 (2018) 17
- Bioorg Med Chem Lett 22: 4693-6 (2012) 4
- ACS Med Chem Lett 12: 93-98 (2021) 2
Institutions 4▿
- Universit£ 104
- H3 Biomedicine 35
- University Of The Mediterranean 18
- Boehringer Ingelheim Pharmaceuticals 17
Affinity: 1 to 1.5E+5 nM▿
- Ki 89
- IC50 75
- EC50 10
- Affinity ≤ nM
Xtal structures: 3
Docked structures: 0
Catalog Cmpds: 10