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Found 174 with Last Name = 'davioud-charvet' and Initial = 'e'
TargetThioredoxin reductase(Plasmodium falciparum (isolate 3D7))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50182122(CHEMBL204688 | bis(2,4-dinitrophenyl)sulfane)
Affinity DataKi:  200nMAssay Description:Binding affinity to Plasmodium falciparum TrxR in presence of thioredoxinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Plasmodium falciparum (isolate 3D7))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50182122(CHEMBL204688 | bis(2,4-dinitrophenyl)sulfane)
Affinity DataKi:  200nMAssay Description:Binding affinity to Plasmodium falciparum TrxR in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Plasmodium falciparum (isolate 3D7))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50182128(4-nitrobenzo[c][1,2,5]thiadiazole | CHEMBL383084)
Affinity DataKi:  650nMAssay Description:Binding affinity to Plasmodium falciparum TrxR in presence of thioredoxinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Plasmodium falciparum (isolate 3D7))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50182128(4-nitrobenzo[c][1,2,5]thiadiazole | CHEMBL383084)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity to Plasmodium falciparum TrxR in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase(Plasmodium falciparum (isolate 3D7))
Université

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataKi:  3.60E+3nMAssay Description:Inhibitory concentration against Plasmodium falciparum glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataKi:  3.70E+3nMAssay Description:Inhibitory concentration against human glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM24778(2-methyl-1,4-dihydronaphthalene-1,4-dione | 2-meth...)
Affinity DataKi:  1.21E+4nMAssay Description:Inhibitory concentration against human glutathione reductase (In presence of glutathione disulfide)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM24778(2-methyl-1,4-dihydronaphthalene-1,4-dione | 2-meth...)
Affinity DataKi:  1.61E+4nMAssay Description:Inhibitory concentration against human glutathione reductase (In presence of NADPH)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50176071(2-(2-Amino-ethylamino)-N-(7-{2-[N'-(5-nitro-furan-...)
Affinity DataIC50:  1nMAssay Description:Inhibitory concentration against human glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50121447(5-Nitro-furan-2-carboxylic acid N'-(2-naphthalen-2...)
Affinity DataIC50:  4.10nMAssay Description:Inhibitory concentration against human glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50075135((S)-4-phenyl-1-(3-(pyrrolidine-1-carbonyl)-3,4-dih...)
Affinity DataIC50:  7nMAssay Description:Inhibition of Prolyl endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50075132(2-(4-Methyl-cyclohexyl)-1-[(S)-3-(pyrrolidine-1-ca...)
Affinity DataIC50:  9nMAssay Description:Inhibition of Prolyl endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50075126(5-Phenyl-1-[(S)-3-(pyrrolidine-1-carbonyl)-3,4-dih...)
Affinity DataIC50:  14nMAssay Description:Inhibition of Prolyl endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50051539((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
Affinity DataIC50:  15nMAssay Description:Inhibition of Prolyl endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50075134(4-(4-Chloro-2-methyl-phenoxy)-1-[(S)-3-(pyrrolidin...)
Affinity DataIC50:  17nMAssay Description:Inhibition of Prolyl endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50075128(CHEMBL138674 | {6-Oxo-6-[(S)-3-(pyrrolidine-1-carb...)
Affinity DataIC50:  21nMAssay Description:Inhibition of Prolyl endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50075129(1-[(S)-3-(Pyrrolidine-1-carbonyl)-3,4-dihydro-1H-i...)
Affinity DataIC50:  21nMAssay Description:Inhibition of Prolyl endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50075125(((1S,2S)-2-Phenyl-cyclopropyl)-[(S)-3-(pyrrolidine...)
Affinity DataIC50:  23nMAssay Description:Inhibition of Prolyl endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50075130(1-[(S)-3-(Pyrrolidine-1-carbonyl)-3,4-dihydro-1H-i...)
Affinity DataIC50:  25nMAssay Description:Inhibition of Prolyl endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50075133(CHEMBL136325 | {5-Oxo-5-[(S)-3-(pyrrolidine-1-carb...)
Affinity DataIC50:  36nMAssay Description:Inhibition of Prolyl endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50075131(1-[(S)-3-(Pyrrolidine-1-carbonyl)-3,4-dihydro-1H-i...)
Affinity DataIC50:  54nMAssay Description:Inhibition of Prolyl endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50075127(CHEMBL341749 | {6-Oxo-6-[(S)-3-(pyrrolidine-1-carb...)
Affinity DataIC50:  55nMAssay Description:Inhibition of Prolyl endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50087158(5-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  300nMAssay Description:Concentration required for inhibition of Trypanothione reductase (TcTR) from Trypanosoma cruzi in the presence of 50 uM TS2 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50087157(5-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  450nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataIC50:  500nMAssay Description:In vitro inhibition of Plasmodium falciparum Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Plasmodium falciparum (isolate 3D7))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50182122(CHEMBL204688 | bis(2,4-dinitrophenyl)sulfane)
Affinity DataIC50:  500nMAssay Description:Inhibition of Plasmodium falciparum TrxRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50087157(5-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  500nMAssay Description:Concentration required for inhibition of Trypanothione reductase (TcTR) from Trypanosoma cruzi in the presence of 50 uM TS2 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50070270(CHEMBL279374 | Pentanedioic acid bis-[(3-{4-bromo-...)
Affinity DataIC50:  550nMAssay Description:Inhibition of trypanothione reductase from T. cruzi, in the presence 57 microM of trypanothione T(SH)2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50087156(5-{3-[4-(3-Dibutylamino-propylcarbamoyl)-butyl]-8-...)
Affinity DataIC50:  600nMAssay Description:Concentration required for inhibition of Trypanothione reductase (TcTR) from Trypanosoma cruzi in the presence of 50 uM TS2 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50096035(6-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  750nMAssay Description:In vitro inhibition of human Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096063(6-(5-Hydroxy-3-{5-[3-(4-methyl-piperazin-1-yl)-pro...)
Affinity DataIC50:  800nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50096062(5-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibition of human Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50087155(5-(3-Methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)...)
Affinity DataIC50:  1.10E+3nMAssay Description:Concentration required for inhibition of Trypanothione reductase (TcTR) from Trypanosoma cruzi in the presence of 50 uM TS2 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096043(5-(3-Methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)...)
Affinity DataIC50:  1.12E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50096035(6-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  1.30E+3nMAssay Description:In vitro inhibition of Plasmodium falciparum Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096064(5-(3-Methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096024(6-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096061(6-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096012(6-(3-Methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096076(5-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50070275(CHEMBL17665 | Heptanedioic acid [3-(2-amino-phenyl...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of trypanothione reductase from T. cruzi, in the presence 57 microM of trypanothione T(SH)2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096023(3-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Plasmodium falciparum (isolate 3D7))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50182128(4-nitrobenzo[c][1,2,5]thiadiazole | CHEMBL383084)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Plasmodium falciparum TrxRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096059(4-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic/2, mitochondrial/3(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50182130(4,6-dinitrobenzo[c][1,2,5]thiadiazole | CHEMBL2061...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human TrxRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Plasmodium falciparum (isolate 3D7))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50182124(6,7-dinitroquinoxaline | CHEMBL380953)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Plasmodium falciparum TrxRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096021(6-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50177103(1-(2'-chlorophenyl)penta-1,4-dien-3-one | CHEMBL22...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Trypanosoma cruzi trypanothione reductase after 5 mins preincubation with NADPH in presence of 100 uM TS2 substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096078(4-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096017(4-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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