TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Irbm, Mrl Rome
Curated by ChEMBL
Irbm, Mrl Rome
Curated by ChEMBL
Affinity DataKi: 0.0100nMAssay Description:Inhibition of hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Irbm, Mrl Rome
Curated by ChEMBL
Irbm, Mrl Rome
Curated by ChEMBL
Affinity DataKi: 0.5nMAssay Description:Inhibition of hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Irbm, Mrl Rome
Curated by ChEMBL
Irbm, Mrl Rome
Curated by ChEMBL
Affinity DataKi: 1.5nMAssay Description:Inhibition of hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Irbm, Mrl Rome
Curated by ChEMBL
Irbm, Mrl Rome
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Inhibition of hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Irbm, Mrl Rome
Curated by ChEMBL
Irbm, Mrl Rome
Curated by ChEMBL
Affinity DataKi: 7nMAssay Description:Inhibition of hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Irbm, Mrl Rome
Curated by ChEMBL
Irbm, Mrl Rome
Curated by ChEMBL
Affinity DataKi: 30nMAssay Description:Inhibition of hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Irbm, Mrl Rome
Curated by ChEMBL
Irbm, Mrl Rome
Curated by ChEMBL
Affinity DataKi: 40nMAssay Description:Inhibition of hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Irbm, Mrl Rome
Curated by ChEMBL
Irbm, Mrl Rome
Curated by ChEMBL
Affinity DataKi: 100nMAssay Description:Inhibition of hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Irbm, Mrl Rome
Curated by ChEMBL
Irbm, Mrl Rome
Curated by ChEMBL
Affinity DataKi: 150nMAssay Description:Inhibition of hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
Affinity DataKi: 600nMAssay Description:Biinding affinity of the compound for enzyme NS3 protease wild-typeMore data for this Ligand-Target Pair
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Irbm, Mrl Rome
Curated by ChEMBL
Irbm, Mrl Rome
Curated by ChEMBL
Affinity DataKi: 600nMAssay Description:Inhibition of hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Irbm, Mrl Rome
Curated by ChEMBL
Irbm, Mrl Rome
Curated by ChEMBL
Affinity DataKi: 640nMAssay Description:Inhibition of hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Irbm, Mrl Rome
Curated by ChEMBL
Irbm, Mrl Rome
Curated by ChEMBL
Affinity DataKi: 700nMAssay Description:Inhibition of hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
Affinity DataKi: 900nMAssay Description:Binding affinity for enzyme K136RMore data for this Ligand-Target Pair
Affinity DataKi: 1.30E+3nMAssay Description:Biinding affinity of the compound for enzyme K136MMore data for this Ligand-Target Pair
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Irbm, Mrl Rome
Curated by ChEMBL
Irbm, Mrl Rome
Curated by ChEMBL
Affinity DataKi: 1.50E+3nMAssay Description:Inhibition of hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
Affinity DataKi: 2.10E+3nMAssay Description:Biinding affinity of the compound for wild type NS3 proteaseMore data for this Ligand-Target Pair
Affinity DataKi: 2.30E+3nMAssay Description:Biinding affinity of the compound for NS3 protease K136RMore data for this Ligand-Target Pair
Affinity DataKi: 4.00E+3nMAssay Description:Biinding affinity of the compound NS3 protease K136MMore data for this Ligand-Target Pair
Affinity DataKi: 7.30E+3nMAssay Description:Biinding affinity of the compound for enzyme NS3 protease wild-typeMore data for this Ligand-Target Pair
Affinity DataKi: 8.30E+3nMAssay Description:Binding affinity for enzyme K136RMore data for this Ligand-Target Pair
Affinity DataKi: 1.35E+4nMAssay Description:Biinding affinity of the compound for enzyme K136MMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity for enzyme human leukocyte HLEMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity for enzyme human leukocyte HLEMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of flag-tagged HDAC3More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of HDAC1 (mean IC50)More data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of flag-tagged HDAC4 by Biomol assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of flag-tagged HDAC4More data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of flag-tagged HDAC4More data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of flag-tagged HDAC4 by Biomol assayMore data for this Ligand-Target Pair
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by ChEMBL
Irbm (Merck Research Laboratories Rome)
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibitory concentration against RNA dependent RNA polymerase nonstructural protein 5B of hepatitis C virusMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Irbm (Merck Research Laboratories Rome)
Curated by ChEMBL
Irbm (Merck Research Laboratories Rome)
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Binding affinity to human ER betaMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Irbm (Merck Research Laboratories Rome)
Curated by ChEMBL
Irbm (Merck Research Laboratories Rome)
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Binding affinity to human ER alphaMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of HDAC3 (mean IC50)More data for this Ligand-Target Pair
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Irbm, Mrl Rome
Curated by ChEMBL
Irbm, Mrl Rome
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against Hepatitis C NS3/NS4A proteaseMore data for this Ligand-Target Pair
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Irbm, Mrl Rome
Curated by ChEMBL
Irbm, Mrl Rome
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against Hepatitis C NS3/NS4A proteaseMore data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Affinity DataIC50: 2.40nMAssay Description:Inhibition of flag-tagged HDAC4 by pull-down assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition of HDAC4 catalytic domain expressed in HEK293 cells by Biomol assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition of flag-tagged HDAC3More data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of flag-tagged HDAC4 expressed in HEK293 cells by Biomol assayMore data for this Ligand-Target Pair
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by ChEMBL
Irbm (Merck Research Laboratories Rome)
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibitory concentration against RNA dependent RNA polymerase nonstructural protein 5B of hepatitis C virusMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Affinity DataIC50: 3.60nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Istituto Di Ricerche Di Biologia Molecolare
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of flag-tagged HDAC4 by pull-down assayMore data for this Ligand-Target Pair
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Irbm, Mrl Rome
Curated by ChEMBL
Irbm, Mrl Rome
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibitory activity against Hepatitis C NS3/NS4A proteaseMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of HDAC2 (mean IC50)More data for this Ligand-Target Pair
Affinity DataIC50: 4.40nMpH: 7.5 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by ChEMBL
Irbm (Merck Research Laboratories Rome)
Curated by ChEMBL
Affinity DataIC50: 4.80nMAssay Description:Inhibitory concentration against RNA dependent RNA polymerase nonstructural protein 5B of hepatitis C virusMore data for this Ligand-Target Pair
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by ChEMBL
Irbm (Merck Research Laboratories Rome)
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibitory activity against RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1More data for this Ligand-Target Pair
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by ChEMBL
Irbm (Merck Research Laboratories Rome)
Curated by ChEMBL
Affinity DataIC50: <6nMAssay Description:Inhibitory concentration against RNA dependent RNA polymerase nonstructural protein 5B of hepatitis C virusMore data for this Ligand-Target Pair