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Found 2019 with Last Name = 'de meester' and Initial = 'i'
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50146972((S)-4-(4-chlorobenzylamino)-2-amino-1-(piperidin-1...)
Affinity DataKi:  0.0820nMAssay Description:Inhibition of DPP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Laboratory Of Medicinal Chemistry University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50146972((S)-4-(4-chlorobenzylamino)-2-amino-1-(piperidin-1...)
Affinity DataKi:  0.0820nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Laboratory Of Medicinal Chemistry University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50050513((R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-y...)
Affinity DataKi:  2nMAssay Description:Inhibition of Dipeptidyl Peptidase IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase FAP(Mus musculus (Mouse))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50434188(CHEMBL2385281 | US9346814, Cmpd No 2 Example 3)
Affinity DataKi:  3nMAssay Description:Inhibition of mouse recombinant FAP expressed in HEK293 cells using Ala-Pro-p-nitroanilide as substrate incubated for 15 mins prior to substrate addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase FAP(Mus musculus (Mouse))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50434169(CHEMBL2385300 | US9346814, Cmpd No 22 Example 26)
Affinity DataKi:  4.10nMAssay Description:Inhibition of mouse recombinant FAP expressed in HEK293 cells using Ala-Pro-p-nitroanilide as substrate incubated for 15 mins prior to substrate addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50350167(CHEMBL1814741)
Affinity DataKi:  6.5nMAssay Description:Competitive inhibition of recombinant human DPP8 assessed as pNA release from Ala-Pro- p-nitroanilide substrate pre-incubated with enzyme for 15 min ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase IV(Porphyromonas gingivalis)
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM11695((2S)-1-{2-[(3-hydroxyadamantan-1-yl)amino]acetyl}p...)
Affinity DataKi:  17nMAssay Description:Inhibition of Porphyromonas gingivalis N-terminal His-tagged DPP4 expressed in Escherichia coli using Gly-Pro-p-nitroanilide as substrate preincubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50350175(CHEMBL1814749)
Affinity DataKi:  37nMAssay Description:Competitive inhibition of recombinant human DPP8 assessed as pNA release from Ala-Pro- p-nitroanilide substrate pre-incubated with enzyme for 15 min ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50050513((R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-y...)
Affinity DataKi:  125nMAssay Description:Inhibition of Dipeptidyl Peptidase II (Quiescent cell proline peptidase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Laboratory Of Medicinal Chemistry University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM11464((2S,3S)-2-amino-3-methyl-1-(1,3-thiazolidin-3-yl)p...)
Affinity DataKi:  126nMAssay Description:Inhibition of Dipeptidyl Peptidase IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Laboratory Of Medicinal Chemistry University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM11464((2S,3S)-2-amino-3-methyl-1-(1,3-thiazolidin-3-yl)p...)
Affinity DataKi:  126nMAssay Description:Inhibitory activity of compound against Dipeptidylpeptidase IV (DPP IV)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Laboratory Of Medicinal Chemistry University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50118940((S)-1-((S)-2-Amino-propionyl)-pyrrolidine-2-carbon...)
Affinity DataKi:  200nMAssay Description:Inhibition of Dipeptidyl Peptidase IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Laboratory Of Medicinal Chemistry University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50366428(CHEMBL1793966)
Affinity DataKi:  218nMAssay Description:Inhibitory activity of compound against Dipeptidylpeptidase IV (DPP IV)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Laboratory Of Medicinal Chemistry University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50118943((2S,3S)-2-amino-3-methyl-1-(pyrrolidin-1-yl)pentan...)
Affinity DataKi:  218nMAssay Description:Inhibition of Dipeptidyl Peptidase IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50118934((S)-2-Amino-1-thiazolidin-3-yl-propane-1-thione | ...)
Affinity DataKi:  277nMAssay Description:Inhibition of Dipeptidyl Peptidase II (Quiescent cell proline peptidase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50118934((S)-2-Amino-1-thiazolidin-3-yl-propane-1-thione | ...)
Affinity DataKi:  277nMAssay Description:Inhibitory activity of compound against Dipeptidylpeptidase II (DPP II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50118946((S)-2-Amino-1-pyrrolidin-1-yl-propane-1-thione | C...)
Affinity DataKi:  1.43E+3nMAssay Description:Inhibition of Dipeptidyl Peptidase II (Quiescent cell proline peptidase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50118946((S)-2-Amino-1-pyrrolidin-1-yl-propane-1-thione | C...)
Affinity DataKi:  1.43E+3nMAssay Description:Inhibitory activity of compound against Dipeptidylpeptidase II (DPP II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Laboratory Of Medicinal Chemistry University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50050513((R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-y...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibitory activity of compound against Dipeptidylpeptidase IV (DPP IV)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Laboratory Of Medicinal Chemistry University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50118934((S)-2-Amino-1-thiazolidin-3-yl-propane-1-thione | ...)
Affinity DataKi:  7.88E+3nMAssay Description:Inhibitory activity of compound against Dipeptidylpeptidase IV (DPP IV)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Laboratory Of Medicinal Chemistry University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50118934((S)-2-Amino-1-thiazolidin-3-yl-propane-1-thione | ...)
Affinity DataKi:  7.88E+3nMAssay Description:Inhibition of Dipeptidyl Peptidase IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM11464((2S,3S)-2-amino-3-methyl-1-(1,3-thiazolidin-3-yl)p...)
Affinity DataKi:  8.17E+3nMAssay Description:Inhibitory activity of compound against Dipeptidylpeptidase II (DPP II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM11464((2S,3S)-2-amino-3-methyl-1-(1,3-thiazolidin-3-yl)p...)
Affinity DataKi:  8.17E+3nMAssay Description:Inhibition of Dipeptidyl Peptidase II (Quiescent cell proline peptidase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Laboratory Of Medicinal Chemistry University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM11695((2S)-1-{2-[(3-hydroxyadamantan-1-yl)amino]acetyl}p...)
Affinity DataKi:  1.70E+4nMAssay Description:Inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50366428(CHEMBL1793966)
Affinity DataKi:  2.47E+4nMAssay Description:Inhibitory activity of compound against Dipeptidylpeptidase II (DPP II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50118943((2S,3S)-2-amino-3-methyl-1-(pyrrolidin-1-yl)pentan...)
Affinity DataKi:  2.47E+4nMAssay Description:Inhibition of Dipeptidyl Peptidase II (Quiescent cell proline peptidase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Laboratory Of Medicinal Chemistry University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50118946((S)-2-Amino-1-pyrrolidin-1-yl-propane-1-thione | C...)
Affinity DataKi:  4.76E+4nMAssay Description:Inhibition of Dipeptidyl Peptidase IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Laboratory Of Medicinal Chemistry University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50118946((S)-2-Amino-1-pyrrolidin-1-yl-propane-1-thione | C...)
Affinity DataKi:  4.76E+4nMAssay Description:Inhibitory activity of compound against Dipeptidylpeptidase IV (DPP IV)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50050513((R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-y...)
Affinity DataKi:  1.25E+5nMAssay Description:Inhibitory activity of compound against Dipeptidylpeptidase II (DPP II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50146987((S)-2-Amino-4-[(4-chloro-benzyl)-methyl-amino]-1-p...)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of human Dipeptidyl-peptidase II (DPP II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50146972((S)-4-(4-chlorobenzylamino)-2-amino-1-(piperidin-1...)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of DPP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50146971(2-(S)-Amino-4-(2-chloro-benzylamino)-1-piperidin-1...)
Affinity DataIC50:  0.230nMAssay Description:Inhibition of human Dipeptidyl-peptidase II (DPP II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50146974((S)-2-Amino-4-(4-chloro-benzylamino)-1-(4-fluoro-p...)
Affinity DataIC50:  0.390nMAssay Description:Inhibition of human Dipeptidyl-peptidase II (DPP II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50146973(2-(S)-Amino-4-(2-benzyloxy-benzylamino)-1-piperidi...)
Affinity DataIC50:  0.390nMAssay Description:Inhibition of human Dipeptidyl-peptidase II (DPP II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50146952(2-(S)-Amino-4-(4-benzyloxy-benzylamino)-1-piperidi...)
Affinity DataIC50:  0.410nMAssay Description:Inhibition of human Dipeptidyl-peptidase II (DPP II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50146972((S)-4-(4-chlorobenzylamino)-2-amino-1-(piperidin-1...)
Affinity DataIC50:  0.480nMAssay Description:Inhibition of DPP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50146972((S)-4-(4-chlorobenzylamino)-2-amino-1-(piperidin-1...)
Affinity DataIC50:  0.480nMAssay Description:Inhibition of human Dipeptidyl-peptidase II (DPP II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50146972((S)-4-(4-chlorobenzylamino)-2-amino-1-(piperidin-1...)
Affinity DataIC50: <0.5nMAssay Description:Inhibition of DPP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50146956((S)-2-Amino-4-(4-chloro-benzylamino)-1-(4-methyl-p...)
Affinity DataIC50:  0.550nMAssay Description:Inhibition of human Dipeptidyl-peptidase II (DPP II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50146967((S)-2-Amino-4-dibenzylamino-1-piperidin-1-yl-butan...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human Dipeptidyl-peptidase II (DPP II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Laboratory Of Medicinal Chemistry University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50146985((S)-2-Amino-4-(4-chloro-benzylamino)-1-(3-fluoro-p...)
Affinity DataIC50:  0.620nMAssay Description:Inhibition of human Dipeptidyl-peptidase II (DPP II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50191168((2S,4S)-4-(4-chlorobenzylamino)-2-amino-1-(piperid...)
Affinity DataIC50:  0.620nMAssay Description:Inhibition of DPP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50146977(2-(S)-Amino-4-(4-methoxy-benzylamino)-1-piperidin-...)
Affinity DataIC50:  0.660nMAssay Description:Inhibition of human Dipeptidyl-peptidase II (DPP II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50146964(2-(S)-Amino-1-piperidin-1-yl-4-[(pyridin-4-ylmethy...)
Affinity DataIC50:  0.75nMAssay Description:Inhibition of human Dipeptidyl-peptidase II (DPP II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50146957(2-(S)-Amino-1-piperidin-1-yl-4-[(thiophen-2-ylmeth...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human Dipeptidyl-peptidase II (DPP II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50146954(2-(S)-Amino-4-phenethylamino-1-piperidin-1-yl-buta...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human Dipeptidyl-peptidase II (DPP II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50146968((S)-2-Amino-4-(4-chloro-benzylamino)-1-(3,6-dihydr...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human Dipeptidyl-peptidase II (DPP II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50146991(2-(S)-Amino-4-[(naphthalen-2-ylmethyl)-amino]-1-pi...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human Dipeptidyl-peptidase II (DPP II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50146955(2-(S)-Amino-4-(cyclohexylmethyl-amino)-1-piperidin...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human Dipeptidyl-peptidase II (DPP II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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