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Found 100 with Last Name = 'deshpande' and Initial = 'ms'
TargetKallikrein(Sus scrofa)
University Hospital

Curated by ChEMBL
LigandPNGBDBM50004610(2-(2-{2-[2-(2-{[1-(2-Acetylamino-3-hydroxy-propion...)
Affinity DataKi:  1.01E+5nMAssay Description:Inhibitory activity against beta-kallikreinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein(Sus scrofa)
University Hospital

Curated by ChEMBL
LigandPNGBDBM50004613(1-(2-Acetylamino-3-hydroxy-propionyl)-pyrrolidine-...)
Affinity DataKi:  1.35E+5nMAssay Description:Inhibitory activity against beta-kallikreinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein(Sus scrofa)
University Hospital

Curated by ChEMBL
LigandPNGBDBM50004609(2-{2-[2-(2-{2-[(1-Acetyl-pyrrolidine-2-carbonyl)-a...)
Affinity DataKi:  1.67E+5nMAssay Description:Inhibitory activity against beta-kallikreinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein(Sus scrofa)
University Hospital

Curated by ChEMBL
LigandPNGBDBM50004605(1-(2-Acetylamino-3-hydroxy-propionyl)-pyrrolidine-...)
Affinity DataKi:  2.23E+5nMAssay Description:Inhibitory activity against beta-kallikreinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein(Sus scrofa)
University Hospital

Curated by ChEMBL
LigandPNGBDBM50004611(2-(2-{2-[2-(2-Acetylamino-3-phenyl-propionylamino)...)
Affinity DataKi:  2.30E+5nMAssay Description:Inhibitory activity against beta-kallikreinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein(Sus scrofa)
University Hospital

Curated by ChEMBL
LigandPNGBDBM50004607(1-Acetyl-pyrrolidine-2-carboxylic acid (1-{1-[1-(1...)
Affinity DataKi:  2.66E+5nMAssay Description:Inhibitory activity against beta-kallikreinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein(Sus scrofa)
University Hospital

Curated by ChEMBL
LigandPNGBDBM50004606(2-(2-Acetylamino-3-phenyl-propionylamino)-5-guanid...)
Affinity DataKi:  4.79E+5nMAssay Description:Inhibitory activity against beta-kallikreinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein(Sus scrofa)
University Hospital

Curated by ChEMBL
LigandPNGBDBM50004614(1-Acetyl-pyrrolidine-2-carboxylic acid {1-[1-(1-ca...)
Affinity DataKi:  5.78E+5nMAssay Description:Inhibitory activity against beta-kallikreinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein(Sus scrofa)
University Hospital

Curated by ChEMBL
LigandPNGBDBM50004604(2-(2-Acetylamino-3-phenyl-propionylamino)-5-guanid...)
Affinity DataKi:  7.18E+5nMAssay Description:Inhibitory activity against beta-kallikreinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein(Sus scrofa)
University Hospital

Curated by ChEMBL
LigandPNGBDBM50004608(2-{2-[2-(2-Acetylamino-5-guanidino-pentanoylamino)...)
Affinity DataKi:  9.50E+5nMAssay Description:Inhibitory activity against beta-kallikreinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein(Sus scrofa)
University Hospital

Curated by ChEMBL
LigandPNGBDBM50004612(1-(2-Acetylamino-3-hydroxy-propionyl)-pyrrolidine-...)
Affinity DataKi:  2.29E+6nMAssay Description:Inhibitory activity against beta-kallikreinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50476941(CHEMBL233363)
Affinity DataIC50:  4nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50476939(CHEMBL233364)
Affinity DataIC50:  5nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50476940(CHEMBL233362)
Affinity DataIC50:  5nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50476947(CHEMBL394661)
Affinity DataIC50:  7nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50476919(CHEMBL232948)
Affinity DataIC50:  12nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50476912(CHEMBL231714)
Affinity DataIC50:  13nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50476922(CHEMBL391377)
Affinity DataIC50:  14nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50476953(CHEMBL232949)
Affinity DataIC50:  14nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50476957(CHEMBL231767)
Affinity DataIC50:  19nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50476917(CHEMBL232152)
Affinity DataIC50:  22nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50476911(CHEMBL394660)
Affinity DataIC50:  23nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50476932(CHEMBL391173)
Affinity DataIC50:  24nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50476935(CHEMBL231731)
Affinity DataIC50:  25nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50476924(CHEMBL393316)
Affinity DataIC50:  33nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50476945(CHEMBL232368)
Affinity DataIC50:  40nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50476943(CHEMBL232758)
Affinity DataIC50:  41nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50476934(CHEMBL231946)
Affinity DataIC50:  49nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50476955(CHEMBL397533)
Affinity DataIC50:  56nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50476937(CHEMBL231766)
Affinity DataIC50:  66nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50476936(CHEMBL231768)
Affinity DataIC50:  72nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50476938(CHEMBL233161)
Affinity DataIC50:  100nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50476954(CHEMBL391695)
Affinity DataIC50:  100nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50476930(CHEMBL393704)
Affinity DataIC50:  140nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50476950(CHEMBL232956)
Affinity DataIC50:  140nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50125662((S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]-4-meth...)
Affinity DataIC50:  160nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50125656((S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]-4-meth...)
Affinity DataIC50:  180nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50476933(CHEMBL231769)
Affinity DataIC50:  180nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50476921(CHEMBL232370)
Affinity DataIC50:  190nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50476931(CHEMBL231972)
Affinity DataIC50:  240nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50125670((S)-4-Methyl-2-(4-methyl-pentanoylamino)-pentanoic...)
Affinity DataIC50:  300nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50476951(CHEMBL232369)
Affinity DataIC50:  350nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50476913(CHEMBL397304)
Affinity DataIC50:  360nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50125653((S)-4-Methyl-2-phenylacetylamino-pentanoic acid ((...)
Affinity DataIC50:  400nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50125658((S)-2-[2-(3-Fluoro-phenyl)-acetylamino]-4-methyl-p...)
Affinity DataIC50:  400nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50476923(CHEMBL397303)
Affinity DataIC50:  400nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50125657((2R,3S)-4-Cyclohexyl-3-{(S)-2-[2-(3,5-difluoro-phe...)
Affinity DataIC50:  450nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50125666((S)-4-Methyl-2-(4-methyl-pentanoylamino)-pentanoic...)
Affinity DataIC50:  550nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50476949(CHEMBL231973)
Affinity DataIC50:  560nMAssay Description:Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50125659((S)-4-Methyl-2-(4-methyl-pentanoylamino)-pentanoic...)
Affinity DataIC50:  580nMAssay Description:Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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