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Found 441 with Last Name = 'dudley' and Initial = 'da'
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50347563(CHEMBL1801740)
Affinity DataKi:  0.690nMAssay Description:Binding affinity to human Angiotensin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-2 angiotensin II receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50347563(CHEMBL1801740)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to human Angiotensin receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50266775((2R,4S)-4-(2-Chlorophenyl)-N1-(4-chlorophenyl)-4-h...)
Affinity DataIC50:  0.0200nMAssay Description:Inhibition of human Factor-10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50266920((2R,4R)-N1-(4-Chlorophenyl)-4-ethoxy-4-ethyl-N2-(2...)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of human Factor-10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50266921((2R,4S)-N1-(4-Chlorophenyl)-N2-(2-fluoro-4-(2-oxop...)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of human Factor-10aMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50266923((2R,4S)-N1-(4-Chlorophenyl)-4-(3,4-difluorophenyl)...)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of human Factor-10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50266924((2R,4S)-N1-(4-Chlorophenyl)-4-(2,4-difluorophenyl)...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human Factor-10aMore data for this Ligand-Target Pair
TargetCoagulation factor X(Oryctolagus cuniculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50266924((2R,4S)-N1-(4-Chlorophenyl)-4-(2,4-difluorophenyl)...)
Affinity DataIC50:  0.108nMAssay Description:Inhibition of rabbit F10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50266773((2R,4S)-N1-(4-Chlorophenyl)-4-hydroxy-N2-(5-(2-oxo...)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of human Factor-10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50266922((2R,4S)-N1-(4-Chlorophenyl)-4-(4-fluorophenyl)-4-h...)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of human Factor-10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50328726((2R,4R)-N1-(4-chlorophenyl)-N2-(3-fluoro-2'-(methy...)
Affinity DataIC50:  0.160nMAssay Description:FXa inhibition were determined by using an inhibition assay.More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50266743((2R,4S)-N1-(4-Chlorophenyl)-4-hydroxy-N2-(5-(2-oxo...)
Affinity DataIC50:  0.180nMAssay Description:Inhibition of human Factor-10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50266893((2R,4R)-N1-(4-Chlorophenyl)-4-ethyl-N2-(2-fluoro-4...)
Affinity DataIC50:  0.180nMAssay Description:Inhibition of human Factor-10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50266919((2R,4R)-N1-(4-Chlorophenyl)-4-ethyl-N2-(2-fluoro-4...)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of human Factor-10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50266891((2R,4R)-N1-(4-Chlorophenyl)-N2-(2-fluoro-4-(2-oxop...)
Affinity DataIC50:  0.310nMAssay Description:Inhibition of human Factor-10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50266774((2R,4S)-N1-(4-Chlorophenyl)-4-hydroxy-N2-(5-(2-oxo...)
Affinity DataIC50:  0.340nMAssay Description:Inhibition of human Factor-10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50328728((2R,4R)-N1-(4-chlorophenyl)-N2-(3-fluoro-2'-(methy...)
Affinity DataIC50:  0.380nMAssay Description:FXa inhibition were determined by using an inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50043280(4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidaz...)
Affinity DataIC50:  0.490nMAssay Description:Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50266892((2R,4R)-N1-(4-Chlorophenyl)-4-ethyl-N2-(2-fluoro-4...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human Factor-10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50266742((2R,4S)-N1-(4-Chlorophenyl)-4-hydroxy-N2-(5-(2-oxo...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human Factor-10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50266890((2R,4R)-N1-(4-Chlorophenyl)-N2-(2-fluoro-4-(3-meth...)
Affinity DataIC50:  0.540nMAssay Description:Inhibition of human Factor-10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50266770((2R,4R)-N~1~-(4-CHLOROPHENYL)-N~2~-[2-FLUORO-4-(2-...)
Affinity DataIC50:  0.570nMAssay Description:Inhibition of human Factor-10aMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM81692(4-Substituted Pyrrolidine Ring, 14)
Affinity DataIC50:  0.75nMAssay Description:FXa inhibition were determined by using an inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50532351(CHEMBL4565958)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of ERK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50532351(CHEMBL4565958)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of ERK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50532350(CHEMBL4571067)
Affinity DataIC50:  0.940nMAssay Description:Inhibition of ERK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50532350(CHEMBL4571067)
Affinity DataIC50:  0.940nMAssay Description:Inhibition of ERK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50021715(CHEMBL3298419)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50021714(CHEMBL3298418)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50021716(CHEMBL3298420)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50021709(CHEMBL3298308)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50021707(CHEMBL3298985)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50021721(CHEMBL3298984)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50021719(CHEMBL3298982)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM81698(4-Substituted Pyrrolidine Ring, 35)
Affinity DataIC50:  1nMAssay Description:FXa inhibition were determined by using an inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50021717(CHEMBL3298414)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM120086(US8697715, 1 | US9259470, 1)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of ERK2 (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM120086(US8697715, 1 | US9259470, 1)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of ERK2 (unknown origin)More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50266772((2R,4S)-N1-(4-Chlorophenyl)-4-hydroxy-N2-(5-(2-oxo...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human Factor-10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM81693(4-Substituted Pyrrolidine Ring, 16 | 4-Substituted...)
Affinity DataIC50:  1.20nMAssay Description:FXa inhibition were determined by using an inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50266924((2R,4S)-N1-(4-Chlorophenyl)-4-(2,4-difluorophenyl)...)
Affinity DataIC50:  1.32nMAssay Description:Inhibition of rat F10aMore data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50347563(CHEMBL1801740)
Affinity DataIC50:  1.60nMAssay Description:Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50328726((2R,4R)-N1-(4-chlorophenyl)-N2-(3-fluoro-2'-(methy...)
Affinity DataIC50:  1.70nMAssay Description:FXa inhibition were determined by using an inhibition assay.More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50532362(CHEMBL4436718)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of ERK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50532362(CHEMBL4436718)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of ERK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50021754(CHEMBL3298417)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50021718(CHEMBL3298678)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50021720(CHEMBL3298983)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50021708(CHEMBL3298199)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50021711(CHEMBL3298310)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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