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Found 196 with Last Name = 'edmondson' and Initial = 'de'
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM15579(CHEMBL972 | DEPRENYL | L-Deprenyl | N-methyl-N-[(2...)
Affinity DataKi:  3.30nMAssay Description:Inhibition of human recombinant soluble MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM15579(CHEMBL972 | DEPRENYL | L-Deprenyl | N-methyl-N-[(2...)
Affinity DataKi:  3.90nMAssay Description:Inhibition of human recombinant microsomal MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
Affinity DataKi:  3.90nMAssay Description:Inhibition of human recombinant soluble MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM19187((2S)-2-[({4-[(3-fluorophenyl)methoxy]phenyl}methyl...)
Affinity DataKi:  5.40nMAssay Description:Inhibition of human recombinant soluble MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 mins b...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)
Affinity DataKi:  7.60nMAssay Description:Inhibition of human recombinant soluble MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)
Affinity DataKi:  14nMAssay Description:Inhibition of human recombinant microsomal MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM19187((2S)-2-[({4-[(3-fluorophenyl)methoxy]phenyl}methyl...)
Affinity DataKi:  17nMAssay Description:Inhibition of human recombinant microsomal MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 min...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50172756(Benzyl-methyl-prop-2-ynyl-amine | CHEMBL673 | Euto...)
Affinity DataKi:  20nMAssay Description:Inhibition of human recombinant microsomal MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University Of Santiago De Chile

Curated by ChEMBL
LigandPNGBDBM50213678((S)-2-amino-1-(4-butylthiophenyl)-propane | CHEMBL...)
Affinity DataKi:  22nMAssay Description:Inhibition of human recombinant MAOA expressed in Pichia pastorisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)
Affinity DataKi:  26nMAssay Description:Inhibition of human recombinant soluble MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50246766(CHEMBL489079 | Mofegiline | US9302986, Mofegiline)
Affinity DataKi:  28nMAssay Description:Inhibition of human recombinant MAOB expressed in Pichia pastoris by kinetic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University Of Santiago De Chile

Curated by ChEMBL
LigandPNGBDBM50213677((S)-2-amino-1-(4-propylthiophenyl)-propane | CHEMB...)
Affinity DataKi:  30nMAssay Description:Inhibition of human recombinant MAOA expressed in Pichia pastorisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50063994(CHEMBL338404 | Ro-166491)
Affinity DataKi:  32nMAssay Description:Inhibition of human recombinant soluble MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50307362((+/-)-2-(4'-Benzyloxyphenyl)thiomorpholine | CHEMB...)
Affinity DataKi:  38nMAssay Description:Inhibition of human recombinant MAOB by spectrophotometricallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50307363((+/-)-2-(4'-Benzyloxyphenyl)thiomorpholin-5-one | ...)
Affinity DataKi:  48nMAssay Description:Inhibition of human recombinant MAOB by spectrophotometricallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50172756(Benzyl-methyl-prop-2-ynyl-amine | CHEMBL673 | Euto...)
Affinity DataKi:  50nMAssay Description:Inhibition of human recombinant soluble MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
University Of Santiago De Chile

Curated by ChEMBL
LigandPNGBDBM50213676((S)-2-amino-1-(4-ethylthiophenyl)-propane | CHEMBL...)
Affinity DataKi:  54nMAssay Description:Inhibition of rat brain MAOAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50307367((+/-)-2-(4'-Butoxyphenyl)thiomorpholine | CHEMBL59...)
Affinity DataKi:  68nMAssay Description:Inhibition of human recombinant MAOB by spectrophotometricallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50029816(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
Affinity DataKi:  72nMAssay Description:Inhibition of human recombinant microsomal MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
University Of Chile

Curated by ChEMBL
LigandPNGBDBM50307363((+/-)-2-(4'-Benzyloxyphenyl)thiomorpholin-5-one | ...)
Affinity DataKi:  74nMAssay Description:Inhibition of MAOB in rat brain mitochondrial suspensionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University Of Santiago De Chile

Curated by ChEMBL
LigandPNGBDBM50213676((S)-2-amino-1-(4-ethylthiophenyl)-propane | CHEMBL...)
Affinity DataKi:  75nMAssay Description:Inhibition of human recombinant MAOA expressed in Pichia pastorisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50037429(8-(3-chlorostyryl)caffeine | 8-[(E)-2-(3-chlorophe...)
Affinity DataKi:  86nMAssay Description:Inhibition of recombinant wild-type MAOB from human liver expressed in Pichia pastorisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50105417(CHEMBL1089 | Nardil | PHENELZINE | Phenethyl-hydra...)
Affinity DataKi:  94nMAssay Description:Inhibition of human recombinant soluble MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM19188(7-(3-chlorobenzyloxy)-4-(methylamino)methyl-coumar...)
Affinity DataKi:  100nM ΔG°:  -40.0kJ/molepH: 7.5 T: 2°CAssay Description:MAO B activities were determined spectrophotometrically at 250 nm using benzylamine as substrate. Competitive Ki values were determined by measuring ...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM11018(2-[(E)-2-(3-chlorophenyl)ethenyl]-3,5,7-trimethyl-...)
Affinity DataKi:  100nM ΔG°:  -40.0kJ/molepH: 7.4 T: 2°CAssay Description:MAO A and MAO B activities were determined spectrophotometrically. Competitive Ki values for both enzymes were determined by measuring initial rates ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
University Of Santiago De Chile

Curated by ChEMBL
LigandPNGBDBM50213677((S)-2-amino-1-(4-propylthiophenyl)-propane | CHEMB...)
Affinity DataKi:  115nMAssay Description:Inhibition of rat brain MAOAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50307366((+/-)-2-(4'-Propoxyphenyl)thiomorpholine | CHEMBL6...)
Affinity DataKi:  130nMAssay Description:Inhibition of human recombinant MAOB by spectrophotometricallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
University Of Chile

Curated by ChEMBL
LigandPNGBDBM50307362((+/-)-2-(4'-Benzyloxyphenyl)thiomorpholine | CHEMB...)
Affinity DataKi:  130nMAssay Description:Inhibition of MAOB in rat brain mitochondrial suspensionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University Of Santiago De Chile

Curated by ChEMBL
LigandPNGBDBM50213675((S)-2-amino-1-(4-methylthiophenyl)-propane | CHEMB...)
Affinity DataKi:  133nMAssay Description:Inhibition of human recombinant MAOA expressed in Pichia pastorisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
University Of Chile

Curated by ChEMBL
LigandPNGBDBM50307364((+/-)-2-(4'-Butoxyphenyl)thiomorpholin-5-one | CHE...)
Affinity DataKi:  160nMAssay Description:Inhibition of MAOB in rat brain mitochondrial suspensionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50049240((+-)-5-((4-(2-(5-ethyl-2-pyridinyl)ethoxy)phenyl)m...)
Affinity DataKi:  199nMAssay Description:Inhibition of human recombinant soluble MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM11018(2-[(E)-2-(3-chlorophenyl)ethenyl]-3,5,7-trimethyl-...)
Affinity DataKi:  200nM ΔG°:  -38.2kJ/molepH: 7.5 T: 2°CAssay Description:MAO A and MAO B activities were determined spectrophotometrically. Competitive Ki values for both enzymes were determined by measuring initial rates ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Mus musculus)
Emory University

LigandPNGBDBM11018(2-[(E)-2-(3-chlorophenyl)ethenyl]-3,5,7-trimethyl-...)
Affinity DataKi:  200nM ΔG°:  -38.2kJ/molepH: 7.4 T: 2°CAssay Description:MAO A and MAO B activities were determined spectrophotometrically. Competitive Ki values for both enzymes were determined by measuring initial rates ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50037429(8-(3-chlorostyryl)caffeine | 8-[(E)-2-(3-chlorophe...)
Affinity DataKi:  210nMAssay Description:Inhibition of human recombinant soluble MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
University Of Santiago De Chile

Curated by ChEMBL
LigandPNGBDBM50213675((S)-2-amino-1-(4-methylthiophenyl)-propane | CHEMB...)
Affinity DataKi:  245nMAssay Description:Inhibition of rat brain MAOAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
University Of Chile

Curated by ChEMBL
LigandPNGBDBM50307367((+/-)-2-(4'-Butoxyphenyl)thiomorpholine | CHEMBL59...)
Affinity DataKi:  270nMAssay Description:Inhibition of MAOB in rat brain mitochondrial suspensionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50049240((+-)-5-((4-(2-(5-ethyl-2-pyridinyl)ethoxy)phenyl)m...)
Affinity DataKi:  271nMAssay Description:Inhibition of human recombinant microsomal MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50259619((E)-5-Styrylisatin | CHEMBL466872)
Affinity DataKi:  310nMAssay Description:Inhibition of recombinant wild-type MAOB from human liver expressed in Pichia pastorisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
University Of Santiago De Chile

Curated by ChEMBL
LigandPNGBDBM50213678((S)-2-amino-1-(4-butylthiophenyl)-propane | CHEMBL...)
Affinity DataKi:  392nMAssay Description:Inhibition of rat brain MAOAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM19189(7-(3-Chlorobenzyloxy)-4-carboxaldehyde-coumarin, 3...)
Affinity DataKi:  400nM ΔG°:  -36.5kJ/molepH: 7.5 T: 2°CAssay Description:MAO B activities were determined spectrophotometrically at 250 nm using benzylamine as substrate. Competitive Ki values were determined by measuring ...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM19187((2S)-2-[({4-[(3-fluorophenyl)methoxy]phenyl}methyl...)
Affinity DataKi:  450nM ΔG°:  -36.2kJ/molepH: 7.5 T: 2°CAssay Description:MAO B activities were determined spectrophotometrically at 250 nm using benzylamine as substrate. Competitive Ki values were determined by measuring ...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50307364((+/-)-2-(4'-Butoxyphenyl)thiomorpholin-5-one | CHE...)
Affinity DataKi:  460nMAssay Description:Inhibition of human recombinant MAOB by spectrophotometricallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B [I199F](Homo sapiens (Human))
Emory University

LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)
Affinity DataKi:  500nMAssay Description:MAO A and MAO B activities were determined spectrophotometrically. Competitive Ki values for both enzymes were determined by measuring initial rates ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B [I199F](Homo sapiens (Human))
Emory University

LigandPNGBDBM11022(2,3-dihydro-1H-indole-2,3-dione | CHEMBL326294 | I...)
Affinity DataKi:  500nMAssay Description:MAO A and MAO B activities were determined spectrophotometrically. Competitive Ki values for both enzymes were determined by measuring initial rates ...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50049240((+-)-5-((4-(2-(5-ethyl-2-pyridinyl)ethoxy)phenyl)m...)
Affinity DataKi:  500nMAssay Description:Competitive inhibition of human MAOB expressed in Pichia pastorisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50155318(CHEMBL3781063)
Affinity DataKi:  550nMAssay Description:Competitive inhibition of human MAOB overexpressed in Pichia pastoris using MMTP as substrate preincubated for 5 mins followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50258885((E)-6-Styrylisatin | CHEMBL450239)
Affinity DataKi:  560nMAssay Description:Inhibition of recombinant wild-type MAOB from human liver expressed in Pichia pastorisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50259621((E)-5-(3-Fluorostyryl)isatin | CHEMBL506301)
Affinity DataKi:  600nMAssay Description:Inhibition of recombinant wild-type MAOB from human liver expressed in Pichia pastorisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM11002((1R)-N-methyl-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-in...)
Affinity DataKi:  600nM ΔG°:  -35.5kJ/molepH: 7.5 T: 2°CAssay Description:MAO A and MAO B activities were determined spectrophotometrically at 316 nm and 250 nm using kynuramine and benzylamine as substrates, respectively. ...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM11020(1,4-diphenyl-2-butene (DPB) | [(2E)-4-phenylbut-2-...)
Affinity DataKi:  700nM ΔG°:  -35.1kJ/molepH: 7.5 T: 2°CAssay Description:MAO A and MAO B activities were determined spectrophotometrically. Competitive Ki values for both enzymes were determined by measuring initial rates ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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