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Found 805 with Last Name = 'emkey' and Initial = 'r'
TargetCannabinoid receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM21281((11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphth...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to CB2 receptorMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50272598(6-Methoxy-5-(2-morpholin-4-yl-ethyl)-2-(1,3,3-trim...)
Affinity DataKi:  1nMAssay Description:Binding affinity to CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM21281((11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphth...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity to CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50272567(1-(4-fluorobenzyl)-N-cyclohexyl-7-methyl-4-oxo-1,4...)
Affinity DataKi:  5.5nMAssay Description:Binding affinity to CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50272567(1-(4-fluorobenzyl)-N-cyclohexyl-7-methyl-4-oxo-1,4...)
Affinity DataKi:  15nMAssay Description:Binding affinity to CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50272598(6-Methoxy-5-(2-morpholin-4-yl-ethyl)-2-(1,3,3-trim...)
Affinity DataKi:  16.4nMAssay Description:Binding affinity to CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50207400(CHEMBL3899832)
Affinity DataKi: >1.79E+6nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor expressed in CHO cells after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50207400(CHEMBL3899832)
Affinity DataKi: >2.40E+6nMAssay Description:Activity at human 5HT1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50207400(CHEMBL3899832)
Affinity DataKi: >2.97E+6nMAssay Description:Activity at human 5HT1F receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50207400(CHEMBL3899832)
Affinity DataKi: >3.02E+6nMAssay Description:Activity at human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50207400(CHEMBL3899832)
Affinity DataKi: >3.30E+6nMAssay Description:Activity at human 5T2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50207400(CHEMBL3899832)
Affinity DataKi: >3.58E+6nMAssay Description:Activity at human 5HT1B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50207400(CHEMBL3899832)
Affinity DataKi: >3.98E+6nMAssay Description:Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1E(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50207400(CHEMBL3899832)
Affinity DataKi: >5.37E+6nMAssay Description:Activity at human 5HT1E receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50207400(CHEMBL3899832)
Affinity DataKi: >6.31E+6nMAssay Description:Displacement of human recombinant 5HT4E receptor expressed in CHO cells after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 5A(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50207400(CHEMBL3899832)
Affinity DataKi: >6.90E+6nMAssay Description:Displacement of human 5HT5A receptor expressed in HEK293 cells after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50207400(CHEMBL3899832)
Affinity DataKi: >7.47E+6nMAssay Description:Activity at human 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50207400(CHEMBL3899832)
Affinity DataKi: >7.87E+6nMAssay Description:Activity at human 5T2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged JAK3 expressed in Sf9 cells using Biotin-LC-EQEDEPEGDYFEWLE as substrate after 90 mins by TR-FR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396274(CHEMBL2172314)
Affinity DataIC50:  1nMAssay Description:Inhibition of ALK enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396260(CHEMBL2172324)
Affinity DataIC50:  1nMAssay Description:Inhibition of ALK enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396268(CHEMBL2172321)
Affinity DataIC50:  1nMAssay Description:Inhibition of ALK enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396263(CHEMBL2172315)
Affinity DataIC50:  1nMAssay Description:Inhibition of ALK enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396264(CHEMBL2172304)
Affinity DataIC50:  1nMAssay Description:Inhibition of ALK enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396243(CHEMBL2172308 | US10370379, Compound TSR-011)
Affinity DataIC50:  1nMAssay Description:Inhibition of ALK enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396273(CHEMBL2172316)
Affinity DataIC50:  1nMAssay Description:Inhibition of ALK enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396272(CHEMBL2172317)
Affinity DataIC50:  1nMAssay Description:Inhibition of ALK enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396240(CHEMBL2172311)
Affinity DataIC50:  1nMAssay Description:Inhibition of ALK enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50361821(CHEMBL1938654)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged JAK2 expressed in Sf9 cells using Biotin-LC-EQEDEPEGDYFEWLE as substrate after 90 mins by TR-FR...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396248(CHEMBL2172335)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of ALK enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396245(CHEMBL2172306)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of ALK enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396239(CHEMBL2172312)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of ALK enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396250(CHEMBL2172333)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of ALK enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396254(CHEMBL2172330)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of ALK enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396240(CHEMBL2172311)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of ALK Tyr1604 phosphorylation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396241(CHEMBL2172310)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of ALK enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396249(CHEMBL2172334)
Affinity DataIC50:  2nMAssay Description:Inhibition of ALK enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396246(CHEMBL2172305)
Affinity DataIC50:  2nMAssay Description:Inhibition of ALK enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396244(CHEMBL2172307)
Affinity DataIC50:  2nMAssay Description:Inhibition of ALK enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396275(CHEMBL2172313)
Affinity DataIC50:  2nMAssay Description:Inhibition of ALK enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396270(CHEMBL2172319)
Affinity DataIC50:  2nMAssay Description:Inhibition of ALK enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396259(CHEMBL2172325)
Affinity DataIC50:  2nMAssay Description:Inhibition of ALK enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50361826(CHEMBL1938659)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged JAK2 expressed in Sf9 cells using Biotin-LC-EQEDEPEGDYFEWLE as substrate after 90 mins by TR-FR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396239(CHEMBL2172312)
Affinity DataIC50:  2nMAssay Description:Inhibition of ALK Tyr1604 phosphorylation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396266(CHEMBL2172302)
Affinity DataIC50:  2nMAssay Description:Inhibition of ALK enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396252(CHEMBL2172332)
Affinity DataIC50:  2nMAssay Description:Inhibition of ALK enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396253(CHEMBL2172331)
Affinity DataIC50:  2nMAssay Description:Inhibition of ALK enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396256(CHEMBL2172328)
Affinity DataIC50:  2nMAssay Description:Inhibition of ALK enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396242(CHEMBL2172309)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of ALK enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged JAK1 expressed in Sf9 cells using Biotin-LC-EQEDEPEGDYFEWLE as substrate after 90 mins by TR-FR...More data for this Ligand-Target Pair
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