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Found 319 with Last Name = 'epshteyn' and Initial = 's'
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402421(CHEMBL2208035)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402413(CHEMBL2208032)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402409(CHEMBL2208034)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402412(CHEMBL2208033)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50310998(CHEMBL1077458 | N-(4-(2-(4-morpholinophenylamino)p...)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402416(CHEMBL2208025)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402424(CHEMBL2208027)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402415(CHEMBL2208028)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402411(CHEMBL2207759)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402420(CHEMBL2207758)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402417(CHEMBL2208024)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402427(CHEMBL2207766)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402414(CHEMBL2208031)
Affinity DataIC50:  8.70nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402410(CHEMBL2207760)
Affinity DataIC50:  9.10nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402426(CHEMBL2207767)
Affinity DataIC50:  11.1nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402419(CHEMBL2207764)
Affinity DataIC50:  12.6nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402418(CHEMBL2208023)
Affinity DataIC50:  12.8nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402423(CHEMBL2208029)
Affinity DataIC50:  39.6nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402421(CHEMBL2208035)
Affinity DataIC50:  61.7nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50429897(CHEMBL2333379)
Affinity DataIC50:  89nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate after 2 hrs by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50429896(CHEMBL2332918)
Affinity DataIC50:  89nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate after 2 hrs by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402431(CHEMBL2207761)
Affinity DataIC50:  104nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402415(CHEMBL2208028)
Affinity DataIC50:  105nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402409(CHEMBL2208034)
Affinity DataIC50:  125nMAssay Description:Inhibition of PDGFRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402428(CHEMBL2207765)
Affinity DataIC50:  130nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402409(CHEMBL2208034)
Affinity DataIC50:  134nMAssay Description:Inhibition of JAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50429895(CHEMBL2333375)
Affinity DataIC50:  137nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate after 2 hrs by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402409(CHEMBL2208034)
Affinity DataIC50:  140nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402412(CHEMBL2208033)
Affinity DataIC50:  160nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50111316(8-[4-(3,6-Dioxo-5-{4-[(thiophene-2-carbonyl)-amino...)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by chromogenic assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402409(CHEMBL2208034)
Affinity DataIC50:  214nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402409(CHEMBL2208034)
Affinity DataIC50:  226nMAssay Description:Inhibition of c-KITMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50429893(CHEMBL2333373)
Affinity DataIC50:  238nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate after 2 hrs by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50429892(CHEMBL2333374)
Affinity DataIC50:  259nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate after 2 hrs by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50111273(6-Benzo[b]thiophen-2-yl-4-hydroxy-2-oxo-1,2-dihydr...)
Affinity DataIC50:  290nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by complex assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402414(CHEMBL2208031)
Affinity DataIC50:  298nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50111280(1-(4-Chloro-phenyl)-4-hydroxy-2-oxo-2,5-dihydro-1H...)
Affinity DataIC50:  300nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by complex assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen activator inhibitor 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50111298(8-{4-[(7-Benzo[b]thiophen-2-yl-4-hydroxy-2-oxo-1,2...)
Affinity DataIC50:  300nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by chromogenic assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402413(CHEMBL2208032)
Affinity DataIC50:  307nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402409(CHEMBL2208034)
Affinity DataIC50:  314nMAssay Description:Inhibition of P70S6KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402413(CHEMBL2208032)
Affinity DataIC50:  328nMAssay Description:Inhibition of JAK2 in HEL 92.1.7 cells assessed as inhibition of STAT1 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402409(CHEMBL2208034)
Affinity DataIC50:  348nMAssay Description:Inhibition of TYK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402420(CHEMBL2207758)
Affinity DataIC50:  368nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402409(CHEMBL2208034)
Affinity DataIC50:  370nMAssay Description:Inhibition of MLK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402409(CHEMBL2208034)
Affinity DataIC50:  375nMAssay Description:Inhibition of IKKbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402409(CHEMBL2208034)
Affinity DataIC50:  386nMAssay Description:Inhibition of JAK2 in HEL 92.1.7 cells assessed as inhibition of STAT1 phosphorylationMore data for this Ligand-Target Pair
LigandPNGBDBM50429891(CHEMBL2333366)
Affinity DataIC50:  398nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate after 2 hrs by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402415(CHEMBL2208028)
Affinity DataIC50:  447nMAssay Description:Inhibition of JAK2 in HEL 92.1.7 cells assessed as inhibition of STAT3 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402413(CHEMBL2208032)
Affinity DataIC50:  452nMAssay Description:Inhibition of JAK2 in HEL 92.1.7 cells assessed as inhibition of STAT3 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50429890(CHEMBL2331575)
Affinity DataIC50:  459nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate after 2 hrs by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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