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Found 313 with Last Name = 'fidock' and Initial = 'da'
TargetEnoyl-acyl carrier reductase ENR(Toxoplasma gondii)
Johns Hopkins Bloomberg School of Public Health

LigandPNGBDBM50174768(5‐chloro‐2‐(2‐chloro‐...)
Affinity DataIC50:  3nMpH: 7.5Assay Description:The reaction mixture (100 µL) contained 100 µM crotonyl-CoA, 1 µL DMSO (or compounds dissolved in DMSO), 5 nM TgENR, 100 mM sodium/pot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin X(Plasmodium falciparum (isolate 3D7))
Ucb

Curated by ChEMBL
LigandPNGBDBM50591320(CHEMBL5190700)
Affinity DataIC50:  7nMAssay Description:Inhibition of PMX in Plasmodium falciparum 3D7 HA epitopeMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPlasmepsin X(Plasmodium falciparum (isolate 3D7))
Ucb

Curated by ChEMBL
LigandPNGBDBM50591320(CHEMBL5190700)
Affinity DataIC50:  7nMAssay Description:Inhibition of Plasmodium falciparum recombinant C-terminal TEV cleavable 8his-tagged PMX by FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPlasmepsin X(Plasmodium falciparum (isolate 3D7))
Ucb

Curated by ChEMBL
LigandPNGBDBM50591317(CHEMBL5191783)
Affinity DataIC50:  7nMAssay Description:Inhibition of Plasmodium falciparum recombinant C-terminal TEV cleavable 8his-tagged PMX by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEnoyl-acyl carrier reductase ENR(Toxoplasma gondii)
Johns Hopkins Bloomberg School of Public Health

LigandPNGBDBM25407(2‐(2,4‐dichlorophenoxy)‐5‐...)
Affinity DataIC50:  8nMpH: 7.5Assay Description:The reaction mixture (100 µL) contained 100 µM crotonyl-CoA, 1 µL DMSO (or compounds dissolved in DMSO), 5 nM TgENR, 100 mM sodium/pot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin X(Plasmodium falciparum (isolate 3D7))
Ucb

Curated by ChEMBL
LigandPNGBDBM50591318(CHEMBL5204196)
Affinity DataIC50:  9nMAssay Description:Inhibition of Plasmodium falciparum recombinant C-terminal TEV cleavable 8his-tagged PMX by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEnoyl-acyl carrier reductase ENR(Toxoplasma gondii)
Johns Hopkins Bloomberg School of Public Health

LigandPNGBDBM50174760(2‐[4‐(benzylamino)‐2‐chlor...)
Affinity DataIC50:  13nMpH: 7.5Assay Description:The reaction mixture (100 µL) contained 100 µM crotonyl-CoA, 1 µL DMSO (or compounds dissolved in DMSO), 5 nM TgENR, 100 mM sodium/pot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin X(Plasmodium falciparum (isolate 3D7))
Ucb

Curated by ChEMBL
LigandPNGBDBM50591315(CHEMBL5172999)
Affinity DataIC50:  15nMAssay Description:Inhibition of Plasmodium falciparum recombinant C-terminal TEV cleavable 8his-tagged PMX by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEnoyl-acyl carrier reductase ENR(Toxoplasma gondii)
Johns Hopkins Bloomberg School of Public Health

LigandPNGBDBM8726(5-chloro-2-(2,4-dichlorophenoxy)phenol | CHEMBL849...)
Affinity DataIC50:  15nMpH: 7.5Assay Description:The reaction mixture (100 µL) contained 100 µM crotonyl-CoA, 1 µL DMSO (or compounds dissolved in DMSO), 5 nM TgENR, 100 mM sodium/pot...More data for this Ligand-Target Pair
TargetEnoyl-acyl carrier reductase ENR(Toxoplasma gondii)
Johns Hopkins Bloomberg School of Public Health

LigandPNGBDBM50174774(2‐({[3‐chloro‐4‐(4‐c...)
Affinity DataIC50:  16nMpH: 7.5Assay Description:The reaction mixture (100 µL) contained 100 µM crotonyl-CoA, 1 µL DMSO (or compounds dissolved in DMSO), 5 nM TgENR, 100 mM sodium/pot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-acyl carrier reductase ENR(Toxoplasma gondii)
Johns Hopkins Bloomberg School of Public Health

LigandPNGBDBM119865(6‐chloro‐3‐(2,4‐dichloroph...)
Affinity DataIC50:  18nMpH: 7.5Assay Description:The reaction mixture (100 µL) contained 100 µM crotonyl-CoA, 1 µL DMSO (or compounds dissolved in DMSO), 5 nM TgENR, 100 mM sodium/pot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-acyl carrier reductase ENR(Toxoplasma gondii)
Johns Hopkins Bloomberg School of Public Health

LigandPNGBDBM50435717(CHEMBL2392450 | N‐{[4‐(2,4‐dichl...)
Affinity DataIC50:  19nMpH: 7.5Assay Description:The reaction mixture (100 µL) contained 100 µM crotonyl-CoA, 1 µL DMSO (or compounds dissolved in DMSO), 5 nM TgENR, 100 mM sodium/pot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-acyl carrier reductase ENR(Toxoplasma gondii)
Johns Hopkins Bloomberg School of Public Health

LigandPNGBDBM119866(3‐chloro‐6‐(2,4‐dichloroph...)
Affinity DataIC50:  23nMpH: 7.5Assay Description:The reaction mixture (100 µL) contained 100 µM crotonyl-CoA, 1 µL DMSO (or compounds dissolved in DMSO), 5 nM TgENR, 100 mM sodium/pot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEnoyl-acyl carrier reductase ENR(Toxoplasma gondii)
Johns Hopkins Bloomberg School of Public Health

LigandPNGBDBM25403(4‐(2,4‐dichlorophenoxy)‐3‐...)
Affinity DataIC50:  24nMpH: 7.5Assay Description:The reaction mixture (100 µL) contained 100 µM crotonyl-CoA, 1 µL DMSO (or compounds dissolved in DMSO), 5 nM TgENR, 100 mM sodium/pot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-acyl carrier reductase ENR(Toxoplasma gondii)
Johns Hopkins Bloomberg School of Public Health

LigandPNGBDBM119867(5‐chloro‐2‐[2‐chloro‐...)
Affinity DataIC50:  26nMpH: 7.5Assay Description:The reaction mixture (100 µL) contained 100 µM crotonyl-CoA, 1 µL DMSO (or compounds dissolved in DMSO), 5 nM TgENR, 100 mM sodium/pot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEnoyl-acyl carrier reductase ENR(Toxoplasma gondii)
Johns Hopkins Bloomberg School of Public Health

LigandPNGBDBM50431922(5‐chloro‐2‐[2‐chloro‐...)
Affinity DataIC50:  30nMpH: 7.5Assay Description:The reaction mixture (100 µL) contained 100 µM crotonyl-CoA, 1 µL DMSO (or compounds dissolved in DMSO), 5 nM TgENR, 100 mM sodium/pot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-acyl carrier reductase ENR(Toxoplasma gondii)
Johns Hopkins Bloomberg School of Public Health

LigandPNGBDBM119869(5‐chloro‐2‐{2‐chloro‐...)
Affinity DataIC50:  31nMpH: 7.5Assay Description:The reaction mixture (100 µL) contained 100 µM crotonyl-CoA, 1 µL DMSO (or compounds dissolved in DMSO), 5 nM TgENR, 100 mM sodium/pot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin X(Plasmodium falciparum (isolate 3D7))
Ucb

Curated by ChEMBL
LigandPNGBDBM50591319(CHEMBL5204856)
Affinity DataIC50:  32nMAssay Description:Inhibition of Plasmodium falciparum recombinant C-terminal TEV cleavable 8his-tagged PMX by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEnoyl-acyl carrier reductase ENR(Toxoplasma gondii)
Johns Hopkins Bloomberg School of Public Health

LigandPNGBDBM119870(N‐{[3‐chloro‐4‐(4‐ch...)
Affinity DataIC50:  33nMpH: 7.5Assay Description:The reaction mixture (100 µL) contained 100 µM crotonyl-CoA, 1 µL DMSO (or compounds dissolved in DMSO), 5 nM TgENR, 100 mM sodium/pot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlasmepsin X(Plasmodium falciparum (isolate 3D7))
Ucb

Curated by ChEMBL
LigandPNGBDBM50591316(CHEMBL5208335)
Affinity DataIC50:  37nMAssay Description:Inhibition of Plasmodium falciparum recombinant C-terminal TEV cleavable 8his-tagged PMX by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEnoyl-ACP reductase(Plasmodium falciparum)
Jacobus Pharmaceutical

LigandPNGBDBM25418(2-(2,4-dichlorophenoxy)-5-(4-fluorophenyl)phenol |...)
Affinity DataIC50:  38nMpH: 7.9 T: 2°CAssay Description:PfENR inhibition assays were carried out on a Cary 100 Bio Spectrophotometer or POLARstar Optima by monitoring oxidation of NADH at 340 nm. The IC50 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-acyl carrier reductase ENR(Toxoplasma gondii)
Johns Hopkins Bloomberg School of Public Health

LigandPNGBDBM50431923(5‐chloro‐2‐(naphthalen‐2&#...)
Affinity DataIC50:  41nMpH: 7.5Assay Description:The reaction mixture (100 µL) contained 100 µM crotonyl-CoA, 1 µL DMSO (or compounds dissolved in DMSO), 5 nM TgENR, 100 mM sodium/pot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-acyl carrier reductase ENR(Toxoplasma gondii)
Johns Hopkins Bloomberg School of Public Health

LigandPNGBDBM119868(2‐{4‐[(4‐butyl‐1,2,3‐...)
Affinity DataIC50:  43nMpH: 7.5Assay Description:The reaction mixture (100 µL) contained 100 µM crotonyl-CoA, 1 µL DMSO (or compounds dissolved in DMSO), 5 nM TgENR, 100 mM sodium/pot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEnoyl-ACP reductase(Plasmodium falciparum)
Jacobus Pharmaceutical

LigandPNGBDBM25403(4‐(2,4‐dichlorophenoxy)‐3‐...)
Affinity DataIC50:  49nMpH: 7.9 T: 2°CAssay Description:PfENR inhibition assays were carried out on a Cary 100 Bio Spectrophotometer or POLARstar Optima by monitoring oxidation of NADH at 340 nm. The IC50 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-acyl-carrier protein reductase(Plasmodium falciparum)
Jacobus Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50174772(CHEMBL200658 | N-(3-chloro-4-(4-chloro-2-hydroxyph...)
Affinity DataIC50:  57nMAssay Description:Inhibition of PfENR enzymatic activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Ucb

Curated by ChEMBL
LigandPNGBDBM50591315(CHEMBL5172999)
Affinity DataIC50:  58nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEnoyl-acyl carrier reductase ENR(Toxoplasma gondii)
Johns Hopkins Bloomberg School of Public Health

LigandPNGBDBM50431920(5‐(4‐chloro‐2‐hydroxypheno...)
Affinity DataIC50:  58nMpH: 7.5Assay Description:The reaction mixture (100 µL) contained 100 µM crotonyl-CoA, 1 µL DMSO (or compounds dissolved in DMSO), 5 nM TgENR, 100 mM sodium/pot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Ucb

Curated by ChEMBL
LigandPNGBDBM50591317(CHEMBL5191783)
Affinity DataIC50:  64nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL
LigandPNGBDBM50238633(CHEMBL4081080)
Affinity DataIC50:  70nMAssay Description:Inhibition of hERG by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEnoyl-ACP reductase(Plasmodium falciparum)
Jacobus Pharmaceutical

LigandPNGBDBM25419(5-benzyl-2-(2,4-dichlorophenoxy)phenol | Triclosan...)
Affinity DataIC50:  71nMpH: 7.9 T: 2°CAssay Description:PfENR inhibition assays were carried out on a Cary 100 Bio Spectrophotometer or POLARstar Optima by monitoring oxidation of NADH at 340 nm. The IC50 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-acyl-carrier protein reductase(Plasmodium falciparum)
Jacobus Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM8726(5-chloro-2-(2,4-dichlorophenoxy)phenol | CHEMBL849...)
Affinity DataIC50:  73nMAssay Description:Inhibition of Plasmodium falciparum ENR enzymatic activityMore data for this Ligand-Target Pair
TargetEnoyl-acyl-carrier protein reductase(Plasmodium falciparum)
Jacobus Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM8726(5-chloro-2-(2,4-dichlorophenoxy)phenol | CHEMBL849...)
Affinity DataIC50:  73nMAssay Description:Inhibition of PfENR enzymatic activityMore data for this Ligand-Target Pair
TargetEnoyl-ACP reductase(Plasmodium falciparum)
Jacobus Pharmaceutical

LigandPNGBDBM8726(5-chloro-2-(2,4-dichlorophenoxy)phenol | CHEMBL849...)
Affinity DataIC50:  73nMpH: 7.9 T: 2°CAssay Description:PfENR inhibition assays were carried out on a Cary 100 Bio Spectrophotometer or POLARstar Optima by monitoring oxidation of NADH at 340 nm. The IC50 ...More data for this Ligand-Target Pair
TargetEnoyl-ACP reductase(Plasmodium falciparum)
Jacobus Pharmaceutical

LigandPNGBDBM25420(2-(2,4-dichlorophenoxy)-5-(2-phenylethyl)phenol | ...)
Affinity DataIC50:  76nMpH: 7.9 T: 2°CAssay Description:PfENR inhibition assays were carried out on a Cary 100 Bio Spectrophotometer or POLARstar Optima by monitoring oxidation of NADH at 340 nm. The IC50 ...More data for this Ligand-Target Pair
TargetEnoyl-acyl carrier reductase ENR(Toxoplasma gondii)
Johns Hopkins Bloomberg School of Public Health

LigandPNGBDBM119871(N‐{[3‐chloro‐4‐(4‐ch...)
Affinity DataIC50:  100nMpH: 7.5Assay Description:The reaction mixture (100 µL) contained 100 µM crotonyl-CoA, 1 µL DMSO (or compounds dissolved in DMSO), 5 nM TgENR, 100 mM sodium/pot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-ACP reductase(Plasmodium falciparum)
Jacobus Pharmaceutical

LigandPNGBDBM25407(2‐(2,4‐dichlorophenoxy)‐5‐...)
Affinity DataIC50:  110nMpH: 7.9 T: 2°CAssay Description:PfENR inhibition assays were carried out on a Cary 100 Bio Spectrophotometer or POLARstar Optima by monitoring oxidation of NADH at 340 nm. The IC50 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-ACP reductase(Plasmodium falciparum)
Jacobus Pharmaceutical

LigandPNGBDBM25412(2-(2,4-dichlorophenoxy)-5-(3-methylbutyl)phenol | ...)
Affinity DataIC50:  120nMpH: 7.9 T: 2°CAssay Description:PfENR inhibition assays were carried out on a Cary 100 Bio Spectrophotometer or POLARstar Optima by monitoring oxidation of NADH at 340 nm. The IC50 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-acyl-carrier protein reductase(Plasmodium falciparum)
Jacobus Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50174775(3-chloro-4-(4-chloro-2-hydroxyphenoxy)benzonitrile...)
Affinity DataIC50:  120nMAssay Description:Inhibition of PfENR enzymatic activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-acyl-carrier protein reductase(Plasmodium falciparum)
Jacobus Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50174766(3-chloro-4-(4-chloro-2-hydroxyphenoxy)benzamide | ...)
Affinity DataIC50:  120nMAssay Description:Inhibition of PfENR enzymatic activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-acyl-carrier protein reductase(Plasmodium falciparum)
Jacobus Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50174760(2‐[4‐(benzylamino)‐2‐chlor...)
Affinity DataIC50:  140nMAssay Description:Inhibition of PfENR enzymatic activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-ACP reductase(Plasmodium falciparum)
Jacobus Pharmaceutical

LigandPNGBDBM25402(2-(2,4-dichlorophenoxy)-5-phenylphenol | Triclosan...)
Affinity DataIC50:  140nMpH: 7.9 T: 2°CAssay Description:PfENR inhibition assays were carried out on a Cary 100 Bio Spectrophotometer or POLARstar Optima by monitoring oxidation of NADH at 340 nm. The IC50 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-acyl-carrier protein reductase(Plasmodium falciparum)
Jacobus Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50174769(CHEMBL198781 | N-(3-chloro-4-(4-chloro-2-hydroxyph...)
Affinity DataIC50:  140nMAssay Description:Inhibition of PfENR enzymatic activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin IX(Plasmodium falciparum (isolate 3D7))
Ucb

Curated by ChEMBL
LigandPNGBDBM50591320(CHEMBL5190700)
Affinity DataIC50:  142nMAssay Description:Inhibition of PMIX in Plasmodium falciparum 3D7 HA epitopeMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPlasmepsin IX(Plasmodium falciparum (isolate 3D7))
Ucb

Curated by ChEMBL
LigandPNGBDBM50591320(CHEMBL5190700)
Affinity DataIC50:  142nMAssay Description:Inhibition of Plasmodium falciparum PMIX by FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL
LigandPNGBDBM79214(1-[1,3-bis(chloranyl)-6-(trifluoromethyl)phenanthr...)
Affinity DataIC50:  160nMAssay Description:Inhibition of hERG by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetEnoyl-acyl-carrier protein reductase(Plasmodium falciparum)
Jacobus Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50174778(1-(3-chloro-4-(4-chloro-2-hydroxyphenoxy)phenyl)ur...)
Affinity DataIC50:  160nMAssay Description:Inhibition of PfENR enzymatic activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-acyl-carrier protein reductase(Plasmodium falciparum)
Jacobus Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50174776(CHEMBL200871 | N-(3-chloro-4-(4-chloro-2-hydroxyph...)
Affinity DataIC50:  170nMAssay Description:Inhibition of PfENR enzymatic activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-acyl-carrier protein reductase(Plasmodium falciparum)
Jacobus Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50174770(5-chloro-2-(2-chloro-4-nitrophenoxy)phenol | CHEMB...)
Affinity DataIC50:  180nMAssay Description:Inhibition of PfENR enzymatic activityMore data for this Ligand-Target Pair
TargetEnoyl-ACP reductase(Plasmodium falciparum)
Jacobus Pharmaceutical

LigandPNGBDBM25410(2-(2,4-dichlorophenoxy)-5-(2-methylpropyl)phenol |...)
Affinity DataIC50:  180nMpH: 7.9 T: 2°CAssay Description:PfENR inhibition assays were carried out on a Cary 100 Bio Spectrophotometer or POLARstar Optima by monitoring oxidation of NADH at 340 nm. The IC50 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Ucb

Curated by ChEMBL
LigandPNGBDBM50591317(CHEMBL5191783)
Affinity DataIC50:  180nMAssay Description:Inhibition of human reninMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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