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Found 71 with Last Name = 'franks' and Initial = 'cf'
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM3530(6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...)
Affinity DataIC50:  50nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291107((3-Chloro-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-...)
Affinity DataIC50:  100nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291110(CHEMBL136011 | Methyl-(1H-pyrazolo[3,4-d]pyrimidin...)
Affinity DataIC50:  180nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291111((6,7-Dimethoxy-quinazolin-4-yl)-methyl-m-tolyl-ami...)
Affinity DataIC50:  180nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31285(BMCL163310 Compound 1 | CHEMBL361103 | benzodiazep...)
Affinity DataIC50:  420nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM6497(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinazolin...)
Affinity DataIC50:  500nMAssay Description:Inhibition of p56 lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291103((6,7-Dimethoxy-quinazolin-4-yl)-methyl-(3-trifluor...)
Affinity DataIC50:  500nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50273281(CHEMBL456375 | CHEMBL543669 | N-methyl-4-anilino-6...)
Affinity DataIC50:  500nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM6497(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinazolin...)
Affinity DataIC50:  500nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31328(1,4-benzodiazepine-2,5-dione antagonist, 13 | Race...)
Affinity DataIC50:  510nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31318(1,4-benzodiazepine-2,5-dione antagonist, 2 | Racem...)
Affinity DataIC50:  540nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291112(CHEMBL541334 | Methyl-phenyl-(1H-pyrazolo[3,4-d]py...)
Affinity DataIC50:  600nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31305(1,4-benzodiazepine-2,5-dione, 12b | BMCL163310 Com...)
Affinity DataIC50:  700nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31338(1,4-benzodiazepine-2,5-dione antagonist, 23)
Affinity DataIC50:  710nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31320(1,4-benzodiazepine-2,5-dione antagonist, 4 | Racem...)
Affinity DataIC50:  850nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31321(1,4-benzodiazepine-2,5-dione antagonist, 5 | Racem...)
Affinity DataIC50:  870nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31336(1,4-benzodiazepine-2,5-dione antagonist, 21)
Affinity DataIC50:  980nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31337(1,4-benzodiazepine-2,5-dione antagonist, 22)
Affinity DataIC50:  1.04E+3nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31327(1,4-benzodiazepine-2,5-dione antagonist, 12 | Race...)
Affinity DataIC50:  1.09E+3nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31339(1,4-benzodiazepine-2,5-dione antagonist, 24)
Affinity DataIC50:  1.11E+3nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291107((3-Chloro-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-...)
Affinity DataIC50:  1.50E+3nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291109((6,7-Dimethyl-quinazolin-4-yl)-methyl-m-tolyl-amin...)
Affinity DataIC50:  1.60E+3nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291116((6,7-Dimethoxy-quinazolin-4-yl)-methyl-p-tolyl-ami...)
Affinity DataIC50:  2.00E+3nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291115(CHEMBL335052 | Methyl-phenyl-(9H-purin-6-yl)-amine)
Affinity DataIC50:  2.00E+3nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291114((4-Chloro-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-...)
Affinity DataIC50:  2.10E+3nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31319(1,4-benzodiazepine-2,5-dione antagonist, 3 | Racem...)
Affinity DataIC50:  2.12E+3nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31331(1,4-benzodiazepine-2,5-dione antagonist, 16 | Race...)
Affinity DataIC50:  2.13E+3nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31335(1,4-benzodiazepine-2,5-dione antagonist, 20 | Race...)
Affinity DataIC50:  2.15E+3nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31323(1,4-benzodiazepine-2,5-dione antagonist, 8 | Racem...)
Affinity DataIC50:  2.18E+3nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31330(1,4-benzodiazepine-2,5-dione antagonist, 15 | Race...)
Affinity DataIC50:  2.82E+3nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291114((4-Chloro-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-...)
Affinity DataIC50:  3.00E+3nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290633(4-(2,3-Dihydro-indol-1-yl)-6,7-dimethoxy-quinazoli...)
Affinity DataIC50:  3.00E+3nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31324(1,4-benzodiazepine-2,5-dione antagonist, 9 | Racem...)
Affinity DataIC50:  3.33E+3nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291115(CHEMBL335052 | Methyl-phenyl-(9H-purin-6-yl)-amine)
Affinity DataIC50:  4.00E+3nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291116((6,7-Dimethoxy-quinazolin-4-yl)-methyl-p-tolyl-ami...)
Affinity DataIC50:  4.00E+3nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50273281(CHEMBL456375 | CHEMBL543669 | N-methyl-4-anilino-6...)
Affinity DataIC50:  4.00E+3nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291102((6,7-Dimethoxy-quinazolin-4-yl)-ethyl-phenyl-amine...)
Affinity DataIC50:  4.00E+3nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31325(1,4-benzodiazepine-2,5-dione antagonist, 10 | Race...)
Affinity DataIC50:  4.35E+3nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290633(4-(2,3-Dihydro-indol-1-yl)-6,7-dimethoxy-quinazoli...)
Affinity DataIC50:  5.00E+3nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291106((2,6-Dichloro-quinazolin-4-yl)-methyl-phenyl-amine...)
Affinity DataIC50:  5.00E+3nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291102((6,7-Dimethoxy-quinazolin-4-yl)-ethyl-phenyl-amine...)
Affinity DataIC50:  5.50E+3nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291109((6,7-Dimethyl-quinazolin-4-yl)-methyl-m-tolyl-amin...)
Affinity DataIC50:  6.50E+3nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31332(1,4-benzodiazepine-2,5-dione antagonist, 17 | Race...)
Affinity DataIC50:  8.22E+3nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31326(1,4-benzodiazepine-2,5-dione antagonist, 11 | Race...)
Affinity DataIC50:  1.02E+4nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291111((6,7-Dimethoxy-quinazolin-4-yl)-methyl-m-tolyl-ami...)
Affinity DataIC50:  1.20E+4nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31333(1,4-benzodiazepine-2,5-dione antagonist, 18)
Affinity DataIC50:  1.33E+4nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50273281(CHEMBL456375 | CHEMBL543669 | N-methyl-4-anilino-6...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of platelet-derived growth factor receptor (PDGF-R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291105((6,8-Dimethyl-quinazolin-4-yl)-methyl-phenyl-amine...)
Affinity DataIC50: >2.00E+4nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291104((6-Methoxy-quinazolin-4-yl)-methyl-phenyl-amine; h...)
Affinity DataIC50:  2.00E+4nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM6497(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinazolin...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of platelet-derived growth factor receptor (PDGF-R)More data for this Ligand-Target Pair
In DepthDetails Article
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