Compile Data Set for Download or QSAR
maximum 50k data
Found 639 with Last Name = 'frett' and Initial = 'b'
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021574(BMS-907351 | CABOZANTINIB | CHEBI:72317 | Cabomety...)
Affinity DataIC50:  0.0350nMAssay Description:Inhibition of recombinant VEGFR2 (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021574(BMS-907351 | CABOZANTINIB | CHEBI:72317 | Cabomety...)
Affinity DataIC50:  0.0350nMAssay Description:Inhibition of human recombinant full length VEGFR2 in presence of ATP by alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50595124(CHEBI:49960 | Caprelsa | GNF-PF-2188 | NSC-744325 ...)
Affinity DataIC50:  0.0400nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50595124(CHEBI:49960 | Caprelsa | GNF-PF-2188 | NSC-744325 ...)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of VEGFR3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50595124(CHEBI:49960 | Caprelsa | GNF-PF-2188 | NSC-744325 ...)
Affinity DataIC50:  0.130nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM144315(Gilteritinib | US11512074, Example T-9 | US8969336...)
Affinity DataIC50:  0.290nMAssay Description:Blocking activity against Beta-2 adrenergic receptor in guinea pig tracheal stripsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50601766(CHEMBL5171764)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of recombinant RET V804L (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of FLT3 (unknown origin) by kinase hotspot assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAurora kinase B(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50565411(CHEMBL4799738)
Affinity DataIC50:  0.316nMAssay Description:Inhibition of recombinant human full-length His-tagged Aurora B expressed in baculovirus expression system using 5-FAM-LRRASLG-CONH2 as substrate pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50579200(CHEMBL4852453)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of human TGFbeta receptor 1 in human HEK293 cells preincubated for 24 hrs followed by addition of TGFbeta1 and measured after 24 hrs by lu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50466808(AZD-1152-HQPA | Barasertib)
Affinity DataIC50:  0.326nMAssay Description:Inhibition of recombinant human full-length His-tagged Aurora B expressed in baculovirus expression system using 5-FAM-LRRASLG-CONH2 as substrate pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoiled-coil domain-containing protein 6(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50382959(CEP-32496 | CHEMBL2029988 | US9730937, Example 261)
Affinity DataIC50:  0.330nMAssay Description:Inhibition of CCDC6-RET (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAurora kinase B(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50565427(CHEMBL4784002)
Affinity DataIC50:  0.336nMAssay Description:Inhibition of recombinant human full-length His-tagged Aurora B expressed in baculovirus expression system using 5-FAM-LRRASLG-CONH2 as substrate pre...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50579201(CHEMBL4858177)
Affinity DataIC50:  0.340nMAssay Description:Inhibition of human TGFbeta receptor 1 in human HEK293 cells preincubated for 24 hrs followed by addition of TGFbeta1 and measured after 24 hrs by lu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50579196(CHEMBL4877947)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of human TGFbeta receptor 1 in human HEK293 cells preincubated for 24 hrs followed by addition of TGFbeta1 and measured after 24 hrs by lu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of wildtype RET (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM374727((7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14- tetrah...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of TRKA G595R mutant (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50601766(CHEMBL5171764)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of recombinant RET M918T (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50601766(CHEMBL5171764)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of wildtype RET (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetCoiled-coil domain-containing protein 6(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50601766(CHEMBL5171764)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of recombinant CCDC6-RET (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret /Nuclear receptor coactivator 4 fusion protein(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50382959(CEP-32496 | CHEMBL2029988 | US9730937, Example 261)
Affinity DataIC50:  0.410nMAssay Description:Inhibition of NCOA4-RET (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  0.420nMAssay Description:Inhibition of recombinant RET V804L (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of BCR-ABL (unknown origin) by kinase hotspot assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50: <0.5nMAssay Description:Inhibition of BTK (unknown origin) after 60 mins by FRET assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50595124(CHEBI:49960 | Caprelsa | GNF-PF-2188 | NSC-744325 ...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50:  0.5nMAssay Description:Irreversible inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair
TargetTGF-beta receptor type-1(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50579206(CHEMBL4846578)
Affinity DataIC50:  0.510nMAssay Description:Inhibition of human TGFbeta receptor 1 in human HEK293 cells preincubated for 24 hrs followed by addition of TGFbeta1 and measured after 24 hrs by lu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50579194(CHEMBL4872884)
Affinity DataIC50:  0.540nMAssay Description:Inhibition of human TGFbeta receptor 1 in human HEK293 cells preincubated for 24 hrs followed by addition of TGFbeta1 and measured after 24 hrs by lu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50579171(CHEMBL4861887)
Affinity DataIC50:  0.620nMAssay Description:Inhibition of human TGFbeta receptor 1 in human HEK293 cells preincubated for 24 hrs followed by addition of TGFbeta1 and measured after 24 hrs by lu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50579198(CHEMBL4872045)
Affinity DataIC50:  0.630nMAssay Description:Inhibition of human TGFbeta receptor 1 in human HEK293 cells preincubated for 24 hrs followed by addition of TGFbeta1 and measured after 24 hrs by lu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50579188(CHEMBL4874893)
Affinity DataIC50:  0.650nMAssay Description:Inhibition of human TGFbeta receptor 1 in human HEK293 cells preincubated for 24 hrs followed by addition of TGFbeta1 and measured after 24 hrs by lu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50514844(CHEMBL4473213)
Affinity DataIC50:  0.670nMAssay Description:Inhibition of RET isoform 9 C634W mutant in human TT cells assessed as reduction in cell proliferation supplemented with fresh medium containing comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoiled-coil domain-containing protein 6(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50514844(CHEMBL4473213)
Affinity DataIC50:  0.670nMAssay Description:Inhibition of CCDC6/RET in human LC2/ad cells assessed as reduction in cell proliferation supplemented with fresh medium containing compound for ever...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50579185(CHEMBL4867170)
Affinity DataIC50:  0.670nMAssay Description:Inhibition of human TGFbeta receptor 1 in human HEK293 cells preincubated for 24 hrs followed by addition of TGFbeta1 and measured after 24 hrs by lu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50514844(CHEMBL4473213)
Affinity DataIC50:  0.670nMAssay Description:Inhibition of RET isoform 9 M918T mutant in human MZ-CRC-1 cells assessed as reduction in cell proliferation supplemented with fresh medium containin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoiled-coil domain-containing protein 6(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50514844(CHEMBL4473213)
Affinity DataIC50:  0.670nMAssay Description:Inhibition of CCDC6/RET in human TPC1 cells assessed as reduction in cell proliferation supplemented with fresh medium containing compound for every ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of recombinant RET M918T (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))TBA
LigandPNGBDBM144315(Gilteritinib | US11512074, Example T-9 | US8969336...)
Affinity DataIC50:  0.730nMAssay Description:Binding affinity towards rat beta adrenergic receptor from heart membranes.More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50579189(CHEMBL4851363)
Affinity DataIC50:  0.790nMAssay Description:Inhibition of human TGFbeta receptor 1 in human HEK293 cells preincubated for 24 hrs followed by addition of TGFbeta1 and measured after 24 hrs by lu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50579197(CHEMBL4863867)
Affinity DataIC50:  0.820nMAssay Description:Inhibition of human TGFbeta receptor 1 in human HEK293 cells preincubated for 24 hrs followed by addition of TGFbeta1 and measured after 24 hrs by lu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50193395(Altiratinib | DCC-2701 | DP-5164)
Affinity DataIC50:  0.850nMAssay Description:Inhibition of TRKA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50579184(CHEMBL4877481)
Affinity DataIC50:  0.880nMAssay Description:Inhibition of human TGFbeta receptor 1 in human HEK293 cells preincubated for 24 hrs followed by addition of TGFbeta1 and measured after 24 hrs by lu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50:  0.980nMAssay Description:Inhibition of TRKA G667C mutant (unknown origin) using poly-EAY peptide as substrate in presence of gamma-33ATP by LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))TBA
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataIC50:  1nMAssay Description:Blocking activity against Beta-2 adrenergic receptor in guinea pig tracheal stripsMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50595124(CHEBI:49960 | Caprelsa | GNF-PF-2188 | NSC-744325 ...)
Affinity DataIC50: >1nMAssay Description:Inhibition of PDGFRbeta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50234990(CHEMBL4062453)
Affinity DataIC50:  1nMAssay Description:Inhibition of N-terminal His6-tagged full-length recombinant human NEK2 expressed in baculovirus infected sf21 cells using biotin labelled-STK-3 subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50595124(CHEBI:49960 | Caprelsa | GNF-PF-2188 | NSC-744325 ...)
Affinity DataIC50: >1nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50579175(CHEMBL4850787)
Affinity DataIC50:  1nMAssay Description:Inhibition of human TGFbeta receptor 1 in human HEK293 cells preincubated for 24 hrs followed by addition of TGFbeta1 and measured after 24 hrs by lu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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