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Found 37 with Last Name = 'galivan' and Initial = 'j'
TargetDihydrofolate reductase(Mus musculus (Mouse))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataKi:  0.00528nMAssay Description:The compound was tested for its inhibitory activity against Dihydrofolate reductase derived from L1210 cells.More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mus musculus (Mouse))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50008293(2-{4-[(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-ylmeth...)
Affinity DataKi:  0.00585nMAssay Description:The compound was tested for its inhibitory activity against dihydrofolate reductase(DHFR) derived from L1210 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50008292(2-{4-[(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin...)
Affinity DataKi:  0.00687nMAssay Description:The compound was tested for its inhibitory activity against dihydrofolate reductase(DHFR) derived from L1210 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  3.90nMAssay Description:Compound was tested for its inhibitory activity on Recombinant Human Dihydrofolate Reductase.More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50010932((10-DA, 10-Deazaminopterin)2-{4-[2-(2,4-Diamino-pt...)
Affinity DataIC50:  4.10nMAssay Description:Compound was tested for its inhibitory activity on Recombinant Human Dihydrofolate Reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50016460((S)-2-{4-[1-(2,4-Diamino-pteridin-6-ylmethyl)-prop...)
Affinity DataIC50:  4.40nMAssay Description:Compound was tested for its inhibitory activity on Recombinant Human Dihydrofolate Reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50010930(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...)
Affinity DataIC50:  5.30nMAssay Description:Compound was tested for its inhibitory activity on Recombinant Human Dihydrofolate Reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50010928(2-{4-[1-(2,4-Diamino-pteridin-6-ylmethyl)-propyl]-...)
Affinity DataIC50:  5.80nMAssay Description:Compound was tested for its inhibitory activity on Recombinant Human Dihydrofolate Reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50010931(2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethyl]-benzoyl...)
Affinity DataIC50:  5.90nMAssay Description:Compound was tested for its inhibitory activity on Recombinant Human Dihydrofolate Reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50010924(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...)
Affinity DataIC50:  6.40nMAssay Description:Compound was tested for its inhibitory activity on Recombinant Human Dihydrofolate Reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50010929(2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethyl]-benzoyl...)
Affinity DataIC50:  8.80nMAssay Description:Compound was tested for its inhibitory activity on Recombinant Human Dihydrofolate Reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
University Of South Alabama

Curated by ChEMBL
LigandPNGBDBM50008294(2-(4-(((2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)m...)
Affinity DataIC50:  10nMAssay Description:Inhibition of pure human thymidyllate synthase from extract of Manca human lymphoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
University Of South Alabama

Curated by ChEMBL
LigandPNGBDBM50008294(2-(4-(((2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)m...)
Affinity DataIC50:  21nMAssay Description:Inhibition of thymidyllate synthase in Lactobacillus caseiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  50nMAssay Description:Inhibitory activity of the compound towards dihydrofolate reductase in L1210 murine leukemia cell linesMore data for this Ligand-Target Pair
TargetThymidylate synthase(Homo sapiens (Human))
University Of South Alabama

Curated by ChEMBL
LigandPNGBDBM50012244(2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylm...)
Affinity DataIC50:  60nMAssay Description:Inhibition of GAR formyltransferase in Lactobacillus caseiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
University Of South Alabama

Curated by ChEMBL
LigandPNGBDBM50012244(2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylm...)
Affinity DataIC50:  60nMAssay Description:Inhibition of pure human thymidyllate synthase from extract of Manca human lymphoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50028272(6-Amino-2-[6-amino-2-(4-carboxy-4-{4-[(2,4-diamino...)
Affinity DataIC50:  86nMAssay Description:Inhibitory activity of the compound towards dihydrofolate reductase in L1210 murine leukemia cell linesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50028274(6-Amino-2-(4-carboxy-4-{4-[(2,4-diamino-pteridin-6...)
Affinity DataIC50:  87nMAssay Description:Inhibitory activity of the compound towards dihydrofolate reductase in L1210 murine leukemia cell linesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
University Of South Alabama

Curated by ChEMBL
LigandPNGBDBM50008290(2-{4-[(2-Amino-4-oxo-3,4-dihydro-pyrido[2,3-d]pyri...)
Affinity DataIC50:  90nMAssay Description:The compound was tested for its inhibitory activity against thymidylate synthase(TS) derived from H35F/F cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
University Of South Alabama

Curated by ChEMBL
LigandPNGBDBM50012244(2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylm...)
Affinity DataIC50:  100nMAssay Description:Inhibition of thymidyllate synthase in Lactobacillus caseiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50028273(6-Amino-2-{6-amino-2-[6-amino-2-(4-carboxy-4-{4-[(...)
Affinity DataIC50:  140nMAssay Description:Inhibitory activity of the compound towards dihydrofolate reductase in L1210 murine leukemia cell linesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
University Of South Alabama

Curated by ChEMBL
LigandPNGBDBM50008295(2-{4-[(2-Amino-4-oxo-3,4-dihydro-pyrido[3,2-d]pyri...)
Affinity DataIC50:  2.40E+3nMAssay Description:The compound was tested for its inhibitory activity against thymidylate synthase(TS) derived from K562 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
University Of South Alabama

Curated by ChEMBL
LigandPNGBDBM50008291(2-{4-[(2-Amino-4-oxo-1,4-dihydro-pteridin-6-ylmeth...)
Affinity DataIC50:  3.90E+3nMAssay Description:The compound was tested for its inhibitory activity (IC50) against thymidylate synthase(TS) derived from L. caseiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Lactobacillus casei)
University Of South Alabama

Curated by ChEMBL
LigandPNGBDBM50008294(2-(4-(((2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)m...)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of dihydrofolate reductase in Lactobacillus caseiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
University Of South Alabama

Curated by ChEMBL
LigandPNGBDBM50017081(2-{4-[(4-Oxo-2-trifluoromethyl-3,4-dihydro-quinazo...)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of purified human thymidylate synthase from a SV40-transformed human fibroblast cell line cloned in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
University Of South Alabama

Curated by ChEMBL
LigandPNGBDBM50017080(2-{4-[(2,3-Dimethyl-4-oxo-3,4-dihydro-quinazolin-6...)
Affinity DataIC50:  1.13E+4nMAssay Description:Inhibition of purified human thymidylate synthase from a SV40-transformed human fibroblast cell line cloned in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University Of South Alabama

Curated by ChEMBL
LigandPNGBDBM50012244(2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylm...)
Affinity DataIC50: >1.70E+4nMAssay Description:Inhibition of GAR formyltransferase in Lactobacillus caseiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University Of South Alabama

Curated by ChEMBL
LigandPNGBDBM50012244(2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylm...)
Affinity DataIC50: >1.70E+4nMAssay Description:Inhibition of thymidyllate synthase in Lactobacillus caseiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50012244(2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylm...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of dihydrofolate reductase in Lactobacillus caseiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Lactobacillus casei)
University Of South Alabama

Curated by ChEMBL
LigandPNGBDBM50012244(2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylm...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of dihydrofolate reductase in Lactobacillus caseiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50010931(2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethyl]-benzoyl...)
Affinity DataIC50: >5.00E+4nMAssay Description:Compound was evaluated for the inhibition of Folyl-polyglutamate synthase in CCRF-CEM Human leukemia cell.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
University Of South Alabama

Curated by ChEMBL
LigandPNGBDBM50012244(2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylm...)
Affinity DataIC50: >6.00E+4nMAssay Description:Inhibition of AICAR formyltransferase from extract of Manca human lymphoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
University Of South Alabama

Curated by ChEMBL
LigandPNGBDBM50012244(2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylm...)
Affinity DataIC50: >6.00E+4nMAssay Description:Inhibition of AICAR formyltransferase from extract of Manca human lymphoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50010928(2-{4-[1-(2,4-Diamino-pteridin-6-ylmethyl)-propyl]-...)
Affinity DataIC50:  1.18E+5nMAssay Description:Compound was evaluated for the inhibition of Folyl-polyglutamate synthase in CCRF-CEM Human leukemia cell.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50010929(2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethyl]-benzoyl...)
Affinity DataIC50: >2.00E+5nMAssay Description:Compound was evaluated for the inhibition of Folyl-polyglutamate synthase in CCRF-CEM Human leukemia cell.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50010930(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...)
Affinity DataIC50: >2.00E+5nMAssay Description:Compound was evaluated for the inhibition of Folyl-polyglutamate synthase in CCRF-CEM Human leukemia cell.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50010924(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...)
Affinity DataIC50: >2.00E+5nMAssay Description:Compound was evaluated for the inhibition of Folyl-polyglutamate synthase in CCRF-CEM Human leukemia cell.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed