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Found 850 with Last Name = 'ganguly' and Initial = 'a'
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50034711((1R,2S)-2-(1H-Imidazol-4-yl)-1-methyl-propylamine ...)
Affinity DataKi:  0.800nMAssay Description:Binding afinity against Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM22904((2R)-1-(1H-imidazol-5-yl)propan-2-amine | (R)-alph...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity of compound towards Histamine H3 receptor was determined in guinea pig brain tissue using [3H]- N alpha-methylhistamine radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM22904((2R)-1-(1H-imidazol-5-yl)propan-2-amine | (R)-alph...)
Affinity DataKi:  1.5nMAssay Description:Binding afinity against Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50135734(1,7,9-Trimethyl-1,4,5,6-tetrahydro-8-thia-1,2-diaz...)
Affinity DataKi:  2nMAssay Description:Binding affinity to recombinant human dopamine receptor D4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50069825(4-Pyrrolidin-3-yl-1H-imidazole | CHEMBL79983)
Affinity DataKi:  2nMAssay Description:Inhibition of [3H]-N-alpha-methylhistamine binding to guinea pig brain Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50069816(4-((3R,4R)-4-Methyl-pyrrolidin-3-yl)-1H-imidazole ...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of [3H]-N-alpha-methylhistamine binding to guinea pig brain Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50034708(4-((2R,3S)-2-Methyl-pyrrolidin-3-yl)-1H-imidazole ...)
Affinity DataKi:  2.80nMAssay Description:Binding afinity against Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50034708(4-((2R,3S)-2-Methyl-pyrrolidin-3-yl)-1H-imidazole ...)
Affinity DataKi:  2.80nMAssay Description:Binding afinity against Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50069823(4-((3S,4R)-4-Methyl-pyrrolidin-3-yl)-1H-imidazole ...)
Affinity DataKi:  3nMAssay Description:Inhibition of [3H]-N-alpha-methylhistamine binding to guinea pig brain Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50135726(1,6,8-Trimethyl-1,4-dihydro-5,7-dithia-1,2-diaza-a...)
Affinity DataKi:  3nMAssay Description:Binding affinity to recombinant human dopamine receptor D4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50034708(4-((2R,3S)-2-Methyl-pyrrolidin-3-yl)-1H-imidazole ...)
Affinity DataKi:  3nMAssay Description:Inhibition of [3H]-N-alpha-methylhistamine binding to guinea pig brain Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM22868(11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-b...)
Affinity DataKi:  3.90nMAssay Description:Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50069822(4-((3S,4S)-4-Methyl-pyrrolidin-3-yl)-1H-imidazole ...)
Affinity DataKi:  5nMAssay Description:Inhibition of [3H]-N-alpha-methylhistamine binding to guinea pig brain Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM35938(1-(p-chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpro...)
Affinity DataKi:  5.5nMAssay Description:Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM35938(1-(p-chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpro...)
Affinity DataKi:  5.5nMAssay Description:Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50063449(8-Chloro-11-piperazin-1-yl-6,11-dihydro-5H-benzo[5...)
Affinity DataKi:  6.40nMAssay Description:Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50073184(8-Chloro-11-(4-methyl-piperazin-1-yl)-6,11-dihydro...)
Affinity DataKi:  6.5nMAssay Description:Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50069818(4-((2R,3S)-2-Methyl-azetidin-3-yl)-1H-imidazole | ...)
Affinity DataKi:  7nMAssay Description:Inhibition of [3H]-N-alpha-methylhistamine binding to guinea pig brain Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12287(SCH 491762 | tert-butyl N-[(1S)-2-[(1R,2S,5S)-2-[(...)
Affinity DataKi:  8nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
TargetHistamine H1 receptor(RAT)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50281832(1-[4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclo...)
Affinity DataKi:  10nMAssay Description:Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails Article
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50034706((1R,2R)-2-(1H-Imidazol-4-yl)-1-methyl-propylamine ...)
Affinity DataKi:  11nMAssay Description:Binding afinity against Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50135732(1,7,9-Trimethyl-1,4,5,6-tetrahydro-8-oxa-1,2-diaza...)
Affinity DataKi:  11nMAssay Description:Binding affinity to recombinant human dopamine receptor D4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50135710(7,9-Dimethyl-1,4,5,6-tetrahydro-8-thia-1,2-diaza-c...)
Affinity DataKi:  12nMAssay Description:Binding affinity to recombinant human dopamine receptor D4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12309((1R,5S)-N-[3-amino-1-(cyclopropylmethyl)-2,3-dioxo...)
Affinity DataKi:  13nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12311((1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxop...)
Affinity DataKi:  14nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
TargetD(4) dopamine receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50135723(7,9-Dichloro-1-methyl-1,4,5,6-tetrahydro-8-thia-1,...)
Affinity DataKi:  14nMAssay Description:Binding affinity to recombinant human dopamine receptor D4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12307((1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxop...)
Affinity DataKi:  16nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Stevens Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50484345(CHEMBL1835926)
Affinity DataKi:  19nMAssay Description:Inhibition of Human immunodeficiency virus 1 protease activity after 60 mins by HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50061467(1-[4-(8-Chloro-3-hydroxymethyl-5,6-dihydro-benzo[5...)
Affinity DataKi:  20nMAssay Description:Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Stevens Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50484351(CHEMBL1835923)
Affinity DataKi:  20nMAssay Description:Inhibition of Human immunodeficiency virus 1 protease activity after 60 mins by HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHistamine H1 receptor(RAT)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50007464(4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b...)
Affinity DataKi:  21nMAssay Description:Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50135709(1-Ethyl-7,9-dimethyl-1,4,5,6-tetrahydro-8-thia-1,2...)
Affinity DataKi:  22nMAssay Description:Binding affinity to recombinant human dopamine receptor D4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12286(1,1-Dimethylethyl-[1(S)-cyclohexyl-2-[(1R,5S)-2(S)...)
Affinity DataKi:  25nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50135725(1,6,8-Trimethyl-4,5-dihydro-1H-7-thia-1,2-diaza-as...)
Affinity DataKi:  26nMAssay Description:Binding affinity to recombinant human dopamine receptor D4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Stevens Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50484348(CHEMBL1835837)
Affinity DataKi:  27nMAssay Description:Inhibition of Human immunodeficiency virus 1 protease activity after 60 mins by HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50135732(1,7,9-Trimethyl-1,4,5,6-tetrahydro-8-oxa-1,2-diaza...)
Affinity DataKi:  28nMAssay Description:Binding affinity of the compound towards cloned human Dopamine receptor D2 was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Stevens Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50484344(CHEMBL1835928)
Affinity DataKi:  29nMAssay Description:Inhibition of Human immunodeficiency virus 1 protease activity after 60 mins by HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Stevens Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50484349(CHEMBL1835931)
Affinity DataKi:  30nMAssay Description:Inhibition of Human immunodeficiency virus 1 protease activity after 60 mins by HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50034707(4-((2S,3R)-2-Methyl-pyrrolidin-3-yl)-1H-imidazole ...)
Affinity DataKi:  33nMAssay Description:Binding afinity against Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Stevens Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50484347(CHEMBL1835921)
Affinity DataKi:  34nMAssay Description:Inhibition of Human immunodeficiency virus 1 protease activity after 60 mins by HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12308((1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxop...)
Affinity DataKi:  35nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12305((2R)-3-methylbutan-2-yl N-[(2S)-1-[(1R,2S,5S)-2-[(...)
Affinity DataKi:  36nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50281836(1-{4-[8-Chloro-3-(1-hydroxy-ethyl)-5,6-dihydro-ben...)
Affinity DataKi:  40nMAssay Description:Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails Article
TargetHistamine H1 receptor(RAT)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50007461(1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,...)
Affinity DataKi:  48nMAssay Description:Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50073186(4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1...)
Affinity DataKi:  49nMAssay Description:Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12314((1R,5S)-N-[3-amino-1-(cyclopropylmethyl)-2,3-dioxo...)
Affinity DataKi:  50nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12315((1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxop...)
Affinity DataKi:  50nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12292(1,1-Dimethylethyl-[2-[(1R,5S)-2(S)-[[[1-(2-amino-1...)
Affinity DataKi:  50nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12274(1-Methyl-1-Phenylethyl-[[3-[[[(1R,5S)-3-[(S)-cyclo...)
Affinity DataKi:  50nM ΔG°:  -42.4kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50007465(1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,...)
Affinity DataKi:  51nMAssay Description:Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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