Compile Data Set for Download or QSAR
maximum 50k data
Found 93 with Last Name = 'gentry' and Initial = 'c'
TargetCannabinoid receptor 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50072775(2-((1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohe...)
Affinity DataIC50:  0.770nMAssay Description:Displacement of [3H]CP-55940 from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50072775(2-((1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohe...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [3H]CP-55940 human CB2 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
TargetCathepsin S(Homo sapiens (Human))
Novartis

LigandPNGBDBM25138(2-cyano-pyrropyrimidine, 7d | 7-(2-cyclopentylethy...)
Affinity DataIC50:  5nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM21281((11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphth...)
Affinity DataIC50:  8.90nMAssay Description:Displacement of [3H]CP-55940 human CB2 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
TargetCathepsin S(Homo sapiens (Human))
Novartis

LigandPNGBDBM25134(2-cyano-pyrropyrimidine, 2 | 7-(2-cyclohexylethyl)...)
Affinity DataIC50:  9nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Novartis

LigandPNGBDBM25136(2-cyano-pyrropyrimidine, 7b | 7-(2-cyclohexylethyl...)
Affinity DataIC50:  9nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Novartis

LigandPNGBDBM25141(2-cyano-pyrropyrimidine, 7g | 7-[2-(4,4-difluorocy...)
Affinity DataIC50:  10nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Mus musculus (Mouse))
Novartis

LigandPNGBDBM25134(2-cyano-pyrropyrimidine, 2 | 7-(2-cyclohexylethyl)...)
Affinity DataIC50:  10nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Novartis

LigandPNGBDBM25137(2-cyano-pyrropyrimidine, 7c | 7-(2-cyclohexylethyl...)
Affinity DataIC50:  11nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50180699(6(4-chloro-3-ethoxy-phenyl)-7-isopropyl-2-methyl-3...)
Affinity DataIC50:  12nMAssay Description:Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50180715(6-(4-chloro-phenyl)-7-isopropyl-2-methyl-3H-quinaz...)
Affinity DataIC50:  13nMAssay Description:Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Mus musculus (Mouse))
Novartis

LigandPNGBDBM25135(2-cyano-pyrropyrimidine, 7a | 7-(2-cyclohexylethyl...)
Affinity DataIC50:  14nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50180717(6(4-chloro-3-methoxy-phenyl)-7-isopropyl-2-methyl-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50218116(CHEMBL244403 | naphthalen-1-yl-(4-pentyloxynaphtha...)
Affinity DataIC50:  15nMAssay Description:Displacement of [3H]CP-55940 from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Novartis

LigandPNGBDBM25139(2-cyano-pyrropyrimidine, 7e | 7-[2-(4-chlorophenyl...)
Affinity DataIC50:  17nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Novartis

LigandPNGBDBM25135(2-cyano-pyrropyrimidine, 7a | 7-(2-cyclohexylethyl...)
Affinity DataIC50:  18nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50180711(7-tert-butyl-6-(4-chloro-phenyl)-2-thioxo-2,3-dihy...)
Affinity DataIC50:  18nMAssay Description:Inhibition of low pH activation of human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Mus musculus (Mouse))
Novartis

LigandPNGBDBM25141(2-cyano-pyrropyrimidine, 7g | 7-[2-(4,4-difluorocy...)
Affinity DataIC50:  20nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50218116(CHEMBL244403 | naphthalen-1-yl-(4-pentyloxynaphtha...)
Affinity DataIC50:  22nMAssay Description:Inhibition of rat CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50180706(6-(4-chloro-3fluoro-phenyl)-7-isopropyl-2-methyl-3...)
Affinity DataIC50:  23nMAssay Description:Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50180708(7-tert-butyl-6-phenyl-2-thioxo-2,3-dihydro-1H-pyri...)
Affinity DataIC50:  25nMAssay Description:Inhibition of low pH activation of rat TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50218121(CHEMBL390675 | naphthalen-1-yl-(4-pentylaminonapht...)
Affinity DataIC50:  25nMAssay Description:Displacement of [3H]CP-55940 from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50180698(6-1,3-benzdioxolo-5-yl-7-isopropyl-2-methyl-3H-qui...)
Affinity DataIC50:  31nMAssay Description:Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50180719(6-(2,4-dichloro-5-ethoxy-phenyl)-7-isopropyl-2-met...)
Affinity DataIC50:  37nMAssay Description:Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50180701(6(4-chloro-3-propoxy-phenyl)-7-isopropyl-2-methyl-...)
Affinity DataIC50:  40nMAssay Description:Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50180703(6(3-chloro-4-methyl-phenyl)-7-isopropyl-2-methyl-3...)
Affinity DataIC50:  42nMAssay Description:Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50218123(CHEMBL244402 | naphthalen-1-yl-(4-butoxynaphthalen...)
Affinity DataIC50:  48nMAssay Description:Displacement of [3H]CP-55940 from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50180708(7-tert-butyl-6-phenyl-2-thioxo-2,3-dihydro-1H-pyri...)
Affinity DataIC50:  49nMAssay Description:Inhibition of low pH activation of human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Novartis

LigandPNGBDBM25140(2-cyano-pyrropyrimidine, 7f | 7-(2-cycloheptylethy...)
Affinity DataIC50:  50nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50212312(6(4-chloro-3-cyclopropylmethoxy-phenyl)-7-isopropy...)
Affinity DataIC50:  50nMAssay Description:Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Novartis

LigandPNGBDBM25138(2-cyano-pyrropyrimidine, 7d | 7-(2-cyclopentylethy...)
Affinity DataIC50:  79nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50180710(6(3-butoxy-4-chloro-phenyl)-7-isopropyl-2-methyl-3...)
Affinity DataIC50:  82nMAssay Description:Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50218123(CHEMBL244402 | naphthalen-1-yl-(4-butoxynaphthalen...)
Affinity DataIC50:  85nMAssay Description:Displacement of [3H]CP-55940 human CB2 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50180708(7-tert-butyl-6-phenyl-2-thioxo-2,3-dihydro-1H-pyri...)
Affinity DataIC50:  90nMAssay Description:Inhibition of calcium influx evoked by capsaicin in rat TRPV1 expressing cells by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50218120(CHEMBL243334 | naphthalen-1-yl-(4-propoxynaphthale...)
Affinity DataIC50:  90nMAssay Description:Displacement of [3H]CP-55940 human CB2 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50218116(CHEMBL244403 | naphthalen-1-yl-(4-pentyloxynaphtha...)
Affinity DataIC50:  98nMAssay Description:Displacement of [3H]CP-55940 human CB2 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50180718(6-(3-chloro-5-methoxy-phenyl)-7-isopropyl-2-methyl...)
Affinity DataIC50:  100nMAssay Description:Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50180708(7-tert-butyl-6-phenyl-2-thioxo-2,3-dihydro-1H-pyri...)
Affinity DataIC50:  100nMAssay Description:Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50212312(6(4-chloro-3-cyclopropylmethoxy-phenyl)-7-isopropy...)
Affinity DataIC50:  105nMAssay Description:Inhibition of low pH activation of rat TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50218121(CHEMBL390675 | naphthalen-1-yl-(4-pentylaminonapht...)
Affinity DataIC50:  120nMAssay Description:Displacement of [3H]CP-55940 human CB2 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50180702(2-amino-6-(4-chloro-phenyl)-7-isopropyl-3H-quinazo...)
Affinity DataIC50:  133nMAssay Description:Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM21281((11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphth...)
Affinity DataIC50:  140nMAssay Description:Displacement of [3H]CP-55940 from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50180704(6(4-chloro-3-cyclobutylmethoxy-phenyl)-7-isopropyl...)
Affinity DataIC50:  144nMAssay Description:Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50218119((4-hexyloxynaphthalen-1-yl)naphthalen-1-ylmethanon...)
Affinity DataIC50:  160nMAssay Description:Displacement of [3H]CP-55940 from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50180712(6-(4-chloro-3-isopropoxy-phenyl)-7-isopropyl-2-met...)
Affinity DataIC50:  201nMAssay Description:Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50180713(6-[4-chloro3-(2-methoxy-ethoxy)-phenyl]-7-isopropy...)
Affinity DataIC50:  216nMAssay Description:Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50180714(6(3-ethoxy-4-methoxy-phenyl)-7-isopropyl-2-methyl-...)
Affinity DataIC50:  286nMAssay Description:Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Novartis

LigandPNGBDBM25137(2-cyano-pyrropyrimidine, 7c | 7-(2-cyclohexylethyl...)
Affinity DataIC50:  290nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50218120(CHEMBL243334 | naphthalen-1-yl-(4-propoxynaphthale...)
Affinity DataIC50:  300nMAssay Description:Displacement of [3H]CP-55940 from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM20284(CHEMBL391997 | CPZ | Capsazepine | N-[2-(4-chlorop...)
Affinity DataIC50:  334nMAssay Description:Inhibition of calcium influx evoked by capsaicin in human TRPV1 expressing cells by fluorescence assayMore data for this Ligand-Target Pair
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