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Found 46 with Last Name = 'ginetti' and Initial = 'a'
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM362044(US10272077, Example 4 | US9833448, Example 4)
Affinity DataKi:  0.0150nMAssay Description:The binding of 125I-CGRP to receptors in SK-N-MC cell membranes was carried out essentially as described (Edvinsson et al. (2001) Eur. J. Pharmacol. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM362171(US10272077, Example 5 | US9833448, Example 5)
Affinity DataKi:  0.0170nMAssay Description:The binding of 125I-CGRP to receptors in SK-N-MC cell membranes was carried out essentially as described (Edvinsson et al. (2001) Eur. J. Pharmacol. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM381649(US10272077, Example 17)
Affinity DataKi:  0.0550nMAssay Description:The binding of 125I-CGRP to receptors in SK-N-MC cell membranes was carried out essentially as described (Edvinsson et al. (2001) Eur. J. Pharmacol. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361595(US10272077, Example 3 | US9833448, Example 3)
Affinity DataKi:  0.0670nMAssay Description:The binding of 125I-CGRP to receptors in SK-N-MC cell membranes was carried out essentially as described (Edvinsson et al. (2001) Eur. J. Pharmacol. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361594(US10272077, Example 1 | US9833448, Example 1)
Affinity DataKi:  0.0670nMAssay Description:The binding of 125I-CGRP to receptors in SK-N-MC cell membranes was carried out essentially as described (Edvinsson et al. (2001) Eur. J. Pharmacol. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM362175(US10272077, Example 26 | US9833448, Example 26)
Affinity DataKi:  0.0930nMAssay Description:The binding of 125I-CGRP to receptors in SK-N-MC cell membranes was carried out essentially as described (Edvinsson et al. (2001) Eur. J. Pharmacol. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM362176(US10272077, Example 30 | US9833448, Example 30)
Affinity DataKi:  0.140nMAssay Description:The binding of 125I-CGRP to receptors in SK-N-MC cell membranes was carried out essentially as described (Edvinsson et al. (2001) Eur. J. Pharmacol. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM362177(US10272077, Example 31 | US9833448, Example 31)
Affinity DataKi:  0.170nMAssay Description:The binding of 125I-CGRP to receptors in SK-N-MC cell membranes was carried out essentially as described (Edvinsson et al. (2001) Eur. J. Pharmacol. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM362172(US10272077, Example 6 | US9833448, Example 6)
Affinity DataKi:  0.210nMAssay Description:The binding of 125I-CGRP to receptors in SK-N-MC cell membranes was carried out essentially as described (Edvinsson et al. (2001) Eur. J. Pharmacol. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM362173(US10272077, Example 11 | US9833448, Example 11)
Affinity DataKi:  0.25nMAssay Description:The binding of 125I-CGRP to receptors in SK-N-MC cell membranes was carried out essentially as described (Edvinsson et al. (2001) Eur. J. Pharmacol. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50576278(CHEMBL4863002)
Affinity DataKi:  0.920nMAssay Description:Inhibition of human PDE2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50576275(CHEMBL4873599)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human PDE2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50576279(CHEMBL4871796)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human PDE2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM362180(US10272077, Example 8 from US 2010/0179166 | US983...)
Affinity DataKi:  1.70nMAssay Description:The binding of 125I-CGRP to receptors in SK-N-MC cell membranes was carried out essentially as described (Edvinsson et al. (2001) Eur. J. Pharmacol. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50576271(CHEMBL4877091)
Affinity DataKi:  1.70nMAssay Description:Inhibition of human PDE2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM385964(US10287293, Example 13 | US10287293, Example 14)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human PDE2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM362179(US10272077, Example 9 from U.S. Pat. No. 7,390,798...)
Affinity DataKi:  1.90nMAssay Description:The binding of 125I-CGRP to receptors in SK-N-MC cell membranes was carried out essentially as described (Edvinsson et al. (2001) Eur. J. Pharmacol. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50576277(CHEMBL4878348)
Affinity DataKi:  2.60nMAssay Description:Inhibition of human PDE2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM362181(US10272077, Example 32 from U.S. Pat. No. 7,390,79...)
Affinity DataKi:  4.30nMAssay Description:The binding of 125I-CGRP to receptors in SK-N-MC cell membranes was carried out essentially as described (Edvinsson et al. (2001) Eur. J. Pharmacol. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM385962(US10287293, Example 11 | US10287293, Example 12)
Affinity DataKi:  7nMAssay Description:Inhibition of human PDE2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM362178(US10272077, Example 8 from U.S. Pat. No. 7,390,798...)
Affinity DataKi:  7.40nMAssay Description:The binding of 125I-CGRP to receptors in SK-N-MC cell membranes was carried out essentially as described (Edvinsson et al. (2001) Eur. J. Pharmacol. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM385952(US10287293, Example 1 | US10287293, Example 2)
Affinity DataKi:  15nMAssay Description:Inhibition of human PDE2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50576268(CHEMBL4853336)
Affinity DataKi:  27nMAssay Description:Inhibition of human PDE2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50576272(CHEMBL4867001)
Affinity DataKi:  27nMAssay Description:Inhibition of human PDE2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM385954(US10287293, Example 3 | US10287293, Example 4)
Affinity DataKi:  65nMAssay Description:Inhibition of human PDE2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM385976(US10287293, Example 25)
Affinity DataKi:  70nMAssay Description:Inhibition of human PDE2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50576273(CHEMBL4850240)
Affinity DataKi:  178nMAssay Description:Inhibition of human PDE2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50576276(CHEMBL4859356)
Affinity DataKi:  208nMAssay Description:Inhibition of human PDE2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50576270(CHEMBL4858230)
Affinity DataKi:  293nMAssay Description:Inhibition of human PDE2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50576274(CHEMBL4859231)
Affinity DataKi:  324nMAssay Description:Inhibition of human PDE2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM385970(US10287293, Example 19 | US10287293, Example 20)
Affinity DataKi:  521nMAssay Description:Inhibition of human PDE2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50576269(CHEMBL4873986)
Affinity DataKi:  2.36E+3nMAssay Description:Inhibition of human PDE2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50576279(CHEMBL4871796)
Affinity DataIC50:  600nMAssay Description:Inhibition of human PDE11More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50576279(CHEMBL4871796)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of human PDE4More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50576275(CHEMBL4873599)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of human PDE4More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50576279(CHEMBL4871796)
Affinity DataIC50:  5.80E+3nMAssay Description:Inhibition of human PDE10More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50576275(CHEMBL4873599)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of human PDE11More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50576279(CHEMBL4871796)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of human PDE6More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50576275(CHEMBL4873599)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of human PDE10More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50576279(CHEMBL4871796)
Affinity DataIC50:  2.10E+4nMAssay Description:Inhibition of human PDE5More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50576275(CHEMBL4873599)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibition of human PDE5More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50576275(CHEMBL4873599)
Affinity DataIC50:  2.70E+4nMAssay Description:Inhibition of human PDE6More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50576275(CHEMBL4873599)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human PDE9More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50576279(CHEMBL4871796)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human PDE9More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50576275(CHEMBL4873599)
Affinity DataIC50: >7.50E+4nMAssay Description:Inhibition of human PDE7More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50576279(CHEMBL4871796)
Affinity DataIC50: >7.50E+4nMAssay Description:Inhibition of human PDE7More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed