BindingDB PrimarySearch_ki

Found 231 with Last Name = 'goto' and Initial = 't'

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM14774(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)

IC50: 0.490nMAssay Description:Inhibition of recombinant human PDE4B using cAMP as substrate after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM14774(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)

IC50: 0.490nMAssay Description:Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50495787(CHEMBL3114956)

IC50: 3nMAssay Description:Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50493949(CHEMBL2442479)

IC50: 3.70nMAssay Description:Inhibition of recombinant human PDE4B using cAMP as substrate after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50495791(CHEMBL3114958)

IC50: 3.80nMAssay Description:Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50495777(CHEMBL3114948)

IC50: 4.60nMAssay Description:Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50491736(CHEMBL2385759)

IC50: 4.70nMAssay Description:Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50495793(CHEMBL3114950)

IC50: 5.20nMAssay Description:Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50495778(CHEMBL3114957)

IC50: 5.90nMAssay Description:Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50491737(CHEMBL2385757)

IC50: 6.60nMAssay Description:Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50493958(CHEMBL2442473)

IC50: 7.10nMAssay Description:Inhibition of recombinant human PDE4B using cAMP as substrate after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50493947(CHEMBL2442465)

IC50: 7.30nMAssay Description:Inhibition of recombinant human PDE4B using cAMP as substrate after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50491759(CHEMBL2385755 | US11401286, Example 270)

IC50: 7.5nMAssay Description:Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50495788(CHEMBL3114954)

IC50: 7.5nMAssay Description:Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50493961(CHEMBL2442478)

IC50: 8.20nMAssay Description:Inhibition of recombinant human PDE4B using cAMP as substrate after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50495755(CHEMBL3114955)

IC50: 8.20nMAssay Description:Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50493946(CHEMBL2442472)

IC50: 8.30nMAssay Description:Inhibition of recombinant human PDE4B using cAMP as substrate after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50495762(CHEMBL3114945)

IC50: 8.30nMAssay Description:Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

KEGG PC cid PC sid

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50495779(CHEMBL3114953)

IC50: 9.90nMAssay Description:Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50495781(CHEMBL3114947)

IC50: 10nMAssay Description:Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

KEGG PC cid PC sid

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50495789(CHEMBL3114936)

IC50: 10nMAssay Description:Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

KEGG PC cid PC sid

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50495771(CHEMBL3112613)

IC50: 11nMAssay Description:Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

KEGG PC cid PC sid

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50493962(CHEMBL2442470)

IC50: 11nMAssay Description:Inhibition of recombinant human PDE4B using cAMP as substrate after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50491753(CHEMBL2385758)

IC50: 11nMAssay Description:Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50493950(CHEMBL2442477)

IC50: 11nMAssay Description:Inhibition of recombinant human PDE4B using cAMP as substrate after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50493948(CHEMBL2442462)

IC50: 13nMAssay Description:Inhibition of recombinant human PDE4B using cAMP as substrate after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50495774(CHEMBL3114940)

IC50: 13nMAssay Description:Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

KEGG PC cid PC sid

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50495763(CHEMBL3114944)

IC50: 14nMAssay Description:Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

KEGG PC cid PC sid

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50495761(CHEMBL3114949)

IC50: 16nMAssay Description:Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50491738(CHEMBL2385753 | US11401286, Example 269)

IC50: 16nMAssay Description:Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50493957(CHEMBL2442461)

IC50: 16nMAssay Description:Inhibition of recombinant human PDE4B using cAMP as substrate after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50493953(CHEMBL2442469)

IC50: 16nMAssay Description:Inhibition of recombinant human PDE4B using cAMP as substrate after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50495760(CHEMBL3114941)

IC50: 19nMAssay Description:Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

KEGG PC cid PC sid

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50495782(CHEMBL3114946)

IC50: 20nMAssay Description:Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

KEGG PC cid PC sid

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50491754(CHEMBL2385756)

IC50: 22nMAssay Description:Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50491740(CHEMBL2385749)

IC50: 25nMAssay Description:Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

KEGG PC cid PC sid

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50491751(CHEMBL2385754)

IC50: 27nMAssay Description:Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50491739(CHEMBL2385750)

IC50: 28nMAssay Description:Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

KEGG PC cid PC sid

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50493966(CHEMBL2442475)

IC50: 29nMAssay Description:Inhibition of recombinant human PDE4B using cAMP as substrate after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50491761(CHEMBL2385573)

IC50: 29nMAssay Description:Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

KEGG PC cid PC sid

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50491746(CHEMBL2385559)

IC50: 29nMAssay Description:Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

KEGG PC cid PC sid

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50495764(CHEMBL3114943)

IC50: 30nMAssay Description:Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

KEGG PC cid PC sid

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50495772(CHEMBL3114926)

IC50: 30nMAssay Description:Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

KEGG PC cid PC sid

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50491735(CHEMBL2385761)

IC50: 33nMAssay Description:Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50495769(CHEMBL3114929)

IC50: 34nMAssay Description:Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

KEGG PC cid PC sid

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50495786(CHEMBL3114928)

IC50: 38nMAssay Description:Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

KEGG PC cid PC sid

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50495783(CHEMBL3114942)

IC50: 38nMAssay Description:Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

KEGG PC cid PC sid

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50495766(CHEMBL3114935)

IC50: 38nMAssay Description:Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

KEGG PC cid PC sid

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50491750(CHEMBL2385760)

IC50: 43nMAssay Description:Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL

PNG

BDBM50495767(CHEMBL3114934)

IC50: 44nMAssay Description:Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

KEGG PC cid PC sid

Details Article PubMed

Displayed 1 to 50 (of 231 total ) | Next | Last >>

Filter my 231 hits

Targets 11▿
- cAMP-specific 3',5'-cyclic phosphodiesterase 4B 93
- Cytochrome P450 2D6 46
- cAMP-specific 3',5'-cyclic phosphodiesterase 4D 45
- Potassium voltage-gated channel subfamily H member 2 13
- Sphingosine 1-phosphate receptor 3 9
- Sphingosine 1-phosphate receptor 1 9
- Cytochrome P450 1A2 5
- Cytochrome P450 2C9 5
- Cytochrome P450 2C19 3
- Androgen receptor 2
- Gag-Pol polyprotein [489-587] 1
- ...
Publications 9▿
- Bioorg Med Chem Lett 24: 893-9 (2014) 87
- Bioorg Med Chem Lett 23: 3325-8 (2013) 28
- Bioorg Med Chem 23: 4638-48 (2015) 28
- Bioorg Med Chem 23: 4624-37 (2015) 26
- Bioorg Med Chem 21: 7025-37 (2013) 23
- Bioorg Med Chem 22: 4246-56 (2014) 18
- Bioorg Med Chem 22: 6899-907 (2014) 18
- Bioorg Med Chem 16: 8022-8 (2008) 2
- Bioorg Med Chem Lett 10: 1227-31 (2000) 1
Institutions 5▿
- Kyushu University 110
- Astellas Pharma 72
- Daiichi Sankyo 46
- Tohoku Pharmaceutical University 2
- Kyoto Pharmaceutical University 1
Affinity: 0.49 to 1.0E+5 nM▿
- IC50 212
- EC50 19
- Affinity ≤ nM
Xtal structures: 5
Docked structures: 0
Catalog Cmpds: 5