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Found 674 with Last Name = 'gowers' and Initial = 'l'
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50218255(CHEMBL290100)
Affinity DataIC50:  1nMAssay Description:Inhibition of Phosphodiesterase 4 (PDE-4) from human U937 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50377180(CHEMBL401633)
Affinity DataIC50:  1nMAssay Description:Inhibition of IRAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50377170(CHEMBL256570 | US11254667, Compound I-2 | US115422...)
Affinity DataIC50:  1nMAssay Description:Inhibition of IRAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50218255(CHEMBL290100)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of Phosphodiesterase 4 from human U937 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50377165(CHEMBL255867)
Affinity DataIC50:  2nMAssay Description:Inhibition of IRAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50218257(CHEMBL69874)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of Phosphodiesterase 4 from human U937 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50271563(CHEMBL482708 | N-cyclohexyl-4-(H-imidazo[1,2-a]pyr...)
Affinity DataIC50:  3nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50377175(CHEMBL436653)
Affinity DataIC50:  3nMAssay Description:Inhibition of IRAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50219014(CHEMBL149559)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human phosphodiesterase 4 from U937 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50377168(CHEMBL255873)
Affinity DataIC50:  4nMAssay Description:Inhibition of IRAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50264777(6,6-dimethyl-2-(6-(6-methylpyridazin-3-ylamino)-2H...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50265362(2-(6-(1-(3-aminopropyl)-3-methyl-1H-pyrazol-4-yl)-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50265318(6,6-dimethyl-2-(6-(1-(pyridin-3-ylmethyl)-1H-pyraz...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50265317(2-(6-(1-benzyl-1H-pyrazol-4-yl)-2H-benzo[b][1,4]ox...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50377163(CHEMBL403358)
Affinity DataIC50:  5nMAssay Description:Inhibition of IRAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50211428(CHEMBL245936 | N-ethyl-4-(4-(2-phenyl-1H-indol-3-y...)
Affinity DataIC50:  5nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50211428(CHEMBL245936 | N-ethyl-4-(4-(2-phenyl-1H-indol-3-y...)
Affinity DataIC50:  5nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50377181(CHEMBL256963 | US11254667, Compound I-15 | US11542...)
Affinity DataIC50:  6nMAssay Description:Inhibition of IRAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50377169(CHEMBL402629)
Affinity DataIC50:  6nMAssay Description:Inhibition of IRAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50264873(6,6-dimethyl-2-(6-(6-phenylpyridazin-3-ylamino)-2H...)
Affinity DataIC50:  6nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50218258(CHEMBL70146)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of Phosphodiesterase 4 from human U937 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Celltech-Chiroscience

Curated by ChEMBL
LigandPNGBDBM50218245(CHEMBL65799)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of rolipram binding to rat brain tissue at 20 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50218245(CHEMBL65799)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of Phosphodiesterase 4 from human U937 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50377186(CHEMBL403433)
Affinity DataIC50:  7nMAssay Description:Inhibition of IRAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Celltech-Chiroscience

Curated by ChEMBL
LigandPNGBDBM50114418(8-Methoxy-2-trifluoromethyl-quinoline-5-carboxylic...)
Affinity DataIC50:  7nMAssay Description:Inhibition of rolipram binding to PDE4 of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50264872(2-(6-(6-methoxypyridazin-3-ylamino)-2H-benzo[b][1,...)
Affinity DataIC50:  7nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50377166(CHEMBL255446)
Affinity DataIC50:  7nMAssay Description:Inhibition of IRAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50377167(CHEMBL402361)
Affinity DataIC50:  8nMAssay Description:Inhibition of IRAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50265319(2-(6-(1,3-dimethyl-1H-pyrazol-4-yl)-2H-benzo[b][1,...)
Affinity DataIC50:  8nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Celltech-Chiroscience

Curated by ChEMBL
LigandPNGBDBM50218257(CHEMBL69874)
Affinity DataIC50:  8.10nMAssay Description:Inhibition of rolipram binding to rat brain tissue at 20 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50218246(CHEMBL68323)
Affinity DataIC50:  8.60nMAssay Description:Inhibition of Phosphodiesterase 4 from human U937 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50377179(CHEMBL256961)
Affinity DataIC50:  9nMAssay Description:Inhibition of IRAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50213867(CHEMBL329303)
Affinity DataIC50:  9nMAssay Description:Inhibition of rolipram bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50264748((R)-2-(6-(1-(2-hydroxy-3-methoxypropyl)-1H-pyrazol...)
Affinity DataIC50:  9nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50377172(CHEMBL404473)
Affinity DataIC50:  10nMAssay Description:Inhibition of IRAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50138394(4-{4-[4-(Piperazine-1-sulfonyl)-phenyl]-pyrimidin-...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity against IKK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50264871(2-(6-(6-(dimethylamino)pyridazin-3-ylamino)-2H-ben...)
Affinity DataIC50:  12nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50211436(2-(4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamin...)
Affinity DataIC50:  13nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50211424(4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-...)
Affinity DataIC50:  13nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50211436(2-(4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamin...)
Affinity DataIC50:  14nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50265364((S)-2-(6-(1-(2-hydroxy-3-methoxypropyl)-1H-pyrazol...)
Affinity DataIC50:  14nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50211430((4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)...)
Affinity DataIC50:  14nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50219013(CHEMBL343205)
Affinity DataIC50:  14nMAssay Description:Inhibition of human phosphodiesterase 4 from U937 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50265282(2-(6-(1-(2-hydroxy-3-methoxypropyl)-1H-pyrazol-4-y...)
Affinity DataIC50:  14nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50377178(CHEMBL402174)
Affinity DataIC50:  15nMAssay Description:Inhibition of IRAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50211438(4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-...)
Affinity DataIC50:  15nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50211426(2-((R)-3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl...)
Affinity DataIC50:  15nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50211443((3S)-3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylam...)
Affinity DataIC50:  15nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50211430((4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)...)
Affinity DataIC50:  15nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50262173(2-(6-(1H-pyrazol-4-yl)-2,3-dihydrobenzo[b][1,4]oxa...)
Affinity DataIC50:  16nMAssay Description:Inhibition of PI3K delta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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