BindingDB PrimarySearch_ki

Found 201 with Last Name = 'harp' and Initial = 'jm'

Translocator protein(Rattus norvegicus (rat))
Vanderbilt University Institute Of Imaging Science (Vuiis)

Curated by ChEMBL

PNG

BDBM50430877(CHEMBL2336480)

Ki: 0.180nMAssay Description:Displacement of [3H]-PK 11195 from TSPO in rat C6 cell lysates after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Translocator protein(Rattus norvegicus (rat))
Vanderbilt University Institute Of Imaging Science (Vuiis)

Curated by ChEMBL

PNG

BDBM50430878(CHEMBL2336474)

Ki: 0.270nMAssay Description:Displacement of [3H]-PK 11195 from TSPO in rat C6 cell lysates after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Translocator protein(Rattus norvegicus (rat))
Vanderbilt University Institute Of Imaging Science (Vuiis)

Curated by ChEMBL

PNG

BDBM50243007(2-(2-(4-(2-Fluoroethoxy)phenyl)-5,7-dimethylpyrazo...)

Ki: 9.70nMAssay Description:Displacement of [3H]-PK 11195 from TSPO in rat C6 cell lysates after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid Patents Similars

Details Article PubMed

Translocator protein(Rattus norvegicus (rat))
Vanderbilt University Institute Of Imaging Science (Vuiis)

Curated by ChEMBL

PNG

BDBM50327238(2-[2-(4'-Methoxyphenyl)-5,7-dimethylpyrazolo[1,5-a...)

Ki: 12nMAssay Description:Displacement of [3H]-PK 11195 from TSPO in rat C6 cell lysates after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid Patents Similars

Details Article PubMed

Muscarinic acetylcholine receptor M4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

PNG

BDBM50596239(CHEMBL5189893)

Ki: 43nMAssay Description:Displacement of [3H]-NMS from human muscarinic acetylcholine M4 receptor expressed in CHO cell membrane by competitive binding assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Translocator protein(Rattus norvegicus (rat))
Vanderbilt University Institute Of Imaging Science (Vuiis)

Curated by ChEMBL

PNG

BDBM50430876(CHEMBL2336473)

Ki: 55nMAssay Description:Displacement of [3H]-PK 11195 from TSPO in rat C6 cell lysates after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Translocator protein(Rattus norvegicus (rat))
Vanderbilt University Institute Of Imaging Science (Vuiis)

Curated by ChEMBL

PNG

BDBM50430887(CHEMBL2336479)

Ki: 68nMAssay Description:Displacement of [3H]-PK 11195 from TSPO in rat C6 cell lysates after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Translocator protein(Rattus norvegicus (rat))
Vanderbilt University Institute Of Imaging Science (Vuiis)

Curated by ChEMBL

PNG

BDBM50430886(CHEMBL2336476)

Ki: 83nMAssay Description:Displacement of [3H]-PK 11195 from TSPO in rat C6 cell lysates after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Translocator protein(Rattus norvegicus (rat))
Vanderbilt University Institute Of Imaging Science (Vuiis)

Curated by ChEMBL

PNG

BDBM50430885(CHEMBL2336482)

Ki: 94nMAssay Description:Displacement of [3H]-PK 11195 from TSPO in rat C6 cell lysates after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Translocator protein(Rattus norvegicus (rat))
Vanderbilt University Institute Of Imaging Science (Vuiis)

Curated by ChEMBL

PNG

BDBM50430884(CHEMBL2336483)

Ki: 157nMAssay Description:Displacement of [3H]-PK 11195 from TSPO in rat C6 cell lysates after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Translocator protein(Rattus norvegicus (rat))
Vanderbilt University Institute Of Imaging Science (Vuiis)

Curated by ChEMBL

PNG

BDBM50430883(CHEMBL2336484)

Ki: 201nMAssay Description:Displacement of [3H]-PK 11195 from TSPO in rat C6 cell lysates after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Translocator protein(Rattus norvegicus (rat))
Vanderbilt University Institute Of Imaging Science (Vuiis)

Curated by ChEMBL

PNG

BDBM50430882(CHEMBL2336478)

Ki: 252nMAssay Description:Displacement of [3H]-PK 11195 from TSPO in rat C6 cell lysates after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Translocator protein(Rattus norvegicus (rat))
Vanderbilt University Institute Of Imaging Science (Vuiis)

Curated by ChEMBL

PNG

BDBM50430881(CHEMBL2336477)

Ki: 277nMAssay Description:Displacement of [3H]-PK 11195 from TSPO in rat C6 cell lysates after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Translocator protein(Rattus norvegicus (rat))
Vanderbilt University Institute Of Imaging Science (Vuiis)

Curated by ChEMBL

PNG

BDBM50430879(CHEMBL2336475)

Ki: >500nMAssay Description:Displacement of [3H]-PK 11195 from TSPO in rat C6 cell lysates after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Translocator protein(Rattus norvegicus (rat))
Vanderbilt University Institute Of Imaging Science (Vuiis)

Curated by ChEMBL

PNG

BDBM50430880(CHEMBL2336481)

Ki: >500nMAssay Description:Displacement of [3H]-PK 11195 from TSPO in rat C6 cell lysates after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Substance-P receptor(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL

PNG

BDBM50283472(CHEMBL4160748)

Ki: 650nMAssay Description:Displacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting methodMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Muscarinic acetylcholine receptor M4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

PNG

BDBM50596231(CHEMBL5182783)

IC50: 1.80nMAssay Description:Inhibition of human muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Muscarinic acetylcholine receptor M4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

PNG

BDBM50596231(CHEMBL5182783)

IC50: 1.80nMAssay Description:Inhibition of human muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Muscarinic acetylcholine receptor M4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

PNG

BDBM50596229(CHEMBL5205163)

IC50: 12nMAssay Description:Inhibition of human muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Muscarinic acetylcholine receptor M4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

PNG

BDBM50596229(CHEMBL5205163)

IC50: 12nMAssay Description:Inhibition of human muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Muscarinic acetylcholine receptor M4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

PNG

BDBM50596242(CHEMBL5185664)

IC50: 18nMAssay Description:Inhibition of human muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Muscarinic acetylcholine receptor M4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

PNG

BDBM50596230(CHEMBL5178468)

IC50: 28nMAssay Description:Inhibition of human muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Muscarinic acetylcholine receptor M4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

PNG

BDBM50596230(CHEMBL5178468)

IC50: 28nMAssay Description:Inhibition of human muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Muscarinic acetylcholine receptor M4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

PNG

BDBM50596237(CHEMBL5172967)

IC50: 33nMAssay Description:Inhibition of human muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Muscarinic acetylcholine receptor M4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

PNG

BDBM50596237(CHEMBL5172967)

IC50: 33nMAssay Description:Inhibition of human muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Muscarinic acetylcholine receptor M4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

PNG

BDBM50596237(CHEMBL5172967)

IC50: 42nMAssay Description:Inhibition of human muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Muscarinic acetylcholine receptor M4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

PNG

BDBM50596237(CHEMBL5172967)

IC50: 42nMAssay Description:Inhibition of human muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Muscarinic acetylcholine receptor M4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

PNG

BDBM50596236(CHEMBL5173887)

IC50: 51nMAssay Description:Inhibition of human muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Muscarinic acetylcholine receptor M4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

PNG

BDBM50596236(CHEMBL5173887)

IC50: 52nMAssay Description:Inhibition of human muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Muscarinic acetylcholine receptor M4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

PNG

BDBM50596234(CHEMBL5203077)

IC50: 54nMAssay Description:Inhibition of human muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Muscarinic acetylcholine receptor M4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

PNG

BDBM50596234(CHEMBL5203077)

IC50: 54nMAssay Description:Inhibition of human muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Muscarinic acetylcholine receptor M4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

PNG

BDBM50596239(CHEMBL5189893)

IC50: 71nMAssay Description:Inhibition of human muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Muscarinic acetylcholine receptor M4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

PNG

BDBM50596239(CHEMBL5189893)

IC50: 71nMAssay Description:Inhibition of human muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Muscarinic acetylcholine receptor M4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

PNG

BDBM50596233(CHEMBL5207446)

IC50: 72nMAssay Description:Inhibition of human muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Muscarinic acetylcholine receptor M4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

PNG

BDBM50596233(CHEMBL5207446)

IC50: 72nMAssay Description:Inhibition of human muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Muscarinic acetylcholine receptor M4(RAT)
Vanderbilt University Medical Center

Curated by ChEMBL

PNG

BDBM50596229(CHEMBL5205163)

IC50: 81nMAssay Description:Inhibition of rat muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentrati...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Muscarinic acetylcholine receptor M4(RAT)
Vanderbilt University Medical Center

Curated by ChEMBL

PNG

BDBM50596229(CHEMBL5205163)

IC50: 81nMAssay Description:Inhibition of rat muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentrati...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Muscarinic acetylcholine receptor M4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

PNG

BDBM50596232(CHEMBL5185022)

IC50: 120nMAssay Description:Inhibition of human muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Muscarinic acetylcholine receptor M4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

PNG

BDBM50596232(CHEMBL5185022)

IC50: 123nMAssay Description:Inhibition of human muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Muscarinic acetylcholine receptor M4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

PNG

BDBM50596238(CHEMBL5198423)

IC50: 126nMAssay Description:Inhibition of human muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Muscarinic acetylcholine receptor M4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

PNG

BDBM50596238(CHEMBL5198423)

IC50: 130nMAssay Description:Inhibition of human muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Muscarinic acetylcholine receptor M4(RAT)
Vanderbilt University Medical Center

Curated by ChEMBL

PNG

BDBM50596242(CHEMBL5185664)

IC50: 228nMAssay Description:Inhibition of rat muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentrati...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Muscarinic acetylcholine receptor M4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

PNG

BDBM50596235(CHEMBL5204478)

IC50: 275nMAssay Description:Inhibition of human muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Muscarinic acetylcholine receptor M4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

PNG

BDBM50596235(CHEMBL5204478)

IC50: 280nMAssay Description:Inhibition of human muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentra...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Cytochrome P450 1A2(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL

PNG

BDBM50283479(CHEMBL4165248)

IC50: 330nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 15 mins followed by NADPH addition measured after 8 min...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details Article PubMed

Muscarinic acetylcholine receptor M4(RAT)
Vanderbilt University Medical Center

Curated by ChEMBL

PNG

BDBM50596230(CHEMBL5178468)

IC50: 525nMAssay Description:Inhibition of rat muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentrati...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Muscarinic acetylcholine receptor M4(RAT)
Vanderbilt University Medical Center

Curated by ChEMBL

PNG

BDBM50596230(CHEMBL5178468)

IC50: 530nMAssay Description:Inhibition of rat muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentrati...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Cytochrome P450 2D6(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

PNG

BDBM50596237(CHEMBL5172967)

IC50: 550nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using cocktail of isoform-specific probe substrateMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Metabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Vanderbilt University

Curated by ChEMBL

PNG

BDBM50280374(CHEMBL4174742)

IC50: 650nMAssay Description:Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as decrease in glutamate-induced thallium...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

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Cytochrome P450 1A2(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL

PNG

BDBM50283483(CHEMBL2361777)

IC50: 690nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 15 mins followed by NADPH addition measured after 8 min...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase PC cid PC sid Similars

Details Article PubMed

Displayed 1 to 50 (of 201 total ) | Next | Last >>

Filter my 201 hits

Targets 19▿
- Muscarinic acetylcholine receptor M4 39
- Metabotropic glutamate receptor 7 36
- Metabotropic glutamate receptor 4 16
- Metabotropic glutamate receptor 8 16
- Translocator protein 14
- Cytochrome P450 1A2 13
- Cytochrome P450 2C9 13
- Cytochrome P450 2D6 13
- Cytochrome P450 3A4 12
- Muscarinic acetylcholine receptor M2 9
- Muscarinic acetylcholine receptor M5 5
- Substance-P receptor 2
- Metabotropic glutamate receptor 2 2
- Metabotropic glutamate receptor 1 2
- Metabotropic glutamate receptor 3 2
- Metabotropic glutamate receptor 6 2
- Muscarinic acetylcholine receptor M1 2
- Metabotropic glutamate receptor 5 2
- Muscarinic acetylcholine receptor M3 1
- ...
Publications 4▿
- ACS Med Chem Lett 8: 1110-1115 (2017) 100
- Bioorg Med Chem Lett 56: (2022) 78
- J Med Chem 56: 3429-33 (2013) 14
- J Med Chem 56: 9351-5 (2013) 9
Institutions 3▿
- Vanderbilt University 109
- Vanderbilt University Medical Center 78
- Vanderbilt University Institute Of Imaging Science (Vuiis) 14
Affinity: 0.18 to 3.2E+4 nM▿
- Ki 16
- IC50 115
- EC50 70
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 11