Affinity DataKi: 0.00230nMAssay Description:Inhibition of trypsin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.0300nMAssay Description:Inhibition of beta-trypsin (unknown origin) using Bz-FVRpNA substrate by spectrophotometry methodMore data for this Ligand-Target Pair
Affinity DataKi: 0.0700nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
TargetCathepsin S(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataKi: <0.100nMAssay Description:Inhibition of human recombinant cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Inhibition of trypsin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Inhibition of KLK4 (unknown origin) expressed in sf9 cells using Ac-FVQR-pNA as substrate preincubated for 30 mins followed by substrate addition and...More data for this Ligand-Target Pair
Affinity DataKi: 0.130nMAssay Description:Inhibition of KLK4 (unknown origin) expressed in sf9 cells using Ac-FVQR-pNA as substrate preincubated for 30 mins followed by substrate addition and...More data for this Ligand-Target Pair
Affinity DataKi: 0.160nMAssay Description:Inhibition of trypsin (unknown origin) using Bz-FVRpNA as substrate incubated for 30 mins measured for 7 mins by morrison plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.160nMAssay Description:Inhibition of beta-trypsin (unknown origin) using Bz-FVRpNA substrate by spectrophotometry methodMore data for this Ligand-Target Pair
Affinity DataKi: 0.260nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
Affinity DataKi: 0.280nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Inhibition of KLK4 (unknown origin) expressed in sf9 cells using Ac-FVQR-pNA as substrate preincubated for 30 mins followed by substrate addition and...More data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Antagonist activity against human adenosine A2A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.340nMAssay Description:Inhibition of recombinant human KLK5 expressed in expressed in Pichia pastoris X-33 cells using Boc-VPR-MCA as susbtrate measured every 60 secs for 1...More data for this Ligand-Target Pair
Affinity DataKi: 0.390nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Antagonist activity against human adenosine A2A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Inhibition of KLK14 (unknown origin) expressed in Sf9 cells using Ac-YANR-pNA substrate by spectrophotometry methodMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
Affinity DataKi: 0.440nMAssay Description:Inhibition of KLK4 (unknown origin) expressed in sf9 cells using Ac-FVQR-pNA as substrate preincubated for 30 mins followed by substrate addition and...More data for this Ligand-Target Pair
Affinity DataKi: 0.480nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
Affinity DataKi: 0.480nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Antagonist activity against human adenosine A2A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.580nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:Inhibition of trypsin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:Binding affinity to human EP4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
Affinity DataKi: 0.730nMAssay Description:Inhibition of recombinant human KLK5 expressed in expressed in Pichia pastoris X-33 cells using Boc-VPR-MCA as susbtrate measured every 60 secs for 1...More data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Inhibition of KLK7 (unknown origin) expressed in Pichia pastoris X33 using KHLY-pNA substrate by spectrophotometry methodMore data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
Affinity DataKi: 0.940nMAssay Description:Binding affinity to human EP4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.960nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
Affinity DataKi: 0.990nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
TargetCathepsin S(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataKi: 1nM ΔG°: -53.4kJ/molepH: 5.5 T: 2°CAssay Description:The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...More data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Binding affinity to human EP4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Antagonist activity against human adenosine A2A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...More data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
TargetCathepsin K(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataKi: 1.20nMAssay Description:Inhibition of human recombinant cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...More data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Inhibition of KLK14 (unknown origin) expressed in Sf9 cells using Ac-YANR-pNA substrate by spectrophotometry methodMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Inhibition of KLK4 (unknown origin) expressed in sf9 cells using Ac-FVQR-pNA as substrate preincubated for 30 mins followed by substrate addition and...More data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Displacement of [3H]citalopram from SERTMore data for this Ligand-Target Pair