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Found 152 with Last Name = 'hechenberger' and Initial = 'm'
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231755(6,6-dimethyl-2-phenylethynyl-7,8-dihydro-6H-quinol...)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231728(5-methoxy-2-phenylethynyl-5,6,7,8-tetrahydro-quino...)
Affinity DataKi:  139nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231738(7,7-dimethyl-2-pyridin-2-ylethynyl-7,8-dihydro-6H-...)
Affinity DataKi:  210nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231741(2-phenylethynyl-7,8-dihydro-6H-quinolin-5-one | CH...)
Affinity DataKi:  800nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231751(6-phenylethynyl-nicotinic acid methyl ester | CHEM...)
Affinity DataKi:  1.40E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231753(2-phenylethynyl-5,6,7,8-tetrahydro-quinoline | CHE...)
Affinity DataKi:  1.50E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231721(2-pyridin-2-ylethynyl-7,8-dihydro-6H-quinolin-5-on...)
Affinity DataKi:  2.36E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231747((R)-2-phenylethynyl-5,6,7,8-tetrahydro-quinolin-5-...)
Affinity DataKi:  4.71E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231719(2-phenylethynyl-5,6,7,8-tetrahydro-quinolin-5-ol |...)
Affinity DataKi:  7.60E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231759((S)-2-phenylethynyl-5,6,7,8-tetrahydro-quinolin-5-...)
Affinity DataKi:  9.28E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231750((3-ethyl-2-methylquinolin-6-yl)(4-methoxycyclohexy...)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231744(CHEMBL399160 | NPS 2390 | quinoxaline-2-carboxylic...)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231749(6-ethyl-5-methyl-3-(1,2,4,5-tetrahydrobenzo[d]azep...)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50231755(6,6-dimethyl-2-phenylethynyl-7,8-dihydro-6H-quinol...)
Affinity DataIC50:  23nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231755(6,6-dimethyl-2-phenylethynyl-7,8-dihydro-6H-quinol...)
Affinity DataIC50:  23nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443088(CHEMBL3087216)
Affinity DataIC50:  27nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438277(CHEMBL2408412)
Affinity DataIC50:  28nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443089(CHEMBL3086715)
Affinity DataIC50:  28nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443089(CHEMBL3086715)
Affinity DataIC50:  28.4nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438295(CHEMBL2408568)
Affinity DataIC50:  34nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443090(CHEMBL3086712)
Affinity DataIC50:  37nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438289(CHEMBL2408574)
Affinity DataIC50:  43nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443091(CHEMBL3087511)
Affinity DataIC50:  47nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443092(CHEMBL3085792)
Affinity DataIC50:  48nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443093(CHEMBL3087217)
Affinity DataIC50:  51nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231748(CHEMBL253347 | quinoline-3-carboxylic acid adamant...)
Affinity DataIC50:  52nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443087(CHEMBL3087214)
Affinity DataIC50:  61nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443086(CHEMBL3087508)
Affinity DataIC50:  65nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438278(CHEMBL2408411)
Affinity DataIC50:  68nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443084(CHEMBL3087220)
Affinity DataIC50:  72nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443085(AFQ056 | Mavoglurant)
Affinity DataIC50:  72nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443083(CHEMBL3087219)
Affinity DataIC50:  76nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231758(2-cyclopentylamino-7,7-dimethyl-5-oxo-5,6,7,8-tetr...)
Affinity DataIC50:  78nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231728(5-methoxy-2-phenylethynyl-5,6,7,8-tetrahydro-quino...)
Affinity DataIC50:  80nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438294(CHEMBL2408569)
Affinity DataIC50:  83nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443082(CHEMBL3087513)
Affinity DataIC50:  85nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438298(CHEMBL2408565)
Affinity DataIC50:  85nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443081(CHEMBL3087212)
Affinity DataIC50:  86nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443080(CHEMBL3087514)
Affinity DataIC50:  103nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443080(CHEMBL3087514)
Affinity DataIC50:  103nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231757(2-[4-(4-fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-yl...)
Affinity DataIC50:  110nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438288(CHEMBL2408575)
Affinity DataIC50:  111nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438305(CHEMBL2408585)
Affinity DataIC50:  120nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438291(CHEMBL2408572)
Affinity DataIC50:  125nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231743(7,7-dimethyl-5-oxo-2-(4-phenyl-piperazin-1-yl)-5,6...)
Affinity DataIC50:  130nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443079(CHEMBL3087225)
Affinity DataIC50:  132nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443078(CHEMBL3087509)
Affinity DataIC50:  137nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438293(CHEMBL2408570)
Affinity DataIC50:  157nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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