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Found 191 with Last Name = 'heintzelman' and Initial = 'gr'
TargetAdenosine receptor A2a(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50161342(2-Amino-4-phenyl-indeno[1,2-d]pyrimidin-5-one | 2-...)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50317007(2-amino-4-(furan-2-yl)-5H-indeno[1,2-d]pyrimidin-5...)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50317008(2-amino-4-(5-chlorofuran-2-yl)-5H-indeno[1,2-d]pyr...)
Affinity DataKi:  0.200nMAssay Description:Antagonist activity at adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156774(CHEMBL3792888)
Affinity DataKi:  0.200nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50317007(2-amino-4-(furan-2-yl)-5H-indeno[1,2-d]pyrimidin-5...)
Affinity DataKi:  0.400nMAssay Description:Antagonist activity at adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156799(CHEMBL3793004)
Affinity DataKi:  0.400nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156784(CHEMBL3792673)
Affinity DataKi:  0.400nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156788(CHEMBL3794104)
Affinity DataKi:  0.400nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50317011(2-amino-4-(thiazol-2-yl)-5H-indeno[1,2-d]pyrimidin...)
Affinity DataKi:  0.5nMAssay Description:Antagonist activity at adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50317008(2-amino-4-(5-chlorofuran-2-yl)-5H-indeno[1,2-d]pyr...)
Affinity DataKi:  0.5nMAssay Description:Antagonist activity at adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156782(CHEMBL3792663)
Affinity DataKi:  0.600nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50317010(2-amino-4-(thiophen-2-yl)-5H-indeno[1,2-d]pyrimidi...)
Affinity DataKi:  0.600nMAssay Description:Antagonist activity at adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156732(CHEMBL3793497)
Affinity DataKi:  0.700nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156683(CHEMBL3793788)
Affinity DataKi:  0.700nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156787(CHEMBL3793404)
Affinity DataKi:  0.800nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50148579(CHEMBL3770836)
Affinity DataKi:  0.800nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156687(CHEMBL3793029)
Affinity DataKi:  0.800nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50316893(2-amino-4-phenyl-8-(2-(pyridin-2-yl)ethylamino)-5H...)
Affinity DataKi:  0.900nMAssay Description:Antagonistic activity at adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50316892(2-amino-4-phenyl-8-(2-(pyridin-4-yl)ethylamino)-5H...)
Affinity DataKi:  0.900nMAssay Description:Antagonistic activity at adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156789(CHEMBL3793505)
Affinity DataKi:  0.900nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156685(CHEMBL3792412)
Affinity DataKi:  0.900nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50317003(2-amino-8-((morpholinoamino)methyl)-4-phenyl-5H-in...)
Affinity DataKi:  1nMAssay Description:Antagonist activity at adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156691(CHEMBL3792435)
Affinity DataKi:  1nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156795(CHEMBL3794270)
Affinity DataKi:  1nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156794(CHEMBL3792666)
Affinity DataKi:  1nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156780(CHEMBL3794298)
Affinity DataKi:  1nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156793(CHEMBL3792921)
Affinity DataKi:  1nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156786(CHEMBL3793489)
Affinity DataKi:  1nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156733(CHEMBL3793296)
Affinity DataKi:  1nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50161342(2-Amino-4-phenyl-indeno[1,2-d]pyrimidin-5-one | 2-...)
Affinity DataKi:  1.10nMAssay Description:Antagonist activity at adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156791(CHEMBL3793969)
Affinity DataKi:  1.20nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156790(CHEMBL3792549)
Affinity DataKi:  1.30nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156783(CHEMBL3792734)
Affinity DataKi:  1.30nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156777(CHEMBL3793516)
Affinity DataKi:  1.30nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50148578(CHEMBL3770730)
Affinity DataKi:  1.5nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156797(CHEMBL3793538)
Affinity DataKi:  1.5nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50317014(2-amino-4-(3-methoxyphenyl)-5H-indeno[1,2-d]pyrimi...)
Affinity DataKi:  1.60nMAssay Description:Antagonist activity at adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156684(CHEMBL3793688)
Affinity DataKi:  1.60nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156688(CHEMBL3792969)
Affinity DataKi:  1.70nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50317003(2-amino-8-((morpholinoamino)methyl)-4-phenyl-5H-in...)
Affinity DataKi:  1.80nMAssay Description:Antagonist activity at adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156711(CHEMBL3792599)
Affinity DataKi:  1.80nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156734(CHEMBL3793235)
Affinity DataKi:  1.80nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156792(CHEMBL3792581)
Affinity DataKi:  2nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156778(CHEMBL3793153)
Affinity DataKi:  2nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156776(CHEMBL3792593)
Affinity DataKi:  2nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156796(CHEMBL3792781)
Affinity DataKi:  2.20nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319005((R)-4-(1-aminoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50316992(2-amino-4-phenyl-9-(pyrrolidin-1-ylmethyl)-5H-inde...)
Affinity DataKi:  2.5nMAssay Description:Antagonist activity at adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50317014(2-amino-4-(3-methoxyphenyl)-5H-indeno[1,2-d]pyrimi...)
Affinity DataKi:  2.5nMAssay Description:Antagonist activity at adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50316899(2-amino-8-(4-methylpiperazin-1-yl)-4-phenyl-5H-ind...)
Affinity DataKi:  2.70nMAssay Description:Antagonistic activity at adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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