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Found 352 with Last Name = 'herbert' and Initial = 'r'
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50095049(3-(1-Phenethyl-piperidin-4-yl)-2-phenyl-1H-indole ...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]-ketanserin from human 5-hydroxytryptamine 2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50095053(3-[1-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-pi...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]-ketanserin from human 5-hydroxytryptamine 2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50095053(3-[1-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-pi...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]-ketanserin from human 5-hydroxytryptamine 2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50451155(CHEMBL3084807)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]-ketanserin from human 5-hydroxytryptamine 2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50451155(CHEMBL3084807)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]ketanserin from human 5-hydroxytryptamine 2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50095048(3-[1-(8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-piper...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]-ketanserin from human 5-hydroxytryptamine 2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50095028(2-Phenyl-3-(2-piperidin-1-yl-ethyl)-1H-indole | CH...)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]-ketanserin from human 5-hydroxytryptamine 2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50095054(1-{2-[4-(2-Phenyl-1H-indol-3-yl)-piperidin-1-yl]-e...)
Affinity DataKi:  7.30nMAssay Description:Displacement of [3H]-ketanserin from human 5-hydroxytryptamine 2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50095055(3-(1-Methyl-piperidin-4-yl)-2-phenyl-1H-indole | C...)
Affinity DataKi:  7.80nMAssay Description:Displacement of [3H]-ketanserin from human 5-hydroxytryptamine 2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50095050(2-Phenyl-3-piperidin-4-yl-1H-indole | 2-phenyl-3-(...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]-ketanserin from human 5-hydroxytryptamine 2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50117522((5S,6R,9S)-5-(4-Fluoro-phenyl)-9-(2-trifluoromethy...)
Affinity DataKi:  28nMAssay Description:Binding affinity of the compound to human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50095051(3-(1-Benzyl-piperidin-4-yl)-2-phenyl-1H-indole | C...)
Affinity DataKi:  28nMAssay Description:Displacement of [3H]-ketanserin from human 5-hydroxytryptamine 2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50117508((5S,6R,9R)-5-(4-Fluoro-phenyl)-9-(2-trifluoromethy...)
Affinity DataKi:  400nMAssay Description:Binding affinity of the compound to human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50002660(((2S,3S)-2-Benzhydryl-1-aza-bicyclo[2.2.2]oct-3-yl...)
Affinity DataIC50:  0.0850nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50290861(5-{3-[1-(3,5-Dichloro-phenyl)-ethoxy]-2-phenyl-pip...)
Affinity DataIC50:  0.0900nMAssay Description:Antagonism of NK1 receptor in rat liver microsomes.More data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50117509((3S,5S,10S)-5-(4-Fluoro-phenyl)-10-[2-methoxy-5-(5...)
Affinity DataIC50:  0.100nMAssay Description:Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50117523(5-{(5S,10S)-5-(4-Fluoro-phenyl)-10-[2-methoxy-5-(5...)
Affinity DataIC50:  0.100nMAssay Description:Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50290865(3-[1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-2-ph...)
Affinity DataIC50:  0.150nMAssay Description:Antagonism of NK1 receptor in rat liver microsomes.More data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50290856(3-[1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-2-ph...)
Affinity DataIC50:  0.160nMAssay Description:Antagonism of NK1 receptor in rat liver microsomes.More data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50290859(5-{3-[1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-2...)
Affinity DataIC50:  0.160nMAssay Description:Antagonism of NK1 receptor in rat liver microsomes.More data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50052280((2S,3S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-2-ph...)
Affinity DataIC50:  0.180nMAssay Description:Antagonism of NK1 receptor in rat liver microsomes.More data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029878((2R,3S)-2-Benzhydryl-3-(3,5-bis-trifluoromethyl-be...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029884((2S,3S)-2-Benzhydryl-3-(3,5-bis-trifluoromethyl-be...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029847(2-Benzhydryl-3-(3-iodo-5-methyl-benzyloxy)-1-aza-b...)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50117515(5-[(3S,5S,10S)-5-(4-Fluoro-phenyl)-10-(2-methoxy-p...)
Affinity DataIC50:  0.560nMAssay Description:Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50000040(((2S,3S)-2-Benzhydryl-1-aza-bicyclo[2.2.2]oct-3-yl...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50049468((2S,3S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-2-ph...)
Affinity DataIC50:  0.800nMAssay Description:Antagonism of NK1 receptor in rat liver microsomes.More data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029871(2-Benzhydryl-3-(3,5-dimethyl-benzyloxy)-1-aza-bicy...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029869(2-Benzhydryl-3-(3-methyl-5-trimethylsilanyl-benzyl...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029871(2-Benzhydryl-3-(3,5-dimethyl-benzyloxy)-1-aza-bicy...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50290863(3-[1-(3,5-Dichloro-phenyl)-ethoxy]-2-phenyl-piperi...)
Affinity DataIC50:  0.910nMAssay Description:Antagonism of NK1 receptor in rat liver microsomes.More data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50455940(CHEMBL8250)
Affinity DataIC50:  1.10nMAssay Description:Compound was evaluated for the displacement of [3H]Q-ICS-205-930 from 5-HT3 recognition sites in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50117510(CHEMBL84881 | {5-[5-(4-Fluoro-phenyl)-9-(2-trifluo...)
Affinity DataIC50:  1.10nMAssay Description:Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50108392((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranesMore data for this Ligand-Target Pair
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50117516((3S,5S,10S)-5-(4-Fluoro-phenyl)-10-(2-methoxy-5-tr...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50117521(CHEMBL85626 | {5-[5-(4-Fluoro-phenyl)-9-(2-trifluo...)
Affinity DataIC50:  1.40nMAssay Description:Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029879(2-Benzhydryl-3-(3-methoxy-5-methyl-benzyloxy)-1-az...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029879(2-Benzhydryl-3-(3-methoxy-5-methyl-benzyloxy)-1-az...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029839(2-Benzhydryl-3-(3,5-bis-trifluoromethyl-benzyloxy)...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029839(2-Benzhydryl-3-(3,5-bis-trifluoromethyl-benzyloxy)...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM85330(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
Affinity DataIC50:  1.90nMAssay Description:Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranesMore data for this Ligand-Target Pair
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM21016(CHEMBL22870 | L 732138 | L-732,138 | L732138 | N-a...)
Affinity DataIC50:  2.5nMAssay Description:Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50455933(CHEMBL1169549)
Affinity DataIC50:  2.60nMAssay Description:Compound was evaluated for the displacement of [3H]Q-ICS-205-930 from 5-HT3 recognition sites in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50117514((3S,5S,10S)-5-(4-Fluoro-phenyl)-10-(5-isopropyl-2-...)
Affinity DataIC50:  2.80nMAssay Description:Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50455913(CHEMBL1169545)
Affinity DataIC50:  2.90nMAssay Description:Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50455942(CHEMBL7788)
Affinity DataIC50:  3.10nMAssay Description:Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50455920(CHEMBL1169546)
Affinity DataIC50:  3.20nMAssay Description:Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50455924(CHEMBL276728)
Affinity DataIC50:  3.5nMAssay Description:Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029850(3-(3,5-Bis-trifluoromethyl-benzyloxy)-2-(1,2-diphe...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50455939(CHEMBL8615)
Affinity DataIC50:  4.80nMAssay Description:Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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